Table 4 Association between ESR1 and APOE gene polymorphisms and ONFH risk stratified by age

rs2982573

Co-dominant

TT

194

167

1

164

196

1

TC

79

73

0.99 (0.35–2.81)

0.990

57

64

0.91 (0.20–4.12)

0.900

CC

8

7

0.94 (0.64–1.38)

0.753

3

4

1.07 (0.71–1.61)

0.760

Dominant

TT

194

167

1

164

196

1

TC + CC

87

80

0.95 (0.65–1.37)

0.765

60

68

1.06 (0.71–1.59)

0.788

Recessive

TT + TC

273

240

1

221

260

1

CC

8

7

1.01 (0.36–2.84)

0.983

3

4

0.89 (0.20–4.04)

0.883

Additive

–

–

–

0.96 (0.69–1.32)

0.798

–

–

1.04 (0.72–1.51)

0.833

rs10872678

Co-dominant

TT

169

147

1

132

158

1

TC

98

88

1.32 (0.55–3.15)

0.532

88

96

1.06 (0.60–1.87)

0.843

CC

14

9

1.00 (0.69–1.44)

0.986

4

10

0.89 (0.61–1.32)

0.573

Dominant

TT

169

147

1

132

158

1

TC + CC

112

97

1.03 (0.72–1.46)

0.878

92

106

0.93 (0.64–1.34)

0.689

Recessive

TT + TC

267

235

1

220

254

1

CC

14

9

1.32 (0.56–3.13)

0.526

4

10

1.13 (0.67–1.90)

0.645

Additive

–

–

–

1.06 (0.78–1.42)

0.723

–

–

0.99 (0.76–1.30)

0.959

rs9322332

Co-dominant

CC

116

65

1

84

95

1

CA

127

135

0.47 (0.28–0.80)

0.005

108

136

0.48 (0.15–1.58)

0.229

AA

38

46

0.52 (0.35–0.77)

0.001

32

34

1.10 (0.76–1.60)

0.606

Dominant

CC

116

65

1

84

95

1

CA + AA

165

181

0.51 (0.35–0.74)

 < 0.001

140

170

1.05 (0.73–1.50)

0.814

Recessive

CC + CA

243

200

1

192

231

1

AA

38

46

0.69 (0.43–1.11)

0.127

32

34

0.47 (0.14–1.51)

0.202

Additive

–

–

–

0.65 (0.50–0.84)

0.001

–

–

0.97 (0.70–1.34)

0.853

rs7259620

Co-dominant

GG

137

115

1

108

137

1

GA

117

111

1.03 (0.55–1.93)

0.931

101

108

0.96 (0.47–1.98)

0.920

AA

26

21

0.88 (0.61–1.26)

0.475

15

20

1.18 (0.82–1.72)

0.373

Dominant

GG

137

115

1

108

137

1

GA + AA

143

132

0.90 (0.64–1.27)

0.553

116

128

1.15 (0.81–1.64)

0.443

Recessive

GG + GA

254

226

1

209

245

1

AA

26

21

1.10 (0.60–2.00)

0.769

15

20

0.89 (0.44–1.79)

0.749

Additive

–

–

–

0.96 (0.73–1.25)

0.742

–

–

1.07 (0.81–1.43)

0.629

rs769446

Co-dominant

TT

232

200

1

189

217

1

TC

48

45

–

0.999

34

47

1.18 (0.07–19.12)

0.905

CC

0

2

0.93 (0.59–1.45)

0.736

1

1

0.83 (0.51–1.35)

0.457

Dominant

TT

232

200

1

189

217

1

TC + CC

49

47

0.88 (0.57–1.38)

0.588

35

48

0.84 (0.52–1.36)

0.474

Recessive

TT + TC

271

245

1

223

264

1

CC

0

2

–

0.999

1

1

1.22 (0.08–19.72)

0.887

Additive

–

–

–

0.84 (0.55–1.30)

0.442

–

–

0.85 (0.54–1.36)

0.505