Articles

The influence of long-term shoulder loading on sagittal spino-pelvic morphology: a population-based retrospective study of Chinese farmers from radiology

To investigate associations between long-term shoulder loading and sagittal spino-pelvic morphology in Chinese farmers from radiology evidences.

Authors: Xuyang Zhang, Wei Yang, Zeyu Zheng, Jiasheng Wang, Bao Huang, Shunwu Fan, Xianjun Wang and Fengdong Zhao

The study of targeted blocking SDF-1/CXCR4 signaling pathway with three antagonists on MMPs, type II collagen, and aggrecan levels in articular cartilage of guinea pigs

To explore the possibility and mechanism of targeted blocking SDF-1/CXCR4 signaling pathway using three antagonists TN14003, T140, and AMD3100 in vivo, and to investigate the function of three antagonists in d...

Authors: Guoliang Wang, Yanlin Li, Xuhan Meng, Xiao Yang and Yaoyu Xiang

Bone restoration after revision hip arthroplasty with femoral bone defects using extensively porous-coated stems with cortical strut allografts

Stress shielding and bone loss of the femur are of great concern after revision total hip arthroplasty (THA) with extensively porous-coated stems, especially in a femur with already bone loss. The femoral bone...

Authors: Zichuan Ding, Tingxian Ling, Ping Mou, Duan Wang, Kai Zhou and Zongke Zhou

Synovial bone sialoprotein indicates aseptic failure in total joint arthroplasty

Until today, a reliable diagnostic discrimination between periprosthetic joint infections (PJI) and aseptic failure (AF) after total joint arthroplasty (TJA) remains challenging. Nearly all recent research foc...

Authors: André Busch, Marcus Jäger, Florian Dittrich, Alexander Wegner, Stefan Landgraeber and Marcel Haversath

Three-dimensional morphological analysis of the femoral neck torsion angle—an anatomical study

The femoral neck torsion angle (FNTA) is an important but often neglected parameter in assessments of the anatomical morphology of the femoral neck, which is often confused with the femoral neck anteversion an...

Authors: Ru-Yi Zhang, Xiu-Yun Su, Jing-Xin Zhao, Jian-Tao Li, Li-Cheng Zhang and Pei-Fu Tang

Short-term outcomes of mirogabalin in patients with peripheral neuropathic pain: a retrospective study

Mirogabalin, which is approved for the treatment of peripheral neuropathic pain in Japan, is a ligand for the α2δ subunit of voltage-gated calcium channels. Both pregabalin and mirogabalin act as nonselective ...

Authors: Tomoko Tetsunaga, Tomonori Tetsunaga, Keiichiro Nishida, Haruo Misawa, Tomoyuki Takigawa, Kentaro Yamane, Hironori Tsuji, Yoshitaka Takei and Toshifumi Ozaki

The primary total knee arthroplasty: a global analysis

The use of total knee arthroplasty (TKA) in treatment of chronic degenerative pathologies of the knee has boasted of an experience of 50 years. The aim of this bibliometric and visualized study is to comprehen...

Authors: Jiaxiang Gao, Dan Xing, Shengjie Dong and Jianhao Lin

Does zero-profile anchored cage accompanied by a higher postoperative subsidence compared with cage-plate construct? A meta-analysis

The zero-profile anchored cage (ZP) has been widely used for its lower occurrence of dysphagia. However, it is still controversial whether it has the same stability as the cage-plate construct (CP) and increas...

Authors: Yingjie Lu, Yuepeng Fang, Xu Shen, Dongdong Lu, Liyu Zhou, Minfeng Gan and Xuesong Zhu

Iliotibial band syndrome rehabilitation in female runners: a pilot randomized study

Iliotibial band syndrome (ITBS) carries marked morbidity in runners. Its management is not standardized and lacks evidence base. We evaluated the effectiveness of three different exercises programs in reducing...

Authors: Janine McKay, Nicola Maffulli, Rocco Aicale and Jack Taunton

Open versus arthroscopic ankle arthrodesis: a systematic review and meta-analysis

Osteoarthritis (OA) is a growing health concern that affects approximately 27 million people in the USA and is associated with a $185 billion annual cost burden. Choosing between open surgery and arthroscopic ...

