Comparison of intramedullary nailing and plate fixation in distal tibial fractures with metaphyseal damage: a meta-analysis of randomized controlled trials
Journal of Orthopaedic Surgery and Research volume 14, Article number: 30 (2019)
Distal metadiaphyseal tibial fractures are commonly seen lower limb fractures. Intramedullary nail fixation (IMN) and plate internal fixation (PL) are the two mainstay treatments for tibial fractures, but agreement on the best internal fixation for distal tibial fractures is still controversial. This meta-analysis was designed to compare the success of IMN and PL fixations in the treatment of distal metadiaphyseal tibial fractures, in terms of complications and functional recovery.
A systematic research of the literature was conducted to identify relevant articles that were published in PubMed, MEDLINE, Embase, the Cochrane Library, SpringerLink, Clinical Trials.gov, and OVID from the database inception to August 2018. All studies comparing the complication rate and functional improvement of I2MN and PL were included. Data on the 12 main outcomes were collected and analyzed using the Review Manager 5.3.
Eleven studies were included in the current meta-analysis. A significant difference in malunion (RR = 1.76, 95%CI 1.21–2.57, P = 0.003), superficial infection (RR = 0.29, 95%CI 0.13–0.63, P = 0.002), FFI (MD = 0.09, 95%CI 0.01–0.17, P = 0.02), and knee pain (RR = 3.85, 95%CI 2.07–7.16, P < 0.0001) was noted between the IMN group and PL group. No significant difference was seen in the operation time (MD = − 10.46, 95%CI − 21.69–0.77, P = 0.07), radiation time (MD = 7.95, 95%CI − 6.65–22.55, P = 0.29), union time (MD = − 0.21, 95%Cl − 0.82–0.40, P = 0.49.), nonunion (RR = 2.17,95%CI 0.79–5.99, P = 0.15), deep infection (RR = 0.85, 95%CI 0.35–2.06, P = 0.72), delay union (RR = 0.92, 95%CI 0.45–1.87, P = 0.82), AOFAS (MD 1.26, 95%Cl − 1.19–3.70, P = 0.31), and Disability Rating Index in 6 or 12 months (MD = − 3.75, 95%CI − 9.32–1.81, P = 0.19, MD = − 17.11, 95%CI − 59.37–25.16, P = 0.43, respectively).
Although no significant difference was seen between IMN and PL fixation with regards to the operation time, radiation time, nonunion, deep infection delay union, union time, AOFAS, and Disability Rating Index, significant differences were seen in occurrence of malunion, superficial infection, FFI, and knee pain. Based on this evidence, IMN appears to be a superior choice for functional improvement of the ankle and reduction of postoperative wound superficial infection. PL internal fixation seems to be more advantageous in achieving anatomical reduction and decreasing knee pain.
The optimal type of internal fixation for treatment of a distal radius fracture is still under debate. The tibia is an important weight bearing bone in the lower limb, which articulates proximally with the femur at the knee and distally with the talus at the ankle. Fractures of the distal tibial metaphysis, diaphysis, and adjacent diaphysis are commonly seen in road traffic accidents or sports injuries. These metadiaphyseal fractures are distinct in terms of their management from articular impaction “pilon” type fractures and middle third diaphyseal injuries . The overall incidence of tibial fractures is 51.7 per 100,000 a year, and the incidence of diaphyseal and distal tibia fractures is 15.7 and 9.1 respectively per 100,000 a year . Common definitions of distal tibial fractures include distal extra-articular tibial fractures which are located between 4 and 12 cm from the tibial plafond (AO 42A1 and 43A1). Further subdivisions are made on the basis of the morphology and degree of comminution of the fracture: 43-A1 are non-comminuted extra-articular fractures, 43-A2 are wedge fractures, and 43-A3 are comminuted extra-articular fractures. Simple extension of the fracture into the joint without depression of the joint surface are classified as 43-B1 and are often treated in the same way as 43-A fractures [3,4,5].
Use of IMN for fracture fixation has been shown that there is limited interference of the device with the soft tissue around the fracture, but the technique of placement is difficult and the learning curve is long. In addition, it has been shown to be linked to complications such as malunion and knee pain after surgery [6,7,9]. Common surgical procedures for internal fixation of the plate include open reduction and internal fixation and bridge fixation (MIPPO). Open reduction and internal fixation is an anatomical reduction under direct vision, but it is very disturbing to the soft tissue surrounding the fracture. In severe soft tissue injury cases, it is often necessary to extend the preoperative preparation time to optimize soft tissue recovery. Compared with open reduction and internal fixation, MIPPO technology requires fixation with a steel plate, but it also indirect bridge fixation. It is more likely to lead to soft tissue injury than open reduction, but also has a higher rate of fracture malformation and increased local soft tissue pressure possibility [10,11,12,13].
