- Research article
- Open Access
The risk for complications and reoperations with the use of mega prostheses in bone reconstructions
Journal of Orthopaedic Surgery and Research volume 16, Article number: 598 (2021)
Despite a relatively high risk for complications and reoperations, mega prostheses are considered a useful method for reconstruction of bone defects after tumour resections. The total number of reoperations has not previously been described, and little is known about the complication rate of mega prostheses used for other indications than primary bone tumours.
The current retrospective observational study aimed to describe the patient population treated with mega prostheses at Sahlgrenska University Hospital, Sweden, during 14 consecutive years, reports the complications leading to reoperation and the number and type of reoperations for different kinds of complications, and reports on implant survival.
All patients treated with a mega prosthesis, regardless of surgical indication and anatomical location, at Sahlgrenska University Hospital during the period 2006–2019 were identified. The medical records for all patients were reviewed. Data regarding age, sex, diagnosis, site of disease, bone resection length, chemotherapeutical treatment and postoperative complications including infections and oncological outcome, were collected and evaluated.
One hundred and fourteen patients treated with 116 mega prostheses were included in the study. The predominant indication for primary surgery with a mega prosthesis was sarcoma of either bone or soft tissue (53.5% of the patients). In total 51 prostheses (44%) did not require any reoperation after the primary surgery. The most common reason for reoperation was infection (22%) followed by soft tissue failure (13%). The risk for prosthetic infection was significantly higher in the group of patients operated due to sarcoma compared with all other indications for surgery regardless of surgical site (p = 0.004).
The study reveals a total reoperation rate of 56% after reconstructive surgery using mega prostheses. Despite the high reoperation rates, at the end of the study period, 83% of the patients had still a functioning prosthesis. Therefore, the use of mega prostheses can be considered a reliable method for reconstruction of large bone defects in selected patients.
Level of Evidence
Level IV, therapeutic study.
During the last 4 decades the use of mega prostheses, also known as tumour endoprostheses, has radically changed the treatment options for patients with malignant primary bone tumours. Mega prostheses are modular endoprostheses, consisting of components that can be assembled in different combinations to fit the specific skeletal defect and allow limb sparing. Today it is considered to be a safe and convenient reconstructive method for upper and lower extremities after tumour resections, with similar failure rates as with reconstruction with allograft [1, 2]. A recent systematic review of the literature showed no significant differences in oncological outcome between amputation and mega prosthesis reconstructions . Despite the need for wide surgical margins in order for malignant primary bone tumours to ensure complete removal, the use of mega prostheses, together with refined imaging technology and improved oncological treatment, has changed the preferred surgical treatment from amputation to limb-sparing surgery at many centres .
One major advantage with mega prosthesis is the allowance of immediate weight-bearing postoperatively, leading to a faster rehabilitation compared with other methods. However, the surgery is often performed in young patients, some still growing, with a long remaining life expectancy and high demands on function which require excellent implant quality.
Aside from reconstructions after tumour surgery, the indications for mega prostheses have been expanded to include also other medical conditions, such as comminute fractures involving the knee joint and revision surgery after conventional knee/hip endoprosthesis failures . However, there are factors connected to mega prostheses that result in a relatively high risk for complications. An overall complication rate between 15 and 45%, including severe complications such as deep infections, soft tissue failures, mechanical failures and aseptic loosening, has been reported [6,7,8,9,10]. This is far higher than reported complication rates after conventional total arthroplasty of hip, knee and shoulder . Furthermore, mega prostheses are associated with higher risks for complications than revision stems; Perticarini et al.  showed promising survivorship in cases of complex femoral bone defect. Not only do complications, such as those listed above, result in reoperations, higher medical costs and increased patient suffering, they may also eventually lead to a joint resection arthrodesis, or an amputation as final outcome.
The first aim of this study was to describe the patient population treated with mega prostheses at Sahlgrenska University Hospital during 14 consecutive years. The second aim was to evaluate the complication rate, according to infections, soft tissue failure, mechanical failure, aseptic loosening and tumour progression, and any required reoperations. The third aim was to investigate overall implant survival.