Authors: Tsz Ngai Mok, Qiyu He, Soundarya Panneerselavam, Huajun Wang, Huige Hou, Xiaofei Zheng, Jinghua Pan and Jieruo Li

Impairment of maturation of BMP-6 (35 kDa) correlates with delayed fracture healing in experimental diabetes

Although it is known that diabetes interferes with fracture healing, the mechanisms remain poorly understood. The aim of this study was to investigate the correlation of BMP-6 and BMP-9 with the impairment in ...

Authors: Qidong Guo, Weijie Wang, Rami Abboud and Zheng Guo

Facet joint parameters which may act as risk factors for chronic low back pain

Facet orientation (FO) and facet tropism (FT) are two important structural parameters of lumbar facet joint. The purpose of this study was to evaluate the association between facet joint parameters and chronic...

Authors: Ming Yang, Naiguo Wang, Xiaoxin Xu, Yu Zhang, Gang Xu, Yvang Chang and Zhonghai Li

Reverse reaming distraction for acetabular reconstruction of chronic pelvic discontinuity

The acetabular distraction technique demonstrates encouraging radiographic and clinical outcomes in treating chronic pelvic discontinuity. The aim of this study is to describe a modified distraction technique ...

Authors: Jing-yang Sun, Ming Ni, Hai-yang Ma, Yin-qiao Du, Jun-min Shen, Ji-ying Chen, Yong-gang Zhou and Guo-qiang Zhang

Modified trapdoor procedures using autogenous tricortical iliac graft without preserving the broken cartilage for treatment of osteonecrosis of the femoral head: a prospective cohort study with historical controls

The aim of the present study was to investigate clinical and radiological outcomes of autologous tricortical iliac grafting performed through a window created at the femoral head without suturing the opened ar...

Authors: Qi Cheng, Feng-chao Zhao, Shi-zhuang Xu, Li Zheng and Xin Zheng

Effect of the short-segment internal fixation with intermediate inclined-angle polyaxial screw at the fractured vertebra on the treatment of Denis type B thoracolumbar fracture

Short-segment internal fixation with intermediate straight-forward monoaxial screws (SSIF-SFM) and long-segment internal fixation (LSIF) are the two major surgical options for thoracolumbar (TL) fracture. Howe...

Authors: Chengjie Xiong, Biwang Huang, Tanjun Wei, Hui Kang and Feng Xu

The one-in-all diagnostic value of ^99mTc-MDP bone scan combining with single-photon emission tomography (SPECT)/CT imaging in spinal osteoblastoma

Osteoblastoma (OB) is an intermediate lesion, which makes the accurate preoperative diagnosis very important. ^99mTc-methylene diphosphonate (^99mTc-MDP) bone scan and SPECT/CT imaging were evaluated for their diag...

Authors: Wenhui Ma, Zhiyong Quan, Jing Wang, Xiangdong Li and Guoquan Li

Anterior approach with mini-bikini incision in open reduction in infants with developmental dysplasia of the hip

The anterior and medial approaches in open reduction for developmental dysplasia of the hip (DDH) had been widely used. The former could not directly approach the intra-articular interposition, while the latte...

Authors: Guoqiang Jia, Enbo Wang, Peng Lian, Tianjing Liu, Shuyi Zhao and Qun Zhao

Surgical treatment outcomes of the Ilizarov and internal osteosynthesis methods in posttraumatic pseudarthrosis of the tibia—a retrospective comparative analysis

This study compared surgical treatment outcomes of the Ilizarov and internal osteosynthesis methods in posttraumatic pseudarthrosis of the tibia.

Authors: Łukasz Szelerski, Sławomir Żarek, Radosław Górski, Karol Mochocki, Ryszard Górski, Piotr Morasiewicz and Paweł Małdyk

Musculoskeletal symptoms in SARS-CoV-2 (COVID-19) patients

Authors: Lucio Cipollaro, Lorenzo Giordano, Johnny Padulo, Francesco Oliva and Nicola Maffulli

Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone

What is the right surface for an implant to achieve biological fixation? Surface technologies can play important roles in encouraging interactions between the implant surface and the host bone to achieve osseo...

