Table 6 Association between ESR1 and APOE gene polymorphisms and ONFH risk stratified by smoking status

rs2982573

Co-dominant

TT

178

198

1

180

165

1

TC

46

72

0.56 (0.14–2.29)

0.421

90

65

1.34 (0.42–4.19)

0.621

CC

3

6

0.70 (0.46–1.07)

0.102

8

5

1.26 (0.86–1.85)

0.244

Dominant

TT

178

198

1

180

165

1

TC + CC

49

78

0.69 (0.46–1.04)

0.079

98

70

1.26 (0.87–1.84)

0.223

Recessive

TT + TC

224

270

1

270

230

1

CC

3

6

0.61 (0.15–2.48)

0.491

8

5

1.24 (0.40–3.88)

0.709

Additive

–

–

–

0.71 (0.49–1.04)

0.077

–

–

1.23 (0.88–1.71)

0.232

rs10872678

Co-dominant

TT

147

161

1

154

144

1

TC

73

106

0.83 (0.30–2.31)

0.727

113

78

0.99 (0.41–2.42)

0.989

CC

7

9

0.76 (0.52–1.10)

0.147

11

10

1.35 (0.93–1.95)

0.114

Dominant

TT

147

161

1

154

144

1

TC + CC

80

115

0.76 (0.53–1.10)

0.148

124

88

1.31 (0.91–1.87)

0.143

Recessive

TT + TC

220

267

1

267

222

1

CC

7

9

0.92 (0.34–2.53)

0.876

11

10

0.88 (0.37–2.13)

0.785

Additive

–

–

–

0.81 (0.58–1.11)

0.187

–

–

1.20 (0.88–1.63)

0.245

rs9322332

Co-dominant

CC

91

88

1

109

72

1

CA

107

150

0.74 (0.42–1.31)

0.306

128

121

0.61 (0.36–1.04)

0.069

AA

29

38

0.70 (0.48–1.03)

0.070

41

42

0.71 (0.48–1.04)

0.081

Dominant

CC

91

88

1

109

72

1

CA + AA

136

188

0.71 (0.49–1.03)

0.067

169

163

0.68 (0.47–0.99)

0.042

Recessive

CC + CA

198

238

1

237

193

1

AA

29

38

0.92 (0.54–1.54)

0.743

41

42

0.75 (0.47–1.21)

0.234

Additive

–

–

–

0.82 (0.62–1.07)

0.137

–

–

0.77 (0.59–0.99)

0.042

rs7259620

Co-dominant

GG

119

130

1

126

122

1

GA

89

123

0.87 (0.45–1.68)

0.676

129

96

1.16 (0.59–2.27)

0.672

AA

19

23

0.80 (0.55–1.16)

0.236

22

18

1.33 (0.92–1.92)

0.128

Dominant

GG

119

130

1

126

122

1

GA + AA

108

146

0.81 (0.57–1.15)

0.243

151

114

1.30 (0.92–1.85)

0.142

Recessive

GG + GA

208

253

1

255

218

1

AA

19

23

0.96 (0.51–1.82)

0.904

22

18

1.01 (0.53–1.94)

0.972

Additive

–

–

–

0.87 (0.66–1.15)

0.335

–

–

1.18 (0.89–1.56)

0.239

rs769446

Co-dominant

TT

186

223

1

235

194

1

TC

40

53

–

0.999

43

39

–

0.999

CC

1

0

0.88 (0.56–1.39)

0.586

0

3

0.92 (0.57–1.48)

0.735

Dominant

TT

186

223

1

235

194

1

TC + CC

41

53

0.91 (0.57–1.43)

0.667

43

42

0.86 (0.54–1.37)

0.520

Recessive

TT + TC

226

276

1

278

233

1

CC

1

0

–

0.999

0

3

–

0.999

Additive

–

–

–

0.94 (0.60–1.46)

0.771

–

–

0.80 (0.51–1.25)

0.332