Skip to main content

Vacuum-assisted closure versus conventional dressing in necrotizing fasciitis: a systematic review and meta-analysis



Necrotizing fasciitis is a rapid and severe soft tissue infection that targets subcutaneous fat tissue, muscle, and fascia. This study compares the clinical outcomes of vacuum-assisted closure (VAC) versus conventional dressing on necrotizing fasciitis.


We systematically searched Embase, Cochrane, and PubMed for clinical trials (published between January 1, 1995 and September 30, 2021), which compared VAC with conventional dressing for necrotizing fasciitis. The mortality rate of necrotizing fasciitis was the primary outcome of this study. The number of debridements, the total length of hospital stay, and the complication rate were secondary outcomes. A random effects model assessed all pooled data.


A total of 230 identified studies and seven controlled clinical trials met the inclusion criteria and were included in this analysis (n = 249 participants). Compared to the conventional dressing, patients treated with VAC had a significantly lower mortality rate [OR = 0.27, 95% CI (0.09, 0.87)] (P = 0.03). Total length of hospital stays [MD = 8.46, 95% CI (− 0.53, 17.45)] (P = 0.07), number of debridements [MD = 0.86, 95% CI (− 0.58, 2.30)] (P = 0.24), and complication rate [OR = 0.64, 95% CI (0.07, 5.94)] (P = 0.69) were not significant. These results did not show significant differences between both groups treated with VAC or conventional treatment.


VAC could significantly decrease the death rate compared to conventional dressing. No significant impacts were found on the number of debridements, the total length of hospital stay, and the complication rate in this study.

Level of evidence Level-III.

Registration Research Registry (reviewregistry1246).


Necrotizing fasciitis (NF) is a rapid, severe, and life-threatening soft tissue infection that targets subcutaneous fat tissue, muscle, and fascia [1]. This disease usually occurs in the lower extremities, genitalia and perineum (Fournier’s gangrene, FG) [2]. NF has different names, including streptococcal gangrene, gas gangrene, suppurative fasciitis, Meleney’s gangrene, necrotizing erysipelas, and Fournier’s gangrene. Wilson first coined the term 'necrotizing fasciitis' to define both non-gas or gas-forming necrotizing infections of the subcutaneous tissue and fascia in 1951 [3].

Familiarity with the pathophysiological development of necrotizing fasciitis is essential for the early and rapid identification of clinical manifestations of disease. The main pathological changes of necrotizing fasciitis are in the superficial fascia. Bacteria colonize and multiply in the superficial fascia, secrete complex enzymes and toxins, and spread rapidly through the fascia [4]. Uncontrolled bacterial proliferation leading to vascular thrombotic microbial invasion with superficial fascial liquefaction and necrosis is the disease progression [5, 6]. Eventually, the skin becomes necrotic due to ischemia, with subcutaneous fat, dermis, and epidermis gangrene.

Surgically successful and timely diagnosis is essential in managing this rare and rapidly progressing disease. A high mortality rate of 12–20% has been reported, especially without early surgical intervention [7, 8]. After wound debridement and systemic antibiotics according to bacterial culture, a large open wound usually remains [9]. The wound is traditionally managed with the conventional dry or wet gauze technique before covering it with a skin graft, flap, or musculocutaneous flap. The morbidities associated with using conventional dressing techniques in handling exposed wounds could be extensive.

In 1997, Morykwas and Argenta first introduced the VAC based on a porcine model study [10]. After 20 years of development, this technology has been evaluated by several clinical and experimental studies and has been proven to promote the coverage of acute or chronic wounds [11,12,13]. VAC by pulling wound edges together to narrow the wound size, promoting granulation tissue formation on the wound bed for skin-grafting, promoting microcirculation, decreasing edema, and removing infectious tissues. To our knowledge, there were no meta-analysis and systematic review incorporating all these trials and comprehensively comparing VAC with conventional dressing techniques in treating NF patients. This meta-analysis study was conducted to compare these two treatments and provide clinically referable evidence about clinical outcomes.

Materials and methods

This recent systematic review and meta-analysis were conducted according to the Cochrane handbook guideline for systematic reviews of interventions [14].

