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Featured Review: Matrix scaffolding for stem cell guidance toward skeletal muscle tissue engineering

Extracellular matrix (ECM) not only provides a support for cells but is also actively involved in cell-cell interaction, proliferation, migration, and differentiation. This leads to the need for investigating new bio-inspired scaffolds or biomaterials, able to mimic ECM in skeletal muscle tissue engineering. 
Here, Fuoco et al. describe a series of natural and synthetic biomaterials employed as ECM mimics for their ability to recreate the correct muscle stem cell niche, by promoting myogenic stem cell differentiation and so, positively affecting muscle repair. 

Editors' profiles

Prof Nicola Maffulli, Editor-in-Chief

Prof Nicola Maffulli is a Consultant at Orthopaedic and Sports Injury Surgeons and is also Chair in Musculoskeletal Disorders in Salerno University School of Medicine, Honorary Chair in Sport and Exercise Medicine at Queen Mary University of London, and has a Visiting Professorship in Trauma and Orthopaedic Surgery at Keele University School of Medicine. His particular scientific interests include physiopathology of sports injuries and arthroscopic techniques of the knee, foot and ankle.

Dr John Furia, Deputy Editor

Dr John Furia is a partner in SUN Orthopedics and Sports Medicine Corporation, located in Lewisburg, Pennsylvania.  He is also Chairman of the Board of Directors and Chief Executive Officer of the Evangelical Ambulatory Surgical Center, president of the Union County Medical Society, and has served as president of Old Trail Imaging, LLC. Dr Furia practices orthopedic surgery and sports medicine and specialises in the use of shock wave therapy as a treatment for various musculoskeletal and sports medicine disorders.

Featured article: Primary stability of a shoulderless Zweymüller hip stem

In this in vitro study, Bieger et al. investigate a modification of the Zweymüller stem design with reduced proximal lateral shoulder with regard to primary stability. This modification allows tissue and bone sparing surgery to be performed. They conclude that reducing the typical shoulder of the Zweymüller-type stem design does not negatively influence axial stability but might negatively influence rotational stability. However, comparable results still suggest a reasonable resistance against rotational forces.

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