Articles

Cornuside I promoted osteogenic differentiation of bone mesenchymal stem cells through PI3K/Akt signaling pathway

Osteoporosis is a common disease closely associated with aging. In this study, we aimed to investigate the role of Cornuside I in promoting osteogenic differentiation of bone mesenchymal stem cells (BMSCs) and...

Authors: Feng Gao, Sheng-Li Xia, Xiu-Hui Wang, Xiao-Xiao Zhou and Jun Wang

Lateral entry pins and Slongo’s external fixation: which method is more ideal for older children with supracondylar humeral fractures?

The standard surgical treatment for supracondylar humeral fractures in children is closed reduction and percutaneous pinning. Given the need for greater fixation strength and higher risk of joint stiffness for...

Authors: Man He, Qian Wang, Jingxin Zhao, Yu Jin and Yu Wang

CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, and fibroblast-like synoviocytes (FLSs) are key effector cells in RA development. Mounting evidence indicates that circular RNAs (circRNAs) pa...

Authors: Zhihuan Luo, Shaojian Chen and Xiaguang Chen

Therapeutic analysis of Herbert screw fixation for capitellar fractures via the anterior approach in adolescent patients

The aim of this study is to analyze the efficacy of open reduction and Herbert screw fixation for coronal fractures of the capitellum via the anterior approach in adolescents.

Authors: Lingpeng Ju, Linjun Jiang, Yuan Zhang, Jun Wu, Ming Li, Xing Liu and Xiangyang Qu

Intraoperative blood loss as indicated by haemoglobin trend is a predictor for the development of postoperative spinal implant infection—a matched-pair analysis

With a reported rate of 0.7–20%, postoperative spinal implant infection (PSII) is one of the most common complications after spine surgery. While in arthroplasty both haematoma formation and perioperative bloo...

Authors: Friederike Schömig, Justus Bürger, Zhouyang Hu, Axel Pruß, Edda Klotz, Matthias Pumberger and Christian Hipfl

Circ-SPG11 knockdown hampers IL-1β-induced osteoarthritis progression via targeting miR-337-3p/ADAMTS5

Osteoarthritis (OA) is responsible for the impotent disability in old people. Circular RNA (circRNA) has been reported to be related to the development of diseases. The lack of research on the role of circRNA ...

Authors: Yongqiang Liu, Qian Li, Zhida Gao, Fang Lei and Xuefeng Gao

The biomechanical effect on the adjacent L4/L5 segment of S1 superior facet arthroplasty: a finite element analysis for the male spine

The superior facet arthroplasty is important for intervertebral foramen microscopy. To our knowledge, there is no study about the postoperative biomechanics of adjacent L4/L5 segments after different methods o...

Authors: Zewen Shi, Lin Shi, Xianjun Chen, Jiangtao Liu, Haihao Wu, Chenghao Wang, Zeming Chen, Fang Yang, Sheng Yu and Qingjiang Pang

Confidence level, challenges, and obstacles faced by orthopedic residents in obtaining informed consent

The objective is to evaluate the opinions of orthopedic residents on current practices, experiences, training, confidence level, difficulties, and challenges faced when obtaining informed consent.

Authors: Abdulaziz Z. Alomar

How much improvement can satisfy patients? Exploring patients’ satisfaction 3 years after total knee arthroplasty

Despite the innovations in total knee arthroplasty (TKA), there is still a subset of patients who do not acquire significant relief or expected satisfaction after primary TKA. However, this subgroup of patient...

Authors: Xiao Yu Fan, Jin Hui Ma, Xinjie Wu, Xin Xu, Lijun Shi, Tengqi Li, Peixu Wang, Chengxin Li, Zhizhuo Li, Qing Yu Zhang and Wei Sun

The EOS 3D imaging system reliably measures posterior tibial slope

One of the values determined during the assessment of knee issues is the posterior tibial slope (PTS). A new option for measuring the PTS is the EOS 3D imaging system, which provides anteroposterior (AP) and l...

Authors: Andreas Hecker, Till D. Lerch, Rainer J. Egli, Emanuel F. Liechti and Frank M. Klenke

Haemoglobin and transfusions in elderly patients with hip fractures: the effect of a dedicated orthogeriatrician

Hip fractures are common in elderly patients, in whom it is important to monitor blood loss; however, unnecessary transfusions should be avoided. The primary objective of this study was to assess whether the e...

