Concordane of OSTA and lumbar spine BMD by DXA in identifying risk of osteoporosis
© Lu et al; licensee BioMed Central Ltd. 2006
Received: 09 April 2006
Accepted: 21 November 2006
Published: 21 November 2006
To investigate the accuracy of Osteoporosis Self-assessment Tool for Asians (OSTA) in identifying the risk of osteoporosis in postmenopausal women. To validate use of OSTA risk index by comparing it with the bone mineral density (BMD) of lumbar spine measured by dual energy X-ray absorptiometry (DXA).
The data of lumbar spine BMD (LS BMD) measurements by DXA of 218 postmenopausal women of Han nationality in Sichuan province were compared with OSTA risk index. The concordance of OSTA and LS BMD were calculated and analyzed by fourfold table and receiver operating characteristic (ROC) curve.
The prevalence of osteoporosis in these women was 40.4% and 61.5%, with the LS BMD T score cutoffs -2.5 and -2.0, respectively. The sensitivity, specificity, and accuracy of OSTA risk index compared with T score cutoff -2.5 of LS BMD were 59.1%, 56.9% and 57.8%, respectively, while they were 57.5%, 63.1%, 59.6% by T score cutoff -2.0.
For identifying risk of osteoporosis, the concurrence was lower than those reported studies when comparing LS BMD measurements to OSTA risk index in Chinese Han nationality postmenopausal women of Sichuan province. Physicians should identify women who need BMD measurement according to more factors rather than age and body weight.
According to the improvement of living standard and life expectancy, osteoporosis (OP) is becoming one of the most common pubic healthy problems in China and worldwide. The prevalence of osteoporosis is progressively increasing. The most severe complication of OP is fracture, which brings great burden to individual, family and society.
Osteoporosis is very common among postmenopausal women [1–3], while women of high risk are often asymptomatic. Therefore, early screening and evaluation of osteoporosis in postmenopausal women are important. It is widely accepted that bone mineral density (BMD) measurement measured by dual X-ray absorptiometry (DXA) is the golden standard of diagnosis of OP. Because of the limited availability and rather expensive cost of DXA, simple tools in identifying women needed DXA measurements have developed.
The Osteoporosis Self-assessment Tool for Asians (OSTA) is an index using chart or formula to predict low BMD simply on the basis of age and weight. It was firstly proposed by Koh LK, which had a sensitivity of 91% and specificity of 45% in identifying women of high risk when compared with final results of femoral neck BMD measurement in Asia women. The index of Osteoporosis Self-assessment Tool (OST) is calculated by the same formula or chart of OSTA, which is reported to predict low BMD in other races of people using different cutoff values.
In this article, 218 Chinese women of Han nationality in Sichuan province were assessed by OSTA index and the usefulness of OSTA was evaluated to predict osteoporosis in comparing with LS BMD which measured by DXA.
2. Data and methods
This study is a diagnostic test. We analyzed the database of DXA measurement for lumbar spine BMD (LS BMD) from August 1st 2005 to September 30th 2005 in our hospital. Most of the patients did not measure femoral neck or hip BMD. In-patient and out-patient postmenopausal women of Han nationality from Sichuan province were selected for further evaluation, among which enrolled in a physical examination clinic, rehabilitation department, geriatric department and endocrinology department were recruited. Patients were ineligible if they had a history in their case files of advanced osteoarthritis, hyperthyroidism, hyperparathyroidism, renal failure, and other knowing severe diseases or conditions that could interfere with bone metabolism. Finally, 218 postmenopausal women were eligible and applied the OSTA index.
LS BMD by DXA was measured with Challenger densitometer (DMS, France), which uses the DMS reference source for the spine. A spine phantom was measured every week to keep the precision error less than 2%. All measurements were completed by one operator. T scores of lumbar spine L2 to L4 were obtained and osteoporosis was defined as T scores of any site equal to or less than -2.5. In addition, when compared with the OSTA index, a T score cutoff for osteoporosis of -2.0 were also applied, according to the consensus of some specialists in China. These postmenopausal women were identified at various BMD thresholds (T score values of -2.0 and -2.5) for osteoporosis and non-osteoporosis (osteopenia or normal).
