- Research article
- Open Access
Calcar screws and adequate reduction reduced the risk of fixation failure in proximal humeral fractures treated with a locking plate: 190 patients followed for a mean of 3 years
Journal of Orthopaedic Surgery and Research volume 13, Article number: 197 (2018)
Fixation of proximal humeral fractures (PHF) with locking plates has gained popularity over conservative treatment, but surgery may be complicated with infection, non-union, avascular necrosis (AVN) of the humeral head and fixation failure. Failure to achieve structural support of the medial column has been suggested to be an important risk factor for fixation failure. The aims of this study were to examine the effect of calcar screws and fracture reduction on the risk of fixation failure and to assess long-term shoulder pain and function.
This was a single-centre retrospective study of 190 adult PHF patients treated with a locking plate between 2011 and 2014. Reoperations due to fixation failure were the primary outcome. Risk factors for fixation failure were assessed using the Cox regression analysis. Postoperative shoulder pain and function were assessed by the Oxford Shoulder Score (OSS).
Thirty-one of 190 (16%) patients underwent a reoperation: 14 (7%) due to fixation failure, 10 (5%) due to deep infection and 2 (1%) due to AVN. The absence of calcar screws and fixation with residual varus malalignment (head-shaft angle < 120°) both increased the risk of fixation failure with an adjusted hazard ratio (95% CI) of 8.6 (1.9–39.3; p = 0.005) and 4.9 (1.3–17.9; p = 0.02), respectively. The median (interquartile range) OSS was 40 (27–46).
The use of calcar screws, as well as the absence of postoperative varus malalignment, significantly reduced the risk of fixation failure. We, therefore, recommend the use of calcar screws and to avoid residual varus malalignment to improve the medial support of proximal humeral fractures treated with a locking plate.
Proximal humeral fractures (PHFs) represent the third most frequent fragility fracture . The incidence of surgical treatment has increased, and fracture fixation with locking plates has become a popular treatment . Cochrane reviews do not support this trend . Patients treated surgically probably need more subsequent surgery than conservatively treated patients . Reoperation rates after primary fixation of PHFs may reach 30%  due to mechanical fixation failure, surgical site infection, screw perforation or avascular necrosis (AVN) of the humeral head. Failure to achieve structural support of the medial column has been suggested to be an important risk factor for fixation failure [6,7,8,9].
We, therefore, studied the effect of calcar screws and postoperative varus malalignment on the risk of fixation failure in adult patients with a PHF treated with a locking plate. A secondary aim was to assess long-term shoulder pain and function reported by these patients.
The patients were retrospectively identified by a digital search for locking plate fixations of PHF performed at Akershus University Hospital, Norway, between January 2011 and December 2014. We identified 229 eligible adult patients (18 years and above). As explained in Table 1, 39 (17%) patients were not included, and we did not send the OSS questionnaire to 43 patients.
For the final analyses, 190 patients were included. The patients’ medical records were reviewed for patient, fracture and procedural characteristics. Furthermore, we recorded clinical and radiological results including surgically related complications and reoperations. Patients were retrospectively observed until whichever of the following events first occurred: re-operation, end of study period or death. The individual times to events were used in the Cox regression analyses, and the end of the study period was July 30, 2016, for all patients.
Two of the authors (SO and AKBW), blinded for the clinical outcome, assessed pre- and post-operative anteroposterior (AP) and trans-scapular shoulder radiographs stored in the hospital’s digital image database. Patients were categorised in two groups by the presence or absence of calcar screws as seen in postoperative radiographs (Fig. 1). Calcar screws were defined as obliquely placed 3.5 mm screws locked to the plate and with purchase in the inferomedial quadrant of the humeral head . Pre and postoperative fracture malalignment was evaluated by measuring the head-shaft angle (HSA) using the method described by Agel  (Fig. 1). Consistent with previously published data, postoperative varus malalignment was defined as an HSA < 120°  and an HSA of 135° defined the physiological reference value . Fractures were categorised according to the number of fragments as two, three or four part fractures, corresponding to the Arbeitsgemeinschaft für osteosynthesefragen/Orthopaedic Trauma Association’s (AO/OTA) classification A, B or C type fractures, respectively .
Patient-reported shoulder pain and function were assessed by a validated Norwegian version of the Oxford Shoulder Score (OSS), consisting of 12 questions with scores ranging from 0 (worst possible result) to 4 (best possible result) . OSS was graded as poor (< 36 points), good (36–41 points) and excellent (> 41 points) . The OSS questionnaire was mailed to 147 of 190 (77%) patients during June and July, 2016, and 43 patients (23%) were not eligible to complete the questionnaire (Table 1).
