Table 1 Characteristics of studies included in the meta-analysis
Author | Year | Country | Sample size | Women, No. (%) | Average age (years) | BMI | Intervention | Operative type | Follow-up | Endpoints | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E | C | E | C | E | C | E | C | E | C | Â | Â | Â | |||
K.-Y. Ho1 [19] | 2010 | Singapore | 23 | 24 | 16(70) | 17(71) | 65.2 | 65.7 | N/A | N/A | 60Â mg of oral duloxetine 2Â h before surgery and the first day after surgery | Duloxetine not used | TKA | 6 months | opioid consumption, dynamic pain scores, AEs |
Jacques T. Ya Deau [20] | 2016 | American | 53 | 53 | 28(52.8) | 26(49.1) | 67 | 63 | N/A | N/A | 60Â mg orally daily for 15 days, starting on the day of surgery | Duloxetine not used | TKA | 3 months | Neasua and vomiting |
In Jun Koh [28] | 2019 | South Korea | 40 | 40 | 35 (88) | 34(85) | 69.1 ± 5.8 | 68.6 ± 9.5 | 25.5 ± 2.3 | 26.4 ± 7.5 | 30 mg of oral duloxetine on the night before surgery and 30 mg per day for 6 weeks after surgery | Duloxetine not used | TKA | 12 Months | Resting pain scores, dynamic pain scores, AEs |
Man Soo Kim [27] | 2021 | South Korea | 19 | 20 | 17(89.5) | 16(80) | 71.2 ± 6.5 | 67 ± 7.1 | 25.7 ± 4.5 | 25.7 ± 3.4 | 30 mg per day from 2 weeks before surgery to 8 weeks after surgery | Duloxetine not used | TKA | 3 months | Resting pain scores, dynamic pain scores, AEs |
Hao Li [21] | 2021 | China | 48 | 48 | 26(54) | 24(50) | 52.7 ± 12.0 | 50.2 + 13.2 | 24.0 ± 2.9 | 23.9 ± 3.4 | 60 mg of oral duloxetine every night since preoperative day 2 till postoperative day 14 | Duloxetine not used | THA | 3 months | opioid consumption, resting pain scores, dynamic pain scores, AEs |
Zi-chuan Ding [26] | 2022 | China | 34 | 33 | 21(61.8) | 18(54.5) | 58 | 61 | 23.8 | 23.6 | 60Â mg of oral duloxetine from the day of surgery to postoperative day 6 | Duloxetine not used | THA | 3 months | AEs |
Jacques T. Ya Deau [22] | 2022 | America | 80 | 80 | 40(50) | 35(44) | 63 ± 11 | 64 ± 7 | 31 ± 8 | 30 ± 7 | 60 mg of oral duloxetine on the day of operation and 60 mg per day for 2 weeks after surgery | Duloxetine not used | TKA | 3 Months | opioid consumption, resting pain scores, dynamic pain scores, AEs |
Mingcheng Yuan [29] | 2022 | China | 50 | 50 | 30 (60) | 27 (54) | 67.8 ± 10.12 | 66.2 ± 9.83 | 24.67 ± 4.35 | 24.83 ± 3.87 | 60 mg of oral duloxetine every night since preoperative day 2 till postoperative day 14 | Duloxetine not used | TKA | 3 Months | opioid consumption, resting pain scores, dynamic pain scores, AEs |