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Imaging diagnosis for chronic lateral ankle ligament injury: a systemic review with meta-analysis

Journal of Orthopaedic Surgery and Research volume 13, Article number: 122 (2018) Cite this article

Abstract

Background

Various imaging techniques have been utilized for the diagnosis of chronic lateral ankle ligament injury. This systemic review will explore the effectiveness of different imaging techniques in diagnosing chronic lateral ankle ligament injury.

Methods

Relative studies were retrieved after searching 3 databases (MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trails). Eligible studies were summarized. Data were extracted to calculate pooled sensitivity and specificity of magnetic resonance imaging (MRI), ultrasonography (US), stress radiography, and arthrography.

Results

Fifteen studies met our inclusion and exclusion criteria. A total of 695 participants were included. The pooled sensitivities in diagnosing chronic ATFL injury were 0.83 [0.78, 0.87] for MRI, 0.99 [0.96, 1.00] for US, and 0.81 [0.68, 0.90] for stress radiography. The pooled specificities in diagnosing chronic ATFL injury were 0.79 [0.69, 0.87] for MRI, 0.91 [0.82, 0.97] for US, and 0.92 [0.79, 0.98] for stress radiography. The pooled sensitivities in diagnosing chronic CFL injury were 0.56 [0.46, 0.66] for MRI, 0.94 [0.85, 0.98] for US, and 0.90 [0.73, 0.98] for arthrography. The pooled specificities in diagnosing chronic CFL injury were 0.88 [0.82, 0.93] for MRI, 0.91 [0.80, 0.97] for US, and 0.90 [0.77, 0.97] for arthrography.

Conclusion

This systematic review with meta-analysis investigated the accuracy of imaging for the diagnosis of chronic lateral ankle ligament injury. Ultrasound manifested high diagnostic accuracy in diagnosing chronic lateral ankle ligament injury. Clinicians should be aware of the limitations of MRI in detecting chronic CFL injuries.

Background

Ankle sprain is one of the most common sports injuries [1,2,3]. The injury mechanism, a combination of inversion and adduction in foot plantar flexion, can cause damage to the lateral ankle ligaments [4]. Lateral ankle ligaments comprise anterior talofibular ligament (ATFL), calcaneofibular ligament (CFL), and posterior talofibular ligament (PTFL) [5]. Chronic lateral ankle ligament injury is a long-term outcome in patients suffering acute ankle sprain. Some long-term cohort studies showed that 10 to 20% patients eventually developed persistent symptoms, including pain, swelling, perception of instability, and recurrent ankle sprain [6,7,8,9]. The precise cause of these symptoms is still in debate and probably multifactorial [5, 10,11,12]. But identifying chronic lateral ankle ligament injury is critical for locating primal symptoms, and thus, the decision making of surgical intervention [13].

Compared to acute ligament injury, the proper diagnosis of chronic ligament injury is difficult because of the uncertain association between initial inversion trauma history and ligament injury and diversified manifestation of chronic injuries on images [14, 15]. The patients’ history and clinical tests are important in diagnosis. A meta-analysis discussed the accuracy of clinical tests in diagnosing ankle ligament injury and claimed that clinicians cannot rule out ligamentous injury when physical tests are negative, and additional imaging is warranted [16]. Imaging is a helpful diagnostic method according to consensus of experts [17, 18]. However, different from acute injury, chronic ligament injury could show as either stretching, rupture, scarring, or thickening of the ligament on images, which confuses the clinical practitioners [19]. Magnetic resonance imaging (MRI), ultrasonography (US), stress radiography, and arthrography are often utilized for diagnosing chronic lateral ankle ligament injury. Separate studies on various imaging diagnostic techniques have been reported; however, the diagnostic effectiveness of different imaging techniques was still controversial, partly due to different existing reference standards [20, 21].

A previous systematic review assessed US for diagnosis of chronic ankle instability, but utilized variable gold standards, and did not provide pooled data [20]. Studies of MRI, US, stress radiography, and arthrography for diagnosis of chronic lateral ankle ligament injury were reported, but no previous systemic review provided synthesized data. This systemic review with meta-analysis is trying to analyze studies on diagnostic accuracy of different imaging techniques on chronic lateral ligament injury. Arthroscopic or surgical findings are set as the gold standards of ligament injuries [12, 22].

Methods

Inclusion and exclusion criteria

The studies that met the following criteria were included: (1) cohort-type or cross-sectional studies; (2) evaluated MRI and/or US and/or stress radiography and/or arthrography for the diagnosis of chronic ATFL and/or CFL injury (regarding the classification of acute and chronic ligament injuries, we followed the decisions adopted by the authors of the studies included); (3) comparing imaging results with arthroscopic or surgical findings as reference standards, and (4) reported data that enabled the calculation of the number of true positive (TP), true negative (TN), false positive (FP), and false negative (FN).

The following criteria were used to exclude underqualified studies: (1) acute injury patients; (2) patients with confounding factors like ankle fracture, history of previous foot, and ankle surgeries; (3) without clearly described arthroscopic or surgical findings as their reference standards; (4) cadaveric studies or studies utilizing animal models; and (5) non-English articles.