Authors: William Robert Walsh, Matthew Henry Pelletier, Nicky Bertollo, Vedran Lovric, Tian Wang, Per Morberg, William Chase Harington Parr and Dario Bergadano

Recurrent disc herniation following percutaneous endoscopic lumbar discectomy preferentially occurs when Modic changes are present

To investigate the relationship between Modic changes (MCs) and recurrent lumbar disc herniation (rLDH) and that between the herniated disc component and rLDH following percutaneous endoscopic lumbar discectom...

Authors: Lu Hao, Shengwen Li, Junhui Liu, Zhi Shan, Shunwu Fan and Fengdong Zhao

Incidence and risk factors of joint stiffness after Anterior Cruciate Ligament reconstruction

Joint stiffness is a common complication after anterior cruciate ligament (ACL) reconstruction, which seriously affects the efficacy of the operation and patient satisfaction. After ACL reconstruction, the ide...

Authors: Bin Wang, Jun-Long Zhong, Xiang-He Xu, Jie Shang, Nan Lin and Hua-Ding Lu

Augmented reality-based navigation increases precision of pedicle screw insertion

Precise insertion of pedicle screws is important to avoid injury to closely adjacent neurovascular structures. The standard method for the insertion of pedicle screws is based on anatomical landmarks (free-han...

Authors: Cyrill Dennler, Laurenz Jaberg, José Spirig, Christoph Agten, Tobias Götschi, Philipp Fürnstahl and Mazda Farshad

MiR-596 inhibits osteoblastic differentiation and cell proliferation by targeting Smad3 in steroid-induced osteonecrosis of femoral head

It is reported that miR-596 has a potential diagnostic value for non-traumatic osteonecrosis of the femoral head (NOFH), but its underlying mechanisms in NOFH is unclear.

Authors: Ligong Fu, Huawei Liu and Weijun Lei

A novel anatomically pre-contoured side-specific titanium plate versus the reconstruction plate for quadrilateral plate fractures of the acetabulum: a propensity-matched cohort study

Surgical treatment of acetabular fractures involving a quadrilateral plate is a challenge to orthopedic surgeons. We have developed a novel fixation technique using a specially shaped reconstruction plate comb...

Authors: Haiyang Wu, Ranran Shang, Ximing Liu, Chengjing Song, Yanzhao Chen and Xianhua Cai

Separate double-layer repair versus en masse repair for delaminated rotator cuff tears: a systematic review and meta-analysis

Delaminated rotator cuff tears are a common shoulder disorder in elderly individuals. Either arthroscopic separate double-layer repair (DR) or en masse repair (ER) is used to treat a delaminated rotator cuff t...

Authors: Jia Chen, Zhen-Yang Zheng and Yi-Ming Ren

In vitro analysis of the effect of Flightless I on murine tenocyte cellular functions

Healing of tendons after injury involves the proliferation of tenocytes and the production of extracellular matrix; however, their capacity to heal is limited by poor cell density and limited growth factor act...

Authors: Jessica E. Jackson, Zlatko Kopecki, Peter J. Anderson and Allison J. Cowin

Biomechanical investigation of pelvic stability in developmental dysplasia of the hip: unilateral salter osteotomy versus one-stage bilateral salter osteotomy

Developmental dysplasia of the hip (DDH) is a common disease in infants and children, and the treatment of bilateral DDH remains controversial. This study aimed to evaluate the stability of one-stage bilateral...

Authors: Lang Li, Xiaodong Yang, Bo Song, Jun Jiang, Lei Yang and Xueyang Tang

Comparison of dorsal closing wedge calcaneal osteotomy versus posterosuperior prominence resection for the treatment of Haglund syndrome

Haglund syndrome is a common disease that causes posterior heel pain. This study compared the clinical outcomes of dorsal closing wedge calcaneal osteotomy (DCWCO) and posterosuperior prominence resection (PPR...

Authors: Zilu Ge, Lin Ma, Hong Tang, Mingyu Yang, Aining Yang, Chengsong Yuan, Xu Tao, Binghua Zhou, Kanglai Tang and Wan Chen

Minimally invasive dual incision with mini plate internal fixation improves outcomes over 30 months in 20 patients with Sanders type III calcaneal fractures

Calcaneal Sanders type III or higher fractures traditionally have been treated with open reduction and internal fixation (ORIF); however, ORIF has associated complications. We investigated a combination of min...

