Fig. 2
Effects of si-circ_0000376 on OS cell progression. MG63 and U2OS cells were transfected with si-NC and si-circ_0000376. A The circ_0000376 expression was evaluated by qRT-PCR. CCK8 assay (B), colony formation assay (C), EDU assay (D), flow cytometry (E, F) and transwell assay (G) were used to measure cell proliferation, apoptosis and invasion. H–J Glucose consumption, lactate production and ATP/ADP ratio were determined to measure cell glycolysis. K, L The protein levels of CyclinD1 and MMP9 were tested by WB analysis. **P < 0.01, ***P < 0.001, ****P < 0.0001