- Research article
- Open Access
Multivariate analysis of risk factors for predicting supplementary posterior instrumentation after anterolateral decompression and instrumentation in treating thoracolumbar burst fractures
© Chen et al.; licensee BioMed Central. 2015
Received: 11 October 2014
Accepted: 3 January 2015
Published: 28 January 2015
Although anterolateral decompression and instrumentation has several advantages in treating thoracolumbar burst fractures, the risk factors for supplementary posterior instrumentation are still unclear.
We retrospectively reviewed 238 patients who underwent anterolateral decompression and instrumentation for single-level thoracolumbar burst fractures from January 2010 and March 2012. The influences of several potential risk factors that might affect supplementary posterior instrumentation were assessed using univariate and multivariate analyses.
Twenty seven patients who developed worsening back pain without neurological deterioration after the anterolateral approach treatment need further posterior instrumentation fixation. The univariate analysis showed that age, disruption of the posterior longitudinal ligament complex (PLC), and fracture level were the risk factors for supplementary posterior instrumentation. However, age and integrity of the PLC were the independent risk factors for supplementary posterior instrumentation by multivariate analyses.
Supplemental posterior instrumentation was necessary in 11.3% of cases following anterolateral decompression and instrumentation in the present study. Older age and disruption of the PLC were the independent risk factors in prediction of supplementary posterior instrumentation in treating thoracolumbar burst fractures.
About 20% of thoracic and lumbar fractures belong to thoracolumbar burst fractures [1,2]. This kind of fracture is frequently associated with neurologic deficits because of encroachment on the neural elements and at times owing to the dynamic nature of the injury.
To some extent, management of thoracolumbar burst fractures is according to clinical and radiographic criteria [3-17]. The purpose of orthopedic surgery includes decompression of the neural elements, restoration of vertebral body height, correction of spinal deformity, and stabilization. Furthermore, surgery can be performed through a posterior approach [18-21] or through an anterolateral retroperitoneal flank approach [22-27], based on the necessity and extent of decompression.
The anterolateral retroperitoneal flank approach allows the surgeon to conduct corpectomy and decompression of the canal. Bone fragments can be withdrawed from the canal under direct vision. After corpectomy, the vertebral column is reconstructed by inserting a prosthesis or graft, restoring height and correcting spinal angulation. When placing anterior instrumentation, the hardware generally incorporates one level above and one level below the fracture.
However, there are about 10% patients who meet failure after anterolateral decompression and stabilization. They need further posterior instrumentation [24,25,27]. Currently, supplementary posterior instrumentation was performed in cases of symptomatic settling and angulation of the spine or instability in spite of anterior instrumentation.
At present, the risk factors for predicting supplementary posterior instrumentation after anterolateral decompression and instrumentation in treating thoracolumbar burst fractures are still unclear. Thus, the purpose of the present study is to identify risk factors that contribute to the need for posterior instrumentation after anterolateral decompression and stabilization for single-level thoracolumbar burst fractures using a multivariate statistical model.
Materials and methods
All the anterolateral approaches were performed by the primary spinal surgeon through the left flank according to standard practice [23-26]. After corpectomy, decompression of the thecal sac was ensured from pedicle to pedicle in the axial plane and from the rostral to the caudal intact endplates of the adjacent vertebrae. The anterior column was reconstructed, using iliac autografts or allografts. The carbon fiber-reinforced polymer cages or expandable titanium cages were used. The graft or cage with the largest footplate was consistently selected to reduce subsidence, or telescoping, of the graft or cage into the adjacent vertebral bodies. Cages were packed with artificial graft or autograft harvested from the patient during decompression, supplemented with corticocancellous allograft if necessary. To facilitate graft or cage insertion, distraction was applied on the rostral and caudal bodies through the bicortical screws. Screw length was calculated from axial CT scans before surgery. Overzealous distraction was avoided to prevent screw loosening or pullout. Gentle pressure on the gibbous in a ventral direction was also helpful. The position of the graft/cage was confirmed using both anteroposterior and lateral fluoroscopy. Lateral instrumentation with bicortical screws and dual rods was used in some cases. All patients wore a thoracolumbar clamshell orthosis postoperatively for 3 months.
The integrity of the PLC was evaluated by one of our authors who was blinded to the management or outcomes of the patients. The T1- and T2-weighted images and the short tau inversion recovery (STIR) sequence were used to assess the integrity of PLC consisting of the supra- and infraspinous ligaments, the ligamentum flavum, and the facet capsules [31-36]. Disruption was diagnosed when the black stripe representing the supraspinous ligament was discontinuous. Injury to the infraspinous ligaments was diagnosed with high signal intensity in the interspinous space produced by hemorrhage.
