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  1. Osteoporosis is a common disease closely associated with aging. In this study, we aimed to investigate the role of Cornuside I in promoting osteogenic differentiation of bone mesenchymal stem cells (BMSCs) and...

    Authors: Feng Gao, Sheng-Li Xia, Xiu-Hui Wang, Xiao-Xiao Zhou and Jun Wang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:397

    Content type: Research article

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  2. The standard surgical treatment for supracondylar humeral fractures in children is closed reduction and percutaneous pinning. Given the need for greater fixation strength and higher risk of joint stiffness for...

    Authors: Man He, Qian Wang, Jingxin Zhao, Yu Jin and Yu Wang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:396

    Content type: Research article

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  3. Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, and fibroblast-like synoviocytes (FLSs) are key effector cells in RA development. Mounting evidence indicates that circular RNAs (circRNAs) pa...

    Authors: Zhihuan Luo, Shaojian Chen and Xiaguang Chen

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:395

    Content type: Research article

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  4. The aim of this study is to analyze the efficacy of open reduction and Herbert screw fixation for coronal fractures of the capitellum via the anterior approach in adolescents.

    Authors: Lingpeng Ju, Linjun Jiang, Yuan Zhang, Jun Wu, Ming Li, Xing Liu and Xiangyang Qu

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:394

    Content type: Research article

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  5. With a reported rate of 0.7–20%, postoperative spinal implant infection (PSII) is one of the most common complications after spine surgery. While in arthroplasty both haematoma formation and perioperative bloo...

    Authors: Friederike Schömig, Justus Bürger, Zhouyang Hu, Axel Pruß, Edda Klotz, Matthias Pumberger and Christian Hipfl

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:393

    Content type: Research article

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  6. Osteoarthritis (OA) is responsible for the impotent disability in old people. Circular RNA (circRNA) has been reported to be related to the development of diseases. The lack of research on the role of circRNA ...

    Authors: Yongqiang Liu, Qian Li, Zhida Gao, Fang Lei and Xuefeng Gao

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:392

    Content type: Research article

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  7. The superior facet arthroplasty is important for intervertebral foramen microscopy. To our knowledge, there is no study about the postoperative biomechanics of adjacent L4/L5 segments after different methods o...

    Authors: Zewen Shi, Lin Shi, Xianjun Chen, Jiangtao Liu, Haihao Wu, Chenghao Wang, Zeming Chen, Fang Yang, Sheng Yu and Qingjiang Pang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:391

    Content type: Research article

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  8. Despite the innovations in total knee arthroplasty (TKA), there is still a subset of patients who do not acquire significant relief or expected satisfaction after primary TKA. However, this subgroup of patient...

    Authors: Xiao Yu Fan, Jin Hui Ma, Xinjie Wu, Xin Xu, Lijun Shi, Tengqi Li, Peixu Wang, Chengxin Li, Zhizhuo Li, Qing Yu Zhang and Wei Sun

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:389

    Content type: Research article

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  9. One of the values determined during the assessment of knee issues is the posterior tibial slope (PTS). A new option for measuring the PTS is the EOS 3D imaging system, which provides anteroposterior (AP) and l...

    Authors: Andreas Hecker, Till D. Lerch, Rainer J. Egli, Emanuel F. Liechti and Frank M. Klenke

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:388

    Content type: Research article

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  10. Hip fractures are common in elderly patients, in whom it is important to monitor blood loss; however, unnecessary transfusions should be avoided. The primary objective of this study was to assess whether the e...

    Authors: Marco Quaranta, Luca Miranda, Francesco Oliva, Filippo Migliorini, Gabriela Pezzuti and Nicola Maffulli

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:387

    Content type: Systematic review

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  11. In cases of postoperative deep wound infection after interbody fusion with cages, it is often difficult to decide whether to preserve or remove the cages, and there is no consensus on the optimal approach for ...

    Authors: Yun-Da Li, Jia-En Chi, Ping-Yeh Chiu, Fu-Cheng Kao, Po-Liang Lai and Tsung-Ting Tsai

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:386

    Content type: Research article

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  12. Arthroscopic rotator cuff surgery is an effective treatment for rotator cuff tears with the considered use of double-row repair techniques becoming popular in the last decade. We aim to compare the effects of ...