Search strategy and selection criteria

We searched for all relevant trials published between January 1, 1995 and September 30, 2021, on Embase, PubMed, and Cochrane. The following research strategy, which combined with several MeSH terms, was used in each database: ("necrotizing fasciitis" OR "necrotizing fascitides" OR "necrotizing fasciitides" OR "necrotizing fasciitis") AND ("vacuum-assisted closure" OR "negative pressure" OR "subatmospheric pressure" OR "suction dressing" OR "topical negative pressure" OR "VAC" OR "vacuum therapy") (Additional file 1). We conducted a manual search based on the references of important articles published in English.

Study selection and data extraction

Two independent investigators (R.L.Z. and Y.H.Z.) reviewed the titles and abstracts of all searched studies, and the studies that met the conditions were downloaded for full-text reading. Disagreement between the two reviewers was resolved by consensus. The senior author made the final decision if a consensus could not be reached.

The inclusion criteria were cohort studies that compared VAC and conventional dressing therapy in NF. Exclusion criteria included the following: (1) the study reported a case or case series; (2) no English-language articles; (3) the study without outcome measures; (4) letter, commentary, editorial or systematic review.

The data from each selected study were extracted: first author, publication year, study type, the total number of participants, and age. The primary outcome was the mortality rate in both treatment groups. Secondary outcomes were the number of debridements, the total length of hospital stay, and the rate of complications. The studies in which the mean and standard deviation were not supplied were estimated statistically using the relevant data [15].

Quality assessment

The quality of all enrolled studies was assessed according to the classic Newcastle Ottawa Scale scores (NOSs) [16]. NOSs consist of eight items with three subscales and range from 0 to 9 points. A study with a score of 7–10 has high quality, 4–6 moderate quality, and 0–3 poor quality.

Statistical analysis

Review Manager 5.4 (The Nordic Cochrane Center, Copenhagen, The Cochrane Collaboration) was applied for statistical analysis. MD (mean difference) was used to analyze continuous variables, and OR (odds ratio) was used to present the dichotomous variables. A random effect model pooled all extracted data if I2 ≥ 50% between included studies was statistically significant. Otherwise, the fixed-effect model was selected. All variables were reported with 95% CI (confidence interval). Statistical heterogeneity between studies was calculated with chi-square and I2 tests. I2 values between 0 and 30% indicated homogeneity, 30–60% indicated moderated heterogeneity, and values above 60% indicated substantial heterogeneity. A two-sided P value < 0.05 was considered statistically significant. Funnel plot analysis was used to reflect publication bias. According to Egger et al. [17], the ability of funnel plots to detect this bias is limited when the number of included studies is small. Consequently, we ensure to provide the funnel plot as a supplementary file.


Search results

Two authors (L.Y.H. and C.Y.Y.) retrieved 230 literature from these three databases. Among them, 54 studies were repeated and excluded. Then, by reviewing the titles and abstracts of the remaining research, 69 studies were eliminated according to inclusion and exclusion criteria, and 100 were eliminated after reviewing the whole texts for these reasons: case reports or case series and literature review, cohort studies separately reported treated with VAC or conventional gauze dressings, animal studies, and non-English article. Finally, seven cohort studies [18,19,20,21,22,23,24], including 249 NF cases, were eligible for literature review, data extraction, and meta-analysis. Figure 1 shows a summary of the trial screening process.

Fig. 1
figure 1

Flow diagram of studies included in the systematic review

Characteristics of the included studies

Table 1 shows a summary of all enrolled studies. All these seven research studies were published between 2006 and 2021. Ultimately, seven cohort studies involving 249 NF patients were included in this review. The number of patients in these seven research studies ranged from 11 to 92. All these studies compared VAC with conventional dressing treatment and reported its efficacy. Outcomes of mortality rate, number of debridements, the total length of hospital stay, and complication rate were extracted for pooling the results. Since a random effect model was adopted, the publication bias risk for the main outcome (mortality rate) was presented by funnel plot and illustrated in Additional file 2: Fig S1. The NOS score was "high quality (ranging from 7 to 9 points)" in all included studies (Table 1).

Table 1 The main characteristics of the included studies

Meta-analysis of clinical outcomes

Mortality rate

Six studies involving 151 patients reported the mortality rate of NF after being treated with VAC or conventional dressing. Under the random effects model (Fig. 2), the mortality rate of NF patients in VAC group was lower than in the conventional dressing group (OR, 0.27; 95% CI, 0.09–0.87), and it has statistical significance (P = 0.03). No statistically significant heterogeneity was observed between these VAC and conventional dressing groups (P = 0.28, I2 = 21%).

