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Table 1 Network meta-analysis

From: Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysis

  

SMD (95% CI)

  

(A)

     

Gn

3.05 (1.52, 4.59)

3.24 (1.43, 5.05)

3.39 (2.27, 4.51)

5.87 (2.44, 9.31)

6.59 (5.43, 7.75)

− 3.05 (− 4.59, − 1.52)

Gao

0.19 (− 1.81, 2.19)

0.34 (− 1.28, 1.96)

2.82 (− 0.81, 6.45)

3.54 (2.04, 5.04)

− 3.24 (− 5.05, − 1.43)

− 0.19 (− 2.19, 1.81)

Gmd

0.15 (− 1.70, 2.00)

2.63 (− 1.11, 6.38)

3.35 (1.58, 5.12)

− 3.39 (− 4.51, − 2.27)

− 0.34 (− 1.96, 1.28)

− 0.15 (− 2.00, 1.70)

Ga

2.48 (− 0.93, 5.89)

3.20 (2.09, 4.31)

− 5.87 (− 9.31, − 2.44)

− 2.82 (− 6.45, 0.81)

− 2.63 (− 6.38, 1.11)

− 2.48 (− 5.89, 0.93)

Gso

0.72 (− 2.67, 4.10)

− 6.59 (− 7.75, − 5.43)

− 3.54 (− 5.04, − 2.04)

− 3.35 (− 5.12, − 1.58)

− 3.20 (− 4.31, − 2.09)

− 0.72 (− 4.10, 2.67)

Gm

(B)

     

Gso

1.14 (− 1.21, 3.50)

4.63 (2.03, 7.22)

4.78 (2.45, 7.10)

5.54 (2.71, 8.38)

8.44 (6.03, 10.86)

− 1.14 (− 3.50, 1.21)

Gn

3.48 (2.18, 4.79)

3.63 (2.66, 4.61)

4.40 (2.64, 6.15)

7.30 (6.27, 8.33)

− 4.63 (− 7.22, − 2.03)

− 3.48 (− 4.79, − 2.18)

Gao

0.15 (− 1.22, 1.51)

0.92 (− 1.06, 2.90)

3.81 (2.50, 5.13)

− 4.78 (− 7.10, − 2.45)

− 3.63 (− 4.61, − 2.66)

− 0.15 (− 1.51, 1.22)

Ga

0.77 (− 0.98, 2.52)

3.67 (2.73, 4.60)

− 5.54 (− 8.38, − 2.71)

− 4.40 (− 6.15, − 2.64)

− 0.92 (− 2.90, 1.06)

− 0.77 (− 2.52, 0.98)

Gmd

2.90 (1.17, 4.63)

− 8.44 (− 10.86, − 6.03)

− 7.30 (− 8.33, − 6.27)

− 3.81 (− 5.13, − 2.50)

− 3.67 (− 4.60, − 2.73)

− 2.90 (− 4.63, − 1.17)

Gm

(C)

     

Gn

0.39 (− 1.60, 2.37)

1.28 (− 0.86, 3.43)

1.86 (0.98, 2.74)

3.23 (1.04, 5.43)

5.71 (4.60, 6.82)

− 0.39 (− 2.37, 1.60)

Gso

0.90 (− 1.89, 3.68)

1.48 (− 0.42, 3.37)

2.85 (0.01, 5.68)

5.22 (3.28, 7.16)

− 1.28 (− 3.43, 0.86)

− 0.90 (− 3.68, 1.89)

Gmd

0.58 (− 1.55, 2.71)

1.95 (− 1.03, 4.92)

4.32 (2.15, 6.49)

− 1.86 (− 2.74, − 0.98)

− 1.48 (− 3.37, 0.42)

− 0.58 (− 2.71, 1.55)

Ga

1.37 (− 0.84, 3.58)

3.74 (− 2.81, 4.67)

− 3.23 (− 5.43, − 1.04)

− 2.85 (− 5.68, − 0.01)

− 1.95 (− 4.92, 1.03)

− 1.37 (− 3.58, 0.84)

Gao

2.37 (− 0.18, 4.57)

− 5.61 (− 6.66, − 4.56)

− 5.22 (− 7.16, − 3.28)