All patients treated with a mega prosthesis, regardless of indication for surgery and anatomical location, at Sahlgrenska University Hospital during the period from January 2006 to May 2019 were identified using the hospital’s operation planning systems and included in the study. All primary surgeries, follow-up and eventual additional surgeries were performed by four surgeons, all of whom were subspecialists in orthopaedic oncology with additional extensive trauma surgery experience.
Background data regarding age, sex, diagnosis, site of disease, bone resection length, chemotherapeutical treatment, postoperative complications including infections and oncological outcome were collected from patient medical records. Furthermore, data regarding neoadjuvant or adjuvant chemotherapy treatment, were collected for all patients with primary bone tumours.
To examine the possible relationship between immunosuppressive effect in close proximity to index surgery and complication rate, data regarding systemic chemotherapy treatment approximately 4 weeks before or after index surgery were collected for patients with metastatic disease.
Data regarding complications after surgery with a mega prosthesis were collected from the medical records. Complications were classified according to the Henderson five type classification : Type 1, soft tissue failures (skin necrosis, flap insufficiency and stiffness/contracture of the reconstructed joint were defined as soft tissue failure); Type 2, aseptic loosening failures; Type 3, structural failures, i.e. fractures of prosthetic components; Type 4, infection; and Type 5, tumour prolapse/progression. Data regarding all complications that led to reoperation/revision of the prosthesis were collected as well as data regarding all reoperations performed (i.e. all reoperations regardless of type of surgery). A revision was defined as a reoperation where any component of the prosthesis was replaced. The number of reoperations, reason, type of reoperation and time from primary surgery to first reoperation for each patient were recorded together with data regarding status, including oncologic status, at latest follow-up. The data were reported according to the STROBE guidelines .
The mega prosthesis primarily used was the Modular Universal Tumor and Revision System, MUTARS™ (Implant Cast, Germany). Both uncemented and cemented stems were used depending on the prerequisites of the bone, site and patient. Most hip replacements were hemiarthroplasties with a dual-mobility cup. Shoulder replacements were either unipolar or reversed total replacements. Rotating hinged knee was used in the total knee replacements. The design of the hinge was changed during the study period; a metal-PEEK™ (polyether ether ketone) coupling was used 2006–2014 and was then changed to the metal-on-metal (MoM) coupling used today.
In smaller, still growing, children, an expandable prosthesis allowing lengthening was used (MUTARS Expand™). Parents, or the patients themselves performed the lengthening procedure at home, with a transcutaneous microwave induction transducer activating a motor-driven telescopic device located inside the prosthesis. No further surgical procedures for lengthening were needed. However, after completion of the lengthening, the motor-driven prosthesis needed to be exchanged to a definitive prosthesis. For large resections of the pelvis, an ice-cone pedestal acetabular replacement according to the LUMIC™ (Implant Cast, Germany) system in combination with a standard Lubinus™ (Link™) femur stem, was used.
Descriptive statistics is given for the study population, with percentages and mean together with range presented where relevant.
A Kaplan–Meier analysis was performed to calculate the implant survival. In the Kaplan–Meier analysis revision, extraction of prosthesis and amputation due to complication were set as events of interest. Patients who died, were amputated or revised due to tumour progression during the study period were censored.
Multivariable regression analysis was performed for calculation of increased risk of infection or other complications. The factors evaluated were anatomic site, length of resection, diagnosis, chemotherapy or radiation in connection with the surgery.
All statistical analyses were performed using IBM SPSS version 27.
A total of 115 patients (55 females (48.2%)) operated with 117 prostheses during the study period were identified. One patient was lost to follow-up due to emigration 1 year after surgery and excluded from the study. Two patients were provided with two prostheses in two different extremities. Thus 114 patients treated with 116 prostheses were evaluated. The mean age at primary surgery was 53.4 years (range 7.1–88.1 years), and the mean follow-up time was 7.6 years (range 1.3–13.3 years) (Table 1). At the end of the study, 56 (49%) patients were alive and 58 (51%) patients had died. All patients who died during the study period were followed until their death.
Two peaks were identified in the age distribution—one in the adolescent-young adult age and one at around 70 years of age. The indication for surgery differed between the two age groups. The peak with the younger age group represented patients mostly diagnosed with sarcoma, and the peak with the older age group contained patients with other diagnoses (Fig. 1).
