Kyphoplasty in osteoporotic vertebral compression fractures - Guidelines and technical considerations
© Robinson et al; licensee BioMed Central Ltd. 2011
Received: 5 February 2011
Accepted: 19 August 2011
Published: 19 August 2011
Osteoporotic vertebral compression fractures are a menace to the elderly generation causing diminished quality of life due to pain and deformity. At first, conservative treatment still is the method of choice. In case of resulting deformity, sintering and persistent pain vertebral cement augmentation techniques today are widely used. Open correction of resulting deformity by different types of osteotomies addresses sagittal balance, but has comparably high morbidity.
Besides conventional vertebral cement augmentation techniques balloon kyphoplasty has become a popular tool to address painful thoracic and lumbar compression fractures. It showed improved pain reduction and lower complication rates compared to standard vertebroplasty. Interestingly the results of two placebo-controlled vertebroplasty studies question the value of cement augmentation, if compared to a sham operation. Even though there exists now favourable data for kyphoplasty from one randomised controlled trial, the absence of a sham group leaves the placebo effect unaddressed. Technically kyphoplasty can be performed with a transpedicular or extrapedicular access. Polymethyl methacrylate (PMMA)-cement should be favoured, since calcium phosphate cement showed inferior biomechanical properties and less effect on pain reduction especially in less stable burst fractures. Common complications of kyphoplasty are cement leakage and adjacent segment fractures. Rare complications are toxic PMMA-monomer reactions, cement embolisation, and infection.
KeywordsKyphoplasty vertebroplasty osteoporosis spinal fractures
Osteoporosis and pathological osteoporotic fractures are common findings in the elderly population. The age-standardised annual incidence of vertebral compression fractures (VCF) is 10.7/1000 in women and 5.7/1000 in men, increasing markedly with age . At the age of 75 to 79 the annual incidence was 29.3/1000 in women and 13.6/1000 in men. Due to the continued aging of our population, VCF represent a major cause of disability and are a burden to the national healthcare budgets . Non-surgical management with pain control and physical therapy-assisted mobilization has for a long time been the only treatment option in VCF. Unfortunatelty a great number of patients remain functionally impaired after VCF, and some of them are severely handicapped due to chronic back pain . The functional and physical consequences of VCF lead to anxiety, depression, and have devastating impact on interpersonal relationships and social roles . It is therefore no surprise that untreated VCF contribute significantly to shorter life-expectancy both in women (mortality ratio 1.66, p < 0.01) and even greater in men (mortality ratio 2.38, p < 0.0001) within one year after onset of symptoms .
Indications for cement augmentation
while medical therapy of osteoporosis improves dramatically, the restoration of quality of life is still a major issue in VCF treatment. Osteoporotic kyphotic compression fractures often lead to a anterior shift of the sagittal plumb line and increased load of the anterior vertebral column, which may cause further compression fractures . This cascade of sequential compression fractures is eventually causing the typical hump of the elderly, with significant thoracic kyphosis and low pelvic incidence, forcing the patient to bend hips and knees to maintain sagittal balance .
Galibert et al  presented the first cases of successful vertebral augmentation by intravertebral injection (vertebroplasty) of polymethyl methacrylate (PMMA) in patients with vertebral haemagiomas. Later, vertebroplasty was successfully introduced for the management of osteoporotic compression fractures . The primary goal of vertebroplasty is pain relief by stabilization of the VCF, improving indirectly pulmonary function and patient quality of life . The biomechanical understanding of increasing anterior column load with progressing kyphosis leading to subsequent VCF established the basic rationale for kyphoplasty. With this technique, partial reduction of VCF is possible by transpedicular intracorporal balloon expansion and retention by PMMA cement augmentation [11, 12]. The results of one multicenter randomised controlled trial found shortened and improved functional recovery after kyphoplasty with a low rate of complications if compared to non-surgical treatment .