Authors: Marco Quaranta, Luca Miranda, Francesco Oliva, Filippo Migliorini, Gabriela Pezzuti and Nicola Maffulli

The comparison between anterior and posterior approaches for removal of infected lumbar interbody cages and a proposal regarding the use of endoscope-assisted technique

In cases of postoperative deep wound infection after interbody fusion with cages, it is often difficult to decide whether to preserve or remove the cages, and there is no consensus on the optimal approach for ...

Authors: Yun-Da Li, Jia-En Chi, Ping-Yeh Chiu, Fu-Cheng Kao, Po-Liang Lai and Tsung-Ting Tsai

Increased acromiohumeral distance in a double-row arthroscopic rotator cuff surgery compared to a single-row surgery after 12 months

Arthroscopic rotator cuff surgery is an effective treatment for rotator cuff tears with the considered use of double-row repair techniques becoming popular in the last decade. We aim to compare the effects of ...

Authors: Kaya Turan, Haluk Çabuk, Cenk Köroğlu and Çağatay Öztürk

Comparison of SDSG and CARDS classifications for L5/S1 lumbar degenerative spondylolisthesis: an independent inter- and intra-observer agreement study

Lumbar degenerative spondylolisthesis (DS) has been a common disease that makes increasing patients to suffer from different degrees of low back pain and radicular symptoms. The Spinal Deformity Study Group (S...

Authors: Zhengwang Sun, Chongqing Xu, Mengchen Yin and Wangjun Yan

Accuracy of tibial tuberosity-trochlear groove distance and tibial tuberosity-posterior cruciate ligament distance in terms of the severity of trochlear dysplasia

Increased tibial tubercle-trochlear groove distance (TT-TG) was proposed as one of the main risk factors for patellofemoral instability (PFI). The increased TT-TG distance indicated externalization of the tibi...

Authors: Conglei Dong, Chao Zhao, Ming Li, Chongyi Fan, Xunkai Feng, Kang Piao, Kuo Hao and Fei Wang

Efficacy and safety of a self-developed home-based enhanced knee flexion exercise program compared with standard supervised physiotherapy to improve mobility and quality of life after total knee arthroplasty: a randomized control study

This randomized controlled study compared standard supervised physiotherapy (SPT) with a self-developed, home-based, enhanced knee flexion exercise program involving a low stool (KFEH) in patients who underwen...

Authors: Tianyang Xu, Dong Yang, Kaiyuan Liu, Qiuming Gao, Hengli Lu, Yue Qiao, Chunyan Zhu and Guodong Li

Patellar retraction versus eversion on functional outcomes in total knee replacement: a randomized controlled study protocol

Patellar mobilization technique during total knee replacement (TKR) has been debated, with some suggesting that lateral retraction, rather than eversion, of the patella may be beneficial. This randomized contr...

Authors: Zhao Wang, Yong Ji, Hongwei Bao, Jingzhao Hou and Yan-xiao Cheng

Biportal endoscopic posterior lumbar decompression and vertebroplasty for extremely elderly patients affected by lower lumbar delayed vertebral collapse with lumbosacral radiculopathy

Lower lumbar osteoporotic vertebral compression fracture in extremely elderly patients can often lead to lumbosacral radiculopathy (LSR) due to delayed vertebral collapse (DVC). Surgical intervention requires ...

Authors: Min-Seok Kang, Dong-Hwa Heo, Hoon-Jae Chung, Ki-Han You, Hyong-Nyun Kim, Jun-Young Choi and Hyun-Jin Park

Expression of VEGF-A Signaling Pathway in Cartilage of ACLT-induced Osteoarthritis Mouse Model

Anterior cruciate ligament transection surgery (ACLT)-induced OA model was often used to investigate the molecular mechanism of knee osteoarthritis (KOA). Researches have shown that vascular endothelial growth...

Authors: Jia-jia Qian, Qi Xu, Wei-min Xu, Ren Cai and Gui-cheng Huang

Conservative versus tailored surgical treatment in patients with first time lateral patella dislocation: a randomized-controlled trial

Patellar instability has a high incidence and occurs particularly in young and female patients. If the patella dislocates for the first time, treatment is usually conservative. However, this cautious approach ...

