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Does tourniquet use affect the periprosthetic bone cement penetration in total knee arthroplasty? A meta-analysis



A tourniquet is a device commonly used to control massive hemorrhage during knee replacement surgery. However, the question remains whether the use of tourniquets affects the permeability of the bone cement around the knee prosthesis. Moreover, the long-term effects and stability of the knee prosthesis are still debatable. The aim of this study was to examine whether the use of a tourniquet increases the thickness of the cement mantle and affects the postoperative blood loss and pain during primary total knee arthroplasty (TKA) using meta-analysis.


We searched the Cochrane Central Library, MEDLINE, Embase, PubMed, CNKI, and Wang Fang databases for randomized controlled trials (RCTs) on primary TKA, from inception to November 2019. All RCTs in primary TKA with and without a tourniquet were included. The meta-analysis was conducted using RevMan 5.2 software.


A total of eight RCTs (677 knees) were analyzed. We found no significant difference in the age and sex of the patients. The results showed that the application of tourniquet affects the thickness of the bone cement around the tibial prosthesis (WMD = 0.16, 95%CI = 0.11 to 0.21, p < 0.00001). However, in our study, there was no significant difference in postoperative blood loss between the two groups was observed (WMD = 12.07, 95%CI = − 78.63 to 102.77, p = 0.79). The use of an intraoperative tourniquet can increase the intensity of postoperative pain (WMD = 1.34, 95%, CI = 0.32 to 2.36, p = 0.01).


Tourniquet application increases the thickness of the bone cement around the prosthesis and may thus increase the stability and durability of the prosthesis after TKA. The application of an intraoperative tourniquet can increase the intensity of postoperative pain.


Total knee arthroplasty (TKA) is a common and effective treatment method for severe knee arthritis. Previous studies have shown that the patient satisfaction rate after TKA is up to 91% [1]. However, one of the most important problems encountered by patients is the high rate of revision TKA for the loosening of the tibial component [2]. There are many reasons for the aseptic loosening of the prosthesis, such as infection, wear and tear, unbalance of force line, and loosening of the bone-cement interface [3]. The thickness of the bone cement is critical for the success of primary TKA [4, 5]. Factors such as bone preparation, use of cement gun or artificial filling, and bone cement penetration during TKAs are related to the thickness of bone cement around the prosthesis [6, 7]. Increased thickness of the bone cement has been justified to improve prosthesis survival and stability [8,9,10,11]. Recent studies have found that a revision rate of 2–5% is due to the loosening of the prosthesis [12]. The cement covering 3–4 mm between the tibial implant and the tibial trabecular bone is considered to be the best option to avoid osteolysis and loosening of the surrounding bone [3]. The use of tourniquets during TKA is highly recommended by the surgeon. Some studies have found that the use of tourniquets causes an increase in cement penetration due to loss of the blood and fat in the cancellous bone during bonding [13, 14]. However, there are also studies that suggest that tourniquet use does not affect cement mantle penetration [15,16,17,18], further clouding the issue. It is unclear whether the use of tourniquets can increase the thickness of the bone cement around the tibial prosthesis and indirectly improve the stability and durability of the prosthesis. Therefore, we conducted a meta-analysis of randomized controlled trials (RCTs) to determine whether the use of tourniquets affected the thickness of the bone cement around the prosthesis.

Materials and methods


The meta-analysis was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and the Guidelines for Meta-Analysis (PRISMA) [19]. Biomedical databases such as PubMed, the Cochrane Library, Embase, MEDLINE, CNKI, and Wanfang were extensively searched for clinical studies with no language constraints evaluating the use of a tourniquet or not in TKA, from inception to November 2019. RevMan 5.2 software was used to carry out the meta-analysis. The following keywords were used to optimize search: tourniquet and bone cement and (total knee arthroplasty or arthroplasties, replacement, knee or arthroplasty, knee replacement or knee replacement arthroplasties or replacement arthroplasties or knee replacement arthroplasty or knee prosthesis). In addition, the reference lists of the reported papers were checked to look for extra studies that might meet the research requirements.

Criteria for inclusion and exclusion

For this meta-analysis, we established the following inclusion criteria: (1) patients who received primary TKA, (2) RCTs, (3) comparing the outcomes with or without a tourniquet in TKA, and (4) outcome measurements should include these parameters (thickness of the bone cement, VAS knee pain scores, calculated blood loss, and complications).

Exclusion criteria were (1) non-RCTs, (2) unpublished results, (3) meeting proceedings, and (4) TKA revision.