Fig. 2
figure 2

Forest plot of the odds ratio of mortality rate between VAC and conventional dressing

Total length of hospital stay

Six studies (238 patients) compared the total hospital stay of NF after being treated with VAC or conventional dressing. Pooled results revealed no statistical difference in the total length of hospital stay between these two groups (MD, 8.46; 95% CI, − 0.53–17.45; P = 0.07). There was significant heterogeneity between these studies (P = 0.01, I2 = 70%), and the random effects model was applied for meta-analysis (Fig. 3).

Fig. 3
figure 3

Forest plot of the mean difference of total length of hospital stay between VAC and conventional dressing

A sensitivity analysis was conducted to evaluate the influence of every single study on the meta-analysis outcome by excluding studies one by one. When eliminating the study performed by Czymek [23] and recalculating the other research studies, the heterogeneity of the total length of hospital stay was decreased from 70 to 19%.

Number of debridements

Four studies (62 in VAC group and 60 in the conventional dressing group) compared the number of debridements of NF after being treated by VAC or conventional dressing. The pooled MD of number of debridements between these two groups was MD = 0.86 (95% CI, − 0.58–2.30), which was not statistically significant (P = 0.24). The random effects model was used in the meta-analysis, and a significant heterogeneity (I2 = 75%) was found between these studies (P = 0.01) (Fig. 4).

Fig. 4
figure 4

Forest plot of the mean difference in the number of debridements between VAC and conventional dressing

When performing the sensitivity analysis, after excluding the studies one by one, it was found that the heterogeneity could not be reduced below 60%. Heterogeneity was lowest at 63% when the study by Czymek [23] was excluded.

Complication rate

Two studies reported the rate of NF complication after being treated with VAC or conventional dressing. The pooled OR for the complication rate was 0.64 between these two groups, which showed no difference (95% CI, 0.07–5.94, P = 0.69). No heterogeneity was revealed between these two treatments (P = 0.66, I2 = 0%), and a random effects model was applied (Fig. 5).

Fig. 5
figure 5

Forest plot of the odds ratio of complication rate between VAC and conventional dressing


This systematic review and meta-analysis included seven cohort studies (249 cases). All relevant observed indicators from the seven selected studies were extracted and pooled. After several analyses, the most important finding of this meta-analysis study is that using VAC could decrease the mortality rate significantly compared to conventional dressing for treating NF patients. However, there was no evidence that VAC could reduce the length of hospital stay, number of debridements, and complication rate.

Treating NF patients is based on complete debridement and antibiotherapy. Recurrent surgical debridement should be performed to remove necrotic soft tissue and ensure sufficient drainage. However, treating the wound that occurs secondary to debridement in patients with NF can be difficult. The complications associated with conventional dressing techniques in managing the residual wound could be diverse. The use of vacuum-assisted closure, such as VAC, for NF infection, has attracted much attention recently [25]. When used in treating NF, it could reduce daily gauze changes and toxin absorbance, resulting in less pain and decreasing narcotic use. Moreover, VAC is useful to preserve residual subcutaneous soft tissue and promote the formation of a better wound bed, which is essential for later reconstructive surgery [26,27,28,29].

This study is the first literature review and meta-analysis to assess VAC and conventional dressing in treating NF patients. Bacteremia and sepsis secondary to necrotizing fasciitis will lead to multiple organ failure and high mortality. The mortality rate of NF is an important parameter in assessing the therapeutic outcome of NF. In this present study, the main outcome was the mortality rate. Among the seven included studies, six documented the mortality rate of NF [18, 20,21,22,23,24]. The combined odds ratio (OR) showed that VAC could reduce mortality by 27% compared to conventional dressing. Among these seven studies, five were NF of the perineal region (Fournier's Gangrene) [18, 19, 21, 23, 24], one was located head and neck [22], and one was located extremities [20]. The mortality of conventional dressing group in head and neck necrotizing fasciitis (HNNF) has the highest mortality rate (66.7%). Consequently, the perineal area (37.5–50%). NF usually appears in the lower extremities and abdominal wall. Previous literature has reported a mortality rate of HNNF as high as 70% [30] because of severe sepsis, acute renal failure, necrotizing mediastinitis or multi-organ failure. The main treatment for Fournier's Gangrene is the complete debridement of necrotic area and administration of empirical broad-spectrum antibiotics to prevent disease progression. However, it is difficult to keep the perineal region covered with a conventional dressing and clean; VAC might be a treatment of choice.

