Table 1 The main characteristics of the included studies
Year, First author | Study design | VAC VS conventional dressing | Location | NOS | ||||
|---|---|---|---|---|---|---|---|---|
Number (VAC vs. conventional dressing) | Age | CRP | Laboratory risk indicator for necrotizing fasciitis (LRINEC) | Management of the wound | ||||
Iacovelli et al. [19] | CS | 33 vs. 59 | 64.25 (54–75), 69.5 (58,82) | 165.7 (45.0–309), 55.45 (9.6–223.8) | – | VAC: 75–125 mmHg negative pressure, with 5 min of suction followed by 2 min rest Conventional dressing: Hydrogen peroxide and povidone/iodine solution were used mainly to soak dressings. The wound dressing was changed daily | Perineum or perianal region (Fournier’s Gangrene) | 9 |
Gul et al. [21] | CS | 12 vs. 10 | 55.50 ± 10.39, 58.10 ± 14.39 | 24.78 ± 8.81, 16.78 ± 12.25 | – | VAC: debridement + VAC Conventional dressing: debridement only | Perineum or perianal region (Fournier’s Gangrene) | 8 |
Zhang et al. [18] | CS | 10 vs. 1 | 60 (45–71) | – | 10.27 ± 1.61, 8 | VAC: negative pressure ranging from − 120 to − 125 mmHg, changed every 3–7 days | Perineum or perianal region (Fournier’s Gangrene) | 7 |
Mustafa et al. [22] | CS | 8 vs. 3 | 55.00 ± 7.75, 63.00 ± 14.73 | 27.56 ± 8.53, 80.33 ± 80.75 | 6.88 ± 1.36, 6.67 ± 2.52 | VAC: intermittent therapy at − 100 mmHg, cycling at 5 min on and 2 min off | Head and neck | 7 |
Yanaral et al. [24] | CS | 23 vs. 31 | 61.6 ± 7.6, 55.8 ± 14.9 | – | – | VAC: Initially, the pressure is set at 50 mm Hg and increased to a maximum of 125 mm Hg. VAC dressings were changed every 48–72 h. Conventional dressing: patients' wounds were covered with conventional antiseptic dressings. Wound dressings were changed twice a day | Perineum or perianal region (Fournier’s Gangrene) | 7 |
Czymek et al. [23] | CS | 19 vs. 16 | 57.2, 58.2 | – | – | VAC: maintained − 125 mmHg, removed every 48–72 h. Conventional dressing: treated with gauze dressing soaked with physiological saline solution, changed three to six times a day | Perineum or perianal region (Fournier’s Gangrene) | 9 |
Huang et al. [20] | CS | 12 vs. 12 | 57.75 (35–78), 62.58 (36–85) | – | – | VAC: maintained − 125 mmHg, removed every 48–72 h Conventional dressing: treated with gauze dressing soaked with physiological saline solution, changed three to six times a day | Extremity | 8 |