Fig. 4

Knockdown of LINC00958 inhibited IL-1β-induced chondrocyte apoptosis by upregulating miR-214-3p. A Cell viability was evaluated by an MTT assay. B LDH release was measured to evaluate cell injury. C Quantification of apoptotic CHON-001 cells. D Flow cytometry analysis of CHON-001 cell apoptosis. E–G The protein levels of BAX and BCL2 were measured by Western blotting. ^■■P < 0.01 versus Control group, ^▲▲P < 0.01 versus IL-1β + siRNA-NC group, ^★P < 0.05, ^★★P < 0.01 versus IL-1β + siRNA-LINC00958 + inhibitor NC group