Skip to main content
  • Systematic review
  • Open access
  • Published:

Open versus minimally invasive TLIF: literature review and meta-analysis

Abstract

Study design

This study is a comparative, literature review.

Objective

The aim of this study is to provide a comparative analysis of open vs. minimally invasive TLIF using a literature review and a meta-analysis.

Summary of background data

Lumbar interbody fusion is a well-established surgical procedure for treating several spinal disorders. Transforaminal lumbar interbody fusion (TLIF) was initially introduced in the early 1980s. To reduce approach-related morbidity associated with traditional open TLIF (OTLIF), minimally invasive TLIF (MITLIF) was developed. We aimed to provide a comparative analysis of open vs. minimally invasive TLIF using a literature review.

Methods

We searched the online database PubMed (2005–2017), which yielded an initial 194 studies. We first searched the articles’ abstracts. Based on our inclusion criteria, we excluded 162 studies and included 32 studies: 18 prospective, 13 retrospective, and a single randomized controlled trial. Operative time, blood loss, length of hospital stay, radiation exposure time, complication rate, and pain scores (visual analogue scale, Oswestry Disability Index) for both techniques were recorded and presented as means. We then performed a meta-analysis.

Results

The meta-analysis for all outcomes showed reduced blood loss (P < 0.00001) and length of hospital stay (P < 0.00001) for MITLIF compared with OTLIF, but with increased radiation exposure time with MITLIF (P < 0.00001). There was no significant difference in operative time between techniques (P = 0.78). The complication rate was lower with MITLIF (11.3%) vs. OTLIF (14.2%), but not statistically significantly different (P = 0.05). No significant differences were found in visual analogue scores (back and leg) and Oswestry Disability Index scores between techniques, at the final follow-up.

Conclusion

MITLIF and OTLIF provide equivalent long-term clinical outcomes. MITLIF had less tissue injury, blood loss, and length of hospital stay. MITLIF is also a safe alternative in obese patients and, in experienced hands, can also be used safely in select cases of spondylodiscitis even with epidural abscess. MITLIF is also a cost-saving procedure associated with reduced hospital and social costs. Long-term studies are required to better evaluate controversial items such as operative time.

Introduction

Lumbar interbody fusion (LIF) is a well-established surgical procedure used to treat several spinal disorders including degenerative disease, trauma, infection, and neoplasia [1]. The procedure involves placing an implant (spacer, graft, or cage) within the intervertebral space after discectomy [2]. Transforaminal lumbar interbody fusion (TLIF), a spinal fusion posterior approach, was initially described by Harms and Rollinger in 1982 [3], and gained popularity after work by Harms and Jeszenszky in 1998 [4]. This technique achieves 360° of circumferential fusion via a single posterolateral approach [3] with less retraction, and thus reduced risk, to the central neural structures, namely the dura. The main disadvantages of TLIF include significant muscle retraction and dissection. Minimally invasive TLIF (MITLIF) was introduced to minimize iatrogenic soft tissue and muscle injury associated with traditional open TLIF (OTLIF) while maintaining comparable clinical, radiological, and economic outcomes. This is a novel surgical procedure first described in the early 2000s by Foley et al. [5] that involves serially inserting tubular retractors via a muscle-dilating approach, which minimizes iatrogenic muscle injury [6].

History

TLIF

TLIF was first reported in the early 1980s as a modification of posterior LIF. As a newer technique, TLIF creates circumferential fusion via a more lateralized unilateral posterolateral approach, without the need to expose the contralateral foramen. This approach reduces retraction of the central neural structures and minimizes the risk of central neurological injury [3].

MITLIF

Developments in instrumentation and imaging have increased the trend and evolution toward minimally invasive spinal surgery [7]. To minimize tissue trauma associated with traditional open posterior approaches, percutaneous pedicle screw-rod fixation systems were developed [7]. These were initially reported by Foley and colleagues in 2001 for posterior LIF [8] and also by other researchers for TLIF [9, 10]. MITLIF was first described by Foley et al. in 2002 [5], who used sequential dilation, tubular retraction, and a percutaneous screw-rod system. MITLIF has since gained popularity and has been used to treat various spinal diseases requiring fusion [11, 12].

Technique

There are certain technical differences between MITLIF and OTLIF. First, in MITLF, intraoperative fluoroscopy is performed to locate the desired spinal level, and the pedicle screws are placed percutaneously above and below the desired interbody fusion segment. Then, a 1–2-in paramedian incision is made on the lateral borders of the facet joints of the desired spinal level on the side of the radicular symptoms. Serial soft tissue dilators are then inserted down to the facet complex. This is followed by spinal canal decompression, disc preparation, and cage insertion in a similar manner as for OTLIF. The tubular retractor is then removed, and finally, compression is applied to the rods before final tightening [13].

Materials and methods

Search method and inclusion criteria

We reviewed the online database PubMed from 2005 to 2017 using the keywords ‘lumbar,’ ‘interbody fusion,’ ‘transforaminal,’ ‘open,’ and ‘minimally invasive,’ which identified 194 studies. We first screened all articles by their abstracts, and we included only English language reports with full text manuscripts. Additional inclusion criteria included (1) studies with a comparative design, (2) studies with populations consisting of adult patients > 18 years of age treated with MITLIF, (3) studies including a control group of patients treated with OTLIF, and (4) studies comparing at least one desirable outcome (e.g., operative time, blood loss, recovery time, or costs). Biomechanical and cadaveric studies and reviews were excluded. After applying our inclusion criteria, 162 studies were excluded leaving 32 articles for inclusion and review (Fig. 1).

