Articles

Biomarker potential of lncRNA GNAS-AS1 in osteosarcoma prognosis and effect on cellular function

Osteosarcoma (OS) is a type of bone cancer that occurs in children and adolescents at a rate of 5%. The purpose of this study is to explore the lncRNA GNAS-AS1 expression profile, prognosis significance in OS,...

Authors: Zhanhu Mi, Yanyun Dong, Zhibiao Wang and Peng Ye

Implementation of Enhanced Recovery After Surgery (ERAS) protocol for elderly patients receiving surgery for intertrochanteric fracture: a propensity score-matched analysis

Enhanced Recovery After Surgery (ERAS) is a multimodal approach to perioperative care that aims to reduce patient perioperative complications, accelerate patient recovery, and improve patient satisfaction by r...

Authors: Wenhao Zhu, Yinjie Yan, Yijin Sun, Zhaoxiang Fan, Niangkang Fang, Yunlu Zhang, Mengchen Yin, Hongbo Wan, Wen Mo, Wei Lu and Xuequn Wu

Proprioceptive elbow training reduces pain and improves function in painful lateral epicondylitis—a prospective trial

In painful epicondylitis, previous studies reported deficiencies in elbow proprioception. In line, proprioceptive training of the lower limb has been reported substantial beneficial in a number of indications....

Authors: B. Schiffke-Juhász, K. Knobloch, P. M. Vogt and L. Hoy

Modified pedicle screw-rod versus anterior subcutaneous internal pelvic fixation for unstable anterior pelvic ring fracture: a retrospective study and finite element analysis

This study compared the stability and clinical outcomes of modified pedicle screw-rod fixation (MPSRF) and anterior subcutaneous internal pelvic fixation (INFIX) for the treatment of anterior pelvic ring fract...

Authors: Zhi-Hong Pan, Fan-Cheng Chen, Jun-Ming Huang, Cheng-Yi Sun and Sheng-Long Ding

Letter to editor regarding “The efficacy and safety of tranexamic acid in high tibial osteotomy: a systematic review and meta-analysis”

Authors: Qian Fang, Zhen Zhang, Limin Wang, Wei Xiong, Yunfeng Tang and Guanglin Wang

Biomechanical effect of intertrochanteric curved varus osteotomy on stress reduction in femoral head osteonecrosis: a finite element analysis

Intertrochanteric curved varus osteotomy (CVO) has been widely used to remove the necrotic bone away from the weight-bearing portion in the treatment of osteonecrosis of the femoral head (ONFH). However, wheth...

Authors: Yuzhu Wang, Go Yamako, Takato Okada, Hideki Arakawa, Yoshihiro Nakamura and Etsuo Chosa

Management of chronic knee pain caused by postsurgical or posttraumatic neuroma of the infrapatellar branch of the saphenous nerve

Injury to the infrapatellar branch of the saphenous nerve (IBSN) is a relatively common complication after knee surgery, which can interfere with patient satisfaction and functional outcome. In some cases, inj...

Authors: G. J. Regev, D. Ben Shabat, M. Khashan, D. Ofir, K. Salame, Y. Shapira, R. Kedem, Z. Lidar and S. Rochkind

Assessment of seawater bacterial infection in rabbit tibia by Illumina MiSeq sequencing and bacterial culture

We aimed to explore the bacterial community composition following ocean bacterial infection using an animal model.

Authors: Du Wang, Qingcong Zheng, Qi Lv, Chaofan Zhang, Yun Zheng, Huidong Chen and Wenming Zhang

Mini-transverse incision using a novel bush-hook versus conventional open incision for treatment of carpal tunnel syndrome: a prospective study

This study aimed to investigate the outcomes of a mini-transverse incision with a bush-hook versus a conventional open incision for carpal tunnel release (CTR).

Authors: Tianxiao Ma, Dongyue Wang, Yuqing Hu, Xiaocui Zhao, Wei Wang and Lihua Song

Enhanced recovery after surgery pathway reduces the length of hospital stay without additional complications in lumbar disc herniation treated by percutaneous endoscopic transforaminal discectomy

Enhanced recovery after surgery (ERAS) pathway in spine surgery is increasingly popular which can reduce the length of hospital stay (LOS). However, there are few studies on the safety and effectiveness of ERA...

