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Table 5 Differentially expressed miRNA and their gene targets based on C2 pathways

From: Aseptic loosening around total joint replacement in humans is regulated by miR-1246 and miR-6089 via the Wnt signalling pathway

miRNA

Target tissue

Pathway

Gene

Direction

Adj-P

logFC

miR-1246

Bone

Wnt

FZD7

Up

0.0038

2.1

Bone

Wnt

PRKCB

Down

0.0032

-2.5

Bone

Wnt

DIXDC1

Up

0.0007

4.0

Bone

Wnt

SFRP4

Up

0.0014

3.6

Bone

Inflammation

TGFB3

Up

0.0014

2.4

Bone

TGFB

TGFB3

Up

0.0014

2.4

Bone

Wnt

FSTL1

Up

0.0037

2.4

miR-574-3p

Bone

JAK-STAT

IL6

Up

0.0080

2.4

miR-6089

Bone

Wnt

RAC2

Down

0.0089

 − 2.3

Bone

Wnt

FRAT2

Down

0.0059

 − 2.2

Bone

Wnt

DIXDC1

Up

0.0008

4.0

Bone

Wnt

WNT9A

Up

0.0021

2.4

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X