Seven trials in the present meta-analysis reported no significant differences in total hospital stay [19,20,21,22]. The length of hospital stay will be lengthened by large tissue defects with exposure of the wound or bacteremic complications up to the axillary and perineal regions. Czymek et al. claimed that the mean length of hospital stay of NF was 96.8 days in the VAC group and 27.8 days in the conventional dressing group [23]. The reason for that was the surgeon did not apply VAC immediately after the first-time debridement but after the second or the third surgery. This may also be one of the reasons why sensitivity analyzes showed increased heterogeneity due to the presence of the study. Czymek et al. concluded that although VAC group stayed much longer than conventional group, VAC could provide a cleaner wound without exudate, even in deep or problematic wounds.

The key to NF treatment is based on prompt and entire debridement. Surgery aims to remove all necrotic tissues to prevent the progression of infection and minimize the general reaction of NF patients. Four studies in the present meta-analysis revealed no significant differences in the number of debridements [21,22,23,24], and three of the four articles reported on Fournier's Gangrene treatment [21, 23, 24]. Yanaral et al. [24] claimed that the time and degree of first debridement are the most important risk factors affecting the mortality rate. Chawla et al. documented that an average of 3.5 debridements was efficient in treating NF [31]. After the first surgical debridement, wound management and adequate nutrition for the patient are essential. Subsequent debridement was performed if necessary.

Complications, including sepsis, respiratory failure, and multiple organ failure, usually occur in NF patients. Corresponding treatment methods, such as blood filtration, dialysis, and ventilator therapy, were adopted for these patients. Of seven included studies, only two had documented the rate of NF complication [18, 22]. The merged odds ratio (OR) showed no significant between VAC and conventional dressing. High-risk factors for NF include advanced age, diabetes mellitus, hypertension, alcohol use, and peripheral vascular or nerve disease. There are several scoring systems, such as neutrophil lymphocyte rate (NLR), laboratory risk indicator for necrotizing fasciitis (LRINEC), and Fournier's Gangrene Severity Index (FGSI) [32]. A previous study reported that an FGSI score greater than nine points was related to a higher mortality rate [33]. In 2004, Wong et al. reported LRINEC score as a predictive index capable of predicting early NF patients [34], a score of no less than 8 is strongly diagnostic of Fournier's Gangrene. In this present meta-analysis study, Zhang et al. [18] and Mustafa et al. [22] used LRINEC score to assess the risk of necrotizing fasciitis. In contrast, the studies by Iacovelli et al. [19] and Gul et al. [21] used FGSI score. Future research must prove which score is clinically meaningful or propose a more widely accepted scoring method in clinical work.

This present study had some limitations. First, NF is a rare and rapid subcutaneous soft tissue infection disease. Most searched studies in this study were case or case series reports. Unfortunately, high-quality RCTs were impossible to find. Second, the seven selected studies included patients with different locations of NF. Inconsistent baseline and distribution of NF may have been an influencing factor of clinical heterogeneity.


This present meta-analysis study displayed that VAC could reduce the mortality rate of necrotizing fasciitis patients. However, no significant differences were found between VAC and conventional dressing groups regarding the number of debridements, the total length of hospital stay, and the complication rate. More VAC versus conventional dressing trials are required from a randomized design perspective to provide a better evaluation of all outcome measures.

Availability of data and materials

All data generated or analyzed during this study are included in this published article.



Vacuum-assisted closure


Neutrophil lymphocyte rate


Laboratory risk indicator for necrotizing fasciitis


Fournier’s gangrene severity index


Odds ratio


Head and neck necrotizing fasciitis


Mean difference


Necrotizing fasciitis


Fournier’s gangrene


Confidence interval


  1. Gelbard RB, Ferrada P, Yeh DD, Williams BH, Loor M, Yon J, et al. Optimal timing of initial debridement for necrotizing soft tissue infection: a practice management guideline from the eastern association for the surgery of trauma. J Trauma Acute Care Surg. 2018;85(1):208–14.