OSTA index was derived according to the formula of 0.2 × (weight in kilograms – age in years), truncated to an integer[4, 5, 8]. Three risk categories were used for the index according to its developer's recommendations and in our study, dichotomous cutoff for Asian women were used as the following: ≥ 0 for low risk and < 0 for moderate-high risk.
A fourfold table was applied to calculate the sensitivity (sen.), specificity (spe.), and accuracy of OSTA compared with different T score cutoffs of LS BMD by DXA. Receiver operating characteristic curves (ROC curves) were constructed and the areas under curve (AUC) as well as its 95% confidence interval (95% CI) was estimated by using SPSS statistical software10.0 (SPSS Inc.). The prevalence of osteoporosis was examined across different categories of the OSTA risk index.
Fourfold table of OSTA comparing with LS BMD by DXA
LS BMD by DXA
T ≤ -2.5
T ≤ -2.0
Performance of OSTA index by LS BMD and various T score cutoffs
T ≤ -2.5
T ≤ -2.0
It's never ending for specialists to find out an easy tool for osteoporosis risk evaluation. The Chinese Medical Association recommended that all women aged 65 and older or postmenopausal women with one or more risk factors should have BMD measurements. But it is not possible for all women satisfied with the conditions mentioned above to receive DXA measurements in China, because of little physicians' and patients' awareness, little public heath policy support, and so on. Therefore, we want to find out patients in high risk of osteoporosis using simple tools such as OSTA, which had been validated well in classifying the osteoporotic risk among postmenopausal women.
Results of OST(A) in diagnostic studies.
Hong Kong women
Compared with QUS*
Canadian white women
Belgian Caucasian women
American white men
We found the performance of OSTA risk index is not as satisfied as those reported in Asian or other races and it can not help us precisely to give judgement on whether a DXA measurement of LS BMD should be given to a postmenopausal women or not. Because our subjects were from hospital, not from an epidemiologic investigation, the prevalence of osteoporosis was rather higher than those reported in Asian women. Through a woman's life, there are so many risk factors for osteoporosis, such as age, race, hormone conditions, heredity, weight, nutritional status, history of fracture, childbearing, and so on. We think there were limitations in OSTA risk index by using only age and weight. According to the OSTA formula, if the weight (in kilograms) of a woman surpasses her age (in years), she will always be in low risk of osteoporosis. It is of some absurd for you to tell your patient that when she was 90 years old, she should keep the body weight 90 kg for prevention of osteoporosis.
The identification of low bone mass in postmenopausal women should be emphasized because of the severe complications. Although some experts should give advice to their patients, most physicians and patients in our country are not aware of osteoporosis. It is only appropriately diagnosed and treated in a very small proportion of patients, even if they had a prior history of osteoporotic fracture. Up to now, BMD measurement is still the golden standard of osteoporosis diagnosis. We recommended that physicians should identify women who are likely to have low BMD according to much more factors than OSTA risk index.
The limitation of this study is that not all patients measured femoral neck BMD, so the data did not compared with OSTA index. Although BMD measurements of total hip and femoral neck were easily influenced by body position, they could be alternative sites for identifying osteoporosis, especially when false high lumbar spine BMD were found because of vertebral fractures, hyperostosis, aortic calcification, and so on.
A risk index of osteoporosis like OSTA has its characteristic of calculating simply and quickly. But the validation of its use in our hospital for postmenopausal women who underwent LS BMD measurements by DXA was somewhat disappointed. The OSTA risk index may not be a very good method in identifying postmenopausal women at high risk of osteoporosis, as measured by DXA, in Sichuan province.
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