Articles

Survivorship and prognostic factors for pleomorphic liposarcoma: a population-based study

Pleomorphic liposarcoma is the least common but most aggressive subtype of liposarcoma. Very few studies have presented data on pleomorphic liposarcoma specifically, often including a limited number of cases a...

Authors: Lu Wan, Chao Tu, Lin Qi and Zhihong Li

Depicting developing trend and core knowledge of hip fracture research: a bibliometric and visualised analysis

Hip fracture is common and carries high morbidity and mortality; thus, it has become a vital concern. We aim to analyse the present status, worldwide trends in hip fracture and state of clinical research.

Authors: Guanrong Peng, Zhenhua Guan, Yunfei Hou, Jiaxiang Gao, Wenqun Rao, Xianyun Yuan, Jiusheng Guo, Xiaohua Huang, Zhangrong Zhong and Jianhao Lin

TKR after posttraumatic and primary knee osteoarthritis: a comparative study

A few literatures reported that the outcomes of total knee replacement (TKR) in posttraumatic osteoarthritis (PTOA) were lower compared to TKR in primary osteoarthritis (primary OA). The study’s purpose was to...

Authors: Ong-art Phruetthiphat, Biagio Zampogna, Sebastiano Vasta, Benyapa Tassanawipas, Yubo Gao and John J. Callaghan

Hemiarthroplasty compared to total hip arthroplasty for the treatment of femoral neck fractures: a systematic review and meta-analysis

Hip replacement is divided into total hip arthroplasty (THA) and hemiarthroplasty (HA); it is still controversial whether to choose THA or HA for femoral neck fractures (FNF). The goal of this study was to rev...

Authors: Xinbo Li and Jianning Luo

The effect of the WKYMVm peptide on promoting mBMSC secretion of exosomes to induce M2 macrophage polarization through the FPR2 pathway

When multicystic vesicles (precursors of exosomes) are formed in cells, there are two results. One is decomposition by lysosomes, and the other is the generation of exosomes that are transported out through th...

Authors: Wenbo Zhao, Junxian Hu and Qingyi He

Knockdown of Circ_SLC39A8 protects against the progression of osteoarthritis by regulating miR-591/IRAK3 axis

The dysregulation of circular RNAs (circRNAs) has been identified in various human diseases, including osteoarthritis (OA). The purpose of this study was to identify the role and mechanism of circ_SLC39A8 in r...

Authors: Jizhe Yu, Yushuang Qin and Naxin Zhou

Comparison of the inner side and two-sided approaches for iliac crest bone graft harvesting for pediatric pelvic osteotomy

The iliac crest is one of the most used bone graft sources. In this study, we aimed to identify the effects of inner side and two-sided approaches for iliac crest bone harvesting on post-surgery ilium growth i...

Authors: Xin Chen, Kai Chen and Yuxi Su

Application of a double reverse traction repositor in the retrograde intramedullary nailing of distal femur fractures

The purpose of this prospective study was to introduce the application of a double reverse traction repositor (DRTR) in the retrograde intramedullary nailing (RE-IMN) of AO/OTA 33A distal femur fractures.

Authors: Xiaodong Lian, Kuo Zhao, Wei Chen, Junzhe Zhang, Junyong Li, Hongyu Meng, Zhiyong Hou and Yingze Zhang

Letter to the Editors regarding the article “Patellar resurfacing in primary total knee arthroplasty: a meta-analysis of randomized controlled trials”

Authors: Zhong-min Fu, Xiu-mei Tang, Duan Wang, Ning Ning and Zong-ke Zhou

Microendoscopy-assisted extraforaminal lumbar interbody fusion for treating single-level spondylodesis

Lumbar interbody fusion is a standard technique for treating degenerative lumbar disorders involving instability. Due to its invasiveness, a minimally invasive technique, extraforaminal lumbar interbody fusion...

Authors: Motohide Shibayama, Guang Hua Li, Li Guo Zhu, Zenya Ito and Fujio Ito

Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts

Circular RNAs (circRNAs) are associated with rheumatoid arthritis (RA) development. The purpose of this study is to explore the function and mechanism of circRNA fragile mental retardation 2 (circ-AFF2) in the...