During the study period, our centre considered patients with the following fracture characteristics for open reduction and locking plate fixation: an HSA < 105° (varus displacement), an HSA > 180° (valgus displacement) and displacement of the tuberosities more than 5 mm and/or less than 50% contact between the shaft and the head fragments. Patients who were offered locking plate fixation, received general anaesthesia, an inter-scalene brachial plexus block, or both, and were positioned in a beach chair position. Open reduction was performed through either a classic deltopectoral approach or by the less invasive deltoid split approach, depending on fracture characteristics and surgeon’s preference. The surgeon reduced the fracture under fluoroscopic guidance by the aid of non-absorbable sutures placed in the rotator cuff and temporary fixation with Kirschner wires. A 5-hole locking plate (PHILOS, DePuy Synthes, West Chester, Pennsylvania, USA) was temporarily fixed to the reduced fracture fragments using Kirschner wires and the cuff sutures and approximated to the humeral shaft using a 3.5 mm cortical screw. If a deltoid split approach was used, the shaft screws were placed percutaneously or through a mini-open approach. Finally, 3.5 mm locking screws were inserted into the humeral head after subtracting 5 mm screw length from the joint line contour to minimise the risk of subsequent perforation. No patients received medial buttress plate or allograft reinforcement during the study period. Bone substitute (HydroSet, Stryker, or STRUCSURE CP, Smith & Nephew) was used in valgus impacted fractures at the surgeon’s discretion. All patients received three doses of perioperative antibiotic prophylaxis (cloxacillin 2 g + 1 g + 1 g, or clindamycin 600 mg + 300 mg + 300 mg in case of penicillin allergy).
Physiotherapists instructed all patients orally and in writing in post-operative rehabilitation exercises as per local guidelines. Patients were routinely scheduled for follow-up after 6–8 weeks (Fig. 2). Patients with prolonged pain, radiologically evident loss of reduction, fixation failure, non-union or AVN were scheduled for additional follow-ups. These patients were followed every 6–8 weeks with radiographs until union, or until they were scheduled for revision surgery with re-fixation or arthroplasty.
The Shapiro–Wilk test was used to assess continuous variables for normal distribution. Normally distributed variables were described by means and standard deviations (SDs) and non-normally distributed variables by medians and interquartile ranges (IQRs). The corresponding statistical tests used to compare differences between the two groups were independent two-sample t test and the Mann–Whitney U test. Categorical variables were described as numbers and percentages, and differences between groups were compared using z-statistics. Inter-rater reliability (IRR) for radiological measurements was assessed using the intraclass correlation coefficient (ICC). The Cox proportional hazards regression analysis was used to assess risk factors for fixation failure. The assumption of proportional hazards was tested by inspection of log-minus-log plots. In the multivariable Cox regression, the variables were adjusted for age and sex. Statistical analyses were performed using the IBM SPSS version 24 for Mac.
The regional ethical committee of south east Norway reviewed and delegated the approval of this study (reference no. 2015/1435) to the Data Protection Official at Akershus University Hospital who granted the ethics approval (reference no. 15–128).
Ninety-three of 190 (49%) patients were operated without calcar screws and 97 of 190 (51%) with calcar screws. The median follow-up time was 35 (range 0.3–65) months, and the median time for the last radiological examination was 3, 4 (range 0,03–53) months.
Patient demographics, fracture characteristics and perioperative circumstances, categorised by application of calcar screws are presented in Table 2.
Patients operated without calcar screws were nearly 5 years younger than those operated with calcar screws (mean difference = 4.7 (95% CI: 0.7–8.7); p = 0.02). Patients with an intact medial column of the proximal humerus were more often operated without calcar screws, and these fractures were more often approached by deltoid split. Patients with preoperative varus (HSA < 105°) were more often fixated in residual varus malalignment (HSA < 120°) compared to those who presented with a preoperative HSA > 105° (8 of 11 (73%) versus 33 of 170 (19%); p < 0.001). Thirty-one of 190 (16%) patients with PHF treated with a locking plate required a reoperation: 14 (7%) due to fixation failure, 10 (5%) due to deep surgical site infection and 2 (1%) due to avascular necrosis of the humeral head. In addition, 5 (3%) patients underwent hardware removal due to presumably implant-related local shoulder pain. Patients operated without calcar screws more often required a reoperation than those who received calcar screws (12 of 93 (13%) versus 2 of 97 (2%); p = 0.005) (Table 3).
Patients operated without calcar screws had a 6-fold increased risk of a reoperation due to fixation failure compared to those who received calcar screws (hazard ratio (HR) = 6.5 (95% CI 1.5–28.9; p = 0.02) (Table 4).
Adjusting for age and gender, the risk of fixation failure without the use of calcar screws was even greater (HR = 8.6 (95% CI 1.9–39.3; p = 0.005) (Table 5).
Fixation of the humeral head with a residual varus malalignment (HSA < 120°) also increased the risk of reoperations due to fixation failure (HR = 5.2 (95% CI 1.5–18.7; p = 0.01), and adjusting for age and gender, HR = 4.9 (95% CI 1.3–17.9; p = 0.02). The interrater agreement for measurements of the postoperative HSA was excellent (ICC (95% CI) = 0.91 (0.88–0.93) .
There were 132 of 148 (89%) patients who completed the OSS questionnaire. The median long-term shoulder function was 40 (IQR 27–46). OSS was available for 19 of 31 (61%) patients who needed a reoperation and for 113 of 117 (97%) patients who did not undergo secondary surgery. Patients who did not require secondary surgery had a significantly better shoulder score than those who underwent a reoperation (median OSS (IQR) = 41 (33–46) versus 25 (13–32); p < 0.001).
