Treatment of refractory hip pain with sodium hyaluronate (Hyalgan©) in a patient with the Marshall-Smith Syndrome: A case report
© Salter et al; licensee BioMed Central Ltd. 2010
Received: 10 April 2010
Accepted: 23 August 2010
Published: 23 August 2010
The Marshall Smith Syndrome (MSS) is a rare congenital disorder, displaying a constellation of unique symptoms, including orofacial dysmorphisms, accelerated osseous maturation and dysplasias, mental retardation, and respiratory maladies. Few individuals with MSS survive past early childhood. In this case report, we describe a unique treatment for a 30 year-old patient with MSS who presented to our pain medicine clinic for management of pain secondary to uncontrolled bilateral hip dysplasias.
The Marshall-Smith Syndrome was first described in 1971 by Marshall et al as a rare congenital disorder, and to date there are fewer than 40 reported cases [1–3]. The etiology is unknown but is presumed to be due to a de novo dominant mutation. It is characterized by a constellation of features involving the neurologic and respiratory systems, and accelerated skeletal maturation leading to skeletal dysplasias. Patients have retarded intellectual development, small chins, glossoptosis, prominent eyes, protruding foreheads and are small in stature. They generally do not survive past early childhood mainly due to respiratory complications, such as aspiration pneumonia. However, if the respiratory conditions are managed aggressively, patients have been known to survive longer. To our knowledge, our patient is one of the oldest living patients with this rare disorder . Given the natural history of the syndrome, one would anticipate that older subjects would suffer a great deal of pain as a result of the accelerated skeletal maturation. We report a unique treatment of incapacitating bilateral hip pain in a 30 year-old MSS patient with intra-articular hyaluronate (Hyalgan©).
L.W. is a 30 year-old woman with MSS. Her medical history was obtained from her parents, who accompanied her and upon whom she was totally dependent for care. The patient had speech and cognitive impairment that limited the ability to obtain a direct history. The parents described a history of worsening hip pain from progressive, bilateral hip dysplasias. Whereas previously their daughter could ambulate with assistance, she was now incapacitated by relentless pain. As best as they were able to determine, the pain radiated from her hips laterally, down her thighs and provoked regular paroxysms of screaming, crying and guarding.
Prior to our encounter, this pain had been managed by an orthopedic surgeon at an outside facility, who performed a series of nine ultrasound-guided intra-articular hip steroid injections, over a period of several years. The last one was performed a few months before presenting. None of the patient's previous records were available to us, but the parents relayed that their daughter's response to the injections had begun to wane with each repeat injection. The most recent recommendation from the orthopedist was to perform bilateral hip arthroplasties. The parents were hesitant to pursue this option, in light of their daughter's previous surgical experience, wherein she required an emergency tracheostomy after failed attempts at securing her airway under anesthesia. Because they were told that future surgeries would require an "awake" tracheostomy for airway protection during surgery, they decided to seek alternative, non-surgical treatments for their daughter's hip pain.
The rest of the review of systems was unremarkable. Notably, the parents denied any history of bleeding diathesis. Though previous diagnostic imaging was not available at the time of our initial consultation, they were reviewed at a later date, prior to treatment, and revealed dysplasia of both acetabula, and severe osteoarthritis and subluxation of both hip joints.
On physical examination, the patient was small in stature (4ft 2in, 65lbs) and had obvious craniofacial abnormalities. The neuromuscular exam was limited due to lack of patient cooperation. The greater trochanters were asymmetrical, with the right side about 2 cm superior compared to the left. Both were easily palpable and visibly appeared to be grossly out of socket. Though muscle tone was good with no flaccidity, the patient's inability to obey commands prevented us from assessing motor or sensory function. Reflex testing revealed patellar and Achilles hyporeflexia.
