Table 4 Subgroup analysis of LS BMD in PWH versus controls
From: Risk of low bone mineral density in patients with haemophilia: a systematic review and meta-analysis
| Â | Number of studies | Number of haemophilia | Number of controls | I2 (%) | Random effects SMD (95% CI) | P |
|---|---|---|---|---|---|---|
Overall | 12 | 509 | 660 | 86 | − 0.78 [− 1.14, − 0.43] | P < 0.0001 |
Subgroup analysis | ||||||
 Mean age | ||||||
  > 18 | 6 | 278 | 256 | 47 | − 0.52 [− 0.77, − 0.26] | P < 0.0001 |
  < 18 | 6 | 231 | 404 | 92 | − 1.04 [− 1.74, − 0.33] | P = 0.004 |
 Region | ||||||
  Asia | 5 | 181 | 209 | 88 | − 1.04 [− 1.71, − 0.36] | P = 0.003 |
  Others | 7 | 328 | 451 | 81 | − 0.60 [− 0.99, − 0.20] | P = 0.003 |
 Country | ||||||
  Developed country | 3 | 160 | 302 | 2 | − 0.28 [− 0.52, − 0.04] | P = 0.02 |
  Developing country | 9 | 349 | 358 | 87 | − 0.95 [− 1.41, − 0.49] | P < 0.0001 |
 Study quality | ||||||
  High | 9 | 396 | 355 | 76 | − 0.62 [− 0.94, − 0.30] | P = 0.0001 |
  Moderate | 3 | 113 | 305 | 94 | − 1.21 [− 2.30, − 0.11] | P = 0.03 |