Authors: Wei Qu, Ling Jiang and Guanhua Hou

Application of WALANT technique for repairing finger skin defect with a random skin flap

Wide-awake local anesthesia no tourniquet (WALANT) technique has emerged among hand surgeons with other indications. Surgeries involving pedicled flap and revascularization are no longer used as contraindicati...

Authors: Jianhua Xu, Lu Yin, Shuming Cao, Haihua Zhan, Jianbing Zhang, Qiang Zhou and Ketong Gong

Etoricoxib is safe and effective in preventing heterotopic ossification after primary total hip arthroplasty

Heterotopic ossifications are a common complication after total hip arthroplasty. Low-dose radiation therapy and non-steroidal anti-inflammatory drugs have proven to effectively reduce the rate of heterotopic ...

Authors: Stella Oberberg, Jan Nottenkämper, Matthias Heukamp, Jan Krapp and Roland E. Willburger

The efficacy and safety of fast track surgery (FTS) in patients after hip fracture surgery: a meta-analysis

Fast track surgery (FTS) has been gradually applied in perioperative management of orthopedic surgery, but there still some research suspected that the prognosis of patients is not as expected and the cost is ...

Authors: Mingyang Jiang, Siyi Liu, Huachu Deng, Xuzhi Liang and Zhandong Bo

COVID-19 pandemic effects on orthopaedic surgeons in British Columbia

COVID-19 was declared a global emergency in the first quarter of 2020. It is has resulted in and continues in over a million deaths worldwide and halted medical systems and particularly elective surgeries worl...

Authors: Maciej J. K. Simon and William D. Regan

The value of the hedgehog signal in osteoblasts in fluoride-induced bone-tissue injury

This study was designed to observe the expression of important hedgehog (Hh) signal factors in the bone tissue of rats with chronic fluorosis and cultured osteoblasts in order to investigate the role and signi...

Authors: Chaonan Deng, Lin Xu, Ying Zhang, Lina Zhao, Yan Linghu and Yanni Yu

Inter-rater variability of three-dimensional fracture reduction planning according to the educational background

Computer-assisted three-dimensional (3D) planning is increasingly delegated to biomedical engineers. So far, the described fracture reduction approaches rely strongly on the performance of the users. The goal ...

Authors: Christoph Zindel, Philipp Fürnstahl, Armando Hoch, Tobias Götschi, Andreas Schweizer, Ladislav Nagy and Simon Roner

The occurrence rate and clinical application of Osteo-line on the femur neck

This study was done to observe the incidence of Osteo-line on the femur neck and to explore the clinical application of Osteo-line in osteotomy.

Authors: Mingchen Zou, Haotian Wu, Shuangquan Yao, Dong Ren, Song Liu, Yueju Liu and Zhaohui Song

Comparison of the modified Smith-Petersen (S-P) and ilioinguinal (I-I) approaches for periacetabular osteotomy in adult developmental dysplasia of the hip: a retrospective study

Adult developmental dysplasia of the hip is an untreated congenital hip dysplasia that results in adult hip pain. One of the usual and effective methods for the treatment of this condition is periacetabular os...

Authors: Rui Luo, Guomin Li, Bo Li, Ruyin Hu and Yankun Li

Value of 3D preoperative planning for primary total hip arthroplasty based on artificial intelligence technology

Accurate preoperative planning is an important step for accurate reconstruction in total hip arthroplasty (THA). Presently, preoperative planning is completed using either a two-dimensional (2D) template or th...

Authors: Jiabang Huo, Guangxin Huang, Dong Han, Xinjie Wang, Yufan Bu, Ya Chen, Daozhang Cai and Chang Zhao

The impact of COVID-19 on the management and outcomes of patients with proximal femoral fractures: a multi-centre study of 580 patients

On the 11th March 2020, the World Health Organization declared the COVID-19 outbreak a pandemic. Multiple new guidelines were proposed and existing models of social, domestic and hospital care altered. Most he...

Authors: Alice Wignall, Vasileios Giannoudis, Chiranjit De, Andrea Jimenez, Simon Sturdee, Sohail Nisar, Hemant Pandit, Aashish Gulati and Jeya Palan

Full recovery of elective orthopedic surgery in the age of COVID-19: an 8-month retrospective cohort study

The coronavirus disease 2019 (COVID-19) pandemic has led to dramatic disruptions to orthopedic services. The purpose of this study is to quantify the reinstatement of elective orthopedic surgeries of our insti...