We found that the use of calcar screws and adequate reduction of the fracture, to achieve medial support, significantly reduced the risk of a reoperation due to fixation failure in patients with a PHF treated with a locking plate.
Medial support can be restored by anatomical reduction in fractures without medial comminution to reduce the risk of fixation failure. In fractures with medial comminution, calcar screws, medialization and impaction of the humeral shaft onto the humeral head or both, may restore a medial support . Alternatively, some authors advocate the use of an additional medial buttress plate , allograft reinforcement [19, 20], bone substitution [9, 21] or intramedullary nailing [22,23,24].
Although we were aware of the possible importance of calcar screws during the study period, calcar screws were only used in half of the patients. One possible explanation was that the less invasive deltoid split approach was introduced during the study period, and that calcar screws were initially avoided using this approach to prevent iatrogenic axillary nerve injury. However, with increased experience with the deltoid split approach, calcar screws could be placed safely . A cadaveric study has shown improved stability in the fracture with calcar screws, both in fractures with medial comminution and in fractures with intact medial column, suggesting the use of calcar screws in all PHFs in an osteoporotic bone . On the other side, calcar screws may not be sufficient to prevent fixation failure if the fracture is fixed in varus and may not be essential when there is good medial support .
In keeping with a previous study, we found that postoperative varus malalignment significantly increased the risk of a reoperation due to fixation failure . Interestingly we did not find that preoperative varus was an independent risk factor for fixation failure, which contradicts the findings presented by Jung et al. . However, both pre and postoperative varus malalignment have been associated with an increased risk of fixation failure . Residual postoperative varus was more often found in patients who presented with a preoperative varus malalignment, and surgeons should be aware that such PHF subtypes may be especially at risk for fixation failure.
In the present retrospective cohort study, the number of reoperations (16%) was in the lower range of previously published data in two systematic review articles, ranging from 13 to 30% [5, 30]. Patients who underwent a reoperation reported poor long-term shoulder function, compared to good shoulder function reported by those who did not undergo a secondary surgery. The poorer outcomes following revision surgery are in line with other studies [31, 32], which points out the importance of a successful first intervention. The overall long-term shoulder function in our cohort was good, which is consistent with a multicentre randomised controlled trial that compared surgical treatment to conservative treatment in adult patients with PHF . The authors of that study did not find any advantage of surgical over conservative management in terms of shoulder pain and function after 2 years. However, critics have questioned the recruitment process, as 1000 of 1250 (80%) eligible patients were not included, counting 87 patients with a “clear indication for surgery” .
Primary reverse total shoulder arthroplasty (RTSA) has been advocated to avoid revision surgery following inadequate reduction and unstable fixation . RTSA has gained popularity and showed promising results, especially in elderly patients , also when compared to locking plate fixation . However, RTSA complications are potentially adverse and include prosthetic joint infection, instability, neurological injury, scapular notching and periprosthetic fractures . Still, RTSA may be a relevant choice for the primary surgical treatment of displaced PHFs among patients aged 65 years and above with poor rotator cuff status and high risk of healing complications [9, 39]. However, there are few level I trials, and two ongoing randomised controlled multicentre trials compare treatment of PHFs with locking plate versus RTSA  and locking plate versus RTSA or versus conservative treatment . Hopefully, these trials will prove high-level evidence and guide the surgical treatment of proximal humeral fractures accordingly.
The main limitations of the current study were the retrospective design, possibly missing complications treated at other hospitals, and the lack of a matched control group to assess shoulder function in conservatively treated patients. Furthermore, we did not have radiographs of the contralateral uninjured shoulder, possibly introducing classification bias when evaluating the postoperative malalignment. The main strengths of our study were the number of patients and the high response rate for OSS questionnaires (89%).
Medial support seems to be important to enhance stability and to avoid fixation failure in proximal humeral fractures and, hence, revision surgeries. In the present retrospective cohort study of 190 patients with a proximal humeral fracture treated with a locking plate, the use of calcar screws and the absence of postoperative varus malalignment (head-shaft angle > 120°), significantly reduced the risk of fixation failure. We, therefore, recommend the use of calcar screws and to avoid residual varus malalignment to improve the medial support of proximal humeral fractures treated with a locking plate.
Intraclass correlation coefficient
Oxford Shoulder Score
Proximal humeral fractures
Reverse total shoulder arthroplasty
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Availability of data and materials
The dataset used and analysed during the current study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
The regional ethical committee of south east Norway reviewed and delegated the approval of this study (reference no. 2015/1435) to the Data Protection Official at Akershus University Hospital who granted the ethics approval (reference no. 15–128).
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Oppebøen, S., Wikerøy, A.K.B., Fuglesang, H.F.S. et al. Calcar screws and adequate reduction reduced the risk of fixation failure in proximal humeral fractures treated with a locking plate: 190 patients followed for a mean of 3 years. J Orthop Surg Res 13, 197 (2018). https://doi.org/10.1186/s13018-018-0906-y
- Proximal humeral fracture
- Locking plate fixation
- Fixation failure
- Calcar screws
- Long-term shoulder function