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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: Exosomal miR-182 derived from bone marrow mesenchymal stem cells drives carfilzomib resistance of multiple myeloma cells by targeting SOX6

Fig. 2

miR-182 was greatly elevated in serum, BMSCs, and BMSCs-Exos from MM patients. A Serum miR-182 level in 12 cases of MM patients and 10 cases of BD patients was detected by qRT-PCR. B The expression of miR-182 in BMSCs from BD patients (n = 10) and MM patients (n = 12) was determined using qRT-PCR. C TEM analysis revealed the characteristic cup-shaped morphology of exosomes. D NTA analysis for measurement of exosome diameter. E Western blot analysis confirmed the presence of exosome-related markers including CD9, TSG101 and Calnexin. F The expression of miR-182 in exosomes derived from BD-BMSCs and MM-BMSCs was quantified using qRT-PCR

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X