Authors: M. Liebensteiner, A. Keiler, R. El Attal, P. Balcarek, F. Dirisamer, J. Giesinger, G. Seitlinger, M. Nelitz, A. Keshmiri, J. Frings, Ch. Becher, P. Kappel, D. Wagner and G. Pagenstert

Sonication fluid culture of antibiotic-loaded bone cement spacer has high accuracy to confirm eradication of infection before reimplantation of new prostheses

Sonication fluid culture of antibiotic-loaded bone cement spacer has been used to predict reinfection of two-stage revision, but its value remains disputable. This study aims to evaluate the association betwee...

Authors: Qingyu Zhang, Baocong Ding, Jinglin Wu, Jun Dong and Fanxiao Liu

Suprascapular nerve block is a clinically attractive alternative to interscalene nerve block during arthroscopic shoulder surgery: a meta-analysis of randomized controlled trials

The interscalene brachial plexus block (ISB) is a commonly used nerve block technique for postoperative analgesia in patients undergoing shoulder arthroscopy surgery; however, it is associated with potentially...

Authors: Changjiao Sun, Xiaolin Ji, Xiaofei Zhang, Qi Ma, Peng Yu, Xu Cai and Huadong Yang

Long-term outcomes of cementless femoral stem revision with the Wagner cone prosthesis

The procedure of femoral stem revision is challenging, and bone conservation with less stress shielding is a mandatory effort in these cases. Although there are several reports of stem revision with stems desi...

Authors: Kyung-Soon Park, Sheng-Yu Jin, Jun-Hyuk Lim and Taek-Rim Yoon

Logistic regression analysis on risk factors of augmented vertebra recompression after percutaneous vertebral augmentation

To explore the high-risk factors of augmented vertebra recompression after percutaneous vertebral augmentation (PVA) in the treatment of osteoporotic vertebral compression fracture (OVCF) and analyze the corre...

Authors: Zhongcheng An, Chen Chen, Junjie Wang, Yuchen Zhu, Liqiang Dong, Hao Wei and Lianguo Wu

The efficacy and safety of tranexamic acid in high tibial osteotomy: a systematic review and meta-analysis

The present meta-analysis was conducted to evaluate the efficacy and safety of the application of tranexamic acid (TXA) in patients undergoing high tibial osteotomy (HTO).

Authors: Jimin Ma, Hanli Lu, Xinxing Chen, Dasai Wang and Qiang Wang

Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China

Hand grip strength is a complex phenotype. The current study aimed to identify the effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among midd...

Authors: Haoyu He, Huaxiang Lu, Shuzhen Liu, Jiansheng Cai, Xu Tang, Chunbao Mo, Xia Xu, Quanhui Chen, Min Xu, Chuntao Nong, Qiumei Liu, Junling Zhang, Jian Qin and Zhiyong Zhang

MiR-24-3p attenuates IL-1β-induced chondrocyte injury associated with osteoarthritis by targeting BCL2L12

MiR-24-3p has been reported to be involved in an osteoarthritis (OA)-resembling environment. However, the functional role and underlying mechanism of miR-24-3p in chondrocyte injury associated with OA remains ...

Authors: Jin Xu, Xiaozhong Qian and Ren Ding

Clinical outcome of femoral neck system versus cannulated compression screws for fixation of femoral neck fracture in younger patients

The clinical outcome of a new fixation device (femoral neck system, FNS) for femoral neck fractures remains unclear. The main purpose of this study was to evaluate two different internal fixation methods for t...

Authors: Huaijian Hu, Jingbo Cheng, Mingli Feng, Zhihua Gao, Jingwei Wu and Shibao Lu

The use of extracorporeal shock wave therapy for the treatment of bone marrow oedema — a systematic review and meta-analysis

Extracorporeal shock wave therapy (ESWT) has been used for various pathologies associated with bone marrow oedema (BME). However, it is still not clear whether ESWT may be favourable in the treatment of BME. T...

Authors: Jonathan Häußer, Juliane Wieber and Philip Catalá-Lehnen

Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats

Adjacent segmental intervertebral disk degeneration (ASDD) is a major complication secondary to lumbar fusion. Although ASSD pathogenesis remains unclear, the primary cause of intervertebral disk degeneration ...