Authors: Teng-fei Lou, Zun Ren, Zheng-hua Sun, Wei Wang and Cun-yi Fan

A novel closed technique for ultrasound-guided plantar fascia release with a needle: review of 107 cases with a minimum follow-up of 24 months

This study aims to analyze the clinical outcome of a new ultrasound-guided surgery for partial plantar fasciotomy performed with a needle for treatment of plantar fasciitis.

Authors: A. Iborra, M. Villanueva, P. Sanz-Ruiz, Antonio Martin and Concepción Noriega

Outcomes of dual-mobility total hip arthroplasty versus bipolar hemiarthroplasty for patients with femoral neck fractures: a systematic review and meta-analysis

Elderly patients with femoral neck fractures are at a higher risk of dislocation after hip arthroplasty procedures. In comparison with total hip arthroplasty (THA), bipolar hemiarthroplasty (HA) and dual-mobil...

Authors: Hsuan-Hsiao Ma, Te-Feng Arthur Chou, Fu-Yuan Pai, Shang-Wen Tsai, Cheng-Fong Chen, Po-Kuei Wu and Wei-Ming Chen

Distribution and imaging characteristics of spina bifida occulta in young people with low back pain: a retrospective cross-sectional study

Spina bifida occulta (SBO) is one of the most common congenital spinal deformities. Although many studies have demonstrated the influence of lumbosacral dysplasia on low back pain (LBP) in young athletes, ther...

Authors: Wenhao Li, Zhencheng Xiong, Chunke Dong, Jipeng Song, Liubo Zhang, Jun Zhou, Yanlei Wang, Ping Yi, Feng Yang, Xiangsheng Tang and Mingsheng Tan

Moringa oleifera leaf extracts protect BMSC osteogenic induction following peroxidative damage by activating the PI3K/Akt/Foxo1 pathway

We aimed to investigate the therapeutic effects of Moringa oleifera leaf extracts on osteogenic induction of rat bone marrow mesenchymal stem cells (BMSCs) following peroxidative damage and to explore the underly...

Authors: Meiling Liu, Haifeng Ding, Hongzhi Wang, Manfeng Wang, Xiaowei Wu, Lu Gan, Luyang Cheng and Xianglu Li

Single-stage total knee arthroplasty and femoral osteotomy for osteoarthritis with severe supracondylar deformity

Knee osteoarthritis associated with extra-articular deformity (EAD) can confront the arthroplasty surgeons with challenges of bone resection and soft tissue balancing. The aim of this study was to describe a s...

Authors: Jing-yang Sun, Guo-qiang Zhang, Jun-min Shen, Yin-qiao Du, Tie-jian Li, Zong-jie Geng, Yong-gang Zhou and Yan Wang

The popliteomeniscal fascicles: from diagnosis to surgical repair: a systematic review of current literature

Popliteomeniscal fascicles (PMF) are considered the posterolateral meniscocapsular extensions which connect the lateral meniscus to the edge of the tibia. PMFs disruption leads to hypermobility of the lateral ...

Authors: Alessio D’Addona, Andrea Izzo, Giovanni Di Vico, Donato Rosa and Nicola Maffulli

Silymarin modulates catabolic cytokine expression through Sirt1 and SOX9 in human articular chondrocytes

Silymarin (SMN), a polyphenolic flavonoid, is involved in multiple bioactive functions including anti-inflammation. Pretreatment with SMN demonstrated chondroprotection against tumour necrosis factor-alpha (TN...

Authors: Wen-Tien Wu, Yi-Ru Chen, Dai-Hua Lu, Fedor Svyatoslavovich Senatov, Kai-Chiang Yang and Chen-Chie Wang

Correlation between growth differentiation factor 5 (rs143383) gene polymorphism and knee osteoarthritis: an updated systematic review and meta-analysis

A great deal of evidence has supported that growth differentiation factor 5 (GDF5) is associated with the occurrence of knee osteoarthritis (KOA), while their results are not consistent. In the present study, ...

Authors: Bin Jia, Yaping Jiang, Yingxing Xu, Yingzhen Wang and Tao Li

Evaluation of muscle volume and degeneration after total hip arthroplasty: a comparison of the posterolateral approach and the anterolateral supine approach

Muscle strength around the hip after total hip arthroplasty (THA) is crucial for preventing dislocation and limping. This study aimed to assess and compare muscle volume and degeneration after THA using the po...