Despite the advances in percutaneous augmentation techniques the conservative medical therapy cannot be replaced. VCF without initial kyphosis, no consecutive sintering and a satisfactory and quick response to conservative treatment should be treated conservatively. Furthermore, since lack of reimbursement in most countries kyphoplasty causes an economic burden, many patients are not willing to take. Beyond that, it has to me emphasised, that it remains unclear whether the benefits of kyphoplasty outweigh its complications.
Guidelines for indications and contraindications for kyphoplasty
Indications for kyphoplasty
- Radiologically confirmed fresh compression fracture (AO type A1) (MRI shows oedema or X-ray/CT-scan proven fracture not older than 3 months)
- Failure of 2 - 6 weeks of conservative treatment including pain medication and physiotherapy (Pain on visual analogous scale (VAS) above 4 of 10)
Contraindications for kyphoplasty
- Burst-fractures (in some A3.1-fractures possible)
- Flexion-/distraction and rotational injuries (AO type B and C)
- Medical contraindications (bleeding disorders, sepsis, etc)
Due to the increased demand in cement augmentation techniques, procedures similar to kyphoplasty have been developed. One competitor is Vesselplasty® (A-Spine), where a porous balloon is inflated within the fractured vertebral body and filled with cement without removing the balloon, thus reducing the risk of cement leakage . Another new product is the Sky® bone expander (Disc-O-Tech), an expandable polymer bone tamp abandoning the use of cement, which had favourable results in clinical case series . Then there is the StaXx® FX system (Spine Wave) where a VCF is reduced percutaneously by gradual insertion of stacked PEEK-chips into the vertebral body to reduce and stabilise the fracture .
Indications for combined cement augmentation and posterior instrumentation
Lately kyphoplasty has been discussed as an alternative therapy even of burst fractures in elderly patients. This is especially true in case of AO type A3.1 fractures, where it could be applied instead of a posterior-only or 360 degrees stabilisation . In many of these cases further sintering of the fractured vertebra with posterior dislocation of an instable fragment with spinal stenosis is a feared complication [26, 27]. Thus several surgeons perform posterior instrumentation of the adjacent vertebrae to protect the posterior wall and to improve the sagittal profile . This can be done using percutaneous posterior instrumentation or with a conventional open technique [28–30]. Possible disadvantages of this technique are due to segmental fusion an increased load of the adjacent segments with degeneration, and possible implant loosening with loss of correction due to low bone quality. Cement augmentation of the implanted pedicle screws can reduce the complication rate regarding the latter mentioned problem .
Limitations of kyphoplasty and indications for open reduction and stabilisation
If multiple VCF lead to kyphosis with fixed sagittal imbalance, cement augmentation will address the fracture pain but not global imbalance. Major spinal imbalance can be a cause of significant functional disability leading to reduced quality of life. Increased kyphosis may additionally cause subsequent VCF due to an increased anterior load . The anterior location of the sagittal plumb line in fixed sagittal imbalance will lead to falls with possible further fractures and morbidity. Therefore the indication for correction of global sagittal imbalance may be given in severe cases. As both open and closing wedge procedures are associated with complications leading to disabling morbidity surgeon are often hesitant to perform these operations in patients with multiple comorbidities . Due to the osteopenic bone quality often long instrumentations are required. Unfortunately these an increased risk of adjacent VCF and pedicle fractures . With regard to open sagittal corrections there is growing evidence that the posterior-only pedicle subtraction osteotomy is superior to multiple Smith-Petersen osteotomies, allowing greater correction with lesser operation time [35, 36].
Operation technique of kyphoplasty
Percutaneous bilateral transpedicular kyphoplasty
Percutaneous unilateral extrapedicular kyphoplasty
Open unilateral interlaminary kyphoplasty
Open interlaminary kyphoplasty should be reserved for cases where an open approach has to be performed to decompress neurological structures, and the spinal canal has to be accessed anyway . After open decompression the dural sac is retracted medially and the posterior wall of the fractured vertebra exposed. Now kyphoplasty can be performed with a single balloon positioned under fluoroscopical guidance in the centre of the vertebral body. After kyphoplasty the spinal canal has to be investigated for cement leakage. This method must be restricted to levels below the conus medullaris to avoid myelopathy due to manipulation within the spinal canal.