Authors: Wang Duojun, Zhang Hui, Lin Zaijun, Ge Yuxiang and Chen Haihong

Study on the potential active components and molecular mechanism of Xiao Huoluo Pills in the treatment of cartilage degeneration of knee osteoarthritis based on bioinformatics analysis and molecular docking technology

Knee osteoarthritis is a common joint degenerative disease. Xiao Huoluo Pills (XHLP) has been used to treat degenerative diseases such as osteoarthritis and hyperosteogeny. However, XHLP’s specific effective i...

Authors: Weijian Chen, Tianye Lin, Qi He, Peng Yang, Gangyu Zhang, Fayi Huang, Zihao Wang, Hao Peng, Baolin Li, Du Liang and Haibin Wang

Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis

Circular RNAs (circRNAs) are emerging as crucial regulators in various human diseases. So far, the expression profile and regulatory mechanism of circRNAs in postmenopausal osteoporosis (PMOP) are less studied...

Authors: Weiyi Diao, Yongguang Wang, Jun Zhang, Haiyu Shao, Yazeng Huang and Mengran Jin

Identification of hub genes in rheumatoid arthritis through an integrated bioinformatics approach

Rheumatoid arthritis (RA) is a common chronic autoimmune disease characterized by inflammation of the synovial membrane. However, the etiology and underlying molecular events of RA are unclear. Here, we applie...

Authors: Rui Wu, Li Long, Qiao Zhou, Jiang Su, Wei Su and Jing Zhu

Effectiveness of iguratimod as monotherapy or combined therapy in patients with rheumatoid arthritis: a systematic review and meta-analysis of RCTs

This study aims to evaluate the efficacy and safety of the iguratimod (IGU) as monotherapy or combined therapy in patients with rheumatoid arthritis (RA) by using meta-analysis.

Authors: Chao-Jun Hu, Li Zhang, Shuang Zhou, Nan Jiang, Jiu-Liang Zhao, Qian Wang, Xin-Ping Tian and Xiao-Feng Zeng

Salidroside promoted osteogenic differentiation of adipose-derived stromal cells through Wnt/β-catenin signaling pathway

Bone disease causes short-term or long-term physical pain and disability. It is necessary to explore new drug for bone-related disease. This study aimed to explore the role and mechanism of Salidroside in prom...

Authors: Xiao-hua Li, Fu-ling Chen and Hong-lin Shen

Rapid preoperative predicting tools for 1-year mortality and walking ability of Asian elderly femoral neck fracture patients who planned for hip arthroplasty

Femoral neck fractures in elderly patients typically warrant operative treatment and are related to high risks of mortality and morbidity. As early hip arthroplasties for elderly femoral neck fractures are wid...

Authors: Guangtao Fu, Mengyuan Li, Yunlian Xue, Hao Wang, Ruiying Zhang, Yuanchen Ma and Qiujian Zheng

Clinical efficacy of closed reduction and percutaneous parallel K-wire interlocking fixation of first metacarpal base fracture

This study aimed to explore the clinical efficacy of treating a first metacarpal base fracture by closed reduction and percutaneous parallel K-wire interlocking fixation between the first and second metacarpals.

Authors: Wu Wang, Min Zeng, Junxiao Yang, Long Wang, Jie Xie and Yihe Hu

Do reverse total shoulder replacements have better clinical and functional outcomes than hemiarthroplasty for patients undergoing proximal humeral tumor resection using devitalized autograft composite reconstruction: a case-control study

To compare the efficacy and prognosis of reverse total shoulder arthroplasty (rTSA) with shoulder hemiarthroplasty (SHA) using devitalized autograft or allograft composite reconstruction after proximal humeral...

Authors: Dongqing Zuo, Haoran Mu, Qingbo Yang, Mengxiong Sun, Jiakang Shen, Hongsheng Wang, Xiaojun Ma, Chongren Wang, Chuanping Li, Wei Sun and Zhengdong Cai

A new quantitative evaluation system for distal radioulnar joint instability using a three-dimensional electromagnetic sensor

The accurate assessment of distal radioulnar joint (DRUJ) instability is still challenging as there is no established objective evaluation method. This study aimed to develop a noninvasive measurement method u...

Authors: Shintaro Mukohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Tomoya Yoshikawa, Issei Shinohara, Yuichi Hoshino, Kouki Nagamune and Ryosuke Kuroda

Salvage of severe knee osteoarthritis: efficacy of tibial condylar valgus osteotomy versus open wedge high tibial osteotomy

To compare the clinical outcomes and the radiographic features between tibial condylar valgus osteotomy (TCVO) and open wedge high tibial osteotomy (OWHTO). New insight into the indication criteria for TCVO wa...