    Article  Google Scholar 

  2. Levine EG, Manders SM. Life-threatening necrotizing fasciitis. Clin Dermatol. 2005;23(2):144–7.

    Article  Google Scholar 

  3. Wilson B. Necrotizing fasciitis. Am Surg. 1952;18(4):416–31.

    CAS  Google Scholar 

  4. Wong CH, Wang YS. The diagnosis of necrotizing fasciitis. Curr Opin Infect Dis. 2005;18(2):101–6.

    Article  Google Scholar 

  5. Bellapianta JM, Ljungquist K, Tobin E, Uhl R. Necrotizing fasciitis. J Am Acad Orthop Surg. 2009;17(3):174–82.

    Article  Google Scholar 

  6. Legbo JN, Legbo JF. Bacterial isolates from necrotizing fasciitis: a clinico-pathological perspective. Niger J Med. 2007;16(2):143–7.

    Article  CAS  Google Scholar 

  7. Kumar T, Kaushik R, Singh S, Sharma R, Attri A. Determinants of mortality in necrotizing soft tissue infections. Hell Cheirourgike. 2020;92(5):159–64.

    Article  Google Scholar 

  8. Suijker J, de Vries A, de Jong VM, Schepers T, Ponsen KJ, Halm JA. Health-related quality of life is decreased after necrotizing soft-tissue infections. J Surg Res. 2020;245:516–22.

    Article  Google Scholar 

  9. Park KR, Kim TG, Lee J, Ha JH, Kim YH. Single-stage reconstruction of extensive defects after Fournier’s gangrene with an exposed iliac crest and testes. Arch Plast Surg. 2013;40(1):74–6.

    Article  Google Scholar 

  10. Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg. 1997;38(6):553–62.

    Article  CAS  Google Scholar 

  11. Yin Y, Zhang R, Li S, Guo J, Hou Z, Zhang Y. Negative-pressure therapy versus conventional therapy on split-thickness skin graft: a systematic review and meta-analysis. Int J Surg (London, England). 2018;50:43–8.

    Article  Google Scholar 

  12. Anghel EL, Kim PJ, Attinger CE. A solution for complex wounds: the evidence for negative pressure wound therapy with instillation. Int Wound J. 2016;13(Suppl 3):19–24.

    Article  Google Scholar 

  13. Brinkert D, Ali M, Naud M, Maire N, Trial C, Teot L. Negative pressure wound therapy with saline instillation: 131 patient case series. Int Wound J. 2013;10(Suppl 1):56–60.

    Article  Google Scholar 

  14. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surgery (London, England). 2021;88:105906.

    Article  Google Scholar 

  15. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5:13.

    Article  Google Scholar 

  16. Cook DA, Reed DA. Appraising the quality of medical education research methods: the medical education research study quality instrument and the Newcastle–Ottawa Scale-Education. Acad Med. 2015;90(8):1067–76.

    Article  Google Scholar 

  17. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.

    Article  CAS  Google Scholar 

  18. Zhang N, Yu X, Zhang K, Liu T. A retrospective case series of Fournier’s gangrene: necrotizing fasciitis in perineum and perianal region. BMC Surg. 2020;20(1):259.

    Article  Google Scholar 

  19. Iacovelli V, Cipriani C, Sandri M, Filippone R, Ferracci A, Micali S, et al. The role of vacuum-assisted closure (VAC) therapy in the management of FOURNIER’S gangrene: a retrospective multi-institutional cohort study. World J Urol. 2021;39(1):121–8.

    Article  Google Scholar 

  20. Huang WS, Hsieh SC, Hsieh CS, Schoung JY, Huang T. Use of vacuum-assisted wound closure to manage limb wounds in patients suffering from acute necrotizing fasciitis. Asian J Surg. 2006;29(3):135–9.

    Article  Google Scholar 

  21. Gul MO, Sunamak O, Kina U, Gunay E, Akyuz C. Fournier’s gangrene: our five-year series and the role of vacuum-assisted closure in the treatment. Niger J Clin Pract. 2021;24(9):1277–82.