Open anterior kyphoplasty
In rare cases kyphoplasty may be performed using an anterior access, too . Through a minimally-invasive anterior access the biopsy needle may be placed directly on the anterior wall of the fractured vertebra and a single balloon be placed into the vertebral body. Then under fluoroscopical control the fracture is reduced and cement is applied.
Operation room setup
Both general an local anesthesia have been successfully applied for the procedure , but many surgeons favour general anestesia allowing closed reduction in a relaxed patient. By patient positioning only, more than 70% of vertebral height restoration can be achieved. Placing the patient in prone position lordosating the fractured segment by pillows or by bending the table will lead to reduction of the fracture with ligamentotaxis .
As in most percutaneus surgical techniques implant positioning and accuracy is controlled with fluoroscopic image intensifiers. Correct positioning of the image intensifier will lead to much lesser radiation dose for the surgeon. Placement of x-ray tube in the image intensifier on the opposite side of the surgeon will causes up to 10 times less radiation exposure .
Balloon placement accuracy can be significantly improved and the radiation exposure during kyphoplasty can be reduced by as much as 76%, if computer-assisted fluoroscopic navigation is applied [44, 45]. While relying on the navigator during the transpedicular balloon placement, balloon inflation and cement injection have to be performed under fluoroscopic control to minimise endplate fractures and cement leakage.
An eggshell-procedure may avoid cement leakage in VCF suscpicious for endplate or posterior wall damage . After reduction with the kyphoplasty balloon a small amount of doughy cement is injected into the cavity, and then the balloon reinserted and reinflated. Once the cement hardens the cavity can be filled with cement within the "eggshell", preventing cement leakage.
Choice of cement
Most vertebroplasty and kyphoplasty procedures have been performed using polymethylmethacrylate (PMMA) cement to augment the fractured vertebra. The increasing availability of injectable calcium phosphate (CaP) cement led to its application in the augmentation of compression fractures as an alternative to PMMA. Advantages are high biocompatibility, no systemic toxic monomers, osteoinductive capacity, and close to isothermal cristallinisation. Disadvantages are besides less clinical long-term experience, lesser compressive strength than PMMA , and the risk of early resorption, leading to defects prone to re-fractures [48–50]. The available data does not encourage the clinical use of CaP-cement in burst-fractures, flexion-distraction injuries, or rotational instable fractures [48, 51].
Results and complications of kyphoplasty
Overview on comparative clinical trials of kyphoplasty
Level of evidence
Control n (levels)
Kyphoplasty n (levels)
Weisskopf et al. 
Improvement in VAS (p < 0.001) Reduced days in hospital (p < 0.01)
Fourney et al. 
No significant differences in VAS and ODI Improvement of kyphosis with kyphoplasty (p < 0.01)
Komp et al. 
Improvement of VAS and ODI with kyophoplasty (p < 0.01)
Kasperk et al 
Improvement of VAS (p < 0.01) and improvement of kyphosis (p < 0.001) with kyphoplasty
Grohs et al. 
No significant difference in ODI, but improvement of VAS with kyphoplasty (p < 0.05). No significant improvement of kyphosis
Masala et al. 
No significant difference in VAS.
Pflugmacher et al 
No significant difference in VAS and ODI. Improvement of kyphosis with kyphoplasty (p < 0.05)
De Negri et al. 
No significant difference in VAS and ODI.
Zhou et al. 
No significant differences in VAS, operation time and blood loss. Improved vertebral height restoration with kyphoplasty (p < 0.01).
Wardlaw et al. 
Significant improvement in EQ-5D (p < 0.05), RMDQ (p < 0.001) VAS (p < 0.0001).
Schmelzer-Schmied et al. 
Significant greater improvement of VAS (p < 0.05) with kyphoplasty, which was lost after 3 months, and vertebral height preservation after 12 months (p < 0.01)
Schofer et al. 