− 4.32 (− 6.49, − 2.15)

− 3.74 (− 4.67, 2.81)

− 2.37 (− 4.57, 0.18)

Gm

(D)

     

Gn

0.67 (− 3.49, 4.83)

1.95 (− 1.52, 5.42)

2.38 (0.57, 4.19)

2.89 (− 1.76, 7.55)

6.89 (4.93, 8.86)

− 0.67 (− 4.83, 3.49)

Gso

1.28 (− 3.93, 6.50)

1.72 (− 2.28, 5.71)

2.23 (− 3.75, 8.21)

6.23 (2.20, 10.25)

− 1.95 (− 5.42, 1.52)

− 1.28 (− 6.50, 3.93)

Gao

0.43 (− 3.22, 4.08)

0.94 (− 4.72, 6.60)

4.94 (1.35, 8.53)

− 2.38 (− 4.19, − 0.57)

− 1.72 (− 5.71, 2.28)

− 0.43 (− 4.08, 3.22)

Ga

0.51 (− 4.12, 5.15)

4.51 (2.69, 6.33)

− 2.89 (− 7.55, 1.76)

− 2.23 (− 8.21, 3.75)

− 0.94 (− 6.60, 4.72)

− 0.51 (− 5.15, 4.12)

Gmd

4.00 (− 0.66, 8.66)

− 6.89 (− 8.86, − 4.93)

− 6.23 (− 10.25, − 2.20)

− 4.94 (− 8.53, − 1.35)

− 4.51 (− 6.33, − 2.69)

− 4.00 (− 8.66, 0.66)

Gm

(E)

     

Gn

0.37 (− 5.30, 6.03)

2.04 (− 2.05, 6.12)

2.81 (0.84, 4.78)

3.13 (− 0.25, 6.50)

6.57 (4.42, 8.71)

− 0.37 (− 6.03, 5.30)

Gso

1.67 (− 5.11, 8.45)

2.44 (− 3.20, 8.09)

2.76 (− 3.62, 9.14)

6.20 (0.53, 11.87)

− 2.04 (− 6.12, 2.05)

− 1.67 (− 8.45, 5.11)

Gao

0.78 (− 3.28, 4.83)

1.09 (− 3.94, 6.12)

4.53 (0.45, 8.62)

− 2.81 (− 4.78, − 0.84)

− 2.44 (− 8.09, 3.20)

− 0.78 (− 4.83, 3.28)

Ga

0.31 (− 3.04, 3.67)

3.76 (1.82, 5.70)

− 3.13 (− 6.50, 0.25)

− 2.76 (− 9.14, 3.62)

− 1.09 (− 6.12, 3.94)

− 0.31 (− 3.67, 3.04)

Gmd

3.44 (0.03, 6.86)

− 6.57 (− 8.71, − 4.42)

− 6.20 (− 11.87, − 0.53)

− 4.53 (− 8.62, − 0.45)

− 3.76 (− 5.70, − 1.82)

− 3.44 (− 6.86, − 0.03)

Gm

(F)

     

Gn

2.15 (− 1.46, 5.77)

3.27 (1.01, 5.53)

4.22 (− 1.11, 9.54)

7.88 (5.48, 10.27)

 

− 2.15 (− 5.77, 1.46)

Gso

1.11 (− 2.17, 4.40)

2.06 (− 3.97, 8.10)

5.72 (2.38, 9.06)

 

− 3.27 (− 5.53, − 1.01)

− 1.11 (− 4.40, 2.17)

Ga

0.95 (− 4.33, 6.23)

4.61 (2.55, 6.66)

 

− 4.22 (− 9.54, 1.11)

− 2.06 (− 8.10, 3.97)

− 0.95 (− 6.23, 4.33)

Gao

3.66 (− 1.64, 8.96)

 

− 7.88 (− 10.27, − 5.48)

− 5.72 (− 9.06, − 2.38)

− 4.61 (− 6.66, − 2.55)

− 3.66 (− 8.96, 1.64)

Gm

 
  1. (A) Lequesne index scale, (B) Mankin score, (C) IL-1β, (D) TNF-α, (E) MMP-3, (F) MMP-13
  2. Bolded font indicates that there was a significant difference between these two interventions (P < 0.05)