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Table 2 Overview on comparative clinical trials of kyphoplasty

From: Kyphoplasty in osteoporotic vertebral compression fractures - Guidelines and technical considerations

Author Year Design Level of evidence Control Group Control n (levels) Kyphoplasty n (levels) Follow-up Outcome
Weisskopf et al. [54] 2003 Retrospective IIIb non-surgical 20 (35) 22 (37) 10 days Improvement in VAS (p < 0.001) Reduced days in hospital (p < 0.01)
Fourney et al. [55] 2003 Retrrospective IIIb vertebroplasty 34 (65) 15 (32) 4,5 months No significant differences in VAS and ODI Improvement of kyphosis with kyphoplasty (p < 0.01)
Komp et al. [56] 2004 Prospective IIb non-surgical 19(19) 21(21) 6 months Improvement of VAS and ODI with kyophoplasty (p < 0.01)
Kasperk et al [57] 2005 Prospective IIb non-surgical 20 (33) 40 (72) 12 months Improvement of VAS (p < 0.01) and improvement of kyphosis (p < 0.001) with kyphoplasty
Grohs et al. [58] 2005 Prospective IIb vertebroplasty 23 (29) 28 (35) 24 months No significant difference in ODI, but improvement of VAS with kyphoplasty (p < 0.05). No significant improvement of kyphosis
Masala et al. [59] 2005 Retrospective IIIb vertebroplasty 26 (33) 7 (7) 6 months No significant difference in VAS.
Pflugmacher et al [30] 2005 Prospective IIb vertebroplasty 20 (32) 22 (35) 12 months No significant difference in VAS and ODI. Improvement of kyphosis with kyphoplasty (p < 0.05)
De Negri et al. [60] 2007 Prospective IIb vertebroplasty 10 (18) 11 (15) 6 months No significant difference in VAS and ODI.
Zhou et al. [61] 2008 Prospective IIIb vertebroplasty 42 56 12 months No significant differences in VAS, operation time and blood loss. Improved vertebral height restoration with kyphoplasty (p < 0.01).
Wardlaw et al. [13] 2009 Randomised Ib non-surgical 149 151 12 months Significant improvement in EQ-5D (p < 0.05), RMDQ (p < 0.001) VAS (p < 0.0001).
Schmelzer-Schmied et al. [51] 2009 Prospective IIb non-surgical 20 20 12 months Significant greater improvement of VAS (p < 0.05) with kyphoplasty, which was lost after 3 months, and vertebral height preservation after 12 months (p < 0.01)
Schofer et al. [62] 2009 Prospective IIIb vertebroplasty 30 30 13 months No significant differences in VAS and SF-36. Greater improvement of kyphotic angle with kyphoplasty (p < 0.001)
Li X et al [63] 2011 Prospective IIIb vertebroplasty 40 45 12 months No significant differences in VAS and ODI. Significantly greater improvement of kyphotic angle with kyphoplasty (p < 0.01)
  1. VAS: Visual Analogous Scale, ODI: Oswestry Disability Index, EQ-5D: EuroQoL, RMDQ: Roland Morris Disability Questionnaire, SF-36: Short Form Health Survey.