Data extraction

Data were collected by two researchers separately in the same layout and after verified by a third party, and all disagreements were resolved by a consensus. We approached the authors for missing data and supporting information wherever necessary. Data related to the publication, demographics, time of tourniquet, time of the procedure, bone cement thickness, blood loss rates, VAS knee pain ratings, and complications (minor and major) were all included.

A complication can be minor or major depending on the need for a second operation. We have identified major complications such as wound dehiscence, vessel injuries, active hemorrhage, infections and hematomas requiring drainage or debriding or revision, and extreme knee rigidity requiring anesthesia manipulation. We identified minor complications such as wound complications such as deep vein thrombosis (DVT), marginal necrosis, oozing, mild knee stiffness, erythema, superficial infection, and severe leg swelling that could be treated by conventional therapy and do not require any further surgery.

Quality assessment

Two investigators separately evaluated the likelihood of bias in the included studies using the following items: blinding of subjects, randomization, incomplete results, allocation concealment, blinding of the assessment of outcomes, selective reporting of results, and other biases [20]. The item was reported as “small,” “high,” or “uncertain” based on the information provided by the included studies. Small indicates low-bias risk, high indicates high-bias risk, and unclear indicates a lack of information or unspecified bias risk.

Statistical analysis

Meta-analysis was performed using RevMan 5.2 software (Cochrane Collaboration, Oxford, UK). The odds ratio (OR) with 95% confidence intervals (CIs) was determined for dichotomous outcomes, and the mean difference (MD) with 95%CIs was used for continuous outcomes. A p value less than 0.05 was considered statistically significant (p < 0.05). Heterogeneities in the studies were examined using the I2 statistic, and we defined the substantial heterogeneity as I2 value greater than 50%. If the meta-analysis showed a substantial heterogeneity, we used a model of random effect; otherwise, we used a model of fixed-effect.


After a thorough evaluation, in the overall meta-analysis, eight separate RCTs with a combined sample size of the 677 knees (Fig. 1).

Fig. 1
figure 1

The flow chart of literature screening

Risk of bias assessment

Most of the studies were relatively well designed. However, several studies did not provide a specific description of the randomization method, which could result in selection bias. Many studies have been short-term, making long-term assessment indexes scarce. Out of the eight selected studies, only in one study, the follow-up duration was 3 years. Another study was followed-up for 1 month after surgery. The rest only observed changes in patient indicators within 1 week after surgery. The methodology quality and the summary of the risk of bias are shown in Figs. 2 and 3, respectively.

Fig. 2
figure 2

Risk of bias methodological quality

Fig. 3
figure 3

Risk of bias summary

Outcome measure

Bone cement penetration

Eight studies reported on bone cement penetration [13,14,15,16,17,18, 21, 22]. Anterior-posterior (AP) and lateral (Lat) view X-rays to measure the cement mantle thickness under the tibial component. The results suggest that the application of tourniquets can increase the thickness of the bone cement around the tibial prosthesis (WMD = 0.16, 95% CI = (0.11 to 0.21), p < 0.00001, I2 = 0%) (Fig. 4).

Fig. 4
figure 4

Forest plot of cement penetration depth

Pain assessment

Four studies reported on the VAS knee pain scores [14, 18, 21, 22]. Pooled results showed that tourniquet use increased postoperative pain (WMD = 1.34, 95% CI = (0.32 to 2.36), p = 0.01, I2 = 98%) (Fig. 5).

Fig. 5
figure 5

Forest plot of VAS knee pain scores

Blood loss

Four studies provided data on the calculated blood loss [14, 18, 21, 22]. We found no major difference in calculated blood loss between the four groups (WMD = 12.07, 95%CI = (− 78.63 to 102.77); p = 0.79, I2 = 99%) (Fig. 6). The reason for this result may be because blood loss calculation methods in the different literature are not uniform and the application schemes and the inflation time of tourniquets are not consistent. The lack of data may be the contributing factor.

Fig. 6
figure 6

Forest plot of intraoperative blood loss


Complications were reported in three studies [15, 17, 22]. The number of patients with minor complications increased following tourniquet use. There was no reference to pulmonary embolism. In the tourniquet group, DVT occurred in 22 patients, and the surgical site was infected in 1 patient, but revision surgery was not required. One patient was diagnosed with high skin temperature of joints, and 31 patients were diagnosed with subcutaneous ecchymosis. One patient had a sluggish wound healing in the non-tourniquet group with no need for reconstruction operation, three patients were diagnosed with subcutaneous ecchymosis, and 6 patients were diagnosed with DVT.