Potential risk factors
Data regarding age, gender, body mass index (BMI), America Spinal Injury Association (ASIA) impairment scale , segmental kyphosis as assessed on preoperative radiography, residual anteroposterior canal diameter as assessed on CT scans, fracture level, fracture age, and surgical approach were collected. ASIA impairment scale was used to assess the neurological deficit on initial examination and at follow-up. Segmental kyphosis was measured on lateral plane radiographs using the angle subtended between the adjacent intact endplates. Residual anteroposterior canal diameter at the injury site was measured from preoperative CT scans and expressed as a percentage of the intact diameter averaged between the rostral and caudal intact canal.
Factors associated with supplementary posterior instrumentation after anterolateral decompression and instrumentation were identified using univariate analysis. The data analysis was performed using SPSS version 19.0 (Chicago, IL, USA).Continuous data were compared between the two groups using the student t test, whereas discontinuous data were analyzed using the chi-squared test. All significance tests were two-tailed, with p < 0.05 representing statistical significance. In addition, a multivariate logistic regression analysis was performed to identify which independent factors helped predict the supplementary posterior instrumentation after anterolateral decompression and instrumentation in treating thoracolumbar burst fractures.
Characteristics of patients
Characteristics of patients
Number of patients
Causes of injury
Level of vertebrae
20.2 ± 8.1 mo
Length of hospitalization
17.5 ± 7.7 d
Injury duration before surgery
10.3 ± 4.4 d
Characteristics of patients with supplementary posterior fixation
Results of univariate analysis for supplementary posterior instrumentation in treating thoracolumbar burst fractures
Number of SPI ( n = 27)
Number of no SPI ( n = 211)
67.1 ± 11.5
57.3 ± 14.5
29.4 ± 15.5
26.4 ± 8.5
ASIA in admission
4.1 ± 1.0
4.0 ± 1.0
ASIA in follow-up
4.5 ± 0.7
4.4 ± 0.7
Residual canal (%)
43.1 ± 13.4
45.6 ± 14.5
Angulation in admission
5.6 ± 12.5
7.4 ± 12.1
Angulation in follow-up
1.5 ± 6.1
1.4 ± 4.2
Disruption of PLC
Kinds of graft
Fracture age (days)
12.4 ± 8.1
9.5 ± 4.1
Risk factors by univariate analysis
Univariate analysis was performed to assess risk factors for supplementary posterior instrumentation after anterolateral decompression compared with other patients who were treated with anterolateral instrumentation alone. The results of univariate analysis showed that age, disruption of the PLC, and fracture level were the risk factors for supplementary posterior instrumentation (Table 2).
Risk factors by multivariate analysis
Results of multivariate analysis for supplementary posterior instrumentation in treating thoracolumbar burst fractures
Disruption of PLC
About half of the thoracic and lumbar fractures occur at the thoracolumbar junction (T10–L2), and the majority of these fractures are burst in type involving the anterior and middle columns [3,6,22,25]. The therapeutic options include conservative treatment and surgery. For patients with burst fractures but neurologically intact, conservative treatment may be optimal [15,16]. Surgery is suitable for patients with neurological deficits or persistent pain and for patient whose fractures are deemed unstable with disruption of the posterior ligaments [35,36]. When anterior decompression is deemed unnecessary, posterior instrumentation may be sufficient [18,21]. However, when significant fragmentation of the vertebral body exists and there is poor apposition of the fragments and deformity, anterior grafts and instrumentation are advised [22,26]. Direct access for canal decompression, reconstruction of anterior column, and correction of kyphosis and instrumented fusion with single approach can be achieved by the anterior approach. Moreover, improvement in neurological function has been consistently demonstrated with relatively minimal complications [7,19,26].
In the present study, rods and bicortical screws were used to supple the strut graft and because of the limitations of plates in rigid compared with rods and bicortical screws. Other studies demonstrated the importance of the anterior strut graft by conducting a test that compares three anterior plates and three anterior rods and screws [38-40]. Although the strut graft was performed, settling continues to occur. In the present study, angulation was corrected significantly, from 7.1 ± 9.1 preoperatively to 0.4 ± 6.5 postoperatively, with a slight increase at follow-up to 1.2 ± 6.6 compared to preoperative. The above results are consistent to those of previous studies [22,26,27]. The loss of correction with the passage of time is commonly encountered, well tolerated, and attributed to settling. The more significant increase in angulation with time has been demonstrated in burst fractures when treated nonoperatively [12,13,15].