    Authors: Kaya Turan, Haluk Çabuk, Cenk Köroğlu and Çağatay Öztürk

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:385

    Content type: Research article

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  13. Lumbar degenerative spondylolisthesis (DS) has been a common disease that makes increasing patients to suffer from different degrees of low back pain and radicular symptoms. The Spinal Deformity Study Group (S...

    Authors: Zhengwang Sun, Chongqing Xu, Mengchen Yin and Wangjun Yan

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:384

    Content type: Research article

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  14. Increased tibial tubercle-trochlear groove distance (TT-TG) was proposed as one of the main risk factors for patellofemoral instability (PFI). The increased TT-TG distance indicated externalization of the tibi...

    Authors: Conglei Dong, Chao Zhao, Ming Li, Chongyi Fan, Xunkai Feng, Kang Piao, Kuo Hao and Fei Wang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:383

    Content type: Research article

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  15. This randomized controlled study compared standard supervised physiotherapy (SPT) with a self-developed, home-based, enhanced knee flexion exercise program involving a low stool (KFEH) in patients who underwen...

    Authors: Tianyang Xu, Dong Yang, Kaiyuan Liu, Qiuming Gao, Hengli Lu, Yue Qiao, Chunyan Zhu and Guodong Li

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:382

    Content type: Research article

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  16. Patellar mobilization technique during total knee replacement (TKR) has been debated, with some suggesting that lateral retraction, rather than eversion, of the patella may be beneficial. This randomized contr...

    Authors: Zhao Wang, Yong Ji, Hongwei Bao, Jingzhao Hou and Yan-xiao Cheng

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:381

    Content type: Study protocol

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  17. Lower lumbar osteoporotic vertebral compression fracture in extremely elderly patients can often lead to lumbosacral radiculopathy (LSR) due to delayed vertebral collapse (DVC). Surgical intervention requires ...

    Authors: Min-Seok Kang, Dong-Hwa Heo, Hoon-Jae Chung, Ki-Han You, Hyong-Nyun Kim, Jun-Young Choi and Hyun-Jin Park

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:380

    Content type: Technical note

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  18. Anterior cruciate ligament transection surgery (ACLT)-induced OA model was often used to investigate the molecular mechanism of knee osteoarthritis (KOA). Researches have shown that vascular endothelial growth...

    Authors: Jia-jia Qian, Qi Xu, Wei-min Xu, Ren Cai and Gui-cheng Huang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:379

    Content type: Research article

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  19. Patellar instability has a high incidence and occurs particularly in young and female patients. If the patella dislocates for the first time, treatment is usually conservative. However, this cautious approach ...

    Authors: M. Liebensteiner, A. Keiler, R. El Attal, P. Balcarek, F. Dirisamer, J. Giesinger, G. Seitlinger, M. Nelitz, A. Keshmiri, J. Frings, Ch. Becher, P. Kappel, D. Wagner and G. Pagenstert

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:378

    Content type: Study protocol

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  20. Sonication fluid culture of antibiotic-loaded bone cement spacer has been used to predict reinfection of two-stage revision, but its value remains disputable. This study aims to evaluate the association betwee...

    Authors: Qingyu Zhang, Baocong Ding, Jinglin Wu, Jun Dong and Fanxiao Liu

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:377

    Content type: Research article

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  21. The interscalene brachial plexus block (ISB) is a commonly used nerve block technique for postoperative analgesia in patients undergoing shoulder arthroscopy surgery; however, it is associated with potentially...

    Authors: Changjiao Sun, Xiaolin Ji, Xiaofei Zhang, Qi Ma, Peng Yu, Xu Cai and Huadong Yang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:376

    Content type: Research article

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  22. The procedure of femoral stem revision is challenging, and bone conservation with less stress shielding is a mandatory effort in these cases. Although there are several reports of stem revision with stems desi...

    Authors: Kyung-Soon Park, Sheng-Yu Jin, Jun-Hyuk Lim and Taek-Rim Yoon

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:375

    Content type: Research article

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  23. To explore the high-risk factors of augmented vertebra recompression after percutaneous vertebral augmentation (PVA) in the treatment of osteoporotic vertebral compression fracture (OVCF) and analyze the corre...

