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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: Discoidin domain receptor 2 activation of p38 mitogen-activated protein kinase as an important pathway for osteonectin-regulating osteoblast mineralization

Fig. 2

DDR2-blocker decreased the gene expressions of OPN, BSP, OCN and P38. the mRNA expressions of OPN, BSP, OCN, DDR2 and P38 were quantified by RT-qPCR; *P < .05, **P < .01, ***P < .001 versus the CON group; NS P > .05, #P < .05, ##P < .01 versus the ON group; the experiments were conducted in triplicates; data were expressed by means ± standard deviation (SD). OPN, osteopontin; BSP, bone sialoprotein; OCN, osteocalcin; P38: p38 mitogen‐activated protein kinase; DDR2: discoidin domain receptor 2; RT-qPCR: reverse transcription-quantitative polymerase chain reaction; CON group: control group, the osteoblasts were added with mineralized solution; ON group: osteonectin group, the osteoblasts were added with mineralized solution + 1 µg/mL osteonectin; inhibitor group: the osteoblasts were added with mineralized solution + 1 µg/mL osteonectin + 230 nM WRG-28

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X