Table 2 Comparison of factors affecting skeletal manifestations in patients with hemophilia

Severity of disease

Severe

6 (7.5)

16 (20)

35 (43.8)

37 (46.3)

53 (66.3)

68 (85)

Non-severe

0 (0)

0 (0)

4 (20)

2 (10)

11 (55)

12 (60)

P value

0.59

0.03

0.07

 < 0.001

0.43

0.02

Type of hemophilia

A

6 (6.7)

14 (15.6)

35 (38.9)

39 (43.3)

59 (65.6)

74 (82.2)

B

0 (0)

2 (20)

4 (40)

0 (0)

5 (50)

6 (60)

P value

 > 0.99

0.66

 > 0.99

 < 0.001

0.48

0.11

Treatment

On-demand

6 (7.3)

11 (13.4)

30 (36.6)

35 (42.7)

55 (67.1)

68 (82.9)

prophylaxis

0 (0)

5 (27.8)

9 (50)

4 (22.2)

9 (50)

12 (66.7)

P value

0.588

0.158

0.301

0.120

0.186

0.189

History of hepatitis C infection

Yes

4 (5.4)

13 (17.6)

29 (39.2)

21 (28.4)

45 (60.8)

56 (75.7)

No

2 (7.7)

3 (11.5)

10 (38.5)

18 (69.2)

19 (73.1)

24 (92.3)

P value

0.649

0.552

 > 0.999

 < 0.001

0.344

0.089

Active hepatitis C infection

Yes

6 (7)

13 (15.1)

36 (41.9)

29 (33.7)

55 (64)

68 (79.1)

No

0 (0)

3 (21.4)

3 (21.4)

10 (71.4)

9 (64.3)

12 (85.7)

P value

0.591

0.693

0.237

0.015

 > 0.999

0.730

Annual bleeding rate

1–3

2 (8.7)

1 (4.3)

10 (43.5)

4 (17.4)

12 (52.2)

13 (56.5)

4–6

1 (4.2)

4 (16.7)

10 (41.7)

8 (33.3)

17 (70.8)

22 (91.7)

 > 6

3 (5.7)

11 (20.8)

19 (35.8)

27 (50.9)

35 (66)

45 (84.9)

P value

0.740

0.221

0.795

0.019

0.357

0.004

Annual bleeding rate

1–3

2 (8.7)

1 (4.3)

10 (43.5)

4 (17.4)

12 (52.2)

13 (56.5)

 > 3

4 (5.2)

15 (19.5)

29 (37.7)

35 (45.5)

52 (67.5)

67 (87)

P value

0.619

0.109

0.634

0.016

0.218

0.003