    Article  CAS  Google Scholar 

  22. Balcı MK, Ciğer E, Arslanoğlu S, İşlek A. Necrotizing fasciitis of the head and neck: our experience with vacuum-assisted closure therapy. Eur Arch Otorhinolaryngol. 2018;275(10):2555–62.

    Article  Google Scholar 

  23. Czymek R, Schmidt A, Eckmann C, Bouchard R, Wulff B, Laubert T, et al. Fournier’s gangrene: vacuum-assisted closure versus conventional dressings. Am J Surg. 2009;197(2):168–76.

    Article  Google Scholar 

  24. Yanaral F, Balci C, Ozgor F, Simsek A, Onuk O, Aydin M, et al. Comparison of conventional dressings and vacuum-assisted closure in the wound therapy of Fournier’s gangrene. Arch Ital Urol Androl. 2017;89(3):208–11.

    Article  Google Scholar 

  25. Zhang BR, Fan X, Zhao JC, Shi K, Yu JA. Negative pressure wound therapy with instillation and dwell time in the wound management of necrotizing fasciitis. J Tissue Viability. 2021;30(2):262–6.

    Article  Google Scholar 

  26. Hu J, Goekjian S, Stone N, Nelson A, Cooper MJ. Negative pressure wound therapy for a giant wound secondary to malignancy-induced necrotizing fasciitis: case report and review of the literature. Wounds. 2017;29(8):E55-e60.

    Google Scholar 

  27. Cuccia G, Mucciardi G, Morgia G, Stagnod’Alcontres F, Galì A, Cotrufo S, et al. Vacuum-assisted closure for the treatment of Fournier’s gangrene. Urol Int. 2009;82(4):426–31.

    Article  Google Scholar 

  28. Chiummariello S, Guarro G, Pica A, Alfano C. Evaluation of negative pressure vacuum-assisted system in acute and chronic wounds closure: our experience. G Chir. 2012;33(10):358–62.

    CAS  Google Scholar 

  29. Sukato DC, Ferzli G, Thakkar P, Gordin E. Concurrent external and intraluminal vacuum-assisted closure in head and neck necrotizing fasciitis. Laryngoscope. 2017;127(6):1361–4.

    Article  Google Scholar 

  30. Lin C, Yeh FL, Lin JT, Ma H, Hwang CH, Shen BH, et al. Necrotizing fasciitis of the head and neck: an analysis of 47 cases. Plast Reconstr Surg. 2001;107(7):1684–93.

    Article  CAS  Google Scholar 

  31. Chawla SN, Gallop C, Mydlo JH. Fournier’s gangrene: an analysis of repeated surgical debridement. Eur Urol. 2003;43(5):572–5.

    Article  Google Scholar 

  32. Sun X, Xie T. Management of necrotizing fasciitis and its surgical aspects. Int J Low Extrem Wounds. 2015;14(4):328–34.

    Article  Google Scholar 

  33. Hong KS, Yi HJ, Lee RA, Kim KH, Chung SS. Prognostic factors and treatment outcomes for patients with Fournier’s gangrene: a retrospective study. Int Wound J. 2017;14(6):1352–8.

    Article  Google Scholar 

  34. Wong CH, Khin LW, Heng KS, Tan KC, Low CO. The LRINEC (laboratory risk indicator for necrotizing fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med. 2004;32(7):1535–41.

    Article  Google Scholar 

Download references


There is no funding for this article.

Author information

Authors and Affiliations



RLZ and CYY designed the project. LYH and YHZ collected all medical records. RLZ and LYH prepared all figures. CYY completed all statistical analyses and wrote the manuscript. All authors discussed the results and reviewed the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Chengyong Yan.

Ethics declarations

Ethics approval and consent to participate

The study was approved by the Institutional Review Board of Third Hospital of Hebei Medical University before data collection and analysis. There was no need to obtain informed consent forms from patients because this was a systematic review and meta-analysis study.

Competing interests

The authors declare no competing financial interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Additional file 1

. MeSH terms and research strategy used in the search process.

Additional file 2

. Fig. S1. Publication bias funnel plot for mortality rate

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, R., Zhang, Y., Hou, L. et al. Vacuum-assisted closure versus conventional dressing in necrotizing fasciitis: a systematic review and meta-analysis. J Orthop Surg Res 18, 85 (2023).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: