- Research article
- Open Access
Correlation and comparison of Risser sign versus bone age determination (TW3) between children with and without scoliosis in Korean population
© Modi et al; licensee BioMed Central Ltd. 2009
- Received: 29 March 2009
- Accepted: 20 September 2009
- Published: 20 September 2009
Most studies comparing the Risser staging for skeletal maturity are representing the American or European standards which are not always applicable to Asian population who have relatively less height and body mass. There is no article available that compares the Risser sign and bone age correlation between patients with idiopathic scoliosis and patients without scoliosis.
Materials and methods
To analyze and compare the skeletal age with the Risser sign between scoliosis and non-scoliosis group, a cross-sectional study was done in 418 scoliosis (untreated, bracing or surgically) and 256 non-scoliosis children of Korean origin. Relationship was found in both groups using Pearson correlation test.
In scoliosis group, Pearson correlation exhibited significant correlation (p < 0.01) between Risser sign and chronological age (r2 = 0.791 for girls, 0.787 for boys) and Risser sign and TW3 age (r2 = 0.718 for girls, 0.785 for boys). Non-scoliosis group also showed significant relationship (p < 0.01) between Risser sign and chronological age (r2 = 0.893 for girls, 0.879 for boys) and Risser sign and TW3 age (r2 = 0.913 for girls, 0.895 for boys). Similarly, comparing Cobb angles of each patient according to their Risser staging, exhibited that if scoliosis remains untreated Cobb angle will increase with the increase in their Risser staging (r2 = 0.363 for girls, 0.443 for boys; p < 0.01).
Our results showed that chronological age is equally as reliable as skeletal age method to compare with Risser sign, and therefore, we do not mean to imply that only the Risser sign compared with skeletal age should be considered in the decision making in idiopathic as well as non-scoliosis patients of Korean ethnicity. Concomitant indicators such as menarchal period, secondary sex characteristics, and recent growth pattern will likely reinforce our data comparing Risser sign with skeletal age in decision making.
- Adolescent Idiopathic Scoliosis
- Idiopathic Scoliosis
- Cobb Angle
- Skeletal Maturity
- Risser Sign
Prognostic studies related to the risk of curve progression in patients with idiopathic scoliosis (IS) have been hampered by poor measurements of skeletal maturity and arbitrary definitions of curve progression. Literature  described a number of potential skeletal maturity indicators, including Risser sign, the Oxford stage, The Greulich and Pyle (GP) and Tanner-Whitehouse-III (TW3) maturity assessments, and a number of serological skeletal maturity markers in girls with idiopathic scoliosis. Using the hand-wrist radiographs, there are two possible analysis schemes are defined for the TW3 method. The first one, named RUS, uses 13 bones (the phalanges, radius, and ulna). The other one uses 20 bones (the 13 bones previously defined and the 7 bones of the carpal region). We have chosen to build a method based on the 13 RUS bones, because the carpal region is not valid after a certain age . Tanner-Whitehouse composite scores are based on osseous stages and events at each level. The Tanner-Whitehouse method involves measuring individual bone parts to create an index value which was matched with prepared table for both male and females to find out their bone age. Senders et al  identified that Tanner-Whitehouse-III RUS skeletal maturity assessment [2, 3] method is the most closely related to curve behavior, or, more specifically, to the timing of curve take-off in early adolescence, which is termed the curve acceleration phase (CAP). Similarly Wang et al  proved that digital bone age assessment (DSA) is a reliable indicator for predicting residual spinal growth potential in idiopathic scoliosis patients, but it should be correlated with menarchal status and chronological ages.
Assessing the skeletal maturity in patients with adolescent idiopathic scoliosis often gives the guideline for the treatment regarding bracing weaning time or surgical consideration. Since chronological age is not an accurate predictor of the maturity, there are several methods have been described in the literature to find out skeletal maturity. However, none of those is proved to be accurate enough to predict the residual growth potential of the spine in idiopathic scoliosis. Risser sign is used most frequently to assess the growth of the patient in relation to clinical problems since it was described by Risser in 1958. Although the Risser sign is still an acceptable prognostic sign in the evaluation of IS patients, there is considerable controversy about its reliability for predicting the cessation of vertebral growth [6–11]. Binodi et al have correlated Risser sign with bone age in 111 patients with adolescent idiopathic scoliosis for assessing the maturity . This study did not have enough number of patients in all groups, and they used the Greulich-Pyle method for bone age assessment. Additionally most of the studies are representing the American or European standards which we think not always applicable to Asian population who have relatively less height and body mass. There is no article available that compares the Risser sign and bone age correlation between patients with idiopathic scoliosis and patients without scoliosis.
In present paper, we correlated Risser sign with chronological and skeletal age measured with Tanner-Whitehouse-III method in our study population with Korean ethnicity. Our aim was to establish the skeletal average age, both in male and females that correlates with the Risser sign the most. In addition we also compared this correlation between the patients with idiopathic scoliosis and without scoliosis to find out if there is any difference exists.