Search strategy

A systematical literature search was conducted to include the following three databases: MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trails (CENTRAL). The detailed search strategies (Table 1) were first developed in MEDLINE and were then adjusted and applied in the other two databases.

Table 1 Detailed search strategies
Full size table

Retrieved articles from each database were at first screened for duplication. Then, after titles and abstracts screening, relevant studies for this systemic review underwent full-text screening. Eligible studies were included according to the aforementioned inclusion and exclusion criteria.

Data extraction and quality assessment

The extracted data include authors, publication years, demographic features of participants, study design, index tests, gold standards, and the numbers of true positive, false negative, false positive, and true negative subjects. The pathologic features of chronic injury lead to various manifestations on images [14, 19, 23]. We eliminated this diversity by dichotomized imaging results to “injured” and “intact” in this study for better comparability among different included studies. Different kind of injuries such as “stretching,” “rupture,” “scarring,” or “thickening” are all categorized as “injured.”

Two authors independently extracted these data and filled previously drafted forms for this review. Results of the two authors were cross-validated, and discrepancies were mediated by the third author. The quality of the included articles was assessed through revised Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool, a widely recommended scale for diagnostic test evaluation [24]. According to QUADAS-2 tool, risk of bias was assessed in terms of patient selection, index test, and reference standard.

Statistical analysis

Sensitivity and specificity of each index test in individual study were calculated in Meta-DiSc, version 1.4.0, using the extracted data of TP, FN, FP, and TN. Pooled sensitivity and specificity were calculated using the total number of TP, FN, FP, and TN subjects in all relevant studies. Likelihood ratio (LR) evaluates the discriminatory properties of the test results [25]. Positive and negative likelihood ratio evaluates the positive and negative test results respectively. Pooled positive and negative likelihood ratio was calculated using random effects model. The diagnostic odds ratio (DOR) is defined as (true positives × true negatives) / (false positives × false negatives), which evaluates the overall diagnostic test performance combining sensitivity, specificity, and likelihood ratio [26]. Pooled DORs were calculated using random effects model.

All final outcomes were presented with 95% confidential interval. Pooled sensitivity, specificity, likelihood ratio, and DOR are calculated concerning each subgroup. Heterogeneity testing was assessed using the I2 test. A value of I2 > 50% was considered to be significant heterogeneity among the pooled data.

Results

Description of included studies

A total of 178 articles were retrieved from MEDLINE. One hundred eighty-eight articles were retrieved from EMBASE. Fifteen articles were retrieved from Cochrane Central Register of Controlled Trails. After deleting duplications, a total of 249 studies were identified in the primary search of three aforementioned databases. Then, these studies were screened for eligible studies as presented in the flow chart (Fig. 1). Twenty-four studies underwent full-text screen, and 9 studies were excluded for the following reasons: inconsistent reference standards among subjects [21, 27,28,29], studies on other lesions associated with chronic ankle instability [30,31,32,33], and heterogeneous population with inadequate data for chronic injury group [34].

Fig. 1
figure 1

Flow diagram of search strategy

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Overall, 15 studies [35,36,37,38,39,40,41,42,43,44,45,46,47,48,49] were eligible for this systemic review and are summarized in Table 2. A total of 695 participants were included. In 3 studies [39, 45, 49], participants were divided into acute injury group and chronic injury one, chronic injury groups of which were included in data synthesis. Two studies [42, 44] reported inter-rater reliability. In one study [48], a number of ankles instead of a number of participants were considered.

Table 2 Summary of included studies
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Methodological quality assessment

Methodological quality assessment was conducted for each study using QUADAS-2 tool (Fig. 2). All studies mentioned that participants were diagnosed of chronic ligament injury, of which 9 studies [36,37,38, 42, 43, 45, 46, 48, 49] mentioned the time from initial ankle inversion trauma to study commencement or duration when patients presented with chronic symptoms. Six of 15 studies [35, 38, 39, 41, 44, 47] were categorized as high risk of bias due to patient selection. All studies mentioned arthroscopic or surgical findings as their reference standards, of which 3 studies [37, 40, 46] mentioned that the reference standard results were interpreted without knowledge of the results of the index tests. All studies mentioned that investigators were blind to arthroscopic or surgical findings when interpreting the diagnostic imaging.

Fig. 2
figure 2

Methodological quality assessment of included studies using QUADAS-2 tool. Red stands for high risk. Green stands for low risk. Yellow stands for unclear risk

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Diagnostic accuracy of imaging techniques

Considering the combination of different ligaments (ATFL and CFL) and imaging techniques (MRI, US, stress radiography, and arthrography), 8 subgroups were analyzed. Extracted data of 8 subgroups are listed in Fig. 3. Pooled sensitivity, pooled specificity, and their 95% confidential interval are listed in Fig. 4 in the form of zones of mostly bad imaging efficacy (ZOMBIE) plot as Richardson [50] described. Detailed pooled data are listed in Table 3.