The aim of this systematic review and meta-analysis was to compare the efficacy of two fixation methods, plate fixation, and intramedullary nail fixation, in the treatment of distal metadiaphyseal tibial fractures with or without articular involvement.
Materials and methods
The databases searched were PubMed, MEDLINE, Embase, the Cochrane Library, SpringerLink, Clinical Trials.gov, and OVID from inception to August 2018. The following search terms were used: distal tibial fracture; intramedullary nail; plate; internal fixation.
To evaluate inclusion eligibility, two investigators independently screened the title and abstracts of all articles. Any disagreements were resolved with discussion between the authors. A third researcher was the adjudicator when there was disagreement between the two investigators. The included studies had to meet the following criteria: (1) must be designed as RCTs; (2) participants must be at least 16 years old; (3) the articles compare intramedullary nail fixation and plate fixation.
Two authors independently extracted the following data from each eligible study: study design, type of study population, age, number of participants, and interventions. Any discrepancies in data extraction were resolved by a third investigator.
Quality and risk of bias assessments
The modified Jadad scale was used to assess the methodological quality of each study. A score of ≥ 4 indicated high quality. The Cochrane Handbook for Reviews of Interventions (RevMan Version 5.3) was used to assess the risk of bias. Two independent authors subjectively reviewed all articles and assigned a value of “high,” “low,” or “unclear” based on the following items: selection bias; performance bias; detection bias; attrition bias; reporting bias and other bias. Any disagreements were resolved with discussion to reach a consensus. If a consensus could not be reached a third investigator was consulted.
The RevMan software was used to analyze the numerical data from the included studies. For binary data, the risk ratios (RR), and 95% confidence intervals (CI) were assessed (ɑ = 0.05 for the inspection standards). For continuous data, means and standard deviations (SD) were pooled to a weighted mean difference (WMD) and a 95% confidence internal (CI) in the meta-analysis. Heterogeneity was tested using the I2 statistic. Studies with an I2 statistic of 25 to 50% were considered to have low heterogeneity, those with an I2 statistic of 50 to 75% were considered to have moderate heterogeneity and those with an I2 statistic > 75% were considered to have high heterogeneity. When the I2 statistic was > 50%, sensitivity analyses were performed to identify potential sources of heterogeneity. Statistical significance was indicated by a P value < 0.05.
Description of studies and demographic characteristics
A total of 889 articles were identified as potentially relevant studies (Fig. 1). A total of 687 full publications were screened based on title and abstracts followed by removal of duplicates (n = 202). Twenty full manuscripts were assessed and a further 9 trials were excluded, leaving 11 trials eligible to be included in the meta-analysis.
The demographic characteristics are summarized in Tables 1 and 2. All studies compared postoperative complication rates, postoperative joint function recovery, fracture healing time, delayed fracture healing, wound infection, soft tissue irritation, and postoperative outcomes in the treatment of distal radius fractures in the INM and PL groups. The incidence of knee pain was also extracted from the studies.
Risk of bias in included studies
Assessment of risk of bias is presented in Fig. 2. All trials included in this study are randomized trial designs [12, 13]. One trial  did not provide detailed information of random sequence generation, and one trial  did not describe the method of concealing group allocation. Blinding of participants and personnel (performance bias) was unclear and incomplete outcome data (attrition bias) was high risk in two trials [15, 16]. Three trials [15,16,17] lost patients to follow-up.
Operation, radiation, and union time
Six studies [14,15,16, 18,19,20] with a total of 494 patients in both groups provided data on operative time. Heterogeneity in these studies was large, and the random-effects model was used (I2 = 93%). The meta-analysis showed no significant difference in operative time between the IMN group compared with PL group (MD = − 10.46, 95%CI − 21.69 to 0.77, P = 0.07) (Fig. 3).
Appropriate data on radiation time were available in 3 articles [14, 16, 19] with a total of 366 patients. Polat et al.  recorded the radiation time in milliseconds, whereas the other two study records in minutes, so the comparison could only be done once the time was converted to minutes. There was significant heterogeneity among the studies requiring analysis with a random-effects model (I2 = 100%). Meta-analysis showed no significant difference in radiation time between the IMN group and the PL group (MD = 7.95, 95%CI − 6.65 to 22.55, P = 0.29) (Fig. 4).
Six studies [13,14,15,16, 18, 20] reported data on union time in the IMN group compared with the PL group. No significant difference in union time was noted between the IMN group and the PL group (MD = − 0.21, 95%Cl − 0.82 to 0.40, P = 0.49) (Fig. 5).
Seven studies [12,13,14,15,16, 18, 20] provided data on nonunion. There was no significant difference in the nonunion rate between the IMN group and the PL group (RR = 2.17, 95%CI 0.79 to 5.99, P = 0.15) (Fig. 6).
