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Table 3 Multivariable logistic regression analysis of covariates associated with various bone diseases in patients with hemophilia

From: Skeletal complications in patients with hemophilia: a single-center experience

Variables

Skeletal complications

Bone disease

Osteoporosis

Target joint

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Treatment*

2.54 (0.64–10.02)

0.182

0.61 (0.19–1.96)

0.408

1.93 (0.49–7.58)

0.341

Age at diagnosis

0.99 (0.95–1.04)

0.944

1.06 (1.00–1.13)

0.051

1.02 (0.95–1.10)

0.436

Annual bleeding rate**

2.10 (0.40–10.97)

0.378

0.69 (0.21–2.22)

0.540

2.00 (0.50–8.06)

0.325

Severity of hemophilia***

2.94 (0.68–12.68)

0.146

14.43 (1.60–129.6)

0.017

10.12 (0.93–109.3)

0.057

History of hepatitis C infection

3.18 (0.98–10.31)

0.053

0.94 (0.34–2.55)

0.909

3.67 (1.28–10.48)

0.015

  1. OR Odds ratio, CI Confidence interval
  2. *Prophylaxis vs. on-demand factor replacement therapy
  3. ** > 3 bleeding/year versus 1–3 bleeding/year
  4. ***Severe hemophilia versus non-severe hemophilia