Fig. 3
figure 3

Forest plot showing sensitivity and specificity for each included study. MRI, US, stress radiography, and arthrography studies for ATFL and CFL are listed in a and b. TP, true positive; FP, false positive; FN, false negative; TN, true negative

Full size image
Fig. 4
figure 4

Zones of mostly bad imaging efficacy (ZOMBIE) plot for ATFL (a) and CFL (b). This is based on the receiver operating characteristic (ROC) plot. The colored dot stands for pooled sensitivity and specificity of each imaging technique, and the colored oval stands for 95% confidence interval of each imaging technique (green, MR; blue, US; red, arthrography; yellow, stress radiograph). Upper-left boomerang-shaped area formed by white and light grey zones defines zone of acceptable efficacy. Upper arm of the boomerang-shaped area stands for negative likelihood ratio below 0.33. Left arm of the boomerang-shaped area stands for positive likelihood ratio above 3

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Table 3 Results of pooled data
Full size table

MRI exhibited the pooled sensitivities of 0.83 [0.78, 0.87] in diagnosing chronic ATFL injury and 0.56 [0.46, 0.66] in diagnosing chronic CFL injury. The pooled specificities were 0.88 [0.82, 0.93] in diagnosing chronic CFL injury and 0.79 [0.69, 0.87] in diagnosing chronic ATFL injury.

US presented the pooled sensitivities of 0.99 [0.96, 1.00] in diagnosing chronic ATFL injury and 0.94 [0.85, 0.98] in diagnosing CFL injury. The pooled specificities were 0.91 [0.82, 0.97] in diagnosing chronic ATFL injury and 0.91 [0.80, 0.97] in diagnosing chronic CFL injury.

Stress radiography demonstrated a sensitivity of 0.81 [0.68, 0.90] and a specificity of 0.92 [0.79, 0.98] in diagnosing chronic ATFL injury. Two studies regarding stress radiography for CFL showed high heterogeneity [43, 48], with I2 for pooled data above 50%.

Sample size regarding arthrography in diagnosing chronic ATFL injury is relatively small, with only 34 subjects included. Arthrography presented the pooled sensitivity of 0.90 [0.73, 0.98] and the pooled specificity of 0.90 [0.77, 0.97] in diagnosing chronic CFL injury.

Discussion

Accurate diagnosis of chronic lateral ankle ligament injury is considered critical for surgical intervention of chronic ankle instability [13]. Imaging diagnosis is usually non-invasive and can be of value when physical tests are ambiguous [16]. Results for the four including imaging diagnostic techniques have been reported; however, the diagnostic accuracy of each imaging technique is variable in different studies, partly due to different reference standards applied [20, 21]. Our study set arthroscopic or surgical findings as the gold standard to investigate four imaging techniques. This gold standard reduced the heterogeneity of different studies.

In our results, the pooled sensitivities and specificities of US in diagnosing chronic ATFL and CFL injury were all above 0.90. When diagnosing chronic ankle instability, another systemic review involving 6 articles reported sensitivity of US ranged from 84.6 to 100% and specificity of US ranged from 90.9 to 100% [20]. In agreement with this systemic review, our results demonstrated US is an effective imaging technique in diagnosing chronic lateral ankle ligament injury.

US can precisely discriminate different ligamentous conditions, such as torn, lax, or thickened ligaments [40]. Comparing US results of healthy people and patients with chronic ankle instability, Liu et al. reported the differences in the thickness of ATFL [51] and Croy et al. reported differences in the length of ATFL [52]. Lee et al. recommended stress US over regular one for diagnosis of chronic lateral ankle ligament injury [53]. The study of Cho et al., which was included in the current review [38], utilized stress US. Other studies included in the current review did not utilize stress US technique, but still presented high diagnostic accuracy. However, US is of limited value in assessing bone or cartilage and highly experience-reliant and may be much less efficacious in less experienced hands. Moreover, only 4 studies [37, 38, 40, 45] included in this systemic review were related to the US examination of chronic lateral ankle ligament injuries, of them only one study [37] involved CFL injuries. Only two included studies [38, 45] compared US with MRI findings and reported similar diagnostic effectiveness. US is an effective imaging technique in diagnosing chronic lateral ankle ligament injury, yet more studies are warranted to compare US with other imaging techniques.