Authors: Qi Sun, Xin-Yu Nan, Fa-Ming Tian, Fang Liu, Shao-Hua Ping, Zhuang Zhou and Liu Zhang

Abstaining from symptomatic implants of modified tension band wiring by nonabsorbable suture fixation for transverse patella fractures

Modified tension band fixation has become commonly used for transverse patella fractures. The conventional stainless steel wire provides sufficient stability but may be associated with complications.

Authors: Puripun Jirangkul and Arkaphat Kosiyatrakul

Comparison of lateral entry and crossed entry pinning for pediatric supracondylar humeral fractures: a meta-analysis of randomized controlled trials

Closed reduction and pinning entry fixation have been proposed as treatment strategies for displaced supracondylar humeral fractures (SCHFs) in children. However, controversy exists regarding the selection of ...

Authors: Huaguo Zhao, Song Xu, Guanyi Liu, Jingyu Zhao, Shandong Wu and Linrui Peng

Fracture of the inferior pole of the patella: tension band wiring versus transosseous reattachment

The optimal surgical technique for the fixation of inferior pole patellar fracture remains controversial. The aims of this study were (1) to compare clinical and radiological outcomes following fixation of inf...

Authors: Chih-Hsun Chang, Hao-Chun Chuang, Wei-Ren Su, Fa-Chuan Kuan, Chih-Kai Hong and Kai-Lan Hsu

NDRG1 regulates osteosarcoma cells via mediating the mitochondrial function and CSCs differentiation

Cancer stem cells (CSCs) are mainly contributed to malignancy metastatic potential and resistant therapy of osteosarcoma (OS). The mitochondria-related apoptosis was generally accepted as the target of tumor t...

Authors: Tong Zhao, Ying Meng, Yongping Wang and Wenji Wang

Accuracy of institutional orthopedic trauma databases: a retrospective chart review

Academic trauma institutions rely on fracture databases as research and quality control tools. Frequently, these databases are populated by trainees, but the completeness and accuracy of such databases has not...

Authors: Aman Chopra, Abigail C. Cortez, Ashraf El Naga, Anthony Ding and Saam Morshed

The effect of aqueous extract of Prunus dulcis on tibial bone healing in the rabbit

Bone fractures are medical emergencies that require prompt intervention to help return bone to its normal function. Various methods and treatments have been utilized to increase the speed and efficiency of bon...

Authors: Nima Anaraki, Amir Hossein Beyraghi, Abbas Raisi, Farshid Davoodi, Ghasem Farjanikish and Amin Bigham Sadegh

First metatarsophalangeal fusion with dorsal plate: clinical outcomes

First metatarsophalangeal joint (MTPJ) fusion is the most effective technique for the treatment of MTPJ primary arthritis, severe hallux valgus and failure of primary corrective surgery of these conditions. It...

Authors: Giuseppe Restuccia, Fabio Cosseddu, Andrea del Chiaro, Matteo Ceccoli, Alessandro Lippi and Sheila Shytaj

Perioperative red blood cell infusion and deep vein thrombosis in patients with femoral and pelvic fractures: a propensity score matching

The relationship between perioperative red blood cell (RBC) infusion and deep vein thrombosis (DVT) has not been determined.

Authors: Linqin Wu and Bo Cheng

Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

WNT1 c.110 T>C and c.505G>T missense mutations have been identified in patients with osteogenesis imperfecta (OI). Whether these mutations affect osteoblast differentiation remains to be determined. This study ai...

Authors: Bashan Zhang, Rong Li, Wenfeng Wang, Xueming Zhou, Beijing Luo, Zinian Zhu, Xibo Zhang and Aijiao Ding

The short-term effectiveness and safety of second-generation patellofemoral arthroplasty and total knee arthroplasty on isolated patellofemoral osteoarthritis: a systematic review and meta-analysis

We aimed to compare second-generation patellofemoral arthroplasty (2G PFA) with total knee arthroplasty (TKA) in treating isolated patellofemoral osteoarthritis (PFOA) by assessing the percentages of revisions...

Authors: Chengxin Li, Zhizhuo Li, Lijun Shi, Fuqiang Gao and Wei Sun

Percutaneous periarticular analgesic injection at one day after simultaneous bilateral total knee arthroplasty: an open-label randomized control trial

The postoperative pain after total knee arthroplasty (TKA) remains a critical issue. The aim of this study was to assess the clinical effectiveness of percutaneous periarticular injection at 1 day following si...