We have analyzed skeletal age and Risser sign with their Cobb angle in 418 patients with idiopathic scoliosis (IS) and 256 patients without scoliosis (control). All the patients with scoliosis and without scoliosis were grouped into group1 and group2, respectively. All patients selected for this study had an age between minimum 9 and maximum 16 years for girls, and minimum 9 and maximum 17 years for boys. Average age was 13.52 years (range, 9-17) and 13.97 years (range, 9.1-17) for group1 and 2, respectively. There were 95 boys and 323 girls in group1 and 140 boys and 116 girls in group2. Bone age determination was done by analyzing left hand posteroanterior (PA) radiogram using TW3  method. All radiograms were taken after obtaining an informed consent from patients and their parents and explaining them the purpose of our study. Specific care was taken that in both groups the date of wrist radiogram, pelvis radiogram (showing Risser sign) and spine (showing Cobb angle) were the same to prevent any biased result. Those radiograms that did not fulfilled all these criteria were excluded from the study. All radiograms were taken by a single radiologist on single radiogram machine to avoid errors regarding patient positioning and distance from the X-ray tube. All patients in group1 did not have any bracing or operative treatment while taking the radiogram and calculating Cobb angle. Risser sign represents progressive maturation of the iliac crest apophysis . In the AP radiographic projection of the pelvis, Risser sign was evaluated for all patients. Similarly, Cobb angle for the patients in group1 was calculated using Cobb method on AP radiogram of whole spine. All skeletal age assessment, Cobb angle measurement and Risser sign evaluation were done separately by two fellows who were familiar with all measurement techniques. All measurements were done on stored digital radiograms using picture-archiving and communication system (PACS).
Skeletal age was subsequently compared with iliac crest apophysis maturation (Risser sign) to determine the reliability of Risser sign as it correlates to the skeletal age determination by TW3 method. Similarly, chronological age were also compared with the Risser staging and Pearsons correlation coefficient graph was plotted to find out any difference from chronological age to TW3 bone age. Comparison was done in both the groups to find out any difference in patients with scoliosis from in patients without scoliosis. Additionally skeletal age and Risser sign were also compared according to severity of curve and gender in entire patients group to find any relation. Linear regression curve was plotted to compare various variables with the Risser sign and skeletal age assessment.
Values of TW3 bone age and chronological age according to their Risser staging with their Cobb angle in idiopathic scoliosis patients (group1).
No of Pt
The Risser sign has been and is still used commonly by orthopedic surgeons as a guide to the initiation or cessation of brace treatment, and the indication for surgery [12, 13]. The reason for using the Risser sign as a measure of skeletal maturity is that the chronological age of the patient is assumed to be inaccurate. Additionally it is readily available on good anteroposterior standing radiogram of spine while evaluating the patients with scoliosis. Therefore it is better to correlate the reliability of Risser sign with skeletal age to find out the average skeletal age of the Risser sign in the population. Most literature correlated the skeletal age with the Risser sign in American or European children, however, no literature has been reported for Asian population in which comparing the Risser sign with skeletal age is not reliable. The purpose of this study was to evaluate the correlation between the Risser sign with skeletal age measured by TW3 method, and also to compare the reliability of skeletal age with that of chronological age in Korean population. Using the control group in our study we also aimed at to find out the difference, if exists, the appearance of the Risser sign and skeletal age in scoliosis patients from control patients (without scoliosis) of the same ethnicity. We believe that this is the first study comparing such difference among scoliotic and non-scoliotic groups.
Binodi et al  found that the correlation coefficient of the Risser stage versus skeletal age was 0.56 for girls while Scoles et al  found it to be 0.81 for Risser stage versus chronological age. Thus they using these methods, chronological age provides a more accurate measure of skeletal age than the Risser sign. Both of these studies were done using Greulich Pyle method. While Dhar et al  compared Risser stages with skeletal age using TW2 atlas . Here in present study we have used TW3 method to find out relationship between the Risser sign and skeletal age in Korean population. We also tried to estimate general appearance of the Risser sign according to skeletal age in Korean population aiming to make a baseline data for this population. We found that the comparison of the Risser staging versus chronological age and the Risser staging versus TW3 bone age in both groups (with scoliosis and without scoliosis) did not differ from each other. Our study proved that that there is no difference on appearance of the Risser sign based on the presence or absence of idiopathic scoliosis in Korean population. We, however, agree that the correlation of Risser sign with chronological and TW3 bone age in non-scoliosis group had a little higher reliability than that of scoliosis group. However, this difference of the chronological and TW3 bone age was not statistically significant between group 1 and 2 (p > 0.05).
Assessment of skeletal maturity is necessary in the management of children with skeletal growth abnormalities and in the decision making of the other deformities like scoliosis. It is quite difficult to determine developmental maturation of children from statural height, weight and chronological age . Recently Wang et al  compared histological examination of superior and inferior endplates of vertebral body and compared them to digital skeletal age (DSA) to identify residual growth potential of spinal column in 39 Chinese girls. Their histological grading of the endplates showed that DSA is a more reliable indicator than menarchal status or chronological age for predicting the spinal residual growth potential in idiopathic scoliosis patients. However, histological grading is not possible in routine clinical practice, rather impractical to find out maturity level. And as per their conclusion, we also used DSA to identify skeletal maturity and that was compared with the Risser sign to establish the average range of DSA using TW3 method in Korean population. Additionally we have compared both genders in our study in both groups with and without scoliosis, and we found that the range and the mean age for the appearance of the Risser sign were similar in boys and girls of both the groups.
Values of TW3 bone age and chronological age according to their Risser staging in non-scoliosis patients (group2).
No of Pt
There were few lacunae in our study. First one is that this study is not a longitudinal study but a cross sectional study in 418 idiopathic scoliosis and 256 non-scoliosis patients. Additionally potential errors in skeletal maturation inherently relate to race, hormonal levels, genetic background, and nutrition. However, we believe that our study was done in a large number of children in Korean population with the same ethnicity. Therefore our data would provide important information regarding the skeletal maturity in this population which is different than American and European ethnicity showing the relationship of Risser sign with skeletal age only. While our data shows that chronological age is equally as reliable as skeletal age method to compare with the Risser sign, and therefore, we do not mean to imply that only the Risser sign compared with skeletal age should be considered in the decision making in idiopathic as well as non-scoliosis patients of Korean ethnicity. Concomitant indicators such as menarchal period, secondary sex characteristics, and recent growth pattern will likely reinforce our data comparing the Risser sign with skeletal age in decision making.
- Senders JO, Browne RH, McConnell SJ, Margraf SA, Cooney TE, Finegold DN: Maturity assessment and curve progression in girls with idiopathic scoliosis. J Bone Joint Surg Am. 2007, 89: 63-73.Google Scholar
- Aja-Fernandez S, De Luis-Garcia R, Martin-Fernandez MA, Alberola-Lopez C: A computational TW3 classifier for skeletal maturity assessment. A Computing with Words approach. J Biomed Inform. 2004, 37: 99-107. 10.1016/j.jbi.2004.01.002.View ArticlePubMedGoogle Scholar
- Tanner JM, Healy MJR, Goldstein H, Cameron N: Assessment of skeletal maturity and prediction of adult height (TW3 method). 2001, London: Saunders, 3Google Scholar
- Wang S, Qui Y, Ma Z, Xia C, Zhu F, Zhu Z: Histologic, Risser sign, and digital skeletal age evaluation for residual spine growth potential in Chinese female idiopathic scoliosis. Spine. 2007, 32 (15): 1648-1654. 10.1097/BRS.0b013e318074c3ed.View ArticlePubMedGoogle Scholar
- Risser JC: The iliac apophysis: an invaluable sign in the management of scoliosis. Clin Orthop. 1958, 11: 111-119.PubMedGoogle Scholar
- Hoppenfeld S, Lonner B, Murthy V: The rib epiphysis and other growth centers as indicators of the end of spinal growth. Spine. 2003, 29: 47-50. 10.1097/01.BRS.0000103941.50129.66.View ArticleGoogle Scholar
- Biondi J, Weiner DS, Bethem D: Correlation of Risser sign and bone age determination in adolescent idiopathic scoliosis. J Pediatr Orthop. 1985, 6: 697-710.View ArticleGoogle Scholar
- Dhar S, Dangerfield PH, Dorgan JC: Bone age and Risser's sign in adolescent idiopathic scoliosis. Spine. 1993, 18: 14-9. 10.1097/00007632-199301000-00003.View ArticlePubMedGoogle Scholar
- Little DG, Sussman MD: The Risser sign: a critical analysis. J Pediatr Orthop. 1994, 14: 569-75.View ArticlePubMedGoogle Scholar
- Scoles P, Salvagno R, Villalba K: Relationship of the iliac crest maturation to skeletal and chronological age. J Pediatr Orthop. 1998, 8: 639-44.View ArticleGoogle Scholar
- Shuren N, Kasser JR, Emans JB: Reevaluation of the use of the Risser sign in idiopathic scoliosis. Spine. 1992, 17: 359-61. 10.1097/00007632-199203000-00020.View ArticlePubMedGoogle Scholar
- Bradford DS, Lonstein JE, Moe J, Ogilvie JW, Winter RB: Moe's textbook of scoliosis and other spinal deformities. 1987, Philadelphia: W.B. Saunders, 210-Google Scholar
- Frymoyer JW, ed: 1993, Rosemont, IL American Academy of Orthopedics Surgeons, 449-4Google Scholar
- Tanner JM, Whitehouse RH, Cameron N, Marshall WA, Healy M, Goldstein H: Assessment of skeletal maturity and prediction of adult height (TW2 method). 1983, London: Academic PressGoogle Scholar
- Tanner JM, Whitehouse RH, Takaishi M: Standards from birth to maturity. Arch Disabled Child. 1966, 41: 613-35. 10.1136/adc.41.220.613.View ArticleGoogle Scholar
- Greliuch WW, Pyle SI: Radiographis atlas of skeletal development of the hand and wrist. 1959, Stanford: Stanford University Press, 2Google Scholar
- Cundy P, Paterson D, Morris L, Foster B: Skeletal age estimation in leg length discrepancy. J Pediatr Orthop. 1988, 8: 513-15.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.