In our results, MRI exhibited the pooled sensitivities of 0.83 in diagnosing chronic ATFL injury and 0.56 in diagnosing chronic CFL injury. The pooled specificities were around 0.8 in diagnosing chronic ATFL and CFL injury. In clinical practice, MRI is highly recommended in diagnosing ligamentous injuries [54]. Also, MRI was reported to be effective in diagnosing intra-articular lesions of chronic ankle instability, including osteochondral lesions of talus, syndesmotic injuries, and impingement syndromes [55, 56]. Using MRI, Tao et al. [57] reported more cartilage lesions in patients with combined injuries of the ATFL and CFL, compared to patients with only ATFL injury. A study showed that 86.7% of the experts recommended MRI before considering surgery in chronic ankle instability patients [18]. However, according to our results, MRI did not provide the highest sensitivity or specificity in diagnosing chronic ligament injuries. It presented different patterns in diagnosing chronic ATFL and CFL injuries. The sensitivity for diagnosing chronic ATFL injury (0.83 [0.78, 0.87]) was higher than that for diagnosing chronic CFL injury (0.56 [0.46, 0.66]). MRI is still irreplaceable in assessing chronic lateral ankle ligament injury because it is frequently performed to confirm or exclude the presence of concomitant lesions and influence the precise surgical technique for a certain patient. Two included studies [38, 45] in the current systemic review compared US with MRI findings and did not report significantly different diagnostic effectiveness.

Arthroscopy was recommended as a complementary to MRI for definitive diagnosis [17, 18, 22]. An expert consensus from Guillo et al. recommended that an arthroscopy should be performed at the time of surgery unless intra-articular pathology has been excluded by MRI scan and there is no history of pain [17].

In our results, stress radiography demonstrated a sensitivity of 0.81 and a specificity of 0.92 in diagnosing chronic ATFL injury. Tourné et al. suggested that stress radiography presented high specificity (up to 100%) but low sensitivity (57%), suggesting dynamic radiographs only have diagnostic value if they are positive [58]. According to our results, stress radiography showed similar high specificity as US. When diagnosing chronic ATFL injury, the sensitivity of stress radiography is still above 0.80, and the pooled LR− is 0.24 [0.11–0.54], similar as that of MRI. Negative stress radiographic findings decreases the post-test probability of chronic ATFL and CFL injury in patients with ankle inversion trauma history. However, ligamentous laxity detected through stress radiography is not synonymous with chronic ankle instability [59]. Large variability in talar tilt and anterior drawer stress radiography precludes their routine use in diagnosing chronic ankle instability [60].

The role of anesthesia in stress radiography was reported by McCaskie et al. [61], suggesting larger discriminative capability under anesthesia. Amongst studies included in the current review, only one study reported stress radiography under anesthesia [43]. The large heterogeneity between stress radiography results for chronic CFL injury may partly explained by anesthetic condition. Though stress radiography is helpful in the diagnosis, it is hardly a useful tool in predicting surgical outcomes. Jeong et al. reported stress radiography-positive patients were not statistically significantly different from stress radiography-negative patients in prognostic features [62].

Arthrography is indicated for staging and detecting intra-articular lesions of chronic lateral ankle instability [63]. Samoto et al. reported that patients with combined injuries of the ATFL and CFL diagnosed through arthrography had worse prognosis than patients with only ATFL injury [64]. Arthrography is an invasive imaging technique. With the spread of arthroscopy, which is also invasive but much more accurate, this technique is now losing its popularity. Only 3 studies before year 2010 discussed arthrography [36, 39, 48].

There are several limitations in the current systemic review. First, 6 of the 15 included studies were graded as high risk of bias due to patient selection. Unlike meta-analysis of clinical intervention, in meta-analysis of diagnostic tests, it is common to include case-control studies considered as high risk of bias [65]. Case-control studies create a preselected patient population and should be interpreted with caution. Second, associated lesions of chronic lateral ankle ligament injury were not discussed in the current review; however, these associated lesions spotted on images would certainly affect the judgement of clinicians. Third, some studies compared the diagnostic accuracy of identical imaging technique with different parameters and/or configurations on diagnosing chronic lateral ankle ligament injury. Strength of the MRI machines varied among different studies. This diversity in configuration may cause the heterogeneity within each subgroup in this study. Moreover, the size of the included studies was relatively small. Of the 15 included studies, only a total of 695 participants were included. Studies reporting the imaging diagnosis of PTFL injury are not sufficient to draw meaningful conclusion. The studies comparing different imaging techniques for the same group of subjects are limited. This suggests more diagnostic studies with high quality are warranted for imaging diagnosing chronic lateral ankle ligament injury.

Conclusion

This systematic review with meta-analysis investigated the accuracy of imaging for the diagnosis of chronic lateral ankle ligament injury. Our results demonstrated that ultrasound manifested high diagnostic accuracy in diagnosing chronic lateral ankle ligament injury. MRI presented the diagnostic sensitivity and specificity around 0.8 for chronic ATFL injuries, but much lower sensitivity for chronic CFL injuries. Clinicians should be aware of the limitations of MRI in detecting chronic CFL injuries. Stress radiography showed similar high specificity as US in diagnosing chronic lateral ankle ligament injury and showed diagnostic value of both positive and negative results. Arthrography demonstrated sensitivity and specificity around 0.9 in diagnosing chronic CFL injury, but limited literature recommended arthrography due to invasiveness, especially in recent years. When the diagnosis of chronic lateral ankle ligament injury is uncertain after careful inquiry of the patient’s history and physical tests, US may be a helpful imaging technique in experienced hands.