Authors: Jianming Chen, Zhongmeng Yang, Changwang Kong and Shijun Wei

Vertebral mobility is a valuable indicator for predicting and determining bone union in osteoporotic vertebral fractures: a conventional observation study

Conservative treatments for osteoporotic vertebral fractures (OVFs) have not been standardized, and criteria for determining bone union have not been established. To determine bone union, we have adopted a cut...

Authors: Kozo Sato, Yuichiro Yamada, Masakazu Kogawa and Takuya Sekiguchi

Covid-19—The real role of NSAIDs in Italy

Authors: Laura de Girolamo, Giuseppe M. Peretti, Nicola Maffulli and Anna T. Brini

Three-year follow-up of changes of cortical bone thickness after implantation of Endo-Exo-Prosthesis (EEP) for transfemoral amputees

Transcutaneous Osseointegrated Prosthetic Systems (TOPS) offer a good alternative for patients who cannot be satisfactorily rehabilitated by conventional suspension sockets. The Endo-Exo-Prothesis (EEP, ESKA O...

Authors: Marcus Örgel, Emmanouil Liodakis, Pratya Jaratjitwilai, Afif Harb, Nils Wirries, Mohamed Omar, Christian Krettek and Horst-Heinrich Aschoff

Correction to: Open reduction and compression with double Kirschner wires for the treatment of old bony mallet finger

Following publication of the original article [1], we have been notified that there was a spelling mistake in the author affiliations. In this Correction, correct and incorrect versions are shown.

Authors: Junjun Tang, Kejian Wu, Jinchang Wang and Jian Zhang

PENK inhibits osteosarcoma cell migration by activating the PI3K/Akt signaling pathway

This article reports the effects of proenkephalin (PENK) on osteosarcoma (OS) cell migration.

Authors: Hai-ping Zhang, Zi-liang Yu, Bing-bing Wu and Fa-rui Sun

The combinations of multiple factors to improve the diagnostic sensitivity and specificity after artificial joint infection

To discuss the sensitivity and specificity of the combinations of multiple factors that work on bone infection after artificial joint, and provide evidence-based medical basis for the early diagnosis of infect...

Authors: Lei Chu, You-Liang Ren, Jun-Song Yang, Jin Yang, Hang Zhou, Hai-Tao Jiang, Lei Shi, Ding-Jun Hao and Zhong-Liang Deng

The relationship between patellar lateralization diagnostic imaging markers and non-contact internal knee derangements

To investigate differences in the tibial tubercle-trochlear groove (TT-TG) and patellar tendon-posterior cruciate ligament (PT-PCL) distances in symptomatic patients with non-contact internal knee derangements...

Authors: Kyle S. Stumetz, M. D. Gothard, Ronald F. Walser, Alan G. Greenwald and Wade W. Justice

Impact of surgeon handedness in manual and robot-assisted total hip arthroplasty

The purpose of this study was to examine whether surgeon handedness could affect cup positioning in manual total hip arthroplasty (THA), and whether robot could diminish or eliminate the impact of surgeon hand...

Authors: Xiangpeng Kong, Minzhi Yang, Xiang Li, Ming Ni, Guoqiang Zhang, Jiying Chen and Wei Chai

Nailing of diaphyseal ulna fractures in adults—biomechanical evaluation of a novel implant in comparison with locked plating

Adult forearm fractures require surgical treatment in most cases. Open reduction and internal fixation with plate osteosynthesis is the therapy of choice. Intramedullary fixation offers several advantages comp...

Authors: Johannes Christof Hopf, Dorothea Mehler, Tobias Eckhard Nowak, Dominik Gruszka, Daniel Wagner and Pol Maria Rommens

Characterization of dimensional, morphological and morphometric features of retrieved 3D-printed acetabular cups for hip arthroplasty

Three-dimensional (3D) printing of porous titanium implants is increasing in orthopaedics, promising enhanced bony fixation whilst maintaining design similarities with conventionally manufactured components. O...

