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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: Two-stage therapeutic utility of ectopically formed bone tissue in skeletal muscle induced by adeno-associated virus containing bone morphogenetic protein-4 gene

Fig. 1

Two-stage therapeutic utility of ectopically formed bone tissue induced by AAV-BMP4 in skeletal muscle. a Experimental design of two-stage therapeutic utility of ectopically formed bone tissue induced by AAV-BMP4 in skeletal muscle. bd H&E staining of sample sections showing that the process of endochondral bone formation was triggered by the AAV-BMP4 with Gelfoam implantation in the muscle pocket. Cartilage (c) and bone (d) tissues were observed at weeks 2 and 4 after the implantation, respectively. eg μCT assessments showed ectopic bone tissues appeared at weeks 2 (e), 12 (f), and 24 (g) after implantation. The density of ectopic bone tissues increased with time

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