Indication for mega prosthesis surgery
The predominant indication for primary surgery with a mega prosthesis was sarcoma of either bone or soft tissue origin (53.5% of the patients). Other malignancies (metastatic disease or haematologic malignancy) were the second most common indication (36.0%).
Patients operated due to a primary sarcoma had lower mean age (42.9 years) than patients operated due to another diagnosis (64.1 years).
Six of the patients had a mega prosthesis reconstruction due to benign bone tumour, i.e. giant cell tumour or pigmented villonodular synovitis (PVNS) with significant destruction of the affected joint.
During the second half of the study period (2004–2019), mega prostheses were introduced as a surgical treatment option for selected trauma patients and for revisions of other endoprostheses; 10% of the patients in this study period received a mega prosthesis for these new indications. The distribution among the other diagnoses otherwise remained the similar during both halves of the study period (Fig. 2).
The distribution of patients according to diagnosis and anatomical location is presented in Table 1. In total six patients were provided with a MUTARS Expand™ prosthesis, one total femur and five distal femur prostheses.
Reoperations and implant survival
In total 51 prostheses (44%) did not need any additional surgery after the primary operation, while 65 prostheses (56%) were subject to at least one reoperation. The number of additional surgeries in each patient differed largely between individuals. One patient underwent 51 procedures. Since 2011 no prosthesis was reoperated more than nine times in total.
The risk for a reoperation was highest during the first year after the primary surgery and after 2 years the risk decreased (Fig. 3). Indication for reoperations varied depending on length of time after the primary surgery was performed. Within the first year after primary surgery, infections and soft tissue failure were the dominant indications, while later it was mechanical failure and aseptic loosening (Table 2).
Of the 65 patients who underwent reoperation for any of the five types of complications according to the Henderson classification , most patients had one (38 patients) or two (10 patients) reoperations. The most common cause for reoperation was infection (69.8% of all reoperations), followed by soft tissue failure (18.9%).
Reoperations included revision of the prosthesis, for any kind of complication, in 31 of the prostheses.
Infection was observed in 35 prosthesis, and as a result, some type of reoperation was required. Among these reoperations 19 included revision, ten in the form of a debridement and implant retention (DAIR) procedure and nine in the form of a two-stage procedure where the primary prosthesis was replaced with an antibiotic-containing bone cement spacer which was subsequently replaced with a secondary prosthesis, as described by Grimer et al. [15, 16]. The remaining 16 of 35 prostheses were surgically treated with debridement of the prosthesis without changing any components. At the end of the study period, 19 patients who had had an deep prosthesis infection at some time during the study period had no remaining signs of infection, four had signs of persistent infection and were planned to be treated with lifelong antibiotic suppressive therapy, two underwent an arthrodesis, and 10 had undergone amputation (Table 4).
Figure 4 shows a Kaplan–Meier analysis of the survival of the implants where revision, extraction of the prosthesis or amputation due to complication was set as endpoints. Patients who died or underwent an amputation or revision due to tumour progression were censored.
Mechanical failure almost exclusively appeared within and/or around the knee joint and the most common failure was related to breakage of the PEEK™ locking mechanism. The mechanical problems for patients with proximal femur replacements were exclusively related to dislocations of the femoral head in the hip. Prosthetic replacement in the pelvis (LUMIC™) and in the proximal tibia was associated with the highest risk for reoperations (four out of five and 14 out of 19, respectively). The most common cause for reoperations of the prosthesis in the pelvis and proximal tibia was infection (60% and 26%, respectively) (Table 3).
Fifteen patients (12.9%) underwent amputation during the study period. Five were amputated due to tumour progression, among them four sarcoma and one metastasis from other malignancies, and ten were amputated due to periprosthetic infections. No other complications than tumour progression or infection led to amputation.
Periprosthetic infection resulted in a risk for amputation, especially when infection occurred in close relation to the knee joint. Altogether most of the infected implants in the distal femur (nine of twelve) and the proximal tibia (four of seven) required explantation or amputation to cure the infection (Table 4).
The risk for a prosthetic infection was significantly higher in the group of patients diagnosed with sarcoma, compared with all other indications for surgery, regardless of surgical site (p = 0.004) (Table 5). A regression analysis including chemotherapy treatment, surgical site and resection length did not show any increased risk for infection or other complications with any of the tested parameters in this material.