In the present study, 27 patients underwent supplemental posterior fixation for symptomatic settling of the cage into the superior endplate of the caudal vertebra. These patients did not experience an increase in deficit. Posterior instrumentation fixation was performed within the next few days of the index operation. Of the 27 patients requiring supplemental posterior instrumentation, 19 had PLC disruption compared with other patients who had successful anterior approach fusion. The multivariate analysis demonstrated that the PLC disruption correlated with the need for posterior fixation. The result was consistent with the previous studies that the PLC was of significance in spinal stability. Therefore, rigid posterior fixation is needed in treating thoracolumbar burst fractures.
Another independent risk factor for the need of supplemental posterior instrumentation was age. The mean age of patients needing further posterior fixation was higher than that of the anterolateral group. To some extent, the association of age with the need of supplementary posterior fixation might be attributed to the age-related decrease in bone mineral density [41,42]. However, the measurement of bone mineral density was not conducted in the present study as a routine.
The reoperation rate (11.3%) in the present study was comparable to that of other studies. McAfee et al.  conducted Kaneda instrumentation in treating thoracolumbar pathology. Two of 35 cases experienced failure who did need further posterior instrumentation. Kaneda et al.  conducted a study about treating thoracolumbar burst fractures by anterolateral Kaneda device. However, pseudoarthrosis was encountered in ten of 150 cases, and further posterior fixation was conducted in ten cases. Sasso et al.  performed anterior fusion in treating thoracolumbar burst fractures in 40 patients. Only three patients required additional posterior instrumentation because of disruption of PLC. In summary, different reoperation rates of the need for further posterior instrumentation may be affected by several factors, such as the recruited patients with differences in severity of injury and bone quality.
The limitations of the present study mainly include the following items: (1) Operator expertise and learning curve may be subjective risk factors. We are unable to cancel out the above effects. (2) We did not objectively measure the bone mineral density, which may place an influence on the reoperation rates. Moreover, patient’s comobilities, smoking status, and living condition which have not been evaluated may be all factors that may influence the risk of supplementary posterior instrumentation. (3) The study design, retrospective study, may place bias on the stability of the results.
In the present study, 27 of 238 patients in which the anterolateral decompression and instrumentation was undertaken in treating single-level thoracolumbar burst fractures did need additional posterior fixation. In univariate analysis, age, disruption of the PLC, and fracture level were the risk factors for further posterior fixation. However, older age and disruption of the PLC were the independent risk factors predicting supplementary posterior instrumentation in treating thoracolumbar burst fractures by multivariate analysis. Further prospective studies are still required to evaluate other potential factors about supplementary posterior instrumentation in treating thoracolumbar burst fractures.
We thank Dr. Haixu Chen for his support in obtaining the approval of the ethics committee in this study.
- Bensch FV, Koivikko MP, Kiuru MJ, Koskinen SK. The incidence and distribution of burst fractures. Emerg Radiol. 2006;12(3):124–9.PubMedView ArticleGoogle Scholar
- Denis F. The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. Spine (Phila Pa 1976). 1983;8(8):817–31.View ArticleGoogle Scholar
- Bailey CS, Dvorak MF, Thomas KC, Boyd MC, Paquett S, Kwon BK, et al. Comparison of thoracolumbosacral orthosis and no orthosis for the treatment of thoracolumbar burst fractures: interim analysis of a multicenter randomized clinical equivalence trial. J Neurosurg Spine. 2009;11(3):295–303.PubMedView ArticleGoogle Scholar
- Cantor JB, Lebwohl NH, Garvey T, Eismont FJ. Nonoperative management of stable thoracolumbar burst fractures with early ambulation and bracing. Spine (Phila Pa 1976). 1993;18(8):971–6.View ArticleGoogle Scholar
