Fig. 7

Loss of SOX6 restrained the biological roles of miR-182 in BMSCs-Exos. A MM.1S and U266 cells were transfected with shNC or shSOX6 for 48 h, then the transfection efficiency was determined by qRT-PCR. MM.1S and U266 cells were treated with Exos^−control, Exos^{−antagomir NC}, Exos^{−miR−182 antagomir} and Exos^{−miR−182 antagomir} + shSOX6. B CCK-8 assay was utilized to evaluate MM.1S and U266 cell proliferation. C, D Transwell assay was performed to assess MM.1S and U266 cell C migration and D invasion. E CCK-8 assay was conducted to determine the IC50 of carfilzomib