No significant differences in VAS and SF-36. Greater improvement of kyphotic angle with kyphoplasty (p < 0.001)
Li X et al 
No significant differences in VAS and ODI. Significantly greater improvement of kyphotic angle with kyphoplasty (p < 0.01)
The comprehensive meta-analysis of Lee et al  summarized all published kyphoplasty complications. Cement leakages occurred in 14% of all cases, but only 0.01% were symptomatic. New vertebral fractures occurred in 17%. Taylor et al  found in their metaanalysis furthermore spinal stenosis with spinal cord compression occurred 0.16% of all cases. Radiculopathy was found in 0.17% of all cases. Furthermore there are anecdotal reports of infections after kyphoplasty . The overall mortality was 4.4%, and the perioperative mortality was 0.13% .
Kyphoplasty is - in the hands of an experienced spine surgeon or radiological interventionalist - an effective tool to treat pain caused by thoracolumbar vertebral compression fractures, but the severity of pulmonary PMMA cement embolism and the urgent need of immediate decompression in relevant spinal stenosis after cement leakage, require an anaesthesiologist and a spinal surgeon on call. The complication rate of kyphoplasty is dramatically lower than in alternative open instrumented procedures, and the immediate pain reduction is significantly greater in kyphoplasty compared to conservative treatment. Therefore its application remains a pillar in VCF treatment.
- Felsenberg D, Silman AJ, Lunt M, Armbrecht G, Ismail AA, Finn JD, Cockerill WC, Banzer D, Benevolenskaya LI, Bhalla A: Incidence of vertebral fracture in europe: results from the European Prospective Osteoporosis Study (EPOS). J Bone Miner Res. 2002, 17: 716-724.View ArticlePubMedGoogle Scholar
- Lad SP, Patil CG, Lad EM, Boakye M: Trends in pathological vertebral fractures in the United States: 1993 to 2004. J Neurosurg Spine. 2007, 7: 305-310. 10.3171/SPI-07/09/305.View ArticlePubMedGoogle Scholar
- Pluijm SM, Tromp AM, Smit JH, Deeg DJ, Lips P: Consequences of vertebral deformities in older men and women. J Bone Miner Res. 2000, 15: 1564-1572. 10.1359/jbmr.2000.15.8.1564.View ArticlePubMedGoogle Scholar
- Gold DT: The clinical impact of vertebral fractures: quality of life in women with osteoporosis. Bone. 1996, 18: 185S-189S. 10.1016/8756-3282(95)00500-5.View ArticlePubMedGoogle Scholar
- Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA: Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet. 1999, 353: 878-882. 10.1016/S0140-6736(98)09075-8.View ArticlePubMedGoogle Scholar
- Rohlmann A, Klockner C, Bergmann G: [The biomechanics of kyphosis]. Orthopade. 2001, 30: 915-918. 10.1007/s001320170003.View ArticlePubMedGoogle Scholar
- Schwab F, Lafage V, Patel A, Farcy JP: Sagittal plane considerations and the pelvis in the adult patient. Spine (Phila Pa 1976). 2009, 34: 1828-1833. 10.1097/BRS.0b013e3181a13c08.View ArticleGoogle Scholar
- Galibert P, Deramond H, Rosat P, Le Gars D: [Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty]. Neurochirurgie. 1987, 33: 166-168.PubMedGoogle Scholar
- Deramond H, Depriester C, Galibert P, Le Gars D: Percutaneous vertebroplasty with polymethylmethacrylate. Technique, indications, and results. Radiol Clin North Am. 1998, 36: 533-546. 10.1016/S0033-8389(05)70042-7.View ArticlePubMedGoogle Scholar