To the best of our knowledge, this study is the first meta-analysis of RCTs to compare the use of a tourniquet with the thickness of the cement mantle in TKA. A significant conclusion of this study was that the use of tourniquets will increase bone cement thickness. Moreover, the application of tourniquets can significantly increase postoperative pain. TKA is a common and successful procedure, with over 1 million TKAs performed annually in OECD countries [23]. According to a survey, tourniquets are commonly used in TKA operations between 37% and 93% [9, 24, 25]. Li et al. observed that tourniquet use will decrease intraoperative bleeding and increase the field of view in a recent meta-analysis [26]. However, tourniquets have caused problems such as leg pain, inflammation of the arms, nerve palsy, subcutaneous thigh fat necrosis, vascular damage, postoperative weakness, slow recovery of quadriceps power, complications of the wound, and DVT [27,28,29,30,31,32].

The finding shows that the use of tourniquets can significantly increase the thickness of the cement mantle. The use of an intraoperative tourniquet is one of the essential elements influencing the formation of TKA bone cement [14]. On the one hand, due to the bloodless field, the use of tourniquets offers a better vision which would contribute to improving cementing quality [33]. On the other hand, the formation of a bloodless surface and dry surface may affect the penetrating loosening of bone cement, which is mainly confined to bone cement structure [14]. Touzopoulos et al. [13, 14] observed that the use of tourniquets may decrease blood flow and fat in cancellous bone during cementing. The use of tourniquets can make the intraoperative trabecular shaft clean and bloodless, achieving the same effect as the suction technique, which has been shown to improve the cement thickness under the tibial component [34, 35].

Our results demonstrate that tourniquet application significantly increased postoperative pain. Many studies have shown that tourniquet use can increase postoperative pain in TKA patients [36, 37]. Studies have found that the extended use of tourniquets may further intensify hypoxia in the soft tissue around the cut, resulting in severe inflammation and muscle damage, which may enhance postoperative pain [35]. Also, the congestive swelling of the soft tissue capsule can cause greater invisible blood loss and direct damage to the nerve structure and soft tissue [36, 38,39,40]. Conversely, lower inflatable pressure and shorter tourniquet use can reduce postoperative pain and thus reduce complications [41, 42]. However, in our study, the time of pain measurement was not uniform. Two studies mentioned that pain was measured at 24 h and 48 h after operation, one study was measured after 4 days of surgery, and another was measured after 6 weeks of surgery. One study did not mention the specific time of measurement. All pain measurement was done at rest and during mobilization and documented on a VAS.

There was no substantial difference between the two groups in postoperative blood loss. The main reason for this finding may be that the methods used to calculate blood loss vary from study to study. Okan et al. calculated the blood transfusion volume and drainage volume 24 h after operation. Tilman et al. used Bourke and Smith’s method to calculate the total blood loss, taking into account both the dominant and the recessive blood loss. Xie et al. included the liquid in the suction bottle minus the liquid used intraoperatively plus the net weight of the gauze pad weight. Yang et al. measured negative pressure drainage bottle drainage volume within 24 h and intraoperative blood loss. The original purpose of using a tourniquet in TKA surgery was to reduce the blood loss. In theory, the premature release of a tourniquet results in a significant increase in both explicit and implicit blood loss. However, many studies have found that the effect of a tourniquet to reduce the blood loss is still controversial, and few researchers consider that tourniquet use may increase the blood loss. This may be due to increased “hidden blood loss” after the tourniquet use resulting in post-ischemic activated fibrinolysis [43, 44], such as hyperperfusion after deflation. Activation of the fibrinolytic enzyme can cause an increase in postoperative blood loss. In few studies, it was observed that the fibrinolytic activity maintained for a short time (30 min), which was not enough sufficient for the main cause of immense postoperative bleeding. The tourniquet was used in most of the studies; however, in our study, the pressure on the cuff inflated varies from 250 to 360 mmHg, and the statistical methods for the blood loss were also inconsistent, which may also be the reason for the non-significant difference between the two groups of patients.

Regarding postoperative complications, this meta-analysis suggests that the use of tourniquets increases the risk of complications. In our contained research, subcutaneous ecchymosis was the most widespread minor complications. The reason for that is because tourniquet use during surgery increases microvascular permeability leading to blood stagnation and hypercoagulation, which is prone to DVT [45, 46]. Certain studies AS reported that an extra 10 min in the operating theater was associated with an increase in complications [35]. Under the same surgical conditions, the use of a tourniquet may reduce the operation time and reduce the risk of infection to a certain extent, which may help to reduce the occurrence of potential complications.

