Correlation between ESR1 and APOE gene polymorphisms and risk of osteonecrosis of the femoral head: a case–control study

Table 8 Results of FPRP analysis for significant findings

Genotype	Crude OR (95% CI)	p	Statistical power	Prior probability
Genotype	Crude OR (95% CI)	p	Statistical power	0.25	0.1	0.01	0.001	0.0001
rs9322332 (A < C)
Overall analysis
A vs C	0.81 (0.68–0.97)	0.020	0.983	0.063	0.167	0.689	0.957	0.996
AA vs CC	0.69 (0.53–0.90)	0.006	0.600	0.030	0.085	0.505	0.912	0.990
CA + AA vs CC	0.70 (0.54–0.90)	0.006	0.648	0.024	0.070	0.452	0.893	0.988
Additive	0.79 (0.66–0.95)	0.013	0.964	0.037	0.103	0.557	0.927	0.992
Age˃51
CA vs CC	0.47 (0.28–0.80)	0.005	0.099	0.141	0.330	0.844	0.982	0.998
AA vs CC	0.52 (0.35–0.77)	0.001	0.107	0.030	0.084	0.502	0.911	0.990
CA + AA vs CC	0.51 (0.35–0.74)	p < 0.001	0.079	0.015	0.043	0.329	0.832	0.980
Additive	0.65 (0.50–0.84)	0.001	0.423	0.007	0.021	0.188	0.701	0.959
Female
AA vs CC	0.51 (0.34–0.78)	0.002	0.108	0.050	0.136	0.634	0.946	0.994
CA + AA vs CC	0.55 (0.37–0.82)	0.004	0.173	0.055	0.149	0.658	0.951	0.995
Smoking-No
CA + AA vs CC	0.68 (0.47–0.99)	0.042	0.541	0.197	0.424	0.890	0.988	0.999
Additive	0.77 (0.59–0.99)	0.042	0.869	0.125	0.301	0.825	0.979	0.998

OR odds ratio; 95% CI 95% confidence interval
While the false-positive report probability threshold at 0.2, noteworthy findings are presented
Bold values indicate noteworthy findings

ISSN: 1749-799X