- Lee JS, Kim KW, Ha KY: The Effect of Vertebroplasty on Pulmonary Function in Patients With Osteoporotic Compression Fractures of the Thoracic Spine. J Spinal Disord Tech.Google Scholar
- Voggenreiter G: Balloon kyphoplasty is effective in deformity correction of osteoporotic vertebral compression fractures. Spine (Phila Pa 1976). 2005, 30: 2806-2812. 10.1097/01.brs.0000190885.85675.a0.View ArticleGoogle Scholar
- Luo J, Bertram W, Sangar D, Adams MA, Annesley-Williams DJ, Dolan P: Is kyphoplasty better than vertebroplasty in restoring normal mechanical function to an injured spine?. Bone. 46: 1050-1057.Google Scholar
- Wardlaw D, Cummings SR, Van Meirhaeghe J, Bastian L, Tillman JB, Ranstam J, Eastell R, Shabe P, Talmadge K, Boonen S: Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial. Lancet. 2009, 373: 1016-1024. 10.1016/S0140-6736(09)60010-6.View ArticlePubMedGoogle Scholar
- Buchbinder R, Osborne RH, Ebeling PR, Wark JD, Mitchell P, Wriedt C, Graves S, Staples MP, Murphy B: A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med. 2009, 361: 557-568. 10.1056/NEJMoa0900429.View ArticlePubMedGoogle Scholar
- Kallmes DF, Comstock BA, Heagerty PJ, Turner JA, Wilson DJ, Diamond TH, Edwards R, Gray LA, Stout L, Owen S: A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med. 2009, 361: 569-579. 10.1056/NEJMoa0900563.PubMed CentralView ArticlePubMedGoogle Scholar
- Rousing R, Andersen MO, Jespersen SM, Thomsen K, Lauritsen J: Percutaneous vertebroplasty compared to conservative treatment in patients with painful acute or subacute osteoporotic vertebral fractures: three-months follow-up in a clinical randomized study. Spine (Phila Pa 1976). 2009, 34: 1349-1354. 10.1097/BRS.0b013e3181a4e628.View ArticleGoogle Scholar
- Fisher CG, Vaccaro AR: The highest level of evidence in a high impact journal: is this the final verdict?. Spine (Phila Pa 1976). 35: E676-677.View ArticleGoogle Scholar
- Karlsson MK, Ohlin A, Hasserius R: Could vertebroplasty and kyphoplasty be regarded as evidence-based treatment of osteoporotic vertebral fractures?. Acta Radiol. 51: 828-831.Google Scholar
- Hasserius R, Ohlin A, Karlsson MK: Vertebroplasty and kyphoplasty--evidence-based methods?. Acta Orthop. 81: 521-523.Google Scholar
- Miller FG, Kallmes DF: The case of vertebroplasty trials: promoting a culture of evidence-based procedural medicine. Spine (Phila Pa 1976). 35: 2023-2026.Google Scholar
- Heini PF: [Vertebroplasty: an update: value of percutaneous cement augmentation after randomized, placebo-controlled trials]. Orthopade. 39: 658-664.Google Scholar
- Flors L, Lonjedo E, Leiva-Salinas C, Marti-Bonmati L, Martinez-Rodrigo JJ, Lopez-Perez E, Figueres G, Raoli I: Vesselplasty: a new technical approach to treat symptomatic vertebral compression fractures. AJR Am J Roentgenol. 2009, 193: 218-226. 10.2214/AJR.08.1503.View ArticlePubMedGoogle Scholar
- Xiong J, Dang Y, Jiang BG, Fu ZG, Zhang DY: Treatment of osteoporotic compression fracture of thoracic/lumbar vertebrae by kyphoplasty with SKY bone expander system. Chin J Traumatol. 13: 270-274.Google Scholar
- Renner S: Restoration of intervertebral disc mechanics after endplate deformity reduction using structural kyphoplasty. J NeuroIntervent Surg. 2009, 1: 76-View ArticleGoogle Scholar