Based on the patient's history, physical examination, and radiographic findings, our impression was that the patient's symptoms arose directly from the articular surfaces of her hips, and possibly from the bilateral impingement of her lateral femoral cutaneous nerves, as a result of her inadequately developed acetabula and subluxed femurs. We suggested a series of three fluoroscopically guided intra-articular hip injections with sodium hyaluronate (Hyalgan©), administered weekly. In the event of an unsatisfactory result from the injections, we intended to perform bilateral lateral femoral cutaneous nerve blocks. The patient's parents elected to pursue injection of sodium hyaluronate, and scheduled an appointment for the procedure.
Most infants affected with MSS succumb to death early in life. This is usually due to pulmonary complications, such as aspiration and chronic lung obstruction leading to pulmonary infections, pulmonary hypertension, and right heart failure [2, 4, 5, 10–13].
The concept of applying viscosupplementation (VS), using modified hyaluronic acid to form hyaluronans (HA) and their cross-linked derivatives, to the treatment of osteoarthritis arose in the mid 1970's, though these compounds had also been investigated for use in various ophthalmologic procedures [14–17]. As joints affected by osteoarthritis are depleted of their natural synovial fluid, which contains the glycosaminoglycan hyaluronic acid, it was postulated that injecting exogenous HA would increase the viscosity and elasticity to the joint, thereby improving joint function and relieving symptoms [18, 19]. While research on, and FDA-approval of, VS is primarily for use in the treatment of knee osteoarthritis, it has also been used successfully in small trials for the treatment of arthritis of the temporomandibular, sacroiliac, hip, shoulder, foot, and ankle joints [17, 20–23]. In 1997, Hyalgan® (sodium hyaluronate), a high molecular-weight HA obtained from rooster's combs, was approved by the FDA [24, 25]. Like other HA, it is only approved for osteoarthritis of the knee, and should be used with caution in patients with sensitivities to avian proteins, feathers, and egg products. It also carries a similar side-effect profile, including local inflammation, injection site pain and itching, anaphylaxis/anaphylactoid reactions, local ecchymosis, nausea/vomiting, diarrhea, anorexia, and headache . While Hyalgan© has a relatively short half-life of about twenty-four hours, the effect of the injections lasts for weeks, which suggests that it augments natural synovium production, mitigates nociception and inflammation, as well as increases the rheological properties (viscosity, elasticity, pseudoplasticity) of synovial fluid [27–29].
Our patient's survival to adulthood is somewhat anomalous, compared to the life expectancy of others afflicted with MSS. Therefore, we can only assume that if other carriers of the disease survived the historically perilous respiratory maladies of childhood, they too would suffer from the chronic pain of disharmonic skeletal development and ensuing arthralgias, as we observed in our patient, and as it has been noted in other carriers . L.W. underwent a series of three intra-articular bilateral hip injections one week apart, and gradual improvement in symptoms over this period was noted. At the time of the first visit, the patient arrived in her wheelchair, and passive movement of her hips caused her great distress. Two months after the last injection, we reevaluated the patient in our clinic. She arrived for her appointment walking, semi-independently, with her parents on either side of her. They felt that the injections successfully decreased the frequency and intensity of her painful episodes, noting a marked improvement in her daily functioning.
We describe a unique treatment alternative for a patient with Marshall Smith Syndrome and debilitating, painful bilateral hip dysplasias using intra-articular sodium hyaluronate injections. This management option should be considered in one's armamentarium, especially in the high-risk surgical population.