Abbreviations

ATFL:

Anterior talofibular ligament

CENTRAL:

Cochrane Central Register of Controlled Trails

CFL:

Calcaneofibular ligament

DOR:

Diagnostic odds ratio

FN:

False negative

FP:

False positive

LR:

Likelihood ratio

MRI:

Magnetic resonance imaging

PTFL:

Posterior talofibular ligament

QUADAS-2:

Revised Quality Assessment of Diagnostic Accuracy Studies

TN:

True negative

TP:

True positive

US:

Ultrasonography

ZOMBIE plot:

Zones of mostly bad imaging efficacy plot

References

  1. Doherty C, Delahunt E, Caulfield B, Hertel J, Ryan J, Bleakley C. The incidence and prevalence of ankle sprain injury: a systematic review and meta-analysis of prospective epidemiological studies. Sports Med. 2014;44(1):123–40.

    Article  PubMed  Google Scholar 

  2. Fong DT, Hong Y, Chan LK, Yung PS, Chan KM. A systematic review on ankle injury and ankle sprain in sports. Sports Med. 2007;37(1):73–94.

    Article  PubMed  Google Scholar 

  3. Waterman BR, Owens BD, Davey S, Zacchilli MA, Belmont PJ Jr. The epidemiology of ankle sprains in the United States. J Bone Joint Surg Am. 2010;92(13):2279–84.

    Article  PubMed  Google Scholar 

  4. Bonnel F, Toullec E, Mabit C, Tourne Y. Chronic ankle instability: biomechanics and pathomechanics of ligaments injury and associated lesions. Orthop Traumatol Surg Res. 2010;96(4):424–32.

    Article  PubMed  CAS  Google Scholar 

  5. Hertel J. Functional anatomy, pathomechanics, and pathophysiology of lateral ankle instability. J Athl Train. 2002;37(4):364–75.

    PubMed  PubMed Central  Google Scholar 

  6. Delahunt E, Coughlan GF, Caulfield B, Nightingale EJ, Lin CWC, Hiller CE. Inclusion criteria when investigating insufficiencies in chronic ankle instability. Med Sci Sports Exerc. 2010;42(11):2106–21.

    Article  PubMed  Google Scholar 

  7. de Vries JS, Krips R, Sierevelt IN, Blankevoort L, van Dijk CN. Interventions for treating chronic ankle instability. Cochrane Database Syst Rev. 2011; 10(8):Cd004124.

  8. Mailuhu AKE, Oei EHG, van Putte-Katier N, van Ochten JM, Bindels PJE, Bierma-Zeinstra SMA, van Middelkoop M. Clinical and radiological predictors for persistent complaints five years after a lateral ankle sprain: a long-term follow-up study in primary care. J Sci Med Sport. 2017; 21(3):250–6.

  9. Pourkazemi F, Hiller CE, Raymond J, Nightingale EJ, Refshauge KM. Predictors of chronic ankle instability after an index lateral ankle sprain: a systematic review. J Sci Med Sport. 2014;17(6):568–73.

    Article  PubMed  Google Scholar 

  10. Vega J, Pena F, Golano P. Minor or occult ankle instability as a cause of anterolateral pain after ankle sprain. Knee Surg Sports Traumatol Arthrosc. 2016;24(4):1116–23.

    Article  PubMed  Google Scholar 

  11. Hubbard TJ, Hertel J, Olmsted-Kramer L, Denegar CR. Contributing factors to chronic ankle instability. Med Sci Sports Exerc. 2006;38(5):S86–7.

    Article  Google Scholar 

  12. Kerr HL, Bayley E, Jackson R, Kothari P. The role of arthroscopy in the treatment of functional instability of the ankle. Foot Ankle Surg. 2013;19(4):273–5.

    Article  PubMed  Google Scholar 

  13. Rodriguez-Merchan EC. Chronic ankle instability: diagnosis and treatment. Arch Orthop Trauma Sur. 2012;132(2):211–9.

    Article  Google Scholar 

  14. Meehan TM, Martinez-Salazar EL, Torriani M. Aftermath of ankle inversion injuries: spectrum of MR imaging findings. Magn Reson Imaging Clin N Am. 2017;25(1):45–61.

    Article  PubMed  Google Scholar 

  15. Hashimoto T, Inokuchi S, Kokubo T. Clinical study of chronic lateral ankle instability: injured ligaments compared with stress X-ray examination. J Orthop Sci. 2009;14(6):699–703.

    Article  PubMed  Google Scholar 

  16. Schneiders A, Karas S. The accuracy of clinical tests in diagnosing ankle ligament injury. Eur J Phys. 2016;18(4):245–53.

    Google Scholar 

  17. Guillo S, Bauer T, Lee JW, Takao M, Kong SW, Stone JW, Mangone PG, Molloy A, Perera A, Pearce CJ, et al. Consensus in chronic ankle instability: aetiology, assessment, surgical indications and place for arthroscopy. Orthop Traumat Surg Res. 2013;99(8 Suppl):S411–9.