Authors: Xiaoyu Wang, Li Shi, Rui Zhang, Wenbo Wang, Lingchi Kong, Haoyu Zhao, Jia Xu and Qinglin Kang

Clinical observation and finite element analysis of cannulated screw internal fixation in the treatment of femoral neck fracture based on different reduction quality

Femoral neck fracture is one of the most common bone types. The effect of reduction quality on hip joint function and complications after screw internal fixation is not fully understood. To investigate the cli...

Authors: Gan Zhao, Ming Liu, Bin Li, Haizhong Sun and Biaofang Wei

Evaluation of using the Anderson-Montesano and the Tuli classifications in pediatric patients with occipital condyle fractures

Occipital condyle fractures (OCFs) in patients before 18 years of age are rare. Classifications of OCF are based on the CT images of the cranio-cervical junction (CCJ) and MRI. The Anderson-Montesano and Tuli ...

Authors: Ryszard Tomaszewski, Jacek Kler, Karol Pethe and Agnieszka Zachurzok

Risk factors for screw loosening in patients with adult degenerative scoliosis: the importance of paraspinal muscle degeneration

Paraspinal muscle is an important component to maintain spinal stability. But the relationship between the degeneration of paraspinal muscle and postoperative screw loosening in patients with adult degenerativ...

Authors: Wei Wang, Weishi Li and Zhongqiang Chen

The relationship between thoracic kyphosis and age, and normative values across age groups: a systematic review of healthy adults

Thoracic kyphosis is reported to increase with ageing. However, this relationship has not been systematically investigated. Peoples’ kyphosis often exceeds 40°, but 40° is the widely accepted cut-off and thres...

Authors: Mattia Zappalá, Stephen Lightbourne and Nicola R. Heneghan

The incidence and risk factors of deep venous thrombosis in lower extremities following surgically treated femoral shaft fracture: a retrospective case-control study

There is still a lack of data on deep vein thrombosis (DVT) following surgically treated femoral shaft fracture (FSF). The goal of this study was to investigate the characteristics of postoperative DVT and the...

Authors: Zhixin Ren, Yufei Yuan, Wei Qi, Yanbao Li and Pengcheng Wang

The use of incisional vacuum-assisted closure system following one-stage incision suture combined with continuous irrigation to treat early deep surgical site infection after posterior lumbar fusion with instrumentation

Previous reports concerning deep surgical site infection (SSI) after posterior spinal instrumentation treated with vacuum-assisted closure (VAC) system indicated that most patients must suffer from a delayed i...

Authors: Hang Shi, Lei Zhu, Zan-Li Jiang, Zhi-Hao Huang and Xiao-Tao Wu

The effect of fascia iliaca block on postoperative pain and analgesic consumption for patients undergoing primary total hip arthroplasty: a meta-analysis of randomized controlled trials

The primary aim of this systematic review and meta-analysis was to compare postoperative pain, analgesic consumption, and complications after fascia iliaca block (FIB) versus control for patients undergoing pr...

Authors: Wenli Dai, Xi Leng, Xiaoqing Hu, Jin Cheng and Yingfang Ao

Retraction Note: Treatment for lumbar spinal stenosis secondary to ligamentum flavum hypertrophy using percutaneous endoscopy through interlaminar approach: a retrospective study

Authors: Yi Liu, Yingjie Qi, Diarra Mohamed Diaty, Guanglei Zheng, Xiaoqiang Shen, Shangben Lin, Jiaqi Chen, Yongwei Song and Xiaomin Gu

The Michigan Hand Outcomes Questionnaire (MHQ-Swe) in patients with distal radius fractures—cross-cultural adaptation to Swedish, validation and reliability

The Michigan Hand Outcomes Questionnaire—MHQ—is a well-known self-assessment questionnaire, where patients’ own perception in terms of recovery, pain and the ability to return to activities of daily living is ...

Authors: J. Blomstrand, J. Karlsson, M. Fagevik Olsén and G. Kjellby Wendt

Bone plate fixation ability on the dorsal and lateral sides of a metacarpal shaft transverse fracture

Metacarpal shaft fractures are a common hand trauma. The current surgical fixation options for such fractures include percutaneous Kirschner wire pinning and nonlocking and locking plate fixation. Although bon...

