- Research article
- Open Access
Impact of graft and tunnel orientation on patient-reported outcome in anterior cruciate ligament reconstruction using bone-patellar tendon-bone autografts
© The Author(s). 2018
- Received: 13 October 2017
- Accepted: 24 September 2018
- Published: 3 October 2018
The optimal positioning of anterior cruciate ligament graft is still controversially discussed. We therefore wanted to determine the tunnel-to-joint (TJA), tunnel-to-shaft (TSA), and graft-tunnel divergence angles which would provide the best outcome, determined by the KOOS (Knee Injury and Osteoarthritis Outcome Score). This study evaluated the clinical influence of graft orientation as measured with the KOOS questionnaire in patients with anterior cruciate ligament reconstruction with bone-patellar tendon-bone autografts.
We designed a prospective cohort study, with a 1 ¼ year recruitment phase from March 2011 to July 2012 and a minimal follow-up period of 1 year. Inclusion criteria were patients ≥ 18 years of age receiving an ACL reconstruction with bone-patellar tendon-bone autografts at our institution after having suffered an acute ACL rupture. The primary outcome was the KOOS. Independent variables were patient age, gender, laterality of rupture, mechanism of trauma, and type of femoral and tibial fixation, as well as sagittal graft-tunnel divergence, TJA, and TSA, the latter two being assessed on coronal slices of magnetic resonance imaging. Equations modeling the relationship between TJA, TSA, and graft-tunnel divergence with the KOOS overall score were fitted, and the optimum angles were mathematically determined.
In total, 31 patients were included in our study. Our cohort with a median age of 28 years was predominantly male. The mathematically determined optimal placement of the implant in the coronal plane was a TJA of 74.8°, a TSA of 80.1°, and a graft-tunnel divergence angle of 8.5°.
With regard to patient-reported outcome, the optimal graft orientation is provided by a coronal tunnel-to-shaft angle of 80° and tunnel-to-joint angle of 75°, respectively. Interestingly, in our series, patients reported best clinical outcomes with a sagittal graft-tunnel divergence. These results should be validated in larger studies.
- Anterior cruciate ligament
- ACL reconstruction
- Bone-patellar tendon-bone
- Graft orientation
Anterior cruciate ligament (ACL) rupture is a frequent sports injury that often leads to post-traumatic knee instability and secondary knee damage with meniscal tears and articular cartilage injuries . The primary goal of ACL reconstruction is to restore knee biomechanics, ensure full functionality permitting the complete resumption of physical activities, and maximize health-related quality of life . Thus, ACL reconstruction has evolved to be a common procedure in orthopedic surgery. Currently, when aiming for an autologous reconstruction, either bone-patellar tendon-bone (BPTB) or hamstring autografts are deployed. The biomechanical properties of both BPTB and hamstring autograft have been investigated to comply well with the native ACL in terms of ultimate failure strength and mean stiffness . Despite increasing knowledge on knee biomechanics and the ACL architecture as well as widespread practice, many aspects regarding the operative technique of ACL reconstruction remain controversial. This also includes the femoral insertion point and the resulting graft orientation. Based on biomechanical studies, a more oblique graft orientation is considered to better restore rotational stability and prevent the pivot-shift phenomenon when compared to vertical graft placements in the femoral notch [4, 5].
The self-administered easy to use Knee Injury and Osteoarthritis Outcome Score (KOOS) developed in 1998 assesses all of the aforementioned outcomes and can be used for assessment of ACL reconstruction outcome . The KOOS has been shown to be a valid, reliable, and responsive outcome measure in numerous studies [7–10].
The objective of this study therefore was to determine the optimal surgical implantation technique with regard to surgical outcome 1 year after surgery, determined by the implant or tunnel angles associated with the minimum KOOS overall score.
We designed a prospective cohort study, with a 1 ¼ year recruitment phase from March 2011 to July 2012 and a minimal follow-up period of 1 year. Inclusion criteria were patients ≥ 18 years of age receiving an ACL reconstruction with bone-patellar tendon-bone autografts at our institution after having suffered an acute ACL rupture. The primary outcome was the KOOS after a minimum follow-up period of 1 year, after which patients were requested to complete the KOOS questionnaire. MR imaging was obtained on the day of filling in the KOOS questionnaire. Exclusion criteria were prior ACL reconstruction (n = 5), additional rheumatic/musculoskeletal disorders (n = 3), and inadequate image quality in any sequence (sagittal T2-weighted fat saturated, coronal and sagittal proton density, and axial fat saturated proton density sequences) of magnetic resonance imaging (MRI) (n = 6). MR imaging was performed using a 1.5 Tesla MR unit (Signa Echospeed EXCITE HDxt; GE Healthcare, Waukesha, Wisconsin, USA). Patients who did not complete the 1-year follow-up period (n = 12) or withdrew their consent to participate in the study (n = 3) were also excluded from the study, as were patients who did not complete the KOOS (n = 2). One patient, who has sustained a re-rupture within the follow-up period, was excluded due to missing assessability of the graft orientation. In total, 63 patients receiving ACL reconstruction at our center during the aforementioned timeframe were screened, of which 31 were included in the final analysis. Both clinicians and patients were blinded as to the results of the MRI assessments to avoid bias.