Fig. 1
figure 1

Flow diagram of the search strategy and study selection process

Statistical methods for the meta-analysis

We analyzed data from the included studies using Review Manager (RevMan version 5.2, The Nordic Cochrane Center, The Cochrane Collaboration, Copenhagen, Denmark), and Microsoft Excel 2010 (Microsoft Corp., Redmond, WA, USA). A formal meta-analysis was conducted for all outcomes if the data were sufficient. We expressed pooled dichotomous data as odds ratio (OR) with 95% confidence intervals (95% confidence interval (CI)); while pooled continuous effect measures was expressed as the mean difference with 95% CI. We explored and quantified between-study statistical heterogeneity using the I2 test. By default, we used the fixed-effect model in all analyses. If heterogeneity was statistically significant (p < 0.05) or I2 was > 50%, we used the Der Simonian and Laird random-effects model instead [43]. Statistical analyses were two-sided with an α-error of 0.05.

Description and interpretation of the forest plots

For quantitative data, the forest plots are composed of (from left to right):

  1. 1.

    The names of the studies arranged by publication year.

  2. 2.

    Data for treatment and control groups including mean, SD, and number of patients in each group.

  3. 3.

    The weight of each study as a percentage of the total of the meta-analysis (100%).

  4. 4.

    The mean difference between the two groups + 95% CI.

  5. 5.

    Year of publication again.

  6. 6.

    On the right side is a figure depicting the results. Each study is represented by a square (square size = study weight, and the square’s center is opposite to the mean’s difference) on a straight line representing the 95% CI of the mean’s difference. The final results of the meta-analysis are represented by a black diamond and the center of the diamond is the mean’s difference across all studies. The tips of the diamond are the 95% CI of the mean’s difference across all studies.

  7. 7.

    The line in the middle of the graph is opposite the 0 value and termed the equator line, which means no difference between the groups. If the lines of any study and/or the diamond touch the equator line, there is a statistical difference between the two groups.

  8. 8.

    The last two lines written in the plot indicate the heterogeneity represented by the I2 statistic as a % and a p value. With p < 0.05, heterogeneity is considerable across the studies, and the results should be considered cautiously. The second line is the p value of the overall results, represented by the diamond in the graph. These results are represented by Z and p values. When p is < 0.05, the overall result is statistically significant.

For qualitative data, the forest plots are composed of (from left to right):

  1. 1.

    The names of the studies arranged by publication year.

  2. 2.

    Data for treatment and control groups including the number of positive events and the total number of patients in each group.

  3. 3.

    The weight of each study as a percentage of the total of the meta-analysis (100%).

  4. 4.

    The OR between the two groups with 95% CI.

  5. 5.

    The publication year again.

  6. 6.

    On the right side, there is a figure depicting the results. Each study is represented by a square with the size of the square = study weight, and the center of the square opposite the OR, on a straight line representing the 95% CI. The result of the meta-analysis is represented by the black diamond with the center of the diamond indicating the OR across all studies and the tips indicating the 95% CI across all studies.

  7. 7.

    The line in the middle of the graph is opposite the 1 value and termed the equator line, which means no difference between the groups. If the lines of any study and/or the diamond touch the equator line, there is statistical difference between the two groups.

  8. 8.

    The last two lines of the plot indicate heterogeneity represented by the I2 statistic as a percentage and a p value. When the p value is < 0.05, heterogeneity is considerable across the studies, and the results should be interpreted cautiously. The second line is the p value of the overall results (represented by the diamond in the graph). The overall results are represented by Z and p values. When p is < 0.05, the overall result is statistically significant.

Results

Search results

Thirty-two studies were included in this review, including 18 prospective studies, 13 retrospective studies, and a single randomized controlled trial (Table 1). Our data are presented in Tables 2, 3, 4, 5, 6, 7, 8, and 9, and the results of the meta-analysis are shown in Figs. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, and 18. The total number of patients was 2385, of which 1285 patients underwent MITLIF and 1100 patients underwent OTLIF. The total number of male patients was 1008 patients, of which 542 patients underwent MITLIF and 466 patients underwent OTLIF. The total number of female patients was 1299 patients, of which 704 patients underwent MITLIF and 595 patients underwent OTLIF. The mean age was 52.87 years in the MITLIF group and 54.19 years in the OTLIF group. The mean follow-up was 27.8 months.

Table 1 Studies
Table 2 Operative time (min)
Table 3 Blood loss (ml)
Table 4 Length of hospital stay (days)
Table 5 Complication rate
Table 6 Radiation exposure time (s)
Table 7 Visual analog scale scores for back pain
Table 8 Visual analog scale scores for leg pain
Table 9 Oswestry Disability Index (%)
Fig. 2
figure 2

Forest plot of the study comparisons: comparison between MITLIF and OTLIF outcomes for operative time

Fig. 3
figure 3

Forest plot of the study comparisons: comparison between MITLIF and OTLIF outcomes for blood loss

Fig. 4
figure 4

Forest plot of the study comparisons: comparison between MITLIF and OTLIF outcomes for length of hospital stay

Fig. 5
figure 5

Forest plot of the study comparisons: comparison between MITLIF and OTLIF outcomes for: complications

