Fig. 7

Proteins interacting with TM9SF2 and their enriched annotations. A The TM9SF2-centered STRING PPI network was enriched in functions “Fc gamma R-mediated phagocytosis,” “Regulation of actin cytoskeleton,” and “Endocytosis” as evidenced by the direct interaction with ARPC5 and BCAR1. B Proteins interacting with TM9SF2 (from BioGRID and HIPPIE databases) were enriched in functions of “activation of phospholipase C activity,” “endocytic vesicle,” and “phagocytic vesicles.” Enriched proteins are shown on the right side (pointed out by arrow), such as LPAR1 and RAB9A. C Knocking down TM9SF2 attenuates PLC-γ1 activation, as reflected by phosphorylation at its Y783 position. Data are representative of three independent experiments. *P < 0.05, **P < 0.01, two-sided t test