- Dai LY. Remodeling of the spinal canal after thoracolumbar burst fractures. Clin Orthop Relat Res 2001(382):119–123.Google Scholar
- Dai LY, Jiang LS, Jiang SD. Conservative treatment of thoracolumbar burst fractures: a long-term follow-up results with special reference to the load sharing classification. Spine (Phila Pa 1976). 2008;33(23):2536–44.View ArticleGoogle Scholar
- Hitchon PW, Torner J, Eichholz KM, Beeler SN. Comparison of anterolateral and posterior approaches in the management of thoracolumbar burst fractures. J Neurosurg Spine. 2006;5(2):117–25.PubMedView ArticleGoogle Scholar
- Hitchon PW, Torner JC, Haddad SF, Follett KA. Management options in thoracolumbar burst fractures. Surg Neurol. 1998;49(6):619–26. 6.PubMedView ArticleGoogle Scholar
- McCormack T, Karaikovic E, Gaines RW. The load sharing classification of spine fractures. Spine (Phila Pa 1976). 1994;19(15):1741–4.View ArticleGoogle Scholar
- Mumford J, Weinstein JN, Spratt KF, Goel VK. Thoracolumbar burst fractures. The clinical efficacy and outcome of nonoperative management. Spine (Phila Pa 1976). 1993;18(8):955–70.View ArticleGoogle Scholar
- Reid DC, Hu R, Davis LA, Saboe LA. The nonoperative treatment of burst fractures of the thoracolumbar junction. J Trauma. 1988;28(8):1188–94.PubMedView ArticleGoogle Scholar
- Siebenga J, Leferink VJ, Segers MJ, Elzinga MJ, Bakker FC, Haarman HJ, et al. Treatment of traumatic thoracolumbar spine fractures: a multicenter prospective randomized study of operative versus nonsurgical treatment. Spine (Phila Pa 1976). 2006;31(25):2881–90.View ArticleGoogle Scholar
- Tropiano P, Huang RC, Louis CA, Poitout DG, Louis RP. Functional and radiographic outcome of thoracolumbar and lumbar burst fractures managed by closed orthopaedic reduction and casting. Spine (Phila Pa 1976). 2003;28(21):2459–65.View ArticleGoogle Scholar
- Vaccaro AR, Lehman RJ, Hurlbert RJ, Anderson PA, Harris M, Hedlund R, et al. A new classification of thoracolumbar injuries: the importance of injury morphology, the integrity of the posterior ligamentous complex, and neurologic status. Spine (Phila Pa 1976). 2005;30(20):2325–33.View ArticleGoogle Scholar
- Willen J, Anderson J, Toomoka K, Singer K. The natural history of burst fractures at the thoracolumbar junction. J Spinal Disord. 1990;3(1):39–46.PubMedView ArticleGoogle Scholar
- Wood K, Buttermann G, Mehbod A, Garvey T, Jhanjee R, Sechriest V. Operative compared with nonoperative treatment of a thoracolumbar burst fracture without neurological deficit. A prospective, randomized study. J Bone Joint Surg Am. 2003;85-A(5):773–81.PubMedGoogle Scholar
- Wood KB, Bohn D, Mehbod A. Anterior versus posterior treatment of stable thoracolumbar burst fractures without neurologic deficit: a prospective, randomized study. J Spinal Disord Tech. 2005;18 Suppl:S15–23.PubMedView ArticleGoogle Scholar
- Dai LY, Jiang LS, Jiang SD. Posterior short-segment fixation with or without fusion for thoracolumbar burst fractures. a five to seven-year prospective randomized study. J Bone Joint Surg Am. 2009;91(5):1033–41.PubMedView ArticleGoogle Scholar
- Danisa OA, Shaffrey CI, Jane JA, Whitehill R, Wang GJ, Szabo TA, et al. Surgical approaches for the correction of unstable thoracolumbar burst fractures: a retrospective analysis of treatment outcomes. J Neurosurg. 1995;83(6):977–83.PubMedView ArticleGoogle Scholar
- McLain RF, Sparling E, Benson DR. Early failure of short-segment pedicle instrumentation for thoracolumbar fractures. A preliminary report. J Bone Joint Surg Am. 1993;75(2):162–7.PubMedGoogle Scholar
- McNamara MJ, Stephens GC, Spengler DM. Transpedicular short-segment fusions for treatment of lumbar burst fractures. J Spinal Disord. 1992;5(2):183–7.PubMedView ArticleGoogle Scholar
- Dai LY, Jiang LS, Jiang SD. Anterior-only stabilization using plating with bone structural autograft versus titanium mesh cages for two- or three-column thoracolumbar burst fractures: a prospective randomized study. Spine (Phila Pa 1976). 2009;34(14):1429–35.View ArticleGoogle Scholar
- Heary RF, Kheterpal A, Mammis A, Kumar S. Stackable carbon fiber cages for thoracolumbar interbody fusion after corpectomy: long-term outcome analysis. Neurosurgery. 2011;68(3):810–8. 3.PubMedView ArticleGoogle Scholar