Fig. 6
figure 6

Forest plot of the study comparisons: comparison between MITLIF and OTLIF outcomes for radiation exposure time

Fig. 7
figure 7

Forest plot of the study comparisons: comparison between MITLIF and OTLIF outcomes for preoperative visual analog scale scores for back pain

Fig. 8
figure 8

Forest plot of the study comparisons: comparison between MITLIF and OTLIF outcomes for preoperative visual analog scale scores for leg pain

Fig. 9
figure 9

Forest plot of the study comparisons: comparison between MITLIF and OTLIF outcomes for visual analog scale scores for back pain at final follow-up

Fig. 10
figure 10

Forest plot of study comparisons: comparison between MITLIF and OTLIF outcomes for visual analog scale scores for leg pain at last follow-up

Fig. 11
figure 11

Forest plot of study comparisons: comparison between preoperative and last follow-up visual analog scale scores for back pain within the MITLIF group

Fig. 12
figure 12

Forest plot of study comparisons: comparison between preoperative and last follow-up visual analog scale scores for leg pain within the MITLIF group

Fig. 13
figure 13

Forest plot of the study comparisons: comparison between preoperative and last follow-up visual analog scale scores for back pain within the OTLIF group

Fig. 14
figure 14

Forest plot of the study comparisons: comparison between preoperative and last follow-up visual analog scale scores for leg pain within the OTLIF group

Fig. 15
figure 15

Forest plot of the study comparisons: comparison between MITLIF and OTLIF outcomes for preoperative Oswestry disability index (%)

Fig. 16
figure 16

Forest plot of the study comparisons: comparison between MITLIF and OTLIF outcomes for Oswestry disability index (%) at last follow-up

Fig. 17
figure 17

Forest plot of the study comparisons: comparison between preoperative and last follow-up Oswestry disability index (%) within the MITLIF group

Fig. 18
figure 18

Forest plot of the study comparisons: comparison between preoperative and last follow-up Oswestry disability index (%) within the OTLIF group

Operative time

Twenty-seven studies had sufficient data regarding the operative time (Table 2). The mean operative time was 214.69 min in the MITLIF group vs. 198.03 min in the OTLIF group. Based on our meta-analysis, the difference was not significant (P = 0.78) (Fig. 2).

Blood loss

Twenty-nine studies had sufficient data regarding the amount of blood loss (Table 3). The mean blood loss volume was 247.82 ml in the MITLIF group vs. 568.18 ml in the OTLIF group. The difference was significant (P < 0.00001) (Fig. 3).

Length of hospital stay

Twenty-five studies had sufficient information on length of hospital stay (LOS) (Table 4). The mean LOS was 5.05 days in the MITLIF group vs. 6.92 days in the OTLIF group. The difference was significant (P < 0.00001) (Fig. 4).

Complications

The number of complications was identified in 17 studies (Table 5). The complication rate was 11.3% in the MITLIF group vs. 14.2% in the OTLIF group. The difference was not statistically significant (P = 0.05) (Fig. 5).

Radiation exposure time

Data regarding radiation exposure time (Table 6) was identified in only seven studies. The mean radiation exposure time was 65.4 s in the MITLIF group vs. 28.3 s in the OTLIF group. The difference was significant (P < 0.00001) (Fig. 6).

Visual analogue scale score (back and leg)

Twenty-two studies had sufficient data regarding the visual analogue scale (VAS) scores. The mean preoperative VAS score for back pain was 7.04 in the MITLIF group vs. 7.10 in the OTLIF group, with a statistically significant difference (P = 0.002). The mean VAS score for back pain at the final follow-up was 2.69 in the MITLIF group vs. 2.88 in the OTLIF group; the difference was not significant (P = 0.15). The mean preoperative VAS score for leg pain was 7.13 in the MITLIF group vs. 7.01 in the OTLIF group, with a statistically significant difference (P = 0.0.1). The mean VAS score for leg pain at the final follow-up was 2.62 in both groups (Tables 7 and 8, Figs. 7, 8, 9, 10, 11, 12, 13, and 14).

Oswestry Disability Index

Twenty studies contained sufficient data on the Oswestry Disability Index (ODI) scores, expressed in percent. The mean preoperative ODI score was 43.08 in the MITLIF group vs. 42.95 in the OTLIF group; the difference was not significant. The mean ODI score at the final follow-up was 19.48 in the MITLIF group vs. 20.62 in the OTLIF group, and the difference was not significant (P = 0.25) (Table 9, Figs. 15, 16, 17, and 18).

Discussion

Since the introduction of MITLIF in the early 2000s by Foley et al. as an alternative to traditional OTLIF, several studies have compared both techniques for perioperative, postoperative, clinical, and radiological outcomes. The parameters that have been compared most often between the two techniques are operative time, blood loss, LOS, complication rate, radiation exposure time, and various pain scores. Other items include fusion rates, clinical and radiological outcomes in selected groups of patients, e.g., overweight patients, and the costs involved in both procedures to evaluate the cost-effectiveness of the techniques. Our literature review identified obvious trends for evaluating certain parameters, such as blood loss, LOS, and radiation exposure time. On the other hand, other parameters, such as operative time and complication rate, remain highly controversial when comparing MITLIF and OTLIF.