    Article  CAS  Google Scholar 

  18. Michels F, Pereira H, Calder J, Matricali G, Glazebrook M, Guillo S, Karlsson J, Acevedo J, Batista J, Bauer T, et al. Searching for consensus in the approach to patients with chronic lateral ankle instability: ask the expert. Knee Surg Sports Traumatol Arthros. 2017. https://doi.org/10.1007/s00167-017-4556-0.

  19. Kwon DG, Sung KH, Chung CY, Park MS, Kim TW, Lee SH, Lee KM. Associations between MRI findings and symptoms in patients with chronic ankle sprain. J Foot Ankle Surg. 2014;53(4):411–4.

    Article  PubMed  Google Scholar 

  20. Radwan A, Bakowski J, Dew S, Greenwald B, Hyde E, Webber N. Effectiveness of ultrasonography in diagnosing chronic lateral ankle instability: a systematic review. Int J Sports Phys Ther. 2016;11(2):164–74.

    PubMed  PubMed Central  Google Scholar 

  21. Jolman S, Robbins J, Lewis L, Wilkes M, Ryan P. Comparison of magnetic resonance imaging and stress radiographs in the evaluation of chronic lateral ankle instability. Foot Ankle Int. 2017;38(4):397–404.

    Article  PubMed  Google Scholar 

  22. Takao M, Uchio Y, Naito K, Fukazawa I, Ochi M. Arthroscopic assessment for intra-articular disorders in residual ankle disability after sprain. Am J Sports Med. 2005;33(5):686–92.

    Article  PubMed  Google Scholar 

  23. Jung HG, Kim NR, Kim TH, Eom JS, Lee DO. Magnetic resonance imaging and stress radiography in chronic lateral ankle instability. Foot Ankle Int. 2017;38(6):621–6.

    Article  PubMed  Google Scholar 

  24. Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, Leeflang MM, Sterne JA, Bossuyt PM. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155(8):529–36.

    Article  PubMed  Google Scholar 

  25. Deeks JJ, Altman DG. Diagnostic tests 4: likelihood ratios. BMJ (Clinical research ed). 2004;329(7458):168–9.

    Article  Google Scholar 

  26. Deeks JJ. Systematic reviews in health care: systematic reviews of evaluations of diagnostic and screening tests. BMJ (Clinical research ed). 2001;323(7305):157–62.

    Article  CAS  Google Scholar 

  27. Park HJ, Lee SY, Park NH, Kim E, Chung EC, Kook SH, Lee JW. Usefulness of the oblique coronal plane in ankle MRI of the calcaneofibular ligament. Clin Radiol. 2015;70(4):416–23.

    Article  PubMed  CAS  Google Scholar 

  28. Park HJ, Lee SY, Park NH, Rho MH, Chung EC, Park JH, Park SJ. Three-dimensional isotropic T2-weighted fast spin-echo (VISTA) ankle MRI versus two-dimensional fast spin-echo T2-weighted sequences for the evaluation of anterior talofibular ligament injury. Clin Radiol. 2016;71(4):349–55.

    Article  PubMed  CAS  Google Scholar 

  29. Park HJ, Lee SY, Choi YJ, Hong HP, Park SJ, Park JH, Kim E. 3D isotropic T2-weighted fast spin echo (VISTA) versus 2D T2-weighted fast spin echo in evaluation of the calcaneofibular ligament in the oblique coronal plane. Clin Radiol. 2017;72(2):176 e171–7.

    Article  Google Scholar 

  30. Scranton PE, McDermott JE, Rogers JV. The relationship between chronic ankle instability and variations in mortise anatomy and impingement spurs. Foot Ankle Int. 2000;21(8):657–64.

    Article  PubMed  Google Scholar 

  31. O'Neill PJ, Van Aman SE, Guyton GP. Is MRI adequate to detect lesions in patients with ankle instability? Clin Orthop Relat Res. 2010;468(4):1115–9.

    Article  PubMed  Google Scholar 

  32. Park HJ, Cha SD, Kim HS, Chung ST, Park NH, Yoo JH, Park JH, Kim JH, Lee TW, Lee CH, et al. Reliability of MRI findings of peroneal tendinopathy in patients with lateral chronic ankle instability. Clin Orthop Surg. 2010;2(4):237–43.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Chun KY, Choi YS, Lee SH, Kim JS, Young KW, Jeong MS, Kim DJ. Deltoid ligament and tibiofibular syndesmosis injury in chronic lateral ankle instability: magnetic resonance imaging evaluation at 3T and comparison with arthroscopy. Korean J Radiol. 2015;16(5):1096–103.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Yi J, Cha JG, Lee YK, Lee BR, Jeon CH. MRI of the anterior talofibular ligament, talar cartilage and os subfibulare: comparison of isotropic resolution 3D and conventional 2D T2-weighted fast spin-echo sequences at 3.0 T. Skelet Radiol. 2016;45(7):899–908.

