Clinicopathologic significance and prognostic value of circRNAs in osteosarcoma: a systematic review and meta-analysis

Table 2 Pooled odds ratios of circRNAs on clinicopathologic features in osteosarcoma

Clinicopathologic feature	Number of studies	Number of patients	Effect size			Heterogeneity		Sensitivity analysis	Publication bias
Clinicopathologic feature	Number of studies	Number of patients	OR	95%CI	p value	I-square (%)	chi-square (p)	Sensitivity analysis	Begg (p)	Egger (p)
Age	37	2239	0.992	0.833–1.181	0.926	0.0%	0.935	Reliable	0.844	0.905
Gender	38	2284	1.086	0.906–1.287	0.342	0.0%	0.898	Reliable	0.297	0.711
Tumor site	19	1229	0.867	0.668–1.125	0.284	0.0%	0.960	Reliable	0.100	0.003
Tumor size	29	1749	2.122	1.418–3.175	< 0.001	70.3%	< 0.001	Not Reliable	0.008	0.005
Clinical stage	35	2120	2.847	2.059–3.935	< 0.001	57.3%	< 0.001	Reliable	0.191	0.156
Metastasis	32	1975	2.630	1.583–4.371	< 0.001	82.2%	<0.001	Reliable	0.019	0.053
Histologic classification	3	161	0.713	0.266–1.908	0.500	0.0%	0.692	Reliable	0.117	0.083
Histologic pattern	4	288	1.000	0.560–1.786	1.000	0.0%	0.820	Reliable	0.042	0.228
Differentiation grade	14	737	1.425	0.841–2.415	0.188	63.8%	0.001	Reliable	0.208	0.181
Chemotherapy response	2	158	0.443	0.231–0.849	0.002	0.0%	0.554	NA	0.317	NA
Chemotherapy resistance	4	282	9.343	5.352–16.309	< 0.001	7.5%	0.365	Reliable	0.497	0.544
Alkaline phosphatase	3	278	1.034	0.648–1.648	0.889	62.9%	0.067	Reliable	0.602	0.743

ISSN: 1749-799X