Among our included studies, 28 studies compared blood loss between patients undergoing MITLIF and OTLIF, of which 26 studies showed that blood loss was significantly lower in the MITLIF group. According to Lau et al. [28], this applies also to obese patients. The authors conducted a retrospective study in 2013 where 127 obese patients (body mass index (BMI) of at least 30 kg/m2) who underwent single-level TLIF were retrospectively identified. Results showed that MITLIF was associated with significantly less blood loss in the three identified obesity classes [28]. However, another study by Lau and colleagues in 2010 showed that perioperative blood loss volume was similar between MITLIF and OTLIF, although more patients undergoing OTLIF required perioperative transfusions [44]. In contrast, Hey and colleagues examined 50 patients and showed no significant difference in blood loss for single-level TLIF between MITLIF and OTLIF, but found higher blood loss volumes in two-level MITLF compared with two-level OTLIF [19].

LOS was discussed in 25 of the studies included in our review. Twenty-three of these studies showed that LOS was significantly shorter in the MITLIF group. However, Sulaiman et al. [13] and Lau et al. [44] showed no significant difference in LOS between MITLIF and OTLIF patients. Hey and Hee showed no significant difference in LOS for single-level TLIF when comparing MITLIF and OTLIF, but found longer LOS for two-level MITLIF vs. two-level OTLIF [18]. Although the results of studying these parameters favor MITLIF, the prolonged radiation exposure time involved in MITLIF is considered a drawback. Ten of our studies discussed radiation exposure time, of which nine studies showed significantly higher radiation exposure time for MITLIF [6, 17, 22, 24, 26, 39, 45, 46]. Gu et al. [24] suggested that the smaller operative field, lack of visualization of the bony landmarks, and the steep learning curve associated with MITLIF explains the prolonged radiation exposure time. Based on our experience, the prolonged fluoroscopy time needed for placing pedicle screws percutaneously with MITLIF is the primary contributor to the higher radiation exposure compared with OTLIF. In our institution, when performing OTLIF, the pedicle screws are placed free-hand, and minimal radiation is needed because screw position is confirmed with fluoroscopy usually only once, after all screws have been placed. On the other hand, in MITLIF, radiation can be needed more than once, when placing each pedicle screw, to ensure correct screw positioning. The cumulative effects of radiation exposure on the patient and the operating team should not be ignored [45]. Seng et al. [26] and Wang et al. [45, 46] suggested that with greater surgical experience, radiation exposure time could be reduced. A prospective study conducted by Schizas et al. to evaluate their initial experience comparing perioperative outcomes between 18 MITLIF patients and 18 OTLIF patients showed no significant difference in radiation exposure time between the two groups [2].

Operative time is another area of interest when comparing MITLIF and OTLIF techniques, which was discussed in most studies comparing the two procedures. Twenty-seven studies from the included studies in our review compared operative time between MITLIF and OTLIF; 13 studies showed longer operative time for MITLIF. Kulkarni et al. [17] conducted a prospective study examining 61 patients and showed longer operative time for MITLIF, which was considered secondary to the steep learning curve associated with MITLIF. Hey and Hee in their prospective study examining 50 patients, also showed significantly longer operative time for MITLIF [18]. This was explained by the technically more demanding MITLIF as a result of the limited visibility of the surgical field. These findings concur with those of Peng et al. [39], where the more technically challenging MITLIF explained the significantly longer operative time. Other authors showed no significant difference in operative time between MITLIF and TLIF [16, 17, 26, 37, 40, 42, 46, 47]. On the other hand, six of our included studies showed shorter operative time for MITLIF [6, 22, 23, 27, 33, 45]. Wong et al. reported in their prospective study examining 198 patients, of which 144 patients underwent MITLIF, significantly shorter operative time for MITLIF [22]. This was because the 144 MITLIF procedures (2006–2008) were well past the initial learning curve of the first 100 MITLIF procedures performed from 2002 to 2004. These results are similar to the findings of Brodano et al. [25] who retrospectively examined 64 patients, of which 30 patients underwent MITLIF. Although the surgical time was longer for MITLIF overall, there was a statistically significant difference in operative time between the initial 15 MITLIF patients (mean time, 3.2 h) and the latter 15 patients (mean time, 1.8 h), which confirms that MITLIF requires a learning curve, and once adequate experience is gained, operative time decreases significantly [25].

The complication rate with MITLIF is controversial when comparing MITLIF and OTLIF with heterogeneity seen among our included studies. Many studies showed no significant difference in the incidence of complications between the techniques [16, 19, 24, 26, 31, 48, 49]. Adogwa et al. [19] conducted a prospective study examining 148 patients who underwent either MITLIF or OTLIF. Complications associated with both techniques included wound infection, nerve root injury, and durotomy. Hardware failure was also reported with both techniques; however, no statistically significant difference between techniques was reported in one study [19]. Other studies reported significantly higher complication rates with OTLIF [13, 21, 22, 28, 39]. Terman et al. [26] retrospectively examined 74 obese patients (BMI > 30 kg/m2) and showed significantly higher complication rates with OTLIF. Complications included general cardiopulmonary complications, durotomy, and wound infection [21]. Wong et al. [22] prospectively studied 198 patients and found a significantly lower rate of systemic respiratory and urinary infections, which was attributed to patients’ overall earlier mobilization and ambulation, and a significantly lower overall wound infection rate with MITLIF. These lower rates were attributed to less tissue trauma, lower blood loss volumes, less need for drainage, and a smaller potential dead space [22]. Lau et al. retrospectively evaluated 127 obese patients (BMI of at least 30 kg/m2), and showed a significantly higher complication rate with OTLIF where patients undergoing OTLIF experienced 36% more complications [28]. In contrast, other studies showed higher complications in patients undergoing MITLIF [44, 18, 40, 42]. Lau et al. [27] showed that the complication rate tended to be higher for MITLIF, explained by higher technical demands with MITLIF, invisibility of the standard landmarks, and the steep learning curve. Dhall et al. retrospectively examined 42 patients and reported a higher rate of complication with MITLIF, including screw misplacement and cage migration, and attributed the higher rates to the steep learning curve and the higher technical demands [40].

