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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: Prevention and treatment of osteoporosis with natural products: Regulatory mechanism based on cell ferroptosis

Fig. 1

The main regulatory pathways of ferroptosis. The first pathway is regulated by the inhibition of the system Xc-, MVA pathway and p53 regulatory axis through the GSH/GPX4 pathway. The second pathway is regulated by Keap1/HO-1, the ATG5-ATG7/NCOA4 pathway and STEAP3. The next pathway is the regulation of lipid metabolism through P53/ALOX15, ACSL4 and LPCAT3. Finally, the NAD(P)H/FSP1/CoQ10 pathway regulates iron-mediated death in concert with GPX4

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X