Fig. 5

CS deactivates PI3K/AKT axis by down-regulating CXCR4. A, B Western blotting analysis was employed to measure p-PI3K, and p-AKT protein levels in Saos-2 and U2OS induced by CS (200 μg/mL, 24 h) or/and transfected by oe-CXCR4. N = 3; the data are calculated as the mean ± standard deviation. Compared with oe-NC group, ^aP < 0.05; compared with oe-NC + CS group, ^bP < 0.05; compared with oe-CXCR4 + CS group, ^cP < 0.05. CS: Caulis Spatholobi; p: phosphorylated