- Stoffel M, Wolf I, Ringel F, Stuer C, Urbach H, Meyer B: Treatment of painful osteoporotic compression and burst fractures using kyphoplasty: a prospective observational design. J Neurosurg Spine. 2007, 6: 313-319. 10.3171/spi.2007.6.4.5.View ArticlePubMedGoogle Scholar
- Robinson Y, Tschoke SK, Stahel PF, Kayser R, Heyde CE: Complications and safety aspects of kyphoplasty for osteoporotic vertebral fractures: a prospective follow-up study in 102 consecutive patients. Patient Saf Surg. 2008, 2: 2-10.1186/1754-9493-2-2.PubMed CentralView ArticlePubMedGoogle Scholar
- Patel AA, Vaccaro AR, Martyak GG, Harrop JS, Albert TJ, Ludwig SC, Youssef JA, Gelb DE, Mathews HH, Chapman JR: Neurologic deficit following percutaneous vertebral stabilization. Spine (Phila Pa 1976). 2007, 32: 1728-1734. 10.1097/BRS.0b013e3180dc9c36.View ArticleGoogle Scholar
- Noldge G, DaFonseca K, Grafe I, Libicher M, Hillmeier J, Meeder PJ, Kauffmann GW, Kasperk C: [Balloon kyphoplasty in the treatment of back pain]. Radiologe. 2006, 46: 506-512. 10.1007/s00117-006-1384-5.View ArticlePubMedGoogle Scholar
- Verlaan JJ, Dhert WJ, Verbout AJ, Oner FC: Balloon vertebroplasty in combination with pedicle screw instrumentation: a novel technique to treat thoracic and lumbar burst fractures. Spine (Phila Pa 1976). 2005, 30: E73-79. 10.1097/01.brs.0000152162.64015.fb.View ArticleGoogle Scholar
- Pflugmacher R, Kandziora F, Schroder R, Schleicher P, Scholz M, Schnake K, Haas N, Khodadadyan-Klostermann C: [Vertebroplasty and kyphoplasty in osteoporotic fractures of vertebral bodies -- a prospective 1-year follow-up analysis]. Rofo. 2005, 177: 1670-1676.View ArticlePubMedGoogle Scholar
- Aydogan M, Ozturk C, Karatoprak O, Tezer M, Aksu N, Hamzaoglu A: The pedicle screw fixation with vertebroplasty augmentation in the surgical treatment of the severe osteoporotic spines. J Spinal Disord Tech. 2009, 22: 444-447. 10.1097/BSD.0b013e31818e0945.View ArticlePubMedGoogle Scholar
- Hato T, Kawahara N, Tomita K, Murakami H, Akamaru T, Tawara D, Sakamoto J, Oda J, Tanaka S: Finite-element analysis on closing-opening correction osteotomy for angular kyphosis of osteoporotic vertebral fractures. J Orthop Sci. 2007, 12: 354-360. 10.1007/s00776-007-1144-z.View ArticlePubMedGoogle Scholar
- Daubs MD, Lenke LG, Cheh G, Stobbs G, Bridwell KH: Adult spinal deformity surgery: complications and outcomes in patients over age 60. Spine (Phila Pa 1976). 2007, 32: 2238-2244. 10.1097/BRS.0b013e31814cf24a.View ArticleGoogle Scholar
- DeWald CJ, Stanley T: Instrumentation-related complications of multilevel fusions for adult spinal deformity patients over age 65: surgical considerations and treatment options in patients with poor bone quality. Spine (Phila Pa 1976). 2006, 31: S144-151. 10.1097/01.brs.0000236893.65878.39.View ArticleGoogle Scholar
- Cho KJ, Bridwell KH, Lenke LG, Berra A, Baldus C: Comparison of Smith-Petersen versus pedicle subtraction osteotomy for the correction of fixed sagittal imbalance. Spine (Phila Pa 1976). 2005, 30: 2030-2037. 10.1097/01.brs.0000179085.92998.ee. discussion 2038View ArticleGoogle Scholar
- Kim YJ, Bridwell KH, Lenke LG, Cheh G, Baldus C: Results of lumbar pedicle subtraction osteotomies for fixed sagittal imbalance: a minimum 5-year follow-up study. Spine (Phila Pa 1976). 2007, 32: 2189-2197. 10.1097/BRS.0b013e31814b8371.View ArticleGoogle Scholar
