Table 3 Subgroup analysis of the risk of low BMD in PWH versus controls
From: Risk of low bone mineral density in patients with haemophilia: a systematic review and meta-analysis
| Â | Number of studies | Number of haemophilia | Number of controls | I2 (%) | Odds ratio (95% CI) | P |
|---|---|---|---|---|---|---|
Overall | 13 | 616 | 511 | 14 | 3.93 [2.78, 5.56] | P < 0.00001 |
Subgroup analysis | ||||||
 Mean age | ||||||
  > 18 | 5 | 253 | 201 | 36 | 2.75 [1.67, 4.54] | P < 0.0001 |
  < 18 | 7 | 274 | 220 | 0 | 5.31 [2.98, 9.46] | P < 0.00001 |
 Region | ||||||
  Asia | 5 | 189 | 192 | 11 | 5.42 [2.91, 10.09] | P < 0.00001 |
  Others | 8 | 427 | 319 | 19 | 3.38 [2.23, 5.14] | P < 0.00001 |
 Country | ||||||
  Developed country | 3 | 167 | 100 | 0 | 1.73 [0.91, 3.30] | P = 0.10 |
  Developing country | 10 | 449 | 411 | 0 | 5.39 [3.54, 8.19] | P < 0.00001 |