- Kaneda K, Taneichi H, Abumi K, Hashimoto T, Satoh S, Fujiya M. Anterior decompression and stabilization with the Kaneda device for thoracolumbar burst fractures associated with neurological deficits. J Bone Joint Surg Am. 1997;79(1):69–83.PubMedGoogle Scholar
- McAfee PC. Complications of anterior approaches to the thoracolumbar spine. Emphasis on Kaneda instrumentation. Clin Orthop Relat Res 1994;(306):110–119Google Scholar
- McDonough PW, Davis R, Tribus C, Zdeblick TA. The management of acute thoracolumbar burst fractures with anterior corpectomy and Z-plate fixation. Spine (Phila Pa 1976). 2004;29(17):1901–8. 1909.View ArticleGoogle Scholar
- Sasso RC, Renkens K, Hanson D, Reilly T, McGuire RJ, Best NM. Unstable thoracolumbar burst fractures: anterior-only versus short-segment posterior fixation. J Spinal Disord Tech. 2006;19(4):242–8.PubMedView ArticleGoogle Scholar
- Magerl F, Aebi M, Gertzbein SD, Harms J, Nazarian S. A comprehensive classification of thoracic and lumbar injuries. Eur Spine J. 1994;3(4):184–201.PubMedView ArticleGoogle Scholar
- Patel AA, Vaccaro AR. Thoracolumbar spine trauma classification. J Am Acad Orthop Surg. 2010;18(2):63–71.PubMedGoogle Scholar
- Rihn JA, Anderson DT, Harris E, Lawrence J, Jonsson H, Wilsey J, et al. A review of the TLICS system: a novel, user-friendly thoracolumbar trauma classification system. Acta Orthop. 2008;79(4):461–6.PubMedView ArticleGoogle Scholar
- Emery SE, Pathria MN, Wilber RG, Masaryk T, Bohlman HH. Magnetic resonance imaging of posttraumatic spinal ligament injury. J Spinal Disord. 1989;2(4):229–33.PubMedView ArticleGoogle Scholar
- Haba H, Taneichi H, Kotani Y, Terae S, Abe S, Yoshikawa H, et al. Diagnostic accuracy of magnetic resonance imaging for detecting posterior ligamentous complex injury associated with thoracic and lumbar fractures. J Neurosurg. 2003;99(1 Suppl):20–6.PubMedGoogle Scholar
- Lee HM, Kim HS, Kim DJ, Suk KS, Park JO, Kim NH. Reliability of magnetic resonance imaging in detecting posterior ligament complex injury in thoracolumbar spinal fractures. Spine (Phila Pa 1976). 2000;25(16):2079–84.View ArticleGoogle Scholar
- Oner FC, van Gils AP, Faber JA, Dhert WJ, Verbout AJ. Some complications of common treatment schemes of thoracolumbar spine fractures can be predicted with magnetic resonance imaging: prospective study of 53 patients with 71 fractures. Spine (Phila Pa 1976). 2002;27(6):629–36.View ArticleGoogle Scholar
- Radcliff K, Kepler CK, Rubin TA, Maaieh M, Hilibrand AS, Harrop J, et al. Does the load-sharing classification predict ligamentous injury, neurological injury, and the need for surgery in patients with thoracolumbar burst fractures?: Clinical article. J Neurosurg Spine. 2012;16(6):534–8.PubMedView ArticleGoogle Scholar
- Radcliff K, Su BW, Kepler CK, Rubin T, Shimer AL, Rihn JA, et al. Correlation of posterior ligamentous complex injury and neurological injury to loss of vertebral body height, kyphosis, and canal compromise. Spine (Phila Pa 1976). 2012;37(13):1142–50.View ArticleGoogle Scholar
- Burns S, Biering-Sorensen F, Donovan W, Graves DE, Jha A, Johansen M, et al. International standards for neurological classification of spinal cord injury, revised 2011. Top Spinal Cord Inj Rehabil. 2012;18(1):85–99.PubMedView ArticleGoogle Scholar
- Brodke DS, Gollogly S, Bachus KN, Alexander MR, Nguyen BK. Anterior thoracolumbar instrumentation: stiffness and load sharing characteristics of plate and rod systems. Spine (Phila Pa 1976). 2003;28(16):1794–801.View ArticleGoogle Scholar
- Kallemeier PM, Beaubien BP, Buttermann GR, Polga DJ, Wood KB. In vitro analysis of anterior and posterior fixation in an experimental unstable burst fracture model. J Spinal Disord Tech. 2008;21(3):216–24.PubMedView ArticleGoogle Scholar
- Maiman DJ, Pintar F, Yoganandan N, Reinartz J. Effects of anterior vertebral grafting on the traumatized lumbar spine after pedicle screw-plate fixation. Spine (Phila Pa 1976). 1993;18(16):2423–30.View ArticleGoogle Scholar
- Khosla S, Riggs BL. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am. 2005;34(4):1015–30.PubMedView ArticleGoogle Scholar
- Riggs BL, Melton ILR, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, et al. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res. 2004;19(12):1945–54.PubMedView ArticleGoogle Scholar
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