Regarding clinical outcomes, measured using the VAS and ODI scores, most of our included studies showed significant improvement in VAS (for back and leg pain) and ODI scores for both MITLIF and OTLIF, with no significant difference between techniques at the final follow-up [6, 13, 15, 17,18,19, 21, 24,25,26,27, 29, 31, 33, 37, 39, 40, 42, 44,45,46,47,48, 50]. Considering direct postoperative pain, patients who underwent MITLIF experienced significantly less postoperative pain [16, 24,25,26, 37, 39, 45] with significantly less use of narcotic medications [39, 47, 48, 50]. This suggests improved early clinical outcomes in favor of MITLIF and explains the early ambulation, early return to work, and reduced LOS with MITLIF. However, studies reported no significant difference in the long-term clinical outcomes between the two techniques.

All included studies showed no statistically significant difference in fusion rates between MITLIF and OTLIF [6, 15, 18, 26, 37, 39, 42, 46, 47]. Villavicencio et al.’s retrospective study examining 139 patients reported successful fusion in all patients in both groups with no difference between MITLIF and OTLIF [42]. Seng et al. retrospectively examined 80 patients with 40 patients undergoing MITLIF and 40 patients undergoing OTLIF [26]. Patients undergoing OTLIF showed slightly better fusion at 6 months and 2 years compared with patients undergoing MITLIF but with no statistically significant difference. However, similar fusion rates in the two groups were achieved at the 5-year follow-up [26].

We also considered obese patients, which are a challenging group of patients when undergoing lumbar spine surgery [19, 28, 45]. Adogwa et al. [19] showed no significant difference in patient-reported outcomes for back pain, leg pain, and functional status 1 and 2 years postoperatively, or in the incidence of postoperative complications between morbidly obese patients undergoing MITLIF or OTLIF. These findings are similar to the results of Terman et al. [21], who showed significant improvement in pain and function in obese patients undergoing MITLIF and OTLIF, with comparable results to non-obese patients; also with no significant difference between MITLIF and OTLIF. Wang et al. [45] also showed promising results in favor of MITLF with significantly lower operative time and blood loss, significantly less postoperative pain, and significantly improved VAS and ODI scores 2 years postoperatively with no significant difference compared with obese patients in patients undergoing OTLIF. These findings indicate that MITLIF is a safe alternative for lumbar fusion in obese patients and provides similar clinical outcomes to OTLIF with no difference in postoperative complication rates [19] but also offers the benefits of less iatrogenic tissue injury and lower blood loss volumes and operative time [45].

A long-term risk after lumbar fusion is adjacent segment disease. Yee et al. [20] retrospectively examined 68 patients, of which 52 patients underwent MITLIF, and showed that the risk of ASD did not differ significantly between MITLIF and OTLIF. However, the MITLIF group showed a nonsignificant trend toward a decreased risk of ASD compared with the OTLIF group, suggesting that MITLIF may be associated with lower long-term morbidity compared with OTLIF [20]. These findings concur with the results of Wong et al., who showed decreased adjacent-level reoperation for MITLIF at 4 years [22].

Spondylodiscitis, a disease with increasing incidence, is a life-threatening condition with high mortality rates [51] for which spinal fusion is indicated in certain conditions including neurological deficits, instability, deformity, medically intractable pain, or disease progression [52, 53]. Patients suffering from spondylodiscitis, primarily patients with severe morbidity, greatly benefit from a minimally invasive approach when undergoing spinal fusion surgery. Tschugg et al. [16] retrospectively examined 67 patients, of which 19 patients underwent MITLIF and 48 patients underwent OTLIF, where lumbar spondylodiscitis was the indication for surgery. The MITLIF group showed favorable results with less postoperative pain, less blood loss, and a similar complication rate to OTLIF. According to Tschugg et al., MITLIF could be used safely and effectively in select cases of spondylodiscitis, even with epidural abscess [16].

To consider MITLIF as an alternative to OTLIF, it is important to determine the costs to evaluate its cost-effectiveness. Parker et al. [50] showed that the total and indirect hospital costs were significantly lower for MITLIF. Another study conducted by Pelton and colleagues to compare the perioperative costs in patients with and without workers’ compensation who underwent MITLIF or OTLIF showed that the total hospital costs were significantly lower for MITLIF with no difference between the workers’ compensation and nonworkers’ compensation patients [33].