At the end of the follow-up period for each patient, or at time of death, 98 patients (83%) still had a functional prosthesis in place, either a primary or revised one.
The most important finding of the current study is that despite a relatively large proportion of patients treated with a mega prosthesis requiring reoperation after the initial operation, most patients preserved a functioning limb with the use of a mega prosthesis implant. The reasons behind the high risk of complications leading to reoperations associated with mega prosthesis surgery are not completely determined. One can assume that large wound exposures and resections of the surrounding soft tissue, prolonged surgical time and the fact that the patients often are treated with chemotherapy and/or radiotherapy in near proximity to the operation might increase the risks . Since the multivariate regression analysis in the current study showed no other significant risk factor for infection than sarcoma, it is difficult to predict the outcome or risk for complications for a certain patient.
The most severe complication, as in all surgery with implants, is infection. As shown in previous studies, the infection rate observed in the current study is much higher than after conventional endoprosthesis surgery . High infection rate after surgery with mega prostheses has been described in several earlier studies. Bus et al., Capanna et al., Morii et al. and Fujiwara et al. showed infection rates of 12–17% [6, 17,18,19]. It is hard to explain why the infection rate in the current study is slightly higher than in these previous studies. One explanation might be different definitions of infected prostheses. Another interesting difference between the results of the current study and previous studies is that in the current study, the frequency of aseptic loosening is lower than in earlier studies. One might speculate that some of the prostheses diagnosed with aseptic loosening in previous studies may have been undiagnosed infections.
The current study shows the difficulties in treating an infection in a mega prosthesis successfully. For patients with an infection involving their mega prosthesis, half required extraction of the prosthesis and one of four resulted in amputation. This entails extensive suffering for the patients, not only because of the repeated surgery but also due to long antibiotic treatment and many days admitted into the hospital. In the current study, 70% of reoperations were due to postoperative infections. The total number of reoperations has not earlier been described in the manner presented herein, which makes it challenging to compare our numbers with previous studies. The high number of reoperations observed in this study is to an extent caused by difficulties in treating the infection. It would be of great benefit to identify the optimal treatment for infected mega prostheses and establish a routine, as is done for infections of conventional prostheses . The relatively small number and diversity of patients, however, makes it difficult to perform a randomized controlled trial (RCT) comparing effect of different treatments for infection in this group of patients. In absence of RCTs, observational cohort studies like the current study can add important knowledge to the field.
A reconstruction with a mega prosthesis enables a patient to regain walking ability with full weight-bearing in close proximity to the surgery for tumour, fracture or endoprosthetic revision . The impression from clinical practice is that a reconstruction using mega prostheses especially in the group of older patients with sometimes a high comorbidity improves the quality of life. However, this remains to be elucidated in future quality of life studies. Earlier studies have mainly focused on outcome for sarcoma patients, who tend to be young patients with high demands on function and often with strong medical anti-tumour treatments [18, 19].
One interesting observation in the current study is the shift over time in the indications for the use of a mega prosthesis. The use of mega prostheses for diagnoses other than primary bone tumours has been described in a previous review as well . The indications have been expanded with good results and have thereby changed from merely a treatment option for primary bone tumours, to also become an alternative for complicated trauma, metastatic disease and revision of conventional prostheses. The findings from the current study demonstrate the benefit of mega prostheses also for patients outside the group of primary bone tumours. The lower rate of postoperative infection for patients treated because of indications other than sarcoma, might not only be caused by the absence of a tumour disease and/or tumour medical treatment, but may partially be due to careful selection of patients suitable for this type of surgery. The Kaplan–Meier analysis in the current study showed that the use of mega prostheses was a reliable option for patients with metastatic disease since most of them did not undergo reoperation and could keep their primary mega prosthesis for the rest of their lives. If surgery with a mega prosthesis in patients subjected to palliative care can help the patients to retain their walking capability, and reduce their pain, a mega prosthesis could be considered a good method, even if their remaining expected lifetime is short .