Authors: Lorenzo Dall’Ava, Harry Hothi, Johann Henckel, Anna Di Laura, Paul Shearing and Alister Hart

Biomechanical study of C1 posterior arch crossing screw and C2 lamina screw fixations for atlantoaxial joint instability

The biomechanics of C1 posterior arch screw and C2 vertebral lamina screw techniques has not been well studied, and the biomechanical performance of the constructs cannot be explained only by cadaver testing.

Authors: Chuang Liu, Allieu Kamara and Yunhui Yan

A model for evaluation of the electric activity and oxygenation in the erector spinae muscle during isometric loading adapted for spine patients

Simultaneous measurement of electromyography (EMG) and local muscle oxygenation is proposed in an isometric loading model adjusted for patients that have undergone spinal surgery.

Authors: Lars Ekström, Qiuxia Zhang, Josefin Abrahamson, Joel Beck, Christer Johansson, Olof Westin, Carl Todd and Adad Baranto

Modified Stoppa as an alternative surgical approach for fixation of anterior fracture acetabulum: a randomized control clinical trial

Fracture acetabulum is a challenging, difficult to treat orthopedic injury due to its location and associated concomitant injuries. The modified Stoppa approach for reduction of fracture acetabulum improves ac...

Authors: Ahmed Saleh Al Adawy, Abdel Hamid Abdel Aziz, Faisal Ahmed El Sherief, Wael Shaban Mahmoud, Mahmoud Mabrook and Yaser El-Sayed Hassan

The effectiveness of a self-made modular elastic compression device for patients with a fracture of the tibia and fibula

To evaluate the effectiveness of a self-made modular elastic compression device for patients with a fracture of the tibia and fibula.

Authors: Lingyuan Zeng, Yongrong Wang, Dongdong He, Yao He, Yuze Wang and Xiaochun Wei

Mid-term and long-term results of restoring rotation center in revision hip arthroplasty

To restore rotation center exactly in revision hip arthroplasty is technically challenging, especially in Paprosky type III. The technical difficulty is attributable to the complicated acetabular bone defect. ...

Authors: Heng Zhang, Jiansheng Zhou, Yang Liu, Jianzhong Guan, Hai Ding, Zhiyan Wang and Qirong Dong

Functional movement compensations persist in individuals with hip osteoarthritis performing the five times sit-to-stand test 1 year after total hip arthroplasty

Methods to quantify and evaluate function are important for development of specific rehabilitation interventions. This study aimed to evaluate functional movement compensation in individuals with hip osteoarth...

Authors: Anna-Clara Esbjörnsson and Josefine E. Naili

Repairing effects of glucosamine sulfate in combination with etoricoxib on articular cartilages of patients with knee osteoarthritis

To evaluate the repairing effects of glucosamine sulfate combined with etoricoxib on articular cartilages of patients with knee osteoarthritis (KOA).

Authors: Yong Sun, Changde Wang and Chunzhu Gong

Shoulder imbalance treated with scapuloplasty surgery in scoliosis patients: a clinical retrospective study

To discuss the clinical efficacy and safety of scapuloplasty treating the shoulder imbalance in scoliosis patients.

Authors: Rui Zhong, Zhengjun Hu, Deng Zhao, Fei Wang, Hehong Zhao and Yijian Liang

An accelerometer-based navigation system provides acetabular cup orientation accuracy comparable to that of computed tomography-based navigation during total hip arthroplasty in the supine position

Inadequate acetabular component orientation is associated with postoperative impingement, dislocation, and accelerated polyethylene wear. Computed tomography (CT)-based navigation systems provide accuracy for ...

Authors: Tomonori Tetsunaga, Kazuki Yamada, Tomoko Tetsunaga, Tomoaki Sanki, Yoshi Kawamura and Toshifumi Ozaki

MicroRNA-505 is involved in the regulation of osteogenic differentiation of MC3T3-E1 cells partially by targeting RUNX2

Evidence suggests that microRNAs (miRNAs) regulate the expression of genes involved in bone metabolism. This study aimed to investigate the role of miR-505 in the osteogenic differentiation of MC3T3-E1 cells.

Authors: Weihua Li, Zongchao Chen, Chuanqi Cai, Gunjun Li, Xiao Wang and Zhenyu Shi