    Article  Google Scholar 

  35. Cha SD, Kim HS, Chung ST, Yoo JH, Park JH, Kim JH, Hyung JW. Intra-articular lesions in chronic lateral ankle instability: comparison of arthroscopy with magnetic resonance imaging findings. Clin Orthop Surg. 2012;4(4):293–9.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Chandnani VP, Harper MT, Ficke JR, Gagliardi JA, Rolling L, Christensen KP, Hansen MF. Chronic ankle instability: evaluation with MR arthrography, MR imaging, and stress radiography. Radiology. 1994;192(1):189–94.

    Article  PubMed  CAS  Google Scholar 

  37. Cheng Y, Cai Y, Wang Y. Value of ultrasonography for detecting chronic injury of the lateral ligaments of the ankle joint compared with ultrasonography findings. Br J Radiol. 2014;87(1033):20130406.

    Article  PubMed  CAS  Google Scholar 

  38. Cho JH, Lee DH, Song HK, Bang JY, Lee KT, Park YU. Value of stress ultrasound for the diagnosis of chronic ankle instability compared to manual anterior drawer test, stress radiography, magnetic resonance imaging, and arthroscopy. Knee Surg Sports Traumatol Arthrosc. 2016;24(4):1022–8.

    Article  PubMed  Google Scholar 

  39. Chou MC, Yeh LR, Chen CK, Pan HB, Chou YJ, Liang HL. Comparison of plain MRI and MR arthrography in the evaluation of lateral ligamentous injury of the ankle joint. J Chin Med Assoc. 2006;69(1):26–31.

    Article  PubMed  Google Scholar 

  40. Hua Y, Yang Y, Chen S, Cai Y. Ultrasound examination for the diagnosis of chronic anterior talofibular ligament injury. Acta Radiol. 2012;53(10):1142–5.

    Article  PubMed  Google Scholar 

  41. Joshy S, Abdulkadir U, Chaganti S, Sullivan B, Hariharan K. Accuracy of MRI scan in the diagnosis of ligamentous and chondral pathology in the ankle. Foot Ankle Surg. 2010;16(2):78–80.

    Article  PubMed  Google Scholar 

  42. Kim YS, Kim YB, Kim TG, Lee SW, Park SH, Lee HJ, Choi YJ, Koh YG. Reliability and validity of magnetic resonance imaging for the evaluation of the anterior talofibular ligament in patients undergoing ankle arthroscopy. Arthroscopy. 2015;31(8):1540–7.

    Article  PubMed  Google Scholar 

  43. Kumar V, Triantafyllopoulos I, Panagopoulos A, Fitzgerald S, Niekerk LV. Deficiencies of MRI in the diagnosis of chronic symptomatic lateral ankle ligament injuries. Foot Ankle Surg. 2007;13(4):171–6.

    Article  Google Scholar 

  44. Lee MH, Cha JG, Lee YK, Choi GC, Paik SH, Lee HK, Park SJ, Kim HJ. The bright rim sign on MRI for anterior talofibular ligament injury with arthroscopic correlation. AJR Am J Roentgenol. 2012;198(4):885–90.

    Article  PubMed  Google Scholar 

  45. Oae K, Takao M, Uchio Y, Ochi M. Evaluation of anterior talofibular ligament injury with stress radiography, ultrasonography and MR imaging. Skelet Radiol. 2010;39(1):41–7.

    Article  Google Scholar 

  46. Park HJ, Cha SD, Kim SS, Rho MH, Kwag HJ, Park NH, Lee SY. Accuracy of MRI findings in chronic lateral ankle ligament injury: comparison with surgical findings. Clin Radiol. 2012;67(4):313–8.

    Article  PubMed  Google Scholar 

  47. Staats K, Sabeti-Aschraf M, Apprich S, Platzgummer H, Puchner SE, Holinka J, Windhager R, Schuh R. Preoperative MRI is helpful but not sufficient to detect associated lesions in patients with chronic ankle instability. Knee Surg Sports Traumatol Arthrosc. 2017. https://doi.org/10.1007/s00167-017-4567-x

  48. Sugimoto K, Takakura Y, Samoto N, Nakayama S, Tanaka Y. Subtalar arthrography in recurrent instability of the ankle. Clin Orthop Relat Res. 2002;394:169–76.

    Article  Google Scholar 

  49. Tan DW, Teh DJW, Chee YH. Accuracy of magnetic resonance imaging in diagnosing lateral ankle ligament injuries: a comparative study with surgical findings and timings of scans. Asia Pac J Sport Med Arthrosc Rehabil Technol. 2017;7:15–20.

    Google Scholar 

  50. Richardson ML. The Zombie plot: a simple graphic method for visualizing the efficacy of a diagnostic test. AJR Am J Roentgenol. 2016; 207(4):W43–W52.

  51. Liu K, Gustavsen G, Royer T, Wikstrom EA, Glutting J, Kaminski TW. Increased ligament thickness in previously sprained ankles as measured by musculoskeletal ultrasound. J Athl Train. 2015;50(2):193–8.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Croy T, Saliba SA, Saliba E, Anderson MW, Hertel J. Differences in lateral ankle laxity measured via stress ultrasonography in individuals with chronic ankle instability, ankle sprain copers, and healthy individuals. J Orthop Sports Phys Ther. 2012;42(7):593–600.