Authors: Yung-Cheng Chiu, Cheng-En Hsu, Tsung-Yu Ho, Yen-Nien Ting, Ming-Tzu Tsai and Jui-Ting Hsu

MiR-330-5p inhibits intervertebral disk degeneration via targeting CILP

Intervertebral disk degeneration (IDD) is caused by nucleus pulposus (NP) degeneration and extracellular matrix (ECM) remodeling and cartilage intermediate layer protein (CILP) expression has been confirmed to...

Authors: Shangzhi Li, Jinwei Liu and Liang Chen

Overexpression of KIAA1199, a novel strong hyaluronidase, is a poor prognostic factor in patients with osteosarcoma

Hyaluronan (HA) has been shown to play important roles in the growth, invasion, and metastasis of malignant tumors. KIAA1199, which has potent HA-degrading activity, has been reported to be expressed in variou...

Authors: Kan Ito, Yoshihiro Nishida, Kunihiro Ikuta, Hiroshi Urakawa, Hiroshi Koike, Tomohisa Sakai, Jiarui Zhang, Yoshie Shimoyama and Shiro Imagama

High-risk factors for subjective discomfort due to lower limb discrepancy after medial open wedge high tibial osteotomy

Medial open wedge high tibial osteotomy (OWHTO) may result in lower limb discrepancy (LLD), and some patients experience uncomfortable symptoms. Studies have found that the degree of LLD is one but not the onl...

Authors: Axiang He, Yin Wang, Yanan Chen, Ying Zhou, Hui Zhang, Yanjie Mao, Wanjun Liu and Xianlong Zhang

Fixed-bearing vs mobile-bearing prostheses for total knee arthroplasty after approximately 10 years of follow-up: a meta-analysis

The benefits and risks of fixed-bearing and mobile-bearing designs for total knee arthroplasty (TKA) were compared, and long-term functional, clinical and radiological outcomes were analysed.

Authors: Dongsheng Hao and Junjie Wang

Anthropometric measurements of patellar ridge using computed tomography-based three-dimensional computer models

The objectives of this study were to investigate the anatomic morphology of patellar ridge using computed tomography-based three-dimensional (3D) computer models and to assess the center of the patellar ridge ...

Authors: Xiaoliang Mei, Hao Ding, Jia Meng and Jianning Zhao

Radiological and clinical outcomes of balloon kyphoplasty for osteoporotic vertebral compression fracture in patients with rheumatoid arthritis

This study was conducted to investigate the outcomes and complications of balloon kyphoplasty (KP) for the treatment of osteoporotic vertebral compression fracture (OVCF) in patients with rheumatoid arthritis ...

Authors: Ji Guo, Weifeng Zhai, Licheng Wei, Jianpo Zhang, Lang Jin, Hao Yan, Zheng Huang and Yongwei Jia

Safety and efficacy studies of kyphoplasty, mesh-container-plasty, and pedicle screw fixation plus vertebroplasty for thoracolumbar osteoporotic vertebral burst fractures

Percutaneous kyphoplasty (PKP), percutaneous mesh-container-plasty (PMCP), and pedicle screw fixation plus vertebroplasty (PSFV) were three methods for osteoporotic vertebral burst fractures (OVBF). The purpos...

Authors: Yimin Li, Yunfan Qian, Guangjie Shen, Chengxuan Tang, Xiqiang Zhong and Shaoqi He

Minimally invasive plate osteosynthesis with dual plating for periprosthetic distal femoral fractures following total knee arthroplasty

Adequate treatment for periprosthetic distal femur fractures is challenging because of various reasons, including severe osteoporosis and distal fragments that are too small or too distal. We have introduced a...

Authors: Yong-Geun Park, Hyunseong Kang, Jung-Kook Song, Jaehwang Lee, Joseph Y. Rho and Sungwook Choi

Bioinformatics integrated analysis to investigate candidate biomarkers and associated metabolites in osteosarcoma

This study hoped to explore the potential biomarkers and associated metabolites during osteosarcoma (OS) progression based on bioinformatics integrated analysis.

Authors: Jun Wang, Mingzhi Gong, Zhenggang Xiong, Yangyang Zhao and Deguo Xing

Precision and accuracy of pre-surgical planning of non-cemented total hip replacement with calibrated digital images and acetates

When approaching a joint replacement procedure, pre-surgical planning is essential to predict an accurate estimation of implant size and position. There are currently two methods to achieve it, analog and digi...

