Table 1 MR analysis of the causal association between circulating inflammatory proteins and risk of LPF and PLI

Axin-1

LPF

7

0.161

0.69(0.50 to 0.94)

0.020

0.373

0.84(0.41 to 1.76)

0.669

0.221

0.69(0.46 to 1.05)

0.101

0.327

0.64(0.35 to 1.17)

0.226

0.328

0.66(0.37 to 1.17)

0.245

Beta-NGF

21

0.105

0.80(0.65 to 0.98)

0.034

0.275

0.72(0.42 to 1.23)

0.246

0.148

0.83(0.63 to 1.11)

0.223

0.247

0.83(0.51 to 1.35)

0.464

0.222

0.83(0.53 to 1.29)

0.416

IFN-gamma

10

0.123

0.72(0.57 to 0.92)

0.008

0.217

0.63(0.41 to 0.96)

0.063

0.170

0.73(0.53 to 1.00)

0.061

0.234

0.71(0.44 to 1.15)

0.178

0.248

0.72(0.46 to 1.12)

0.210

SULT-1A1

21

0.078

1.18(1.01 to 1.37)

0.036

0.201

1.30(0.88 to 1.93)

0.208

0.116

1.19(0.95 to 1.48)

0.139

0.176

1.06(0.75 to 1.49)

0.748

0.133

1.17(0.89 to 1.53)

0.262

Beta-NGF

PLI

21

0.073

0.81(0.70 to 0.94)

0.005

0.191

0.97(0.67 to 1.41)

0.887

0.105

0.80(0.65 to 0.99)

0.037

0.226

0.83(0.53 to 1.31)

0.434

0.201

0.71(0.48 to 1.05)

0.100

IFN-gamma

10

0.086

0.83(0.70 to 0.98)

0.028

0.151

0.89(0.66 to 1.20)

0.465

0.114

0.86(0.69 to 1.07)

0.187

0.160

0.85(0.62 to 1.17)

0.350

0.148

0.88(0.66 to 1.17)

0.401

IL-4

11

0.079

1.24(1.06 to 1.44)

0.007

0.197

1.27(0.87 to 1.87)

0.251

0.104

1.28(1.04 to 1.57)

0.018

0.159

1.33(0.98 to 1.82)

0.101

0.148

1.31(0.99 to 1.75)

0.094

MIP-1a

14

0.047

1.11(1.01 to 1.21)

0.033

0.076

0.98(0.84 to 1.13)

0.754

0.057

1.04(0.93 to 1.17)

0.461

0.143

1.06(0.81 to 1.38)

0.712

0.059

1.04(0.93 to 1.16)

0.541

STAM-BP

11

0.106

0.76(0.62 to 0.93)

0.009

0.290

0.88(0.50 to 1.54)

0.659

0.152

0.76(0.57 to 1.00)

0.068

0.233

0.88(0.56 to 1.39)

0.607

0.212

0.71(0.47 to 1.08)

0.143