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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Exosomes derived from umbilical cord-mesenchymal stem cells inhibit the NF-κB/MAPK signaling pathway and reduce the inflammatory response to promote recovery from spinal cord injury

Fig. 5

UC-MSC-derived exosomes inhibited the MAPK/NF-κB pathway in BV2 microglia. (A) Representative blots showing the levels of P-P65 and IκBα in cells after exosome treatment. Relative levels of (B) P-P65 to P65 (C) and IκBα to β-actin. (D) Representative blots showing the P-P38, P-Jnk, and P-Erk levels in cells after exosome treatment. (E-G) Representative graphs showing the relative expression of P-Erk (E), P-P38 (F), and P-Jnk (G). (H-K) Representative images showing the levels of P-P65 (H), P-Erk (I), P-Jnk (J), and P-P38 (K) by immunofluorescence. Scale bar = 50 μm. *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X