- Boszczyk BM, Bierschneider M, Hauck S, Beisse R, Potulski M, Jaksche H: Transcostovertebral kyphoplasty of the mid and high thoracic spine. Eur Spine J. 2005, 14: 992-999. 10.1007/s00586-005-0943-1.View ArticlePubMedGoogle Scholar
- Ryu KS, Park CK, Kim MK, Kim DH: Single balloon kyphoplasty using far-lateral extrapedicular approach: technical note and preliminary results. J Spinal Disord Tech. 2007, 20: 392-398. 10.1097/BSD.0b013e31802da846.View ArticlePubMedGoogle Scholar
- Boszczyk BM, Bierschneider M, Schmid K, Grillhosl A, Robert B, Jaksche H: Microsurgical interlaminary vertebro- and kyphoplasty for severe osteoporotic fractures. J Neurosurg. 2004, 100: 32-37.PubMedGoogle Scholar
- Boszczyk B, Bierschneider M, Potulski M, Robert B, Vastmans J, Jaksche H: [Extended kyphoplasty indications for stabilization of osteoporotic vertebral compression fractures]. Unfallchirurg. 2002, 105: 952-957. 10.1007/s00113-002-0495-3.View ArticlePubMedGoogle Scholar
- Cagli S, Isik HS, Zileli M: Vertebroplasty and kyphoplasty under local anesthesia: review of 91 patients. Turk Neurosurg. 20: 464-469.Google Scholar
- Cawley DT, Sexton P, Murphy T, McCabe JP: Optimal patient positioning for ligamentotaxis during balloon kyphoplasty of the thoracolumbar and lumbar spine. J Clin Neurosci.Google Scholar
- Choi HC: Fluoroscopic Radiation Exposure during Percutaneous Kyphoplasty. J Korean Neurosurg Soc. 49: 37-42.Google Scholar
- Kang JD, An H, Boden S, Phillips F, Foley K, Abdu W: Cement augmentation of osteoporotic compression fractures and intraoperative navigation: summary statement. Spine (Phila Pa 1976). 2003, 28: S62-63.Google Scholar
- Ohnsorge JA, Siebert CH, Schkommodau E, Mahnken AH, Prescher A, Weisskopf M: [Minimally-invasive computer-assisted fluoroscopic navigation for kyphoplasty]. Z Orthop Ihre Grenzgeb. 2005, 143: 195-203. 10.1055/s-2005-836514.View ArticlePubMedGoogle Scholar
- Greene DL, Isaac R, Neuwirth M, Bitan FD: The eggshell technique for prevention of cement leakage during kyphoplasty. J Spinal Disord Tech. 2007, 20: 229-232.View ArticlePubMedGoogle Scholar
- Wilke HJ, Mehnert U, Claes LE, Bierschneider MM, Jaksche H, Boszczyk BM: Biomechanical evaluation of vertebroplasty and kyphoplasty with polymethyl methacrylate or calcium phosphate cement under cyclic loading. Spine (Phila Pa 1976). 2006, 31: 2934-2941. 10.1097/01.brs.0000248423.28511.44.View ArticleGoogle Scholar
- Blattert TR, Jestaedt L, Weckbach A: Suitability of a calcium phosphate cement in osteoporotic vertebral body fracture augmentation: a controlled, randomized, clinical trial of balloon kyphoplasty comparing calcium phosphate versus polymethylmethacrylate. Spine (Phila Pa 1976). 2009, 34: 108-114. 10.1097/BRS.0b013e31818f8bc1.View ArticleGoogle Scholar
- Heo HD, Cho YJ, Sheen SH, Kuh SU, Cho SM, Oh SM: Morphological changes of injected calcium phosphate cement in osteoporotic compressed vertebral bodies. Osteoporos Int. 2009, 20: 2063-2070. 10.1007/s00198-009-0911-4.PubMed CentralView ArticlePubMedGoogle Scholar
- Heo DH, Chin DK, Yoon YS, Kuh SU: Recollapse of previous vertebral compression fracture after percutaneous vertebroplasty. Osteoporos Int. 2009, 20: 473-480. 10.1007/s00198-008-0682-3.View ArticlePubMedGoogle Scholar
- Schmelzer-Schmied N, Cartens C, Meeder PJ, Dafonseca K: Comparison of kyphoplasty with use of a calcium phosphate cement and non-operative therapy in patients with traumatic non-osteoporotic vertebral fractures. Eur Spine J. 2009, 18: 624-629. 10.1007/s00586-008-0880-x.PubMed CentralView ArticlePubMedGoogle Scholar
