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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Identification of sulfur metabolism-related gene signature in osteoarthritis and TM9SF2’s sustenance effect on M2 macrophages' phagocytic activity

Fig. 5

Functional enrichment analysis and cell-specificity analysis. A Functionally enriched annotations from GO and KEGG analyses for the positively correlated genes of TM9SF2, suggesting potential functions, including antigen processing and presentation, lysosome, and phagosome. B Enriched KEGG annotations in high- or low-TM9SF2 expression samples after GSEA, suggesting potential functions, including lysosome, phagocytosis, and tyrosine metabolism. C The heatmap shows the correlation between the six genes and CIBERSORT-identified immune cells. There is a strong correlation between TM9SF1 and macrophages M1/M2. D The heatmap shows the correlation between the six genes and xCell-identified immune cells. There is a strong correlation between TM9SF1 and macrophage M2

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X