Authors: Takuya Iseki, Sachiyuki Tsukada, Motohiro Wakui, Kenji Kurosaka, Shinichi Yoshiya and Toshiya Tachibana

The effect of care transition pathway implementation on patients undergoing joint replacement during the COVID-19 pandemic: a quasi-experimental study from a tertiary care hospital orthopedic department in Beijing, China

The coronavirus disease (COVID-19) pandemic has had a massive impact on individuals globally. The Chinese government has formulated effective response measures, and medical personnel have been actively respond...

Authors: Ya-ping Xu, Pei-yu Zhao, Yi-tong Bai and Shuang Li

Incidence and missed diagnosis risk of occult posterior malleolar fractures associated with the tibial shaft fractures: a systematic review

Tibial shaft fractures (TSFs) combined with occult posterior malleolar fractures (PMFs) are becoming widely recognized in the field of orthopedics. The purpose of this study was to determine the clinical incid...

Authors: Zhongzheng Wang, Wei Chen, Yanbin Zhu, Siyu Tian, Kuo Zhao, Jialiang Guo, Zhiyong Hou, Qi Zhang and Yingze Zhang

Treadmill running induces remodeling of the infrapatellar fat pad in an intensity-dependent manner

To investigate the response of the infrapatellar fat pad (IFP) to running at different intensities and further explore the underlying mechanisms of these responses under different running-induced loadings.

Authors: Ni Zeng, Tao Liao, Xin-Yuan Chen, Zhi-Peng Yan, Jie-Ting Li and Guo-Xin Ni

Measurement of operative femoral anteversion during cementless total hip arthroplasty and influencing factors for using neck-adjustable femoral stem

Placement of femoral stem in excessive anteversion or retroversion can cause reduced range of motion, prosthetic impingement, and dislocation. The aim of this study was to assess the operative femoral antevers...

Authors: Jingyang Sun, Bohan Zhang, Lei Geng, Qingyuan Zheng, Juncheng Li, Wenzhe Cao, Ming Ni and Guoqiang Zhang

Safety and efficacy of umbilical cord-derived Wharton’s jelly compared to hyaluronic acid and saline for knee osteoarthritis: study protocol for a randomized, controlled, single-blind, multi-center trial

Osteoarthritis (OA) is the most common joint disorder in the United States of America (USA) with a fast-rising prevalence. Current treatment modalities are limited, and total knee replacement surgeries have sh...

Authors: Ashim Gupta, Nicola Maffulli, Hugo C. Rodriguez, Eric W. Carson, Randa A. Bascharon, Kristin Delfino, Howard J. Levy and Saadiq F. El-Amin III

Potential of biomarkers during pharmacological therapy setting for postmenopausal osteoporosis: a systematic review

Biochemical markers of bone turnover (BTMs), such as the bone alkaline phosphatase (bALP), procollagen type I N propeptide (PINP), serum cross-linked C-telopeptides of type I collagen (bCTx), and urinary cross...

Authors: Filippo Migliorini, Nicola Maffulli, Filippo Spiezia, Giuseppe Maria Peretti, Markus Tingart and Riccardo Giorgino

Minimally invasive internal fixation for unstable pelvic ring fractures: a retrospective study of 27 cases

This study aimed to evaluate the radiographic and clinical outcomes of anterior subcutaneous internal fixation (INFIX) with or without posterior fixation for the treatment of unstable pelvic fractures.

Authors: Shuang Wu, Jialei Chen, Yun Yang, Wei Chen, Rong Luo and Yue Fang

miR-520c-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GAS2

MicroRNAs (miRNAs) have been shown to be associated with osteoarthritis (OA) progression. This study aimed to explore the role of miR-520c-3p in OA progression.

Authors: Le Peng, Ming Deng, Yonggang Ma, Wei Hu and Fan Liang

Retraction Note: Comparison of bone morphogenetic protein and autologous grafting in the treatment of limb long bone nonunion: a systematic review and meta-analysis

Authors: Yong-Qiang Zhou, Hong-Liang Tu, Yan-Ji Duan and Xiao Chen