- Lee MJ, Dumonski M, Cahill P, Stanley T, Park D, Singh K: Percutaneous treatment of vertebral compression fractures: a meta-analysis of complications. Spine (Phila Pa 1976). 2009, 34: 1228-1232. 10.1097/BRS.0b013e3181a3c742.View ArticleGoogle Scholar
- Taylor RS, Fritzell P, Taylor RJ: Balloon kyphoplasty in the management of vertebral compression fractures: an updated systematic review and meta-analysis. Eur Spine J. 2007, 16: 1085-1100. 10.1007/s00586-007-0308-z.PubMed CentralView ArticlePubMedGoogle Scholar
- Weisskopf M, Herlein S, Birnbaum K, Siebert C, Stanzel S, Wirtz DC: [Kyphoplasty - a new minimally invasive treatment for repositioning and stabilising vertebral bodies]. Z Orthop Ihre Grenzgeb. 2003, 141: 406-411.View ArticlePubMedGoogle Scholar
- Fourney DR, Schomer DF, Nader R, Chlan-Fourney J, Suki D, Ahrar K, Rhines LD, Gokaslan ZL: Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg. 2003, 98: 21-30. 10.3171/jns.2003.98.1.0021.View ArticlePubMedGoogle Scholar
- Komp M, Ruetten S, Godolias G: [Minimally-invasive therapy for functionally unstable osteoporotic vertebral fractures by means of kyphoplasty: prospective comparative study of 19 surgically and 17 conservatively treated patients.]. J Miner Stoffwechs. 2004, 11: 604-612.Google Scholar
- Kasperk C, Hillmeier J, Noldge G, Grafe IA, Dafonseca K, Raupp D, Bardenheuer H, Libicher M, Liegibel UM, Sommer U: Treatment of painful vertebral fractures by kyphoplasty in patients with primary osteoporosis: a prospective nonrandomized controlled study. J Bone Miner Res. 2005, 20: 604-612.View ArticlePubMedGoogle Scholar
- Grohs JG, Matzner M, Trieb K, Krepler P: Minimal invasive stabilization of osteoporotic vertebral fractures: a prospective nonrandomized comparison of vertebroplasty and balloon kyphoplasty. J Spinal Disord Tech. 2005, 18: 238-242.PubMedGoogle Scholar
- Masala S, Lunardi P, Fiori R, Liccardo G, Massari F, Ursone A, Simonetti G: Vertebroplasty and kyphoplasty in the treatment of malignant vertebral fractures. J Chemother. 2004, 16 (Suppl 5): 30-33.PubMedGoogle Scholar
- De Negri P, Tirri T, Paternoster G, Modano P: Treatment of painful osteoporotic or traumatic vertebral compression fractures by percutaneous vertebral augmentation procedures: a nonrandomized comparison between vertebroplasty and kyphoplasty. Clin J Pain. 2007, 23: 425-430. 10.1097/AJP.0b013e31805593be.View ArticlePubMedGoogle Scholar
- Zhou JL, Liu SQ, Ming JH, Peng H, Qiu B: Comparison of therapeutic effect between percutaneous vertebroplasty and kyphoplasty on vertebral compression fracture. Chin J Traumatol. 2008, 11: 42-44.View ArticlePubMedGoogle Scholar
- Schofer MD, Efe T, Timmesfeld N, Kortmann HR, Quante M: Comparison of kyphoplasty and vertebroplasty in the treatment of fresh vertebral compression fractures. Arch Orthop Trauma Surg. 2009, 129: 1391-1399. 10.1007/s00402-009-0901-1.View ArticlePubMedGoogle Scholar
- Li X, Yang H, Tang T, Qian Z, Chen L, Zhang Z: Comparison of Kyphoplasty and Vertebroplasty for Treatment of Painful Osteoporotic Vertebral Compression Fractures: Twelve-month Follow-up in a Prospective Nonrandomized Comparative Study. J Spinal Disord Tech.Google Scholar
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