    Authors: Zhongcheng An, Chen Chen, Junjie Wang, Yuchen Zhu, Liqiang Dong, Hao Wei and Lianguo Wu

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:374

    Content type: Research article

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  24. Hand grip strength is a complex phenotype. The current study aimed to identify the effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among midd...

    Authors: Haoyu He, Huaxiang Lu, Shuzhen Liu, Jiansheng Cai, Xu Tang, Chunbao Mo, Xia Xu, Quanhui Chen, Min Xu, Chuntao Nong, Qiumei Liu, Junling Zhang, Jian Qin and Zhiyong Zhang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:372

    Content type: Research article

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  25. MiR-24-3p has been reported to be involved in an osteoarthritis (OA)-resembling environment. However, the functional role and underlying mechanism of miR-24-3p in chondrocyte injury associated with OA remains ...

    Authors: Jin Xu, Xiaozhong Qian and Ren Ding

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:371

    Content type: Research article

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  26. The clinical outcome of a new fixation device (femoral neck system, FNS) for femoral neck fractures remains unclear. The main purpose of this study was to evaluate two different internal fixation methods for t...

    Authors: Huaijian Hu, Jingbo Cheng, Mingli Feng, Zhihua Gao, Jingwei Wu and Shibao Lu

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:370

    Content type: Research article

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  27. Extracorporeal shock wave therapy (ESWT) has been used for various pathologies associated with bone marrow oedema (BME). However, it is still not clear whether ESWT may be favourable in the treatment of BME. T...

    Authors: Jonathan Häußer, Juliane Wieber and Philip Catalá-Lehnen

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:369

    Content type: Systematic review

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  28. Adjacent segmental intervertebral disk degeneration (ASDD) is a major complication secondary to lumbar fusion. Although ASSD pathogenesis remains unclear, the primary cause of intervertebral disk degeneration ...

    Authors: Qi Sun, Xin-Yu Nan, Fa-Ming Tian, Fang Liu, Shao-Hua Ping, Zhuang Zhou and Liu Zhang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:368

    Content type: Research article

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  29. Modified tension band fixation has become commonly used for transverse patella fractures. The conventional stainless steel wire provides sufficient stability but may be associated with complications.

    Authors: Puripun Jirangkul and Arkaphat Kosiyatrakul

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:367

    Content type: Research article

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  30. Closed reduction and pinning entry fixation have been proposed as treatment strategies for displaced supracondylar humeral fractures (SCHFs) in children. However, controversy exists regarding the selection of ...

    Authors: Huaguo Zhao, Song Xu, Guanyi Liu, Jingyu Zhao, Shandong Wu and Linrui Peng

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:366

    Content type: Research article

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  31. The optimal surgical technique for the fixation of inferior pole patellar fracture remains controversial. The aims of this study were (1) to compare clinical and radiological outcomes following fixation of inf...

    Authors: Chih-Hsun Chang, Hao-Chun Chuang, Wei-Ren Su, Fa-Chuan Kuan, Chih-Kai Hong and Kai-Lan Hsu

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:365

    Content type: Research article

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  32. Cancer stem cells (CSCs) are mainly contributed to malignancy metastatic potential and resistant therapy of osteosarcoma (OS). The mitochondria-related apoptosis was generally accepted as the target of tumor t...

    Authors: Tong Zhao, Ying Meng, Yongping Wang and Wenji Wang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:364

    Content type: Research article

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  33. Academic trauma institutions rely on fracture databases as research and quality control tools. Frequently, these databases are populated by trainees, but the completeness and accuracy of such databases has not...

    Authors: Aman Chopra, Abigail C. Cortez, Ashraf El Naga, Anthony Ding and Saam Morshed

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:363

    Content type: Research article

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  34. Bone fractures are medical emergencies that require prompt intervention to help return bone to its normal function. Various methods and treatments have been utilized to increase the speed and efficiency of bon...

    Authors: Nima Anaraki, Amir Hossein Beyraghi, Abbas Raisi, Farshid Davoodi, Ghasem Farjanikish and Amin Bigham Sadegh

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:362

    Content type: Research article

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  35. First metatarsophalangeal joint (MTPJ) fusion is the most effective technique for the treatment of MTPJ primary arthritis, severe hallux valgus and failure of primary corrective surgery of these conditions. It...