One could expect a better implant survival in the non-malignant group than for sarcoma patients, as the patients suitable for reconstruction with a mega prosthesis are carefully selected and does not undergo any anti-tumoural treatment. The seemingly worse survival of implants for benign tumours or fracture/endoprosthetic revision shown in this study therefor was surprising. In the fracture/endoprosthetic revision group one patient had an aseptic loosening of the implant, one suffered an infection, and one got a fracture of the femoral stem. Due to the small number of patients in this specific subgroup these complications had a large impact on the result. Until confirmed in larger cohorts the results in this group of patients need to be interpreted with caution.
Not all surgeries required after the primary operation can be attributed due to complication but sometimes should be considered more as “service procedures” due to wear or growing of a young patient . In the current study, it was found that the highest risk for reoperation for sarcoma patients is during the first 2 years after the primary surgery and that after 5 years there was a low risk for reoperations. One reasonable explanation for this might be the consequences after anti-tumour treatment often given for several months after the surgery. Further studies aiming to find methods to protect patients from complications the first years after the primary surgery are warranted.
Strengths and limitations
Limitations within the current study are the single-centre design and the relatively small number of patients. However, this also enabled the relatively long follow-up and very few patients were lost to follow-up, since all patients but one remained for care at the centre with long-term data available, which is a strength of the study.
Another limitation is that this study cannot determine the final function and whether the patients suffer from pain postoperatively because no functional, quality of life or pain score was included in the study design. The use of mega prostheses is still limited to highly specialised units and for specific patients, why it can be difficult to achieve large cohorts and every case has a big impact on the overall outcome in cohort studies. This shows, as earlier described , the need for prospective databases used by multiple centres/nations for structured collection of data regarding complicating events after reconstructions with mega prostheses.
The study reveals a total reoperation rate of 56% after reconstructive surgery using mega prostheses. Despite the high reoperation rate, at the end of the study period, 83% of the patients still had a functioning prosthesis. Therefore, mega prosthesis can be considered a reliable method for reconstruction of large bone defects, not only for sarcoma patients but also, and maybe even with better results, for other diagnoses entailing bone defects.
Availability of data and materials
The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Pigmented villonodular synovitis
Modular Universal Tumour and Revision System
Debridement, antibiotics and implant retention
Strengthening the Reporting of OBservational studies
Albergo JI, Gaston CL, Aponte-Tinao LA, Ayerza MA, Muscolo DL, Farfalli GL, Jeys LM, Carter SR, Tillman RM, Abudu AT, Grimer RJ. Proximal tibia reconstruction after bone tumor resection: are survivorship and outcomes of endoprosthetic replacement and osteoarticular allograft similar? Clin Orthop Relat Res. 2017;475:676–82.
Gkavardina A, Tsagozis P. The use of megaprostheses for reconstruction of large skeletal defects in the extremities: a critical review. Open Orthop J. 2014;8:384–9.
Jauregui JJ, Nadarajah V, Munn J, Pivec R, Kapadia BH, Lerman DM, Maheshwari AV. Limb salvage versus amputation in conventional appendicular osteosarcoma: a systematic review. Indian J Surg Oncol. 2018;9:232–40.
Hwang JS, Mehta AD, Yoon RS, Beebe KS. From amputation to limb salvage reconstruction: evolution and role of the endoprosthesis in musculoskeletal oncology. J Orthop Traumatol. 2014;15:81–6.
Vaishya R, Thapa SS, Vaish A. Non-neoplastic indications and outcomes of the proximal and distal femur megaprosthesis: a critical review. Knee Surg Relat Res. 2020;32:18.
Morii T, Morioka H, Ueda T, Araki N, Hashimoto N, Kawai A, Mochizuki K, Ichimura S. Deep infection in tumor endoprosthesis around the knee: a multi-institutional study by the Japanese musculoskeletal oncology group. BMC Musculoskelet Disord. 2013;14:51.
Pala E, Trovarelli G, Calabro T, Angelini A, Abati CN, Ruggieri P. Survival of modern knee tumor megaprostheses: failures, functional results, and a comparative statistical analysis. Clin Orthop Relat Res. 2015;473:891–9.
Puchner SE, Kutscha-Lissberg P, Kaider A, Panotopoulos J, Puchner R, Bohler C, Hobusch G, Windhager R, Funovics PT. Outcome after reconstruction of the proximal tibia-complications and competing risk analysis. PLoS ONE. 2015;10:e0135736.