Written informed consent was obtained from the parent/guardian of the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Marshall R, Graham B, Scott C, Smith D: Syndrome of Accelerated Skeletal Maturation and Relative Failure to Thrive: A Newly Recognized Clinical Growth Disorder. J Ped. 1971, 78 (1): 95-101. 10.1016/S0022-3476(71)80269-X.View ArticleGoogle Scholar
- Johnson J, Carey J, Glassy F, Paglieroni T, Lipson M: Marshall-Smith Syndrome: Two Case Reports and a Review of Pulmonary Manifestations. Pediatrics. 1983, 71: 219-21.PubMedGoogle Scholar
- Travan L, Oretti C, Zennaro F, Demarani S: Marshall-Smith Syndrome and Septo-Optic Dysplasia: An Unreported Association. Am J Med Gen Part A. 2008, 146A: 2138-2140. 10.1002/ajmg.a.32430.View ArticleGoogle Scholar
- Dernedde G, Pendeville P, Veyckemans F, Verellen G, Gillerot Y: Anaesthetic Management of a Child with Marshall-Smith Syndrome. Can J Anaesth. 1998, 45 (7): 660-663. 10.1007/BF03012097.View ArticlePubMedGoogle Scholar
- Yoder C, Wiswell T, Cornish J, Cunningham B, Crumbaker D: Marhsall-Smith Syndrome: Further Delineation. South Med J. 1998, 81 (10): 1297-300.View ArticleGoogle Scholar
- Sperli D, Concolino D, Barbato C, Strisciuglio P, Andria G: Long Survival of a Patient with Marshall-Smith Syndrome without Respiratory Complications. J Med Genet. 1993, 30: 877-879. 10.1136/jmg.30.10.877.PubMed CentralView ArticlePubMedGoogle Scholar
- Adam M, Hennekam R, Keppen L, Bull M, Clericuzio C, Burke L, Ormond K, Hoyme H: Natural History and Evidence of an Osteochondrodysplasia with Connective Tissue Abnormalities. American Journal of Medical Genetics. 2005, 137A: 117-124. 10.1002/ajmg.a.30580.View ArticleGoogle Scholar
- Eich G, Silver M, Weksberg R, Daneman A, Costa T: Marshall-Smith Syndrome: New Radiographic, Clinical, and Pathologic Observations. Radiology. 1991, 181 (1): 183-188.View ArticlePubMedGoogle Scholar
- Williams D, Carlton D, Green S, Pearman K, Cole T: Marshall-Smith Syndrome: The Expanding Phenotype. J Med Genet. 1997, 34: 842-845. 10.1136/jmg.34.10.842.PubMed CentralView ArticlePubMedGoogle Scholar
- Summers D, Cooper H, Butler M: Marshall-Smith Syndrome: Case Report of a Newborn Male and Review of the Literature. Clin Dysmorph. 1999, 8 (3): 207-10. 10.1097/00019605-199907000-00010.PubMedGoogle Scholar
- Desphande C, Forrest M, Russell-Eggitt I, Hall C, Mehta R, Paterson J: Visual Impairment and Prolonged Survival in a Girl with Marshall-Smith Syndrome. Clin Dysmorph. 2006, 15: 111-113. 10.1097/01.mcd.0000194408.30794.2f.View ArticleGoogle Scholar
- Cullen A, Clarke T, O'Dwyer T: The Marshall-Smith Syndrome: A Review of Laryngeal Complications. Eur J Pediatr. 1997, 156: 463-464. 10.1007/s004310050640.View ArticlePubMedGoogle Scholar
- Diab M, Raff M, Gunther D: Osseous Fragility in Marshall-Smith Syndrome. Amer J Med Gen. 2003, 119A: 218-222. 10.1002/ajmg.a.10173.View ArticleGoogle Scholar
- Wen D: Intra-articular Hylarunonic Acid Injections for Knee Osteoarthritis. American Family Physician. 2001, 62: 565-70.Google Scholar
- De La Pena E, Sala S, Rovira J, Schmidt R, Belmonte C: Elastoviscous Substances with Analgesic Effects on Joint Pain Reduce Stretch-Activated Ion Channel Activity in Vitro. Pain. 2002, 99: 501-508. 10.1016/S0304-3959(02)00260-9.View ArticlePubMedGoogle Scholar
- Srejic U, Calvillo O, Kabakibou K: Viscosupplementation: A New Concept in the Treatment of Sacroiliac Joint Syndrome: A Preliminary Report of Four Cases. Regional Anesthesia and Pain Medicine. 1999, 24 (1): 84-88.PubMedGoogle Scholar
