Fig. 1

RUNX2-circRNAs and RUNX2 mRNA are upregulated in OS which is mediated by CBX4. A Expression of circ_0076684, circ_0003563, circ_0076691 and RUNX2 mRNA in OS tissues detected by qRT-PCR. B Expression of circ_0076684, circ_0003563, circ_0076691 and RUNX2 mRNA in OS cell lines detected by qRT-PCR. C, D Regulation of CBX4 on the expression of circ_0076684, circ_0003563, circ_0076691 and RUNX2 mRNA. E Expression of CBX4 mRNA in OS tissues detected by qRT-PCR. F, I Correlation of CBX4 mRNA with circ_0076684, circ_0003563, circ_0076691 or RUNX2 mRNA assessed by Pearson analysis. J Schematic diagram showing CBX4 mediating RUNX2-circRNAs and RUNX2 mRNA upregulation. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001