    Article  PubMed  Google Scholar 

  53. Lee KT, Park YU, Jegal H, Park JW, Choi JP, Kim JS. New method of diagnosis for chronic ankle instability: comparison of manual anterior drawer test, stress radiography and stress ultrasound. Knee Surg Sports Traumatol Arthrosc. 2014;22(7):1701–7.

    Article  PubMed  Google Scholar 

  54. Martella I, Azzali E, Milanese G, Pratico FE, Ruggirello M, Trunfio V, Parziale R, Corrado M, Della Casa G, Capasso R, et al. MRI in acute ligamentous injuries of the ankle. Acta bio-medica : Atenei Parmensis. 2016;87(Suppl 3):13–9.

    Google Scholar 

  55. van Putte-Katier N, van Ochten JM, van Middelkoop M, Bierma-Zeinstra SM, Oei EH. Magnetic resonance imaging abnormalities after lateral ankle trauma in injured and contralateral ankles. Eur J Radiol. 2015;84(12):2586–92.

    Article  PubMed  Google Scholar 

  56. Choi WJ, Lee JW, Han SH, Kim BS, Lee SK. Chronic lateral ankle instability: the effect of intra-articular lesions on clinical outcome. Am J Sports Med. 2008;36(11):2167–72.

    Article  PubMed  Google Scholar 

  57. Tao H, Hu Y, Qiao Y, Ma K, Yan X, Hua Y, Chen S. T2—mapping evaluation of early cartilage alteration of talus for chronic lateral ankle instability with isolated anterior talofibular ligament tear or combined with calcaneofibular ligament tear. J Magn Reson Imaging. 2017; 47(1):69–77.

  58. Tourne Y, Besse JL, Mabit C. Chronic ankle instability. Which tests to assess the lesions? Which therapeutic options? Orthop Traumatol, Surg Res. 2010;96(4):433–46.

    Article  CAS  Google Scholar 

  59. Ferran NA, Oliva F, Maffulli N. Ankle instability. Sports Med Arthrosc Rev. 2009;17(2):139–45.

    Article  PubMed  Google Scholar 

  60. Frost SC, Amendola A. Is stress radiography necessary in the diagnosis of acute or chronic ankle instability? Clin J Sport Med. 1999;9(1):40–5.

    Article  PubMed  CAS  Google Scholar 

  61. McCaskie AW, Gale DW, Finlay D, Allen MJ. Chronic ankle instability: the value of talar tilt under general anaesthesia. Br J Sports Med. 1995;29(2):103–4.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  62. Jeong BO, Kim TY, Song WJ. Effect of preoperative stress radiographic findings on radiographic and clinical outcomes of the modified Brostrom procedure for chronic ankle instability. J Foot Ankle Surg. 2016;55(1):125–8.

    Article  PubMed  Google Scholar 

  63. Trnka HJ, Ivanic G, Trattnig S. Arthrography of the foot and ankle. Ankle and subtalar joint. Foot Ankle Clin. 2000;5(1):49–62. vi.

    PubMed  CAS  Google Scholar 

  64. Samoto N, Sugimoto K, Takaoka T, Fujita T, Kitada C, Takakura Y. Comparative results of conservative treatments for isolated anterior talofibular ligament (ATFL) injury and injury to both the ATFL and calcaneofibular ligament of the ankle as assessed by subtalar arthrography. J Orthop Sci. 2007;12(1):49–54.

    Article  PubMed  Google Scholar 

  65. Kopkow C, Freiberg A, Kirschner S, Seidler A, Schmitt J. Physical examination tests for the diagnosis of posterior cruciate ligament rupture: a systematic review. J Orthop Sports Phys Ther. 2013;43(11):804–13.

    Article  PubMed  Google Scholar 

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Funding

Dr. Xin Ma is currently receiving grants from National Natural Science Foundation of China (Grant No. 81171670 and Grant No. 81472037). Dr. Chen Wang is currently receiving grants from National Natural Science Foundation of China (Grant No. 81601862).

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  1. Shengxuan Cao and Chen Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Orthopedics, Huashan Hospital, Fudan University, No.12, Middle Wulumuqi Road, Jingan District, Shanghai, China

    Shengxuan Cao, Chen Wang, Xin Ma, Xu Wang, Jiazhang Huang & Chao Zhang

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  1. Shengxuan Cao
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  3. Xin Ma
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Contributions

All authors were fully involved in the study and preparation of the manuscript. SC and CW contributed to the study design and preparation of the manuscript. XM contributed to the search strategies. XW contributed to the statistical analysis. JH and CZ contributed to the article screening and data extraction. All authors read and approved the final manuscript.

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Cao, S., Wang, C., Ma, X. et al. Imaging diagnosis for chronic lateral ankle ligament injury: a systemic review with meta-analysis. J Orthop Surg Res 13, 122 (2018). https://doi.org/10.1186/s13018-018-0811-4

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Keywords

Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X