There are some limitations to this study. First, the small sample size of the included studies, only eight RCTs have been included, which may have contributed to inexact findings and the complication percentages were not established. Second, the use of the tourniquet in the included studies was inconsistent; the pressure on the cuff inflated varies from 250 to 360 mmHg, which may have influenced the final outcome. Third, although some findings have been documented in the included studies, some details have not been adequately provided such as inflammation of the limbs, hemoglobin or hematocrit levels, deep vein thrombosis, tourniquet time, and joint function. In addition, only the cement mantle thickness of the tibial portion was examined. More assessment of the femoral mantle thickness and the use of three-dimensional computed tomography scans can provide a more accurate picture. Finally, in most RCTs, the follow-up time was comparatively short, which could neglect long-term effects such as the durability of prosthetic attachment and regeneration of joint function. A shorter and variable follow-up duration in most of the selected studies could be another limitation. Further prospective studies are needed in the future to confirm that tourniquet affects the stability and durability of the pretibial prosthesis of the TKA.


In conclusion, the application of tourniquet in primary TKA increases the stiffness of the implant-cement-bone composite of the tibia and may have an impact on the long-term survival of the implant; however, its use also increases postoperative pain and its complications. Our study results will assist orthopedic surgeons when selecting the best surgical technique for their patients. In the future, further prospective studies are needed to evaluate the effect of tourniquet on the thickness of bone cement around the prosthesis. To validate this study, a large and well-designed RCT with comprehensive follow-up is required.

Availability of data and materials

The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.



Total knee arthroplasty


Randomized controlled trials


Deep vein thrombosis


  1. Lange JK, Lee YY, Spiro SK, Haas SB. Satisfaction rates and quality of life changes following total knee arthroplasty in age-differentiated cohorts. J Arthroplast. 2018;33:1373–8.

    Article  Google Scholar 

  2. Sharkey PF, Hozack WJ, Rothman RH, Shastri S, Jacoby SM. Insall Award paper. Why are total knee arthroplasties failing today? Clin Orthop Relat Res. 2002;7-13.

  3. Bauze AJ, Costi JJ, Stavrou P, Rankin WA, Hearn TC, Krishnan J, et al. Cement penetration and stiffness of the cement-bone composite in the proximal tibia in a porcine model. J Orthop Surg (Hong Kong). 2004;12:194–8.

    Article  CAS  Google Scholar 

  4. Argenson JN, Parratte S, Ashour A, Saintmard B, Aubaniac JM. The outcome of rotating-platform total knee arthroplasty with cement at a minimum of ten years of follow-up. J Bone Joint Surg Am. 2012;94:638–44.

    Article  Google Scholar 

  5. Feng B, Weng X, Lin J, Jin J, Wang W, Qiu G. Long-term follow-up of cemented fixed-bearing total knee arthroplasty in a Chinese population: a survival analysis of more than 10 years. J Arthroplast. 2013;28:1701–6.

    Article  Google Scholar 

  6. Bert JM, McShane M. Is it necessary to cement the tibial stem in cemented total knee arthroplasty? Clin Orthop Relat Res. 1998:73–8.

  7. Peters CL, Craig MA, Mohr RA, Bachus KN. Tibial component fixation with cement: full- versus surface-cementation techniques. Clin Orthop Relat Res. 2003:158–68.

  8. Walker PS, Soudry M, Ewald FC, McVickar H. Control of cement penetration in total knee arthroplasty. Clin Orthop Relat Res. 1984:155–64.

  9. Arsoy D, Pagnano MW, Lewallen DG, Hanssen AD, Sierra RJ. Aseptic tibial debonding as a cause of early failure in a modern total knee arthroplasty design. Clin Orthop Relat Res. 2013;471:94–101.

    Article  Google Scholar 

  10. Wang K, Ni S, Li Z, Zhong Q, Li R, Li H, et al. The effects of tourniquet use in total knee arthroplasty: a randomized, controlled trial. Knee Surg Sports Traumatol Arthrosc. 2017;25:2849–57.

    Article  Google Scholar 

  11. Vanlommel J, Luyckx JP, Labey L, Innocenti B, De Corte R, Bellemans J. Cementing the tibial component in total knee arthroplasty: which technique is the best? J Arthroplast. 2011;26:492–6.

