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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Overexpression of lncRNA LINC00665 inhibits the proliferation and chondroblast differentiation of bone marrow mesenchymal stem cells by targeting miR-214-3p

Fig. 5

Transfection of pcDNA3.1-LINC00665-miR-214-3p mimic reversed the effect of LINC00665 overexpression on BMSCs. A. Relative expression of miR-214-3p in BMSCs after different transfection. B. The inhibitory effect of pcDNA3.1-LINC00665 on the proliferation of BMSCs was restored after transfection with pcDNA3.1-LINC00665-miR-214-3p mimic using CCK-8 method. C. The promoting function of pcDNA3.1-LINC00665 on the apoptosis rate of BMSCs was recovered after transfection with pcDNA3.1-LINC00665-miR-214-3p mimic according to flow cytometry detection. D. GAG content in BMSCs was increased after transfection of pcDNA3.1-LINC00665-miR-214-3p mimic. (***P < 0.001, compared with the control group. #P < 0.05, ###P < 0.001, compared to the pcDNA3.1-LINC00665)

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X