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Fig. 8 | Journal of Orthopaedic Surgery and Research

Fig. 8

From: Baicalin inhibits IL-1β-induced ferroptosis in human osteoarthritis chondrocytes by activating Nrf-2 signaling pathway

Fig. 8

Baicalin inhibited IL-1β-induced ferroptosis in chondrocytes by activating Nrf2 signaling pathway. Chondrocytes were treated with IL-1β, and with or without baicalin for 24 h, and then the Nrf2 signaling pathway was blocked by transfection of siNrf2. A The expression levels of GPX4, SLC7A11, P53, ACSL4 were detected by Western blot. The relevant data was shown in (B). Baicalin reduced IL-1β-induced ROS (C), LPO (D) and MDA (E) accumulation by activating Nrf2 signaling pathway. *P < 0.05; **P < 0.01

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X