Mechanism of Circ_HECW2 regulating osteoblast apoptosis in osteoporosis by attenuating the maturation of miR-1224-5p

Table 2 Clinical characteristics of patients

Data	Control (n = 65)	OP (n = 65)	P value
Age (years)	56.89 ± 5.99	56.03 ± 6.44	0.431
Gender (Male/Female)	26/39	21/44	0.361
BMI (kg/m²)	22.89 ± 2.54	23.14 ± 2.39	0.564
BMD (g/cm²)	0.89 ± 0.09	0.53 ± 0.06	< 0.001
Lumbar spine (L1–L4) T-score	− 0.24 ± 0.03	− 2.74 ± 0.10	< 0.001
PTH (ng/L)	43.49 ± 14.65	40.49 ± 11.50	0.197
β-CTx (ng/L)	359.72 ± 112.97	425.61 ± 138.38	0.004
tP1NP (ng/L)	44.24 ± 9.97	45.66 ± 11.28	0.449
Calcium (mmol/L)	2.27 ± 0.14	2.28 ± 0.15	0.693
Inorganic phosphorus (mmol/L)	1.20 ± 0.08	1.17 ± 0.10	0.063
25(OH) D (ng/ml)	22.04 ± 5.81	23.16 ± 5.10	0.243
WBC (10⁹/L)	6.40 ± 0.51	6.38 ± 0.40	0.795
Lymphocyte count (10⁹/L)	2.24 ± 0.18	2.26 ± 0.14	0.470
Monocyte count (10⁹/L)	0.49 ± 0.03	0.50 ± 0.04	0.113

BMI: Body mass index; BMD: bone mineral density; PTH: parathyroid hormone; β-CTx: beta-isomer of the C-terminal telopeptide of type I collagen; tP1NP: total procollagen I N-terminal propeptide; 25(OH) D: 25-hydroxyvitamin D; WBC: white blood counts. The data of age, BMI, BMD, lumbar spine (L1–L4) T-score, PTH, β-CTx, tP1NP, calcium, inorganic phosphorus, 25(OH) D, WBC, lymphocyte count, and monocyte count were expressed as mean ± standard deviation and subjected to t test. The gender data were represented by number of cases and subjected to χ² test

ISSN: 1749-799X