Authors: Taku Ukai, Goro Ebihara, Haruka Omura and Masahiko Watanabe

Synovial fluid IL-1β appears useful for the diagnosis of chronic periprosthetic joint infection

The purpose of this study was to investigate the role of synovial fluid interleukin (IL)-1β in diagnosing chronic periprosthetic joint infection (PJI) and to identify the optimal threshold of synovial fluid IL...

Authors: Hai Wang, Leilei Qin, Jiawei Wang and Wei Huang

Umbilical cord-derived Wharton’s jelly for treatment of knee osteoarthritis: study protocol for a non-randomized, open-label, multi-center trial

Osteoarthritis (OA) is the most common joint disorder in the USA, and knee OA has the highest prevalence. Inflammation and decrease in vascularization are key factors in the degeneration of articular cartilage...

Authors: Ashim Gupta, Nicola Maffulli, Hugo C. Rodriguez, Cassidy E. Lee, Howard J. Levy and Saadiq F. El-Amin III

Inertial measurement units for the detection of the effects of simulated leg length inequalities

Leg length inequalities (LLI) are a common condition that can be associated with detrimental effects like low back pain and osteoarthritis. Inertial measurement units (IMUs) offer the chance to analyze daily a...

Authors: Hannah Lena Siebers, Jörg Eschweiler, Valentin M. Quack, Markus Tingart and Marcel Betsch

Percutaneous autologous impaction bone graft for advanced femoral head osteonecrosis: a retrospective observational study of unsatisfactory short-term outcomes

Half of osteonecrosis of the femoral head (ONFH) patients suffer femoral head collapse at initial diagnosis, and more than half are bilaterally affected. This study developed a percutaneous autologous impactio...

Authors: Yutaka Kuroda, Manabu Nankaku, Yaichiro Okuzu, Toshiyuki Kawai, Koji Goto and Shuichi Matsuda

Contemporary indications for first-time revision surgery after primary cementless total hip arthroplasty with emphasis on early failures

To clarify contemporary indications for first-time revision surgery after primary cementless total hip arthroplasty (THA) for addressing potential issues with cementless THA.

Authors: Goro Motomura, Satoshi Hamai, Satoshi Ikemura, Masanori Fujii, Shinya Kawahara, Soichiro Yoshino and Yasuharu Nakashima

Anterior cruciate ligament reconstruction in a rabbit model using a silk-collagen scaffold modified by hydroxyapatite at both ends: a histological and biomechanical study

To investigate osteointegration at the graft-bone interface and the prevention of osteoarthritis after anterior cruciate ligament (ACL) reconstruction using a silk-collagen scaffold with both ends modified by ...

Authors: Fanggang Bi, Yangdi Chen, Junqi Liu, Yafei Wang, Danfeng Xu and Ke Tian

Finite element analysis of wedge and biconcave deformity in four different height restoration after augmentation of osteoporotic vertebral compression fractures

Biomechanical comparison of wedge and biconcave deformity of different height restoration after augmentation of osteoporotic vertebral compression fractures was analyzed by three-dimensional finite element ana...

Authors: Xiao-Hua Zuo, Yin-Bing Chen, Peng Xie, Wen-Dong Zhang, Xiang-Yun Xue, Qian-Xi Zhang, Ben Shan, Xiao-Bing Zhang, Hong-Guang Bao and Yan-Na Si

Surgical drainage after limb salvage surgery and endoprosthetic reconstruction: is 30 mL/day critical?

Periprosthetic infection is a major cause of failure after segmental endoprosthetic reconstruction. The purpose of this study is to determine whether certain aspects of drain output affect infection risk, part...

Authors: Jiayong Liu, Zhengfu Fan, Marc El Beaino, Valerae O. Lewis, Bryan S. Moon, Robert L. Satcher, Justin E. Bird, Spencer J. Frink and Patrick P. Lin

Silencing of Vangl2 attenuates the inflammation promoted by Wnt5a via MAPK and NF-κB pathway in chondrocytes

The Wnt planar cell polarity (PCP) pathway is implicated in osteoarthritis (OA) both in animals and in humans. Van Gogh-like 2 (Vangl2) is a key PCP protein that is required for the orientation and alignment o...