Racano A, Pazionis T, Farrokhyar F, Deheshi B, Ghert M. High infection rate outcomes in long-bone tumor surgery with endoprosthetic reconstruction in adults: a systematic review. Clin Orthop Relat Res. 2013;471:2017–27.
Zajonz D, Zieme A, Prietzel T, Moche M, Tiepoldt S, Roth A, Josten C, von Salis-Soglio GF, Heyde CE, Ghanem M. Periprosthetic joint infections in modular endoprostheses of the lower extremities: a retrospective observational study in 101 patients. Patient Saf Surg. 2016;10:6.
Springer BD, Cahue S, Etkin CD, Lewallen DG, McGrory BJ. Infection burden in total hip and knee arthroplasties: an international registry-based perspective. Arthroplast Today. 2017;3:137–40.
Perticarini L, Rossi SMP, Fioruzzi A, Jannelli E, Mosconi M, Benazzo F. Modular tapered conical revision stem in hip revision surgery: mid-term results. BMC Musculoskelet Disord. 2021;22:29.
Henderson ER, O’Connor MI, Ruggieri P, Windhager R, Funovics PT, Gibbons CL, Guo W, Hornicek FJ, Temple HT, Letson GD. Classification of failure of limb salvage after reconstructive surgery for bone tumours: a modified system Including biological and expandable reconstructions. Bone Joint J. 2014;96-B:1436–40.
Vandenbroucke JP, von Elm E, Altman DG, Gotzsche PC, Mulrow CD, Pocock SJ, Poole C, Schlesselman JJ, Egger M, Initiative S. Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. Epidemiology. 2007;18:805–35.
Grimer JR, Belthur RM, Chandrasekar MC, Carter MS, Tillman MR. Two-stage revision for infected endoprostheses used in tumor surgery. Clin Orthop Relat Res. 2002;395:193–203.
Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med. 2004;351:1645–54.
Fujiwara T, Ebihara T, Kitade K, Setsu N, Endo M, Iida K, Matsumoto Y, Matsunobu T, Oda Y, Iwamoto Y, Nakashima Y. Risk factors of periprosthetic infection in patients with tumor prostheses following resection for musculoskeletal tumor of the lower limb. J Clin Med. 2020;9:3133.
Bus MP, van de Sande MA, Fiocco M, Schaap GR, Bramer JA, Dijkstra PD. What are the long-term results of MUTARS(®) modular endoprostheses for reconstruction of tumor resection of the distal femur and proximal tibia? Clin Orthop Relat Res. 2017;475:708–18.
Capanna R, Scoccianti G, Frenos F, Vilardi A, Beltrami G, Campanacci DA. What was the survival of megaprostheses in lower limb reconstructions after tumor resections? Clin Orthop Relat Res. 2015;473:820–30.
Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR. Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013;56:e1–25.
De Gori M, D’Arienzo A, Andreani L, Beltrami G, Campanacci DA, De Biase P, Frenos F, Giannotti S, Sacchetti F, Totti F, Parchi P, Capanna R. Complications and survival of megaprostheses after resection of bone metastases. J Biol Regul Homeost Agents. 2017;31:43–50.
Hardes J, Guder W, Dudda M, Nottrott M, Podleska LE. Streitburger A [Current results of tumour endoprosthetics in adolescents and adults]. Orthopade. 2019;48:744–51.
Thornley P, Vicente M, MacDonald A, Evaniew N, Ghert M, Velez R. Causes and frequencies of reoperations after endoprosthetic reconstructions for extremity tumor surgery: a systematic review. Clin Orthop Relat Res. 2019;477:894–902.
The study was performed with kind support from the Johan Jansson Foundation.
Open access funding provided by University of Gothenburg.
Ethics and consent to participate
The study was approved by the Swedish Ethical Review Authority, Gothenburg 2019-04041.
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The authors declare that they have no competing interests.
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Cite this article
Berger, C., Larsson, S., Bergh, P. et al. The risk for complications and reoperations with the use of mega prostheses in bone reconstructions. J Orthop Surg Res 16, 598 (2021). https://doi.org/10.1186/s13018-021-02749-z
- Mega prostheses
- Orthopaedic oncology
- Bone reconstruction
- Bone tumours