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Table 2 MR sensitivity analysis

From: No evidence of genetic causality between diabetes and osteonecrosis: a bidirectional two-sample Mendelian randomization analysis

Exposure

Outcome

Inverse variance weighted

Egger-intercept method

Q

df

pval

Intercept

Se

pval

T2DM|ebi-a-GCST006867

Osteonecrosis

136.87

106

0.023376

0.000599

0.011389

0.958181

T2DM|ebi-a-GCST005413

Osteonecrosis

58.29

53

0.287162

0.000591

0.015444

0.969617

T2DM|GCST90006934

Osteonecrosis

35.63

39

0.624461

0.025642

0.018571

0.175415

T2DM|GCST90026414

Osteonecrosis

2.29

8

0.970642

 − 0.004402

0.033005

0.897648

T2DM|GCST90026417

Osteonecrosis

6.32

19

0.997049

0.046037

0.037987

0.241215

T2DM|GCST90043636

Osteonecrosis

9.27

10

0.506353

0.089844

0.069779

0.230023

Osteonecrosis

T2DM|ebi-a-GCST006867

10.38

5

0.064952

0.016064

0.018001

0.422631

Osteonecrosis

T2DM|ebi-a-GCST005413

8.00

13

0.843280

0.000131

0.009208

0.988823

Osteonecrosis

T2DM|GCST90006934

16.01

14

0.312732

 − 0.003945

0.013111

0.768242

Osteonecrosis

T2DM|GCST90026414

7.52

6

0.274852

 − 0.109841

0.201825

0.609660

Osteonecrosis

T2DM|GCST90026417

16.78

6

0.010129

 − 0.036664

0.190863

0.855224

Osteonecrosis

T2DM|GCST90043636

6.83

13

0.910530

 − 0.013187

0.090997

0.887184

T1DM|ebi-a-GCST005536

Osteonecrosis

67.64

62

0.290772

0.014023

0.010387

0.181985

T1DM|ebi-a-GCST010681

Osteonecrosis

134.07

141

0.647964

 − 0.002389

0.00733

0.745224

T1DM|ebi-a-GCST90000529

Osteonecrosis

88.79

82

0.285089

 − 0.000662

0.006769

0.922240

T1DM|ebi-a-GCST90014023

Osteonecrosis

160.31

155

0.368407

0.005564

0.005403

0.304699

T1DM|ebi-a-GCST90018925

Osteonecrosis

46.82

59

0.874183

 − 0.00208

0.010029

0.836413

Osteonecrosis

T1DM|ebi-a-GCST005536

None

None

None

None

None

None

Osteonecrosis

T1DM|ebi-a-GCST010681

20.91

14

0.103741

0.020082

0.015770

0.225186

Osteonecrosis

T1DM|ebi-a-GCST90000529

21.08

11

0.032524

0.061855

0.024800

0.031768

Osteonecrosis

T1DM|ebi-a-GCST90014023

32.49

14

0.003405

0.015989

0.012557

0.225222

Osteonecrosis

T1DM|ebi-a-GCST90018925

8.10

14

0.883871

0.002244

0.010742

0.837731