Conclusion

MITLIF is a novel surgical procedure developed to reduce approach-related morbidity associated with traditional OTLIF. To the best of our knowledge, ours is the largest literature review, with the largest number of included studies, comparing MITLIF and OTLIF. Our review showed that MITLIF provides good long-term clinical outcomes and is associated with less blood loss, and less postoperative pain with significantly less narcotic medications use, which lead to shorter LOS, earlier ambulation, and earlier return to work. Operative time remains a controversial parameter, with many studies showing longer operative time for MITLIF, some studies showing longer operative time for OTLIF, and still others showing no significant difference between the techniques. This heterogeneity is explained by the finding that our reviewed studies included MITLIF cases performed by surgeons during their initial learning curve, which required longer operative times. We suggest that MITLIF has a steep learning curve, but once adequate surgical experience is gained, the surgical time could be significantly reduced. This applies also to the complication rate, which is another controversial item. Complications associated with MITLIF included primarily screw misplacement and cage migration, attributed to the steep learning curve and the technical demands of MITLIF. Otherwise, we found no significant difference in complication rates between MITLIF and OTLIF.

Prolonged radiation exposure time is the main drawback of MITLIF, resulting primarily from the small operative field, lack of visualization of the bony landmarks, steep learning curve and, based on our experience, the prolonged fluoroscopy time needed to place the pedicle screws percutaneously. Therefore, long-term studies evaluating these parameters, namely operative time, complication rate, and radiation exposure time, are needed after adequate initial experience is gained. MITLIF may be associated with a lower risk of ASD; however, long-term studies are also needed to evaluate this parameter.

MITLIF is a safe alternative in obese patients and, in experienced hands, can also be used safely in select cases of spondylodiscitis even with epidural abscess. Economically, MITLIF is a cost-saving procedure associated with reduced hospital and social costs.

Abbreviations

ASD:

Adjacent segment disease

BMI:

Body mass index

LOS:

Length of hospital stay

MITLIF:

Minimally invasive transforaminal lumbar interbody fusion

ODI:

Oswestry Disability Index

OTLIF:

Open transforaminal lumbar interbody fusion

TLIF:

Transforaminal lumbar interbody fusion

VAS:

Visual analogue scale

References

  1. Resnick DK, Choudhri TF, Dailey AT, et al. Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 7: intractable low-back pain without stenosis or spondylolisthesis. J Neurosurg Spine. 2005;2:670–2.

    Article  Google Scholar 

  2. Talia AJ, Wong ML, Lau HC, et al. Comparison of the different surgical approaches for lumbar interbody fusion. J Clin Neurosci. 2015;22:243–51.

    Article  Google Scholar 

  3. Harms J, Rolinger H. A one-stager procedure in operative treatment of spondylolisthesis: dorsal traction-reposition and anterior fusion. Z Orthop Ihre Grenzgeb. 1982;120:343–7. (in German)

    Article  CAS  Google Scholar 

  4. Harms J, Jeszenszky D. The unilateral transforaminal approach for posterior lumbar interbody fusion. Orthop Traumatol. 1998;6:88–99.

    Google Scholar 

  5. Foley KT, Holly LT, Schwender JD. Minimally invasive lumbar fusion. Spine (Phila Pa 1976). 2003;15:S26–35.

    Google Scholar 

  6. Lee KH, Yue WM, Yeo W, et al. Clinical and radiological outcomes of open versus minimally invasive transforaminal lumbar interbody fusion. Eur Spine J. 2012;21:2265–70.

    Article  Google Scholar 

  7. Samartzis D, Shen FH, Perez-Cruet MJ, et al. Minimally invasive spine surgery: a historical perspective. Orthop Clin North Am. 2007;38:305–26.

    Article  Google Scholar 

  8. Foley KT, Gupta SK, Justis JR, et al. Percutaneous pedicle screw fixation of the lumbar spine. Neurosurg Focus. 2001;15:E10.

    Google Scholar 

  9. Isaacs RE, Podichetty VK, Santiago P, et al. Minimally invasive microendoscopy-assisted transforaminal lumbar interbody fusion with instrumentation. J Neurosurg Spine. 2005;3(2):98–105.

    Article  Google Scholar 

  10. Schwender JD, Holly LT, Rouben DP, et al. Minimally invasive transforaminal lumbar interbody fusion (TLIF): technical feasibility and initial results. J Spinal Disord Tech. 2005;18(Suppl):S1–6.

    Article  Google Scholar 

  11. Foley KT, Lefkowitz MA. Advances in minimally invasive spine surgery. Clin Neurosurg. 2002;49:449–517.

    Google Scholar 

  12. Lee HJ, Kim JS, Ryu KS. Minimally invasive TLIF using unilateral approach and single cage at single level in patients over 65. Biomed Res Int. 2016;2016:4679865.

    PubMed  PubMed Central  Google Scholar 

  13. Sulaiman WA, Singh M. Minimally invasive versus open transforaminal lumbar interbody fusion for degenerative spondylolisthesis grades 1-2: patient-reported clinical outcomes and cost-utility analysis. Ochsner J. 2014;14:32–7.

    PubMed  PubMed Central  Google Scholar 

  14. Zhang H, Chen ZX, Sun ZM, et al. Comparison of the total and hidden blood loss in patients undergoing open and minimally invasive transforaminal lumbar interbody fusion. World Neurosurg. 2017;107:739–743.

    Article  Google Scholar 

  15. Yang Y, Zhang L, Liu B, et al. Hidden and overall haemorrhage following minimally invasive and open transforaminal lumbar interbody fusion. J Orthop Traumatol. 2017;18:395–400.