- Itokazu M, Matsunaga T: Clinical Evaluation of High-Molecular-Weight Sodium Hyaluronate for the Treatment of Patients with Periarthritis of the Shoulder. Clinical Therapeutics. 1995, 17 (5): 946-10.1016/0149-2918(95)80072-7.View ArticlePubMedGoogle Scholar
- Smith G, Myers S, Brandt K, Mickler E: Effect of Intra-articular Hyaluronan Injection in Experimental Canine Osteoarthritis. Arthritis and Rheumatism. 1998, 41 (6): 976-985. 10.1002/1529-0131(199806)41:6<976::AID-ART4>3.0.CO;2-R.View ArticlePubMedGoogle Scholar
- Bannuru R, Natov N, Obadan I, Price L, Schmid C, McAlindon T: Therapeutic Trajectory of Hyaluronic Acid Versus Corticosteroids in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis. Arthritis Care & Management. 2009, 61 (12): 1704-1711.View ArticleGoogle Scholar
- Perdikis D: Sustained Effect of Hyaluronate Viscosupplementation in Chronic Sacroiliac Joint Pain. The Journal of Pain. 2006, 7 (4): S34-10.1016/j.jpain.2006.01.127.View ArticleGoogle Scholar
- Salk R, Chang T, D'Costa W, Soomekh D, Grogan K: Sodium Hyaluronate in the Treatment of Osteoarthritis of the Ankle: A Controlled, Randomized, Double-blind pilot study. The Journal of Bone and Joint Surgery. 2006, 88: 295-302. 10.2106/JBJS.E.00193.View ArticlePubMedGoogle Scholar
- Perdikis D: Intra-articular Hyaluronate Improves Chronic Temporomandibular Joint Pain. The Journal of Pain. 2006, 7 (4): S62-10.1016/j.jpain.2006.01.248.View ArticleGoogle Scholar
- Van den Bekerom M, Lamme B, Sermon A, Mulier M: What is the Evidence for Viscosupplementation in the Treatment of Patients with Hip Osteoarthritis? Systematic Review of the Literature. Archives of Orthopaedic and Trauma Surgery. 2008, 128: 815-823. 10.1007/s00402-007-0447-z.View ArticlePubMedGoogle Scholar
- Briem K, Axe M, Snyder-Mackler L: Medical Knee Joint Loading Increases in Those Who Respond to Hyaluronan Injection for Medical Knee Osteoarthritis. Journal of Orthopoedic Research. 2009, 27: 1420-1425. 10.1002/jor.20899.View ArticleGoogle Scholar
- Sanofi Aventis/Hyalgan.http://www.hyalgan.com/docs/pdf/Complete_Patient_Information.pdf
- Juni P, Reichenbach S, Trelle S, Tschannen B, Wandel S, Jordi B, Zullig M, Guetg R, Hauselmann H, Schwarz H, Theiler R, Ziswiler H, Dieppe P, Villiger P, Egger M: Efficacy and Safety of Intraarticular Hylan or Hyaluronic Acids for Osteoarthritis of the Knee. Arthritis & Rheumatism. 2007, 56 (11): 3610-3619.View ArticleGoogle Scholar
- Jansen E, Emans P, Douw C, Guldemond N, Van Rhijn L, Bulstra S, Kuijer R: One Intra-Articular Injection of Hyaluronan Prevents Cell Death and Improves Cell Metabolism in a Model of Injured Articular Cartilage in the Rabbit. Journal Orthopaedic Research. 2008, 26 (5): 624-630. 10.1002/jor.20569.View ArticleGoogle Scholar
- Gomis A, Miralles A, Schmidt R, Belmonte C: Nociceptive Nerve Activity in an Experimental Model of Knee Joint Oteoarthritis of the Guinea Pig: Effect of Intra-articular Hyaluronan Application. Pain. 2007, 130: 126-136. 10.1016/j.pain.2006.11.012.View ArticlePubMedGoogle Scholar
- Jean Y, Wen Z, Chang Y, Lee H, Hsieh S, Wu C, Yeh C, Wong C: Hyaluronic Acid Attenuates Osteoarthritis Development in the Anterior Cruciate Ligament-Transected Knee: Association with Excitatory Amino Acid Release in the Joint Dialysate. Journal of Orthopaedic Research. 2006, 24 (5): 1052-1061. 10.1002/jor.20123.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.