Data was collected in spreadsheets (Microsoft Excel 2010, Microsoft Corporation, Redmond, USA, version 14.0.7140.5002). All statistical analyses were performed using IBM SPSS Statistics version 22 (IBM Corporation, Armonk, USA, Release 188.8.131.52). Distribution of independent variables was assessed with descriptive statistics. The relationship between TSA, TJA, graft-tunnel divergence angle, and the primary outcome, the KOOS, was graphically assessed. Presuming there is an optimum for which the KOOS would be the lowest (in absolute numbers, not in a normalized scale), we fitted quadratic functions of the type y = k + ß1 × x + ß2 × x2 to model the relationship between the KOOS and TSA or TJA respectively. We fitted linear and quadratic functions to model the relationship between the KOOS and graft-tunnel divergence angle. The optimal TJA, TSA, and graft-tunnel divergence angles in the coronal plane were determined mathematically by resolving the curve’s equation for the minimum KOOS, i.e., where the derivative of the independent variable was 0.
Patient characteristics (n = 31)
19 months (± 3.7)
Graft-tunnel divergence (°)
Summary of the model equations, the KOOS overall score being the dependent variable (n = 31)
With the optimum outcome being the minimum KOOS, the optimal implant angles can be mathematically determined by resolving the equation for y’ = f’(x) = 0. In the coronal plane, the optimal angles hence were a TJA of 74.8° and a TSA of 80.1°. In the sagittal plane, the curve morphology did not admit the abovementioned calculations of optimum values due to its convexity. The optimal graft-tunnel divergence angle was calculated to be 8.5°.
Assessing the relationship between post-surgical outcome determined by the KOOS and surgical ACL implantation technique determined by the TSA, TJA, and graft-tunnel divergence angles in a prospective cohort study with 31 patients, we mathematically determined the optimum angles to be 80.1°, 74.8°, and 8.5°, respectively.
Although calculated in a small study population, the sagittal graft-tunnel divergence angle was conspicuous. Derived from the surgical technique of implantation with drilling a bone tunnel over a leading wire, we expected the optimal graft-tunnel divergence angle to lean towards zero. Especially when considering the supine position of the patient during the image acquisition, a posterior graft-tunnel divergence seems surprising. Graft-tunnel divergence at the tibial site could possibly be associated to tibial tunnel widening through a wiper effect. Eventually, this observation and its biomechanical or clinical relevance need to be verified and further investigated in larger studies.
This study certainly has limitations. The small sample size substantially limited the statistical possibilities and the validity of the results. However, as this is a primarily radiological investigation, we did not want to compromise the imaging quality and excluded patients with poor post-surgical imaging. Therefore, we accepted a high dropout rate. The recruitment process is illustrated below. Despite the small sample size and weak statistics, our results did not show significant differences when compared to other series .
The study design also contains the weakness of acquiring the imaging at different points in the course of treatment. The postoperative MRI was obtained between 11 and 23 months (median 20 months) postoperatively. Even though it is doubtful, that the graft orientation changes during this time, imaging earlier in the postoperative course might have allowed inclusion of patients that have sustained a graft re-rupture (n = 1). This might have yielded valuable information on the desirable graft orientation.
Even though the exact time required for ligament remodeling is not known and most likely highly individual, we considered a least follow-up period of 1 year to be sufficient. Radiologically, an incorporation of the remnant stump is seen after 8 months . As stated above, the confounding effect of implant remodeling on the graft orientation is questionable. In our collective, only 12% of patients did not return to sports at this time (2 soccer players, 1 skier, 1 motorcyclist).
For our analyses, we did measure the intraarticular graft orientation as proposed by Scanlan et al. . This method uses the coronal and sagittal joint line in three-dimensional (3D) MR models as respective reference. However, 3D models were not available and the overall sagittal joint line is difficult to assess at a single slice. We did address this problem by measuring the graft orientation with reference to the tibial shaft, which is easier to realize and can also be applied in sectional images. For this reason, the sagittal graft-tunnel divergence is calculated with reference to the tibial shaft.