    Article  Google Scholar 

  12. Kopec M, Milbrandt JC, Duellman T, Mangan D, Allan DG. Effect of hand packing versus cement gun pressurization on cement mantle in total knee arthroplasty. Can J Surg. 2009;52:490–4.

    PubMed  PubMed Central  Google Scholar 

  13. Touzopoulos P, Ververidis A, Mpogiatzis C, Chatzigiannakis A, Drosos GI. The use of tourniquet may influence the cement mantle thickness under the tibial implant during total knee arthroplasty. Eur J Orthop Surg Traumatol. 2019;29:869–75.

    Article  Google Scholar 

  14. Pfitzner T, von Roth P, Voerkelius N, Mayr H, Perka C, Hube R. Influence of the tourniquet on tibial cement mantle thickness in primary total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2016;24:96–101.

    Article  Google Scholar 

  15. Jawhar A, Stetzelberger V, Kollowa K, Obertacke U. Tourniquet application does not affect the periprosthetic bone cement penetration in total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2019;27:2071–81.

    Article  Google Scholar 

  16. Herndon CL, Grosso MJ, Sarpong NO, Shah RP, Geller JA, Cooper HJ. Tibial cement mantle thickness is not affected by tourniquetless total knee arthroplasty when performed with tranexamic acid. Knee Surg Sports Traumatol Arthrosc. 2019;.

  17. Vertullo CJ, Nagarajan M. Is cement penetration in TKR reduced by not using a tourniquet during cementation? A single blinded, randomized trial. J Orthop Surg (Hong Kong). 2017;25:2309499016684323.

    Article  Google Scholar 

  18. Ozkunt O, Sariyilmaz K, Gemalmaz HC, Dikici F. The effect of tourniquet usage on cement penetration in total knee arthroplasty: a prospective randomized study of 3 methods. Medicine (Baltimore). 2018;97:e9668.

    Article  Google Scholar 

  19. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62:1006–12.

    Article  Google Scholar 

  20. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version5.1.0.In:The cochrane collaboration; http:// Accessed 15 Nov 2016. 2011;.

  21. Xie XW, Yue C, Huang ZY, Kang PD, Zhou ZK, Yang J. Total knee arthroplasty with or without tourniquet: a randomized controlled trial. Orthopedic Journal of China. 2017;25:1572–6.

    Google Scholar 

  22. Yang JQWL, Zhang JQ, Huang XQ. The effect of the tourniquet on cement mantle thickness in total knee arthroplasty. Chongqing Medicine. 2017;46:782–5.

    Google Scholar 

  23. Pabinger C, Lothaller H, Geissler A. Utilization rates of knee-arthroplasty in OECD countries. Osteoarthr Cartil. 2015;23:1664–73.

    Article  CAS  Google Scholar 

  24. National Joint Registry for England and Wales 1st Annual Report. Hemel Hempstead. England: National Joint Registry for England and Wales. 2004;.

  25. Berry DJ, Bozic KJ. Current practice patterns in primary hip and knee arthroplasty among members of the American Association of hip and Knee Surgeons. J Arthroplast. 2010;25:2–4.

    Article  Google Scholar 

  26. Li X, Yin L, Chen ZY, Zhu L, Wang HL, Chen W, et al. The effect of tourniquet use in total knee arthroplasty: grading the evidence through an updated meta-analysis of randomized, controlled trials. Eur J Orthop Surg Traumatol. 2014;24:973–86.

    Article  Google Scholar 

  27. Ochoa J, Fowler TJ, Gilliatt RW. Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet. J Anat. 1972;113:433–55.

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Kumar SN, Chapman JA, Rawlins I. Vascular injuries in total knee arthroplasty. A review of the problem with special reference to the possible effects of the tourniquet. J Arthroplast. 1998;13:211–6.

    Article  CAS  Google Scholar 

  29. Tamvakopoulos GS, Toms AP, Glasgow M. Subcutaneous thigh fat necrosis as a result of tourniquet control during total knee arthroplasty. Ann R Coll Surg Engl. 2005;87:W11–3.

    Article  Google Scholar 

  30. Saunders KC, Louis DL, Weingarden SI, Waylonis GW. Effect of tourniquet time on postoperative quadriceps function. Clin Orthop Relat Res. 1979:194–9.

  31. Kageyama K, Nakajima Y, Shibasaki M, Hashimoto S, Mizobe T. Increased platelet, leukocyte, and endothelial cell activity are associated with increased coagulability in patients after total knee arthroplasty. J Thromb Haemost. 2007;5:738–45.

