Table 5 Association between ESR1 and APOE gene polymorphisms and ONFH risk stratified by gender

rs2982573

Co-dominant

TT

200

220

1

158

143

1

TC

78

75

0.72 (0.25–2.07)

0.543

58

62

2.23 (0.42–11.66)

0.344

CC

6

9

1.14 (0.79–1.65)

0.491

5

2

0.84 (0.55–1.28)

0.411

Dominant

TT

200

220

1

158

143

1

TC + CC

84

84

1.09 (0.76–1.57)

0.622

63

64

0.88 (0.58–1.34)

0.548

Recessive

TT + TC

278

295

1

216

205

1

CC

6

9

0.70 (0.24–1.98)

0.498

5

2

2.34 (0.45–12.22)

0.312

Additive

–

–

–

1.04 (0.76–1.42)

0.823

–

–

0.95 (0.65–1.39)

0.775

rs10872678

Co-dominant

TT

164

184

1

137

121

1

TC

112

106

0.59 (0.25–1.44)

0.250

74

78

2.20 (0.67–7.20)

0.193

CC

8

15

1.18 (0.84–1.66)

0.331

10

4

0.83 (0.56–1.24)

0.372

Dominant

TT

164

184

1

137

121

1

TC + CC

120

121

1.11 (0.80–1.54)

0.534

84

82

0.90 (0.61–1.33)

0.595

Recessive

TT + TC

276

290

1

211

199

1

CC

8

15

0.56 (0.23–1.34)

0.190

10

4

2.35 (0.73–7.63)

0.154

Additive

–

–

–

1.01 (0.76–1.34)

0.932

–

–

1.00 (0.71–1.41)

0.997

rs9322332

Co-dominant

CC

103

97

1

97

63

1

CA

142

154

0.68 (0.41–1.12)

0.128

93

117

0.74 (0.40–1.38)

0.347

AA

39

54

0.87 (0.61–1.25)

0.446

31

26

0.51 (0.34–0.78)

0.002

Dominant

CC

103

97

1

97

63

1

CA + AA

181

208

0.82 (0.58–1.15)

0.256

124

143

0.55 (0.37–0.82)

0.004

Recessive

CC + CA

245

251

1

190

180

1

AA

39

54

0.74 (0.47–1.16)

0.186

31

26

1.10 (0.62–1.93)

0.746

Additive

–

–

–

0.83 (0.66–1.06)

0.135

–

–

0.75 (0.56–1.00)

0.052

rs7259620

Co-dominant

GG

138

159

1

107

93

1

GA

124

125

1.20 (0.63–2.28)

0.578

94

94

0.81 (0.41–1.62)

0.551

AA

22

21

1.15 (0.82–1.61)

0.430

19

20

0.86 (0.58–1.29)

0.474

Dominant

GG

138

159

1

107

93

1

GA + AA

146

146

1.15 (0.83–1.59)

0.388

113

114

0.85 (0.58–1.25)

0.420

Recessive

GG + GA

262

284

1

201

187

1

AA

22

21

1.13 (0.61–2.10)

0.705

19

20

0.87 (0.45–1.69)

0.682

Additive

–

–

–

1.12 (0.86–1.45)

0.397

–

–

0.89 (0.66–1.19)

0.421

rs769446

Co-dominant

TT

246

250

1

175

167

1

TC

37

55

–

0.999

46

37

–

0.999

CC

1

0

0.68 (0.43–1.07)

0.097

0

3

1.20 (0.74–1.95)

0.454

Dominant

TT

246

250

1

175

167

1

TC + CC

38

55

0.70 (0.45–1.10)

0.120

46

40

1.11 (0.69–1.79)

0.663

Recessive

TT + TC

283

305

1

221

204

1

CC

1

0

–

0.999

0

3

–

0.999

Additive

–

–

–

0.73 (0.47–1.13)

0.157

–

–

1.01 (0.65–1.59)

0.954