    Article  Google Scholar 

  16. Tschugg A, Hartmann S, Lener S, et al. Minimally invasive spine surgery in lumbar spondylodiscitis: a retrospective single-center analysis of 67 cases. Eur Spine J. 2017;26:3141–6.

    Article  Google Scholar 

  17. Kulkarni AG, Bohra H, Dhruv A, et al. Minimal invasive transforaminal lumbar interbody fusion versus open transforaminal lumbar interbody fusion. Indian J Orthop. 2016;50:464–72.

    Article  Google Scholar 

  18. Hey HW, Hee HT. Open and minimally invasive transforaminal lumbar interbody fusion: comparison of intermediate results and complications. Asian Spine J. 2015;9:185–93.

    Article  Google Scholar 

  19. Adogwa O, Carr K, Thompson P, et al. A prospective, multi-institutional comparative effectiveness study of lumbar spine surgery in morbidly obese patients: does minimally invasive transforaminal lumbar interbody fusion result in superior outcomes? World Neurosurg. 2015;83:860–6.

    Article  Google Scholar 

  20. Yee TJ, Terman SW, La Marca F, et al. Comparison of adjacent segment disease after minimally invasive or open transforaminal lumbar interbody fusion. J Clin Neurosci. 2014;21:1796–801.

    Article  Google Scholar 

  21. Terman SW, Yee TJ, Lau D, et al. Minimally invasive versus open transforaminal lumbar interbody fusion: comparison of clinical outcomes among obese patients. J Neurosurg Spine. 2014;20:644–52.

    Article  Google Scholar 

  22. Wong AP, Smith ZA, Stadler JA 3rd, et al. Minimally invasive transforaminal lumbar interbody fusion (MI-TLIF): surgical technique, long-term 4-year prospective outcomes, and complications compared with an open TLIF cohort. Neurosurg Clin N Am. 2014;25:279–304.

    Article  Google Scholar 

  23. Singh K, Nandyala SV, Marquez-Lara A, et al. A perioperative cost analysis comparing single-level minimally invasive and open transforaminal lumbar interbody fusion. Spine J. 2014;14:1694–701.

    Article  Google Scholar 

  24. Gu G, Zhang H, Fan G, et al. Comparison of minimally invasive versus open transforaminal lumbar interbody fusion in two-level degenerative lumbar disease. Int Orthop. 2014;38:817–24.

    Article  Google Scholar 

  25. Brodano GB, Martikos K, Lolli F, et al. Transforaminal lumbar interbody fusion in degenerative disc disease and spondylolisthesis grade I: minimally invasive versus open surgery. J Spinal Disord Tech. 2015;28:E559–64.

    Article  Google Scholar 

  26. Seng C, Siddiqui MA, Wong KP, et al. Five-year outcomes of minimally invasive versus open transforaminal lumbar interbody fusion: a matched pair comparison study. Spine (Phila Pa 1976). 2013;38:2049–55.

    Article  Google Scholar 

  27. Cheng JS, Park P, Le H, et al. Short-term and long-term outcomes of minimally invasive and open transforaminal lumbar interbody fusions: is there a difference? Neurosurg Focus. 2013;35:E6.

    Article  Google Scholar 

  28. Lau D, Khan A, Terman SW, et al. Comparison of perioperative outcomes following open versus minimally invasive transforaminal lumbar interbody fusion in obese patients. Neurosurg Focus. 2013;35:E10.

    Article  Google Scholar 

  29. Rodríguez-Vela J, Lobo-Escolar A, Joven E, et al. Clinical outcomes of minimally invasive versus open approach for one-level transforaminal lumbar interbody fusion at the 3- to 4- year follow-up. Eur Spine J. 2013;22:2857–63.

    Article  Google Scholar 

  30. Parker SL, Mendenhall SK, Shau DN,et al. Minimally invasive versus open transforaminal lumbar interbody fusion for degenerative spondylolisthesis: comparative effectiveness and cost-utility analysis. World Neurosurg. 2014;82:230–238.

    Article  Google Scholar 

  31. Adogwa O, Johnson K, Min ET, et al. Extent of intraoperative muscle dissection does not affect long-term outcomes after minimally invasive surgery versus open-transforaminal lumbar interbody fusion surgery: a prospective longitudinal cohort study. Surg Neurol Int. 2012;3(Suppl 5):S355–61.

    Article  Google Scholar 

  32. Wang J, Zhou Y, Feng Zhang Z, et al. Comparison of the clinical outcome in overweight or obese patients after minimally invasive versus open transforaminal lumbar interbody fusion. J Spinal Disord Tech. 2014; 27:202–206.

    Article  CAS  Google Scholar 

  33. Pelton MA, Phillips FM, Singh K. A comparison of perioperative costs and outcomes in patients with and without workers’ compensation claims treated with minimally invasive or open transforaminal lumbar interbody fusion. Spine (Phila Pa 1976). 2012;37:1914–9.

    Article  Google Scholar 

  34. Parker SL, Adogwa O, Bydon A, et al. Cost-effectiveness of minimally invasive versus open transforaminal lumbar interbody fusion for degenerative spondylolisthesis associated low-back and leg pain over two years. World Neurosurg.2012;78:178–184.

    Article  Google Scholar 

  35. Lau D, Lee JG, Han SJ, et al. Complications and perioperative factors associated with learning the technique of minimally invasive transforaminal lumbar interbody fusion (TLIF). J Clin Neurosci.2011;18:624–627. https://doi.org/10.1016/j.jocn.2010.09.004. Epub.

