Levels of 91 circulating inflammatory proteins and risk of lumbar spine and pelvic fractures and peripheral ligament injuries: a two-sample mendelian randomization study

Table 2 Sensitive analysis of the causal association between circulating inflammatory proteins and risk of LPF and PLI

Inflammatory proteins	Outcomes	SNPs	Cochran’s Q test		MR-Egger intercept		MR-Presso		MR-Steiger
Inflammatory proteins	Outcomes	SNPs	IVW	MR Egger	Egger intercept	p value	Global Test RSSobs	p value	causal direction
Axin-1	LPF	7	0.541	0.461	-0.023	0.568	7.120	0.558(Outlier-corrected, 0 Outlier)	TRUE
Beta-NGF		21	0.843	0.807	0.010	0.683	15.440	0.859(Outlier-corrected, 0 Outlier)	TRUE
IFN-gamma		10	0.849	0.840	0.020	0.448	5.720	0.861(Outlier-corrected, 0 Outlier)	TRUE
SULT-1A1		21	0.572	0.525	-0.011	0.602	19.334	0.614(Outlier-corrected, 0 Outlier)	TRUE
Beta-NGF	PLI	21	0.518	0.522	-0.017	0.317	22.318	0.515(Outlier-corrected, 0 Outlier)	TRUE
IFN-gamma		10	0.925	0.903	-0.010	0.578	4.631	0.943(Outlier-corrected, 0 Outlier)	TRUE
IL-4		11	0.842	0.775	-0.003	0.873	6.709	0.843(Outlier-corrected, 0 Outlier)	TRUE
MIP-1a		14	0.497	0.797	0.024	0.055	17.641	0.472(Outlier-corrected, 0 Outlier)	TRUE
STAM-BP		11	0.670	0.607	-0.018	0.607	8.995	0.710(Outlier-corrected, 0 Outlier)	TRUE

ISSN: 1749-799X