Six studies [12, 14,15,16, 18, 20, 21] with a total of 579 patients in both groups reported deep infection. There was no heterogeneity among these studies (I2 = 0%). Data were pooled using the random-effects model and the meta-analysis indicated that there was no significant difference in deep infection occurrence between IMN and PL groups. (RR = 0.85, 95%CI 0.35 to 2.06, P = 0.72) (Fig. 7).
Seven studies [12, 14, 15, 17,18,19,20] with a total of 676 patients in both groups reported malunion. Mild heterogeneity existed among these studies (I2 = 4%). Data were pooled by fixed-effects analysis and the meta-analysis indicated that the IMN group had significantly higher malunion versus the PL group. (RR = 1.76, 95%CI 1.21 to 2.57, P = 0.003) (Fig. 8).
Four studies [14, 17, 18, 20] of 249 patients in both groups reported on knee pain. Heterogeneity was substantial heterogeneity among studies (I2 = 53%). Data were pooled using a fixed-effects analysis, and the meta-analysis indicated that the IMN group had significantly higher knee pain versus the PL group (RR = 3.85, 95%CI 2.07 to 7.16, P < 0.0001) (Fig. 9).
Eight studies [13,14,15,16, 18,19,20,21] of 577 patients in both groups reported on superficial infection. There was no heterogeneity among the studies (I2 = 16%). Data were pooled using a fixed-effects analysis, and the meta-analysis indicated that the IMN group had significantly lower superficial infection rates compared to the PL group (RR = 0.29, 95%CI 0.13 to 0.63, P = 0.002) (Fig. 10).
Five studies [15, 16, 18, 20, 21] of 337 patients in both groups provided data on delayed union. There was no heterogeneity among studies (I2 = 0%). Data were pooled using the fixed-effects model, and the meta-analysis indicated no significant difference between the two groups (RR = 0.92,95%CI 0.45 to 1.87, P = 0.82) (Fig. 11).
American Orthopaedic Foot and Ankle Surgery (AOFAS) score at the 6-month follow-up
Three studies [16, 18, 19] of 297 patients in both groups provided data on the AOFAS at 6 months follow-up. A significant difference in the AOFAS score was noted between the PRP group and the HA group (MD 1.26, 95%Cl − 1.19 − 3.70, P = 0.31). However, this result should be interpreted with caution due to presence of low or insignificant statistical heterogeneity (χ2 = 0.88, I2 = 0%) (Fig. 12).
Foot Function Index
Four studies [13, 14, 17, 19] comprising of 297 patients in both groups provided date on the Foot Function Index. Low heterogeneity among the studies indicated use of the fixed-effects model (I2 = 0%). The meta-analysis found a significant difference in the Foot Function Index between the IMN group compared to the PL group (MD = 0.09, 95%CI 0.01 to 0.17, P = 0.02) (Fig. 13).
Disability rating index
Two studies [21, 22] focusing on 338 patients in both groups, reported on the Disability Rating Index. Low heterogeneity among the studies at the 6 month time point required adoption of the fixed-effects model (I2 = 0%). The meta-analysis showed no significant difference in the Disability Rating Index between the IMN group compared with the PL group (MD = − 3.75, 95%CI − 9.32 to 1.81, P = 0.19) (Fig. 14). High heterogeneity among the studies at the 12 month time point required adoption of the random-effects model (I2 = 71%). Meta-analysis showed no significant difference in the Disability Rating Index between the IMN group and the PL group (MD = − 17.11, 95%CI − 59.37 to 25.16, P = 0.43). Low heterogeneity among the studies in the subgroup analysis indicated use of the fixed-effects model (I2 = 27%) and no statistically significant difference was noted (MD = − 2.92,95%CI − 8.71 to 2.87, P = 0.32) (Fig. 14).
The earliest PubMed record describing the use of intramedullary nails in the treatment of fractures was a 1946 paper by Otoole reporting the treatment of femoral fractures ; use was later reported in the treatment of tibiofibular fractures , and subsequently widely applied in limb lengthening. Even in irregular bones such as clavicle fractures, the bone is characterized by highest protection of periosteal blood supply and lowest soft tissue irritation at the fracture end, thus providing a favorable soft tissue environment for fracture healing. IMN can be either reamed or non-reamed, where reaming is more beneficial for reduction. Animal studies have confirmed that there is no significant increase in blood perfusion and osteophyte strength at the fracture end when comparing reamed with unreamed IMN . However, stress occlusion of the fracture end can lead to destruction of local fracture integrity and lead to negative clinical outcomes, occurrences which are expected to decrease with improvement of instrument design techniques and surgery . After the fracture end is reset, the locking nail is locked and pressurized, and the fracture end micro-motion is provided to promote fracture healing, however, if fixed too firmly, the alignment may be poor, the rotation is deformed, or the nail broken . In contrast, open reduction and internal fixation is direct reduction and fixation, so contralateral alignment of the fracture end is superior to IMN fixation. MIPPO is similar to IMN fixation but does not require alignment of the fracture end under direct vision. In addition, it does not require strong fixation and emphasizes soft tissue and blood around the fracture. Limiting the disruption of the blood supply ensures adequate perfusion and maintenance of the biological environment at the fracture ends [28,29,30]. In addition, treatment of distal radius fractures includes external fixation, external fixation combined with limited open reduction and internal fixation, intramedullary nail and steel plate fixation, but these are not included in the scope of this meta-analysis.