    Article  Google Scholar 

  36. Adogwa O, Parker SL, Bydon A, et al. Comparative effectiveness of minimally invasive versus open transforaminal lumbar interbody fusion: 2-year assessment of narcotic use, return to work, disability, and quality of life. J Spinal Disord Tech.2011; 24:479–484.

  37. Wang J, Zhou Y, Zhang ZF, et al. Comparison of one-level minimally invasive and open transforaminal lumbar interbody fusion in degenerative and isthmic spondylolisthesis grades 1 and 2. Eur Spine J. 2010;19:1780–4.

    Article  Google Scholar 

  38. Shunwu F, Xing Z, Fengdong Z, et al. Minimally invasive transforaminal lumbar interbody fusion for the treatment of degenerative lumbar diseases. Spine (Phila Pa 1976).2010;35:1615–1620.

    Article  Google Scholar 

  39. Peng CW, Yue WM, Poh SY, et al. Clinical and radiological outcomes of minimally invasive versus open transforaminal lumbar interbody fusion. Spine (Phila Pa 1976). 2009;34:1385–9.

    Article  Google Scholar 

  40. Dhall SS, Wang MY, Mummaneni PV. Clinical and radiographic comparison of mini-open transforaminal lumbar interbody fusion with open transforaminal lumbar interbody fusion in 42 patients with long-term follow-up. J Neurosurg Spine. 2008;9:560–5.

    Article  Google Scholar 

  41. Schizas C, Tzinieris N, Tsiridis E, et al. Minimally invasive versus open transforaminal lumbar interbody fusion: evaluating initial experience. Int Orthop.2009; 33:1683–1688.

    Article  Google Scholar 

  42. Villavicencio AT, Burneikiene S, Roeca CM, et al. Minimally invasive versus open transforaminal lumbar interbody fusion. Surg Neurol Int. 2010;1:12.

    Article  Google Scholar 

  43. Der Simonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  Google Scholar 

  44. Lau D, Lee JG, Han SJ, et al. Complications and perioperative factors associated with learning the technique of minimally invasive transforaminal lumbar interbody fusion (TLIF). J Clin Neurosci. 2011;18:624–7.

    Article  Google Scholar 

  45. Wang J, Zhou Y, Zhang ZF, et al. Comparison of the clinical outcome in overweight or obese patients after minimally invasive versus open transforaminal lumbar interbody fusion. J Spinal Disord Tech. 2014;27:202–6.

    Article  CAS  Google Scholar 

  46. Wang J, Zhou Y, Zhang ZF, et al. Minimally invasive or open transforaminal lumbar interbody fusion as revision surgery for patients previously treated by open discectomy and decompression of the lumbar spine. Eur Spine J. 2011;20:623–8.

    Article  Google Scholar 

  47. Schizas C, Tzinieris N, Tsiridis E, et al. Minimally invasive versus open transforaminal lumbar interbody fusion: evaluating initial experience. Int Orthop. 2009;33:1683–8.

    Article  Google Scholar 

  48. Parker SL, Mendenhall SK, Shau DN, et al. Minimally invasive versus open transforaminal lumbar interbody fusion for degenerative spondylolisthesis: comparative effectiveness and cost-utility analysis. World Neurosurg. 2014;82:230–8.

    Article  Google Scholar 

  49. Shunwu F, Xing Z, Fengdong Z, et al. Minimally invasive transforaminal lumbar interbody fusion for the treatment of degenerative lumbar diseases. Spine (Phila Pa 1976). 2010;35:1615–20.

    Article  Google Scholar 

  50. Adogwa O, Parker SL, Bydon A, et al. Comparative effectiveness of minimally invasive versus open transforaminal lumbar interbody fusion: 2-year assessment of narcotic use, return to work, disability, and quality of life. J Spinal Disord Tech. 2011;24:479–84.

    PubMed  Google Scholar 

  51. Kehrer M, Pedersen C, Jensen TG, et al. Increased short- and long-term mortality among patients with infectious spondylodiscitis compared with a reference population. Spine J. 2015;15:1233–40.

    Article  Google Scholar 

  52. Grados F, Lescure FX, Senneville E, et al. Suggestions for managing pyogenic (non-tuberculous) discitis in adults. Joint Bone Spine. 2007;74:133–9.

    Article  Google Scholar 

  53. StĂ¼er C, Stoffel M, Hecker J, et al. A staged treatment algorithm for spinal infections. J Neurol Surg A Cent Eur Neurosurg. 2013;74:87–95.

    Article  Google Scholar 

Download references

Acknowledgments

We would like to thank our reviewers for reviewing this report. No funding was utilized for this report.

Availability of data and materials

All data generated and analyzed during this review are included in this published article and its supplementary information files.

Author information

Authors and Affiliations

Authors

Contributions

AH, AW, AA, ON, and FG have participated in the conception and design of this review and were involved in drafting and revising the manuscript. AH performed the final revisions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ahmed Hammad.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests. No funding was utilized for this report.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hammad, A., Wirries, A., Ardeshiri, A. et al. Open versus minimally invasive TLIF: literature review and meta-analysis. J Orthop Surg Res 14, 229 (2019). https://doi.org/10.1186/s13018-019-1266-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s13018-019-1266-y

Keywords