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Table 2 Micro-CT analysis of mice trabecular bone (n = 6). Iron accumulation in KO mice markedly reduced trabecular bone mass and significantly affected other related parameters

From: Iron accumulation induced by hepcidin1 knockout accelerates the progression of aging osteoporosis

 

WT

KO

Trabecular BMD (mg/mm2)

0.11 ± 0.09

0.04 ± 0.016*

BV/TV (%)

9.73 ± 1.15

6.02 ± 1.63*

Trabecular number (1/mm)

0.93 ± 0.06

0.76 ± 0.10*

Trabecular thickness (µm)

89.41 ± 3.65

78.47 ± 4.67*

Tb.sp (µm)

498.25 ± 25.13

667.91 ± 22.83*

SMI

2.11 ± 0.09

2.75 ± 0.12*

ConnD (1/mm3)

8.59 ± 0.81

6.33 ± 0.43*

Cortical bone

–

–

  1. The asterisks (*) indicate significant differences at P < 0.05
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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X