Fig. 7From: Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysisThe main mechanism of acupuncture in animal models of KOA.The mechanism of KOA involves several inflammation pathways, NF-κB signaling is central to these inflammatory pathways. Acupuncture may have a therapeutic effect on KOA by inhibiting these pathways and reducing the destruction of cartilage and synovium by inflammatory factors and MMPsBack to article page