To our knowledge, this is the first meta-analysis looking at the most recent randomized controlled trials comparing the efficacy of IMN and PL in distal tibial fractures and distal metadiaphyseal tibial fractures. This meta-analysis was based on 11 RCTs that included 526 patients treated with IMN and 571 patients treated with PL fixation. The main outcomes investigated were union time, operation time, nonunion, and delay union, superficial infection, deep infection, malunion, and knee pain. In our meta-analysis, when IMN is compared with the PL group, there was no significant difference in AOFAS, delayed union time, deep infection, operation time, and radiation time. However, the IMN group was superior to the PL group in terms of the FFI, knee pain, and malunion. In terms of superficial infection occurrence, the PL group was significantly higher than the IMN group. These results highlight that IMN and PL are effective fixation methods for distal tibial fractures, with no significant differences in fracture healing time and operative time. But the INM group was shown to recover better than the PL group, and the superficial infection rate was lower. However, the malunion and postoperative knee pain in the IMN group were higher than those in the PL group. The operation time, fracture healing time, and intraoperative fluoroscopy time showed no statistically significant difference.
Prior studies [13, 31,32,33] and several meta-analyses [34,35,36,37] investigating the efficacy of IMN have shown that IMN has no superiority over PL when the two methods are compared in well-designed double-blinded trials. The reported beneficial effects of IMN in most trials may have been due to insufficient blinding methods. Our results showed that there was a statistically significant difference in malunion between the IMN and the PL group, with a higher rate of malunion in the IMN group. This is consistent with the results of a prior meta-analysis where no significant difference in operation time and radiation time between INM and PL group was seen (P = 0.07, P = 0.29, respectively) . This is not consistent with our conclusions. In addition, the limited number of RCTs and patients may also affect these results.
As is the case of many meta-analyses, our study is not devoid of limitations. First, the current meta-analysis focuses only on papers that have been previously published. Inclusion of unpublished research may have increased heterogeneity and changed the current results. Second, the frequency of follow-up varied between studies, with five studies following up for more than 18 months, five studies limited to a year, and one study following up for only 6 months. This variation may affect heterogeneity and hence the results. Furthermore, the type of incision and plate were not consistent across the different studies. There exist several different types of surgical incisions in the use of steel plate fixation, four studies used the MIPPO technique, whereas the rest used open reduction and internal fixation. In terms of type of steel plate, two studies used non-locking steel plates, five used compression-type steel plates, one used an anatomical steel plate, two used a bridge steel plate, and one used ordinary steel plates. Further rigorously designed RCTs, with larger sample sizes, are necessary to better compare the efficacy of IMN and PL fixation.
The results of this meta-analysis highly support that both the IMN and PL internal fixation methods are effective for the treatment of distal tibial fractures with metaphyseal involvement. However, knee pain has been recorded following use of IMN, malunion is more frequent with IMN fixation, and the risk of superficial wound infection is higher in PL internal fixation than IMN use. In terms of FFI scores, IMN internal fixation appears to be superior to PL. Further studies investigating the use of IMN internal fixation for knee pain after distal tibial fractures are required. Furthermore, the rate of fracture deformity is higher with IMN fixation, while treatment and prevention of superficial wound infections after PL surgery increases the ankle joint function.
Indicates not reported by the study
The American Orthopaedic Foot and Ankle Surgery
Disability Rating Index
Distal tibial fracture
Extra-articular fracture of distal tibia fracture
- EQ-5D-3 L:
The EuroQol Health-Related Quality-of-Life 3-level score
Foot Function Index
The Knee Society’s Knee Scoring System
Musculoskeletal Function Assessment
Minimally invasive plate osteosynthesis
The Olerud and Molander Ankle Score
Orthopaedic Trauma Association
Gustilo and Anderson type
Proximal tibial plating
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Hu, L., Xiong, Y., Mi, B. et al. Comparison of intramedullary nailing and plate fixation in distal tibial fractures with metaphyseal damage: a meta-analysis of randomized controlled trials. J Orthop Surg Res 14, 30 (2019). https://doi.org/10.1186/s13018-018-1037-1