Authors: Ke Zhang, Zhuoying Li, Yunyang Lu, Linyi Xiang, Jiadong Sun and Hong Zhang

Rivaroxaban versus aspirin in prevention of venous thromboembolism following total joint arthroplasty or hip fracture surgery: a meta-analysis

To evaluates the efficacy and safety of rivaroxaban versus aspirin in prevention of venous thromboembolism (VTE) following total hip (THA) or knee arthroplasty (TKA) or hip fracture surgery.

Authors: Bangsheng Hu, Lianxiang Jiang, Haixia Tang, Meizhu Hu, Jun Yu and Zeping Dai

Tibial component coverage affects tibial bone resorption and patient-reported outcome measures for patients following total knee arthroplasty

The aim of this study is to investigate the prognostic value of tibial component coverage (over-hang and under-hang) and the alignment of total knee arthroplasty (TKA) components 1 week after surgery. We selec...

Authors: Changquan Liu, Guanglei Zhao, Kangming Chen, Jinyang Lyu, Jie Chen, Jingsheng Shi, Gangyong Huang, Feiyan Chen, Yibing Wei, Siqun Wang and Jun Xia

Comprehensive analysis of lncRNA and mRNA based on expression microarray profiling reveals different characteristics of osteoarthritis between Tibetan and Han patients

Osteoarthritis (OA) is thought to be the most prevalent chronic joint disease, especially in Tibet of China. Here, we aimed to explore the integrative lncRNA and mRNA landscape between the OA patients of Tibet...

Authors: Junming Luo, Xiaoqin Luo, Zhili Duan, Wenbin Bai, Xiaoming Che, Zhongshu Shan, Xiaona Li and Jinwu Peng

Co-treatment with disulfiram and glycyrrhizic acid suppresses the inflammatory response of chondrocytes

Osteoarthritis (OA) is a kind of systemic musculoskeletal disorder and a most important factor for causing disability and physical painfulness. Nevertheless, due to the fact that OA can be triggered by multipl...

Authors: Chao Li, Li Li and Tian Lan

Three-dimensional evaluations of preoperative planning reproducibility for the osteosynthesis of distal radius fractures

Three-dimensional preoperative planning was applied for the osteosynthesis of distal radius fractures. The objective of this study was to evaluate the reproducibility of three-dimensional preoperative planning...

Authors: Yuichi Yoshii, Takeshi Ogawa, Atsuo Shigi, Kunihiro Oka, Tsuyoshi Murase and Tomoo Ishii

Integrated traditional Chinese medicine alleviates sciatica while regulating gene expression in peripheral blood

Although integrated traditional Chinese medicine (TCM) has long been indicated to be effective in the treatment of sciatica and is widely used in the management of this condition, the mechanism by which integr...

Authors: Yi Wang, Guogang Dai, Yan Xu, Ling Jiang, Zhibin Fu, Jiao Xia, Guogang Tian and Wanli Du

Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway

Secreted frizzled-related protein 5 (SFRP5) is an endogenous inhibitor of Wnt5a (wingless-type family member 5a), which has been implicated in anti-inflammatory response. In this study, we aimed to investigate...

Authors: Minghui Sun, Weijun Wang, Lingtian Min, Cheng Chen, Qing Li and Wenjie Weng

The burden of cycling-related trauma to the orthopaedic and trauma department of a level 1 trauma hospital in Adelaide, South Australia

With the fourth largest metropolitan population density, motor vehicle drivers in Adelaide, South Australia, record the most number of motor vehicle insurance claims in Australia. Previous studies have shown a...

Authors: John M. Abrahams, Christopher Sagar and Mark Rickman

Effect of femoral posterior condyle offset on knee joint function after total knee replacement: a network meta-analysis and a sequential retrospective cohort study

This study was conducted with the aim to compare the effect of posterior condyle offset (PCO) changes on knee joint function of patients following total knee replacement (TKR).

Authors: Yimin Zhang, Jun Wang, Miao Zhang and Yun Xu

Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion

Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected ...

Authors: Keisuke Oe, Feibi Zeng, Tomoaki Fukui, Munenobu Nogami, Takamichi Murakami, Tomoyuki Matsumoto, Ryosuke Kuroda and Takahiro Niikura