    Article  CAS  Google Scholar 

  32. Horlocker TT, Hebl JR, Gali B, Jankowski CJ, Burkle CM, Berry DJ, et al. Anesthetic, patient, and surgical risk factors for neurologic complications after prolonged total tourniquet time during total knee arthroplasty. Anesth Analg. 2006;102:950–5.

    Article  Google Scholar 

  33. Tai TW, Lin CJ, Jou IM, Chang CW, Lai KA, Yang CY. Tourniquet use in total knee arthroplasty: a meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2011;19:1121–30.

    Article  Google Scholar 

  34. Breusch S, Heisel C, Muller J, Borchers T, Mau H. Influence of cement viscosity on cement interdigitation and venous fat content under in vivo conditions: a bilateral study of 13 sheep. Acta Orthop Scand. 2002;73:409–15.

    Article  Google Scholar 

  35. Olivecrona C, Lapidus LJ, Benson L, Blomfeldt R. Tourniquet time affects postoperative complications after knee arthroplasty. Int Orthop. 2013;37:827–32.

    Article  Google Scholar 

  36. Abdel-Salam A, Eyres KS. Effects of tourniquet during total knee arthroplasty. A prospective randomised study. J Bone Joint Surg Br. 1995;77:250–3.

    Article  CAS  Google Scholar 

  37. Ledin H, Aspenberg P, Good L. Tourniquet use in total knee replacement does not improve fixation, but appears to reduce final range of motion. Acta Orthop. 2012;83:499–503.

    Article  Google Scholar 

  38. Li B, Wen Y, Wu H, Qian Q, Lin X, Zhao H. The effect of tourniquet use on hidden blood loss in total knee arthroplasty. Int Orthop. 2009;33:1263–8.

    Article  Google Scholar 

  39. Vandenbussche E, Duranthon LD, Couturier M, Pidhorz L, Augereau B. The effect of tourniquet use in total knee arthroplasty. Int Orthop. 2002;26:306–9.

    Article  Google Scholar 

  40. Zhang Y, Li L, Wang J, Li ZH, Shi ZJ. Do patients benefit from tourniquet in arthroscopic surgeries of the knee? Knee Surg Sports Traumatol Arthrosc. 2013;21:1125–30.

    Article  Google Scholar 

  41. Manen Berga F, Novellas Canosa M, Angles Crespo F, Bernal DJ. Effect of ischemic tourniquet pressure on the intensity of postoperative pain. Rev Esp Anestesiol Reanim. 2002;49:131–5.

    CAS  PubMed  Google Scholar 

  42. Worland RL, Arredondo J, Angles F, Lopez-Jimenez F, Jessup DE. Thigh pain following tourniquet application in simultaneous bilateral total knee replacement arthroplasty. J Arthroplast. 1997;12:848–52.

    Article  CAS  Google Scholar 

  43. Aglietti P, Baldini A, Vena LM, Abbate R, Fedi S, Falciani M. Effect of tourniquet use on activation of coagulation in total knee replacement. Clin Orthop Relat Res. 2000:169–77.

  44. Klenerman L, Chakrabarti R, Mackie I, Brozovic M, Stirling Y. Changes in haemostatic system after application of a tourniquet. Lancet. 1977;1:970–2.

    Article  CAS  Google Scholar 

  45. Chang CW, Lan SM, Tai TW, Lai KA, Yang CY. An effective method to reduce ischemia time during total knee arthroplasty. J Formos Med Assoc. 2012;111:19–23.

    Article  Google Scholar 

  46. Risberg B. The response of the fibrinolytic system in trauma. Acta Chir Scand Suppl. 1985;522:245–71.

    CAS  PubMed  Google Scholar 

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This work was supported by the Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine (20183001) and Research Project of Guangdong Bureau of Traditional Chinese Medicine (20191021). The funding bodies had no role in the design of the study, the collection, analysis, or interpretation of the data, or writing the manuscript.

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Analysis: Anan Li, Yuning Cai, and Huai Wu; Software: Min Song; Supervision: Wengang Liu and Xuemeng Xu; Writing—original draft: Chao Lu, Min Song, and Jin Chen; Writing—review and editing: Chao Lu, Wengang Liu, and Xuemeng. The authors read and approved the final manuscript.

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Lu, C., Song, M., Chen, J. et al. Does tourniquet use affect the periprosthetic bone cement penetration in total knee arthroplasty? A meta-analysis. J Orthop Surg Res 15, 602 (2020).

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