Authors: Luis Fernando Useche Gómez, Hernando Gaitán-Lee, María Alejandra Duarte, Patrick Dennis Halley, Alejandro Romero Jaramillo and Efraim Leal García

Width of pubic symphysis relating to age and sex in Koreans

Diastasis of the pubic symphysis has been reported to occur in 13–16% of pelvic ring injuries. In Asians, there are only a few data showing the width of the pubic symphysis. The aim of this study is to see the...

Authors: Kun Hwang, Xiajing Wu and Chan Yong Park

Effect of pedicle-screw rod fixation on oblique lumbar interbody fusion in patients with osteoporosis: a retrospective cohort study

A retrospective cohort study.

Authors: Kaiwen Cai, Kefeng Luo, Jinjin Zhu, Kai Zhang, Shengkai Yu, Yi Ye and Guoqiang Jiang

Biomechanical study of transsacral-transiliac screw fixation versus lumbopelvic fixation and bilateral triangular fixation for “H”- and “U”-type sacrum fractures with traumatic spondylopelvic dissociation: a finite element analysis study

To compare the biomechanical stability of transsacral-transiliac screw fixation and lumbopelvic fixation for “H”- and “U”-type sacrum fractures with traumatic spondylopelvic dissociation.

Authors: Ye Peng, Gongzi Zhang, Shuwei Zhang, Xinran Ji, Junwei Li, Chengfei Du, Wen Zhao and Lihai Zhang

Correction of complex three-dimensional deformities at the proximal femur using indirect reduction with angle blade plate and patient-specific instruments: a technical note

Corrective osteotomies for complex proximal femoral deformities can be challenging; wherefore, subsidies in preoperative planning and during surgical procedures are considered helpful. Three-dimensional (3D) p...

Authors: Lukas Jud, Lazaros Vlachopoulos and Karl Grob

A cadaveric assessment of percutaneous trigger finger release with 15° stab knife: its effectiveness and complications

Percutaneous release of the A1 pulley has been introduced as a therapeutic approach for trigger fingers and is suggested as an effective and safe alternative, where conservative treatments fail. The aim of the...

Authors: Abbas Abdoli, Majid Asadian, Seyed Houssein Saeed Banadaky and Rabeah Sarram

Validation of a portable marker-based motion analysis system

The Opti_Knee system, a marker-based motion capture system, tracks and analyzes the 6 degrees of freedom (6DOF) motion of the knee joint. However, the validation of the accuracy of this gait system had not bee...

Authors: Shaobai Wang, Xiaolong Zeng, Liang Huangfu, Zhenyan Xie, Limin Ma, Wenhan Huang and Yu Zhang

The intraoperative use of a calliper predicts leg length and offset after total hip arthroplasty. Component subsidence influences the leg length

The purpose of total hip arthroplasty (THA) post-surgery and proper physiotherapy is positive recovery for the patient. Consideration is given to hip replacement biomechanics by ensuring no discrepancies in li...

Authors: Maliha Fansur, Nagib A. Yurdi and Reinhard Stoewe

Surgical outcomes and risk factors for poor outcomes in patients with cervical spine metastasis: a prospective study

Few studies have addressed the impact of palliative surgery for cervical spine metastasis on patients’ performance status (PS) and quality of life (QOL). We investigated the surgical outcomes of patients with ...

Authors: Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Zhongying Zhang, Takashi Yurube, Shingo Miyazaki, Yuji Kakiuchi, Yoshiki Takeoka, Ryu Tsujimoto, Kunihiko Miyazaki, Hiroki Ohnishi, Yuichi Hoshino, Toru Takada and Ryosuke Kuroda

Repair of symptomatic bilateral L5 spondylolysis with autogenous iliac crest graft and temporary intersegmental pedicle screw fixation in youth

When symptomatic spondylolysis fail to respond to nonoperative treatment, surgical management may be required. A number of techniques have been described for repair by intrasegmental fixation with good results...

Authors: Zhi-Cheng Zhang, Yang Zhang, Li-Zhi Zhang, Kai Guan, Guang-Min Zhao, Da-Jiang Ren, Fang Li and Tian-Sheng Sun

Identification and validation of key long non-coding RNAs in resveratrol protect against IL-1β-treated chondrocytes via integrated bioinformatic analysis

Long non-coding RNAs (lncRNAs) participate in regulation of gene transcription, but little is known about the correlation among resveratrol and lncRNAs. This study aimed to identify and validate the key lncRNA...

Authors: Hong Yi, Wei Zhang, Sheng-Yu Cui, Jian-Bo Fan, Xin-Hui Zhu and Wei Liu