    Authors: Giuseppe Restuccia, Fabio Cosseddu, Andrea del Chiaro, Matteo Ceccoli, Alessandro Lippi and Sheila Shytaj

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:361

    Content type: Research article

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  36. WNT1 c.110 T>C and c.505G>T missense mutations have been identified in patients with osteogenesis imperfecta (OI). Whether these mutations affect osteoblast differentiation remains to be determined. This study ai...

    Authors: Bashan Zhang, Rong Li, Wenfeng Wang, Xueming Zhou, Beijing Luo, Zinian Zhu, Xibo Zhang and Aijiao Ding

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:359

    Content type: Research article

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  37. We aimed to compare second-generation patellofemoral arthroplasty (2G PFA) with total knee arthroplasty (TKA) in treating isolated patellofemoral osteoarthritis (PFOA) by assessing the percentages of revisions...

    Authors: Chengxin Li, Zhizhuo Li, Lijun Shi, Fuqiang Gao and Wei Sun

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:358

    Content type: Systematic review

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  38. The postoperative pain after total knee arthroplasty (TKA) remains a critical issue. The aim of this study was to assess the clinical effectiveness of percutaneous periarticular injection at 1 day following si...

    Authors: Takuya Iseki, Sachiyuki Tsukada, Motohiro Wakui, Kenji Kurosaka, Shinichi Yoshiya and Toshiya Tachibana

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:357

    Content type: Research article

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  39. The coronavirus disease (COVID-19) pandemic has had a massive impact on individuals globally. The Chinese government has formulated effective response measures, and medical personnel have been actively respond...

    Authors: Ya-ping Xu, Pei-yu Zhao, Yi-tong Bai and Shuang Li

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:356

    Content type: Research article

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  40. Tibial shaft fractures (TSFs) combined with occult posterior malleolar fractures (PMFs) are becoming widely recognized in the field of orthopedics. The purpose of this study was to determine the clinical incid...

    Authors: Zhongzheng Wang, Wei Chen, Yanbin Zhu, Siyu Tian, Kuo Zhao, Jialiang Guo, Zhiyong Hou, Qi Zhang and Yingze Zhang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:355

    Content type: Systematic review

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  41. To investigate the response of the infrapatellar fat pad (IFP) to running at different intensities and further explore the underlying mechanisms of these responses under different running-induced loadings.

    Authors: Ni Zeng, Tao Liao, Xin-Yuan Chen, Zhi-Peng Yan, Jie-Ting Li and Guo-Xin Ni

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:354

    Content type: Research article

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  42. Placement of femoral stem in excessive anteversion or retroversion can cause reduced range of motion, prosthetic impingement, and dislocation. The aim of this study was to assess the operative femoral antevers...

    Authors: Jingyang Sun, Bohan Zhang, Lei Geng, Qingyuan Zheng, Juncheng Li, Wenzhe Cao, Ming Ni and Guoqiang Zhang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:353

    Content type: Research article

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  43. Osteoarthritis (OA) is the most common joint disorder in the United States of America (USA) with a fast-rising prevalence. Current treatment modalities are limited, and total knee replacement surgeries have sh...

    Authors: Ashim Gupta, Nicola Maffulli, Hugo C. Rodriguez, Eric W. Carson, Randa A. Bascharon, Kristin Delfino, Howard J. Levy and Saadiq F. El-Amin III

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:352

    Content type: Study protocol

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  44. Biochemical markers of bone turnover (BTMs), such as the bone alkaline phosphatase (bALP), procollagen type I N propeptide (PINP), serum cross-linked C-telopeptides of type I collagen (bCTx), and urinary cross...

    Authors: Filippo Migliorini, Nicola Maffulli, Filippo Spiezia, Giuseppe Maria Peretti, Markus Tingart and Riccardo Giorgino

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:351

    Content type: Systematic review

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  45. This study aimed to evaluate the radiographic and clinical outcomes of anterior subcutaneous internal fixation (INFIX) with or without posterior fixation for the treatment of unstable pelvic fractures.

    Authors: Shuang Wu, Jialei Chen, Yun Yang, Wei Chen, Rong Luo and Yue Fang

    Citation: Journal of Orthopaedic Surgery and Research 2021 16:350

    Content type: Research article

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