We clinically and radiologically analyzed 31 patients with a minimum follow-up of 1 year after ACL reconstruction using a bone-patellar tendon-bone autograft. With regard to patient-reported outcome, the optimal graft orientation is provided by a coronal tunnel-to-shaft angle of 80° and tunnel-to-joint angle of 75°, respectively. Interestingly, in our series, patients reported best clinical outcomes with a sagittal graft-tunnel divergence of 8.5°. These results should be validated in larger studies.
Availability of data and materials
All data analyzed during this study are included in this published article and its supplements.
CJL and TM drafted the manuscript. EJU and MM carried out the radiological measurements. TM accomplished the statistical analyses. GA and BDC made substantial contributions in the conception of the study and supervised the conduction of it. CJL, EJU, MAF, and GA revised the manuscript. All authors proof-read and approved the final manuscript.
Ethics approval and consent to participate
Patient consent was obtained from all patients prior to study inclusion. The study was approved by the Cantonal Ethics Committee Zurich (ref. 2010-0437).
Consent for publication
The authors declare that they have no competing interests.
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- Zantop T, Petersen W, Sekiya JK, Musahl V, Fu FH. Anterior cruciate ligament anatomy and function relating to anatomical reconstruction. Knee Surg Sports Traumatol Arthrosc. 2006;14:982–92.View ArticleGoogle Scholar
- Goebel JC, Bolbos R, Pham M, Galois L, Rengle A, Loeuille D, Netter P, Gillet P, Beuf O, Watrin-pinzano A. In vivo high-resolution MRI (7T) of femoro-tibial cartilage changes in the rat anterior cruciate ligament transection model of osteoarthritis: a cross-sectional study. Rheumatology (Oxford). 2010;49:1654–64.View ArticleGoogle Scholar
- Wilson TW, Zafuta MP, Zobitz M. A biomechanical analysis of matched bone-patellar tendon-bone and double-looped semitendinosus and gracilis tendon grafts. Am J Sports Med. 1999;27:202–7.View ArticleGoogle Scholar
- Jepsen CF, Lundberg-Jensen AK, Faunoe P. Does the position of the femoral tunnel affect the laxity or clinical outcome of the anterior cruciate ligament-reconstructed knee? A clinical, prospective, randomized, double-blind study. Arthroscopy. 2007;23:1326–33.View ArticleGoogle Scholar
- Lee MC, Seong SC, Lee S, Chang CB, Park YK, Jo H, Kim CH. Vertical femoral tunnel placement results in rotational knee laxity after anterior cruciate ligament reconstruction. Arthroscopy. 2007;23:771–8.View ArticleGoogle Scholar
- Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD. Knee Injury and Osteoarthritis Outcome Score (KOOS)—development of a self-administered outcome measure. J Orthop Sports Phys Ther. 1998;28:88–96.View ArticleGoogle Scholar
- Roos EM, Toksvig-Larsen S. Knee injury and Osteoarthritis Outcome Score (KOOS) - validation and comparison to the WOMAC in total knee replacement. Health Qual Life Outcomes. 2003;1:17.View ArticleGoogle Scholar
- Salavati M, Akhbari B, Mohammadi F, Mazaheri M, Khorrami M. Knee injury and Osteoarthritis Outcome Score (KOOS); reliability and validity in competitive athletes after anterior cruciate ligament reconstruction. Osteoarthr Cartil. 2011;19:406–10.View ArticleGoogle Scholar
- White DK, Master H. Patient-reported measures of physical function in knee osteoarthritis. Rheum Dis Clin N Am. 2016;42:239–52.View ArticleGoogle Scholar
- Collins NJ, Prinsen CAC, Christensen R, Bartels EM, Terwee CB, Roos EM. Knee Injury and Osteoarthritis Outcome Score (KOOS): systematic review and meta-analysis of measurement properties. Osteoarthr Cartil. 2016;24:1317–29.View ArticleGoogle Scholar
- Scanlan SF, Blazek K, Chaudhari AMW, Safran MR, Andriacchi TP. Graft orientation influences the knee flexion moment during walking in patients with anterior cruciate ligament reconstruction. Am J Sports Med. 2009;37:2173–8.View ArticleGoogle Scholar
- Whitehead TS. Failure of anterior cruciate ligament reconstruction